Effect of acid secretion blockade by omeprazole on the relative bioavailability of orally administered furazolidone in healthy volunteers.

abstract：:Residual effects of brotizolam (0.25 mg) and flurazepam (30 mg) were studied in healthy young adults. Performance and subjective assessments were observed from 7 to 8 h after overnight ingestion, and effects were compared with that of placebo. Visuo-motor coordination, visuo-mental processing time, visuo-motor reactio...

journal_title：British journal of clinical pharmacology

authors： Krueger H,Müller-Limmroth W

更新日期：1983-01-01 00:00:00

abstract：AIM:Omalizumab, a humanized IgG monoclonal antibody that binds to human immunoglobulin E (IgE), interrupts the allergic cascade in asthmatic patients. The aim was to compare simultaneously drug exposure and IgE biomarker responses in Japanese and White patient populations. METHODS:An instantaneous equilibrium drug-lig...

journal_title：British journal of clinical pharmacology

authors： Hayashi N,Tsukamoto Y,Sallas WM,Lowe PJ

更新日期：2007-05-01 00:00:00

abstract：:1 The potency of single doses of the aldosterone antagonist SC8109 relative to spironolactone in reversing the urinary electrolyte effects of fludrocortisone was examined in a double-blind, balanced, crossover study in six healthy volunteers. 2 For the urinary ratio log10 10Na/K, the relative potency of SC8109; spiron...

journal_title：British journal of clinical pharmacology

authors： McInnes GT,Harrison IR,Shelton JR,Perkins RM

更新日期：1981-11-01 00:00:00

abstract：AIMS:Continuous noninvasive blood pressure measurement by photoplethysmography has been regularly used in the experimental paradigm of angiotensin challenges, applied to the phase I clinical testing of angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists. This work aims to evaluate the performa...

journal_title：British journal of clinical pharmacology

authors： Buclin T,Buchwalder-Csajka C,Brunner HR,Biollaz J

更新日期：1999-10-01 00:00:00

abstract：AIMS:The CYP3A metric 4β-hydroxycholesterol (4βOHC) has been shown to correlate with tacrolimus steady-state apparent oral clearance (CL/F). Recently, pretransplant 4βOHC was shown not to predict tacrolimus CL/F after transplantation in a cohort of renal recipients (n = 79). The goal of the current study was determine ...

journal_title：British journal of clinical pharmacology

authors： Vanhove T,Hasan M,Annaert P,Oswald S,Kuypers DRJ

更新日期：2017-11-01 00:00:00

abstract：AIM:To investigate the effect of the P-glycoprotein inhibitor verapamil on the pharmacokinetics and pharmacodynamics of dabigatran etexilate (DE). METHOD:In this two part multiple crossover trial in 40 healthy subjects, DE 150 mg was given alone or with verapamil at different doses, duration of treatment (single vs. m...

journal_title：British journal of clinical pharmacology

authors： Härtter S,Sennewald R,Nehmiz G,Reilly P

更新日期：2013-04-01 00:00:00

abstract：AIMS:Data regarding the cardiac toxicity of cabozantinib lacks. The aim of our study was to assess the risk of cabozantinib-related cardiotoxicity in mRCC patients. METHODS:We performed a multicentre prospective study on mRCC patients treated with cabozantinib between October 2016 and November 2017. Transthoracic echo...

journal_title：British journal of clinical pharmacology

authors： Iacovelli R,Ciccarese C,Fornarini G,Massari F,Bimbatti D,Mosillo C,Rebuzzi SE,Di Nunno V,Grassi M,Fantinel E,Ardizzoni A,Tortora G

更新日期：2019-06-01 00:00:00

abstract：:High consumption of irrational fixed-dose combination (FDC) antibiotics may pose a threat of antimicrobial resistance. In India, ampicillin-cloxacillin was the second highest sold FDC antibiotic behind amoxicillin and clavulanic acid. There remain, however, questions about its efficacy and safety and a lack of regulat...

journal_title：British journal of clinical pharmacology

authors： Sayer B,Bortone B,Sharland M,Hsia Y

更新日期：2020-12-23 00:00:00

abstract：AIMS:To investigate the extent of dose-related off-label antibiotic paediatric prescribing in primary care and to identify any potential clinical effects, particularly of lower than recommended dose prescribing. METHODS:Assessment of antibiotic prescribing in 168 396 children aged 0-16 years for the year 1999-2000 fro...

journal_title：British journal of clinical pharmacology

authors： Ekins-Daukes S,McLay JS,Taylor MW,Simpson CR,Helms PJ

更新日期：2003-07-01 00:00:00

abstract：:The ability to recall details of current and prior drug therapy was evaluated in two studies employing a total of 94 patients with inflammatory polyarthritis. Ten per cent of patients were unable to completely recall the names of their current anti-inflammatory drugs and eighty-three per cent of patients to completely...

journal_title：British journal of clinical pharmacology

authors： Bellamy N,Grace E,Hanna B,Grant E,Tugwell P,Buchanan WW

更新日期：1984-06-01 00:00:00

abstract：AIMS:Ibandronate, a highly potent nitrogen-containing bisphosphonate, is the subject of an ongoing clinical development programme that aims to maximize the potential of simplified, less frequent oral and intravenous (i.v.) administration in osteoporosis. A modelling and simulation project was undertaken to characterize...

journal_title：British journal of clinical pharmacology

authors： Pillai G,Gieschke R,Goggin T,Jacqmin P,Schimmer RC,Steimer JL

更新日期：2004-12-01 00:00:00

abstract：:Infections due to resistant and multidrug resistant (MDR) organisms in haematology patients and haematopoietic stem cell transplant recipients are an increasingly complex problem of global concern. We outline the burden of illness and epidemiology of resistant organisms such as gram-negative pathogens, vancomycin-resi...

journal_title：British journal of clinical pharmacology

authors： Trubiano JA,Worth LJ,Thursky KA,Slavin MA

更新日期：2015-02-01 00:00:00

abstract：:1. In order to investigate accurately the biochemical effects of renin inhibition in man, we have developed a sensitive assay to measure angiotensin I (1-10) decapeptide. 2. Angiotensins were extracted from plasma by adsorption to phenylsilylsilica, and angiotensin I (Ang I) was quantified by radioimmunoassay. The det...

journal_title：British journal of clinical pharmacology

authors： Chauveau D,Guyenne TT,Cumin F,Chatellier G,Corvol P,Ménard J

更新日期：1992-03-01 00:00:00

abstract：:Twelve healthy volunteers were given orally placebo, itraconazole 100 mg or terbinafine 250 mg for 4 days. Midazolam 7.5 mg was ingested on the fourth day, after which plasma samples were collected and psychomotor performance tests carried out for 17 h. Itraconazole increased the area under the midazolam concentration...

journal_title：British journal of clinical pharmacology

authors： Ahonen J,Olkkola KT,Neuvonen PJ

更新日期：1995-09-01 00:00:00

abstract：:Serum free fractions of nifedipine, verapamil and some of their metabolites were measured in patients with ischaemic heart disease receiving single oral dose and chronic monotherapy and were compared with those obtained in vitro. The percentages of unbound nifedipine and verapamil in vitro (concentration range 50-200 ...

journal_title：British journal of clinical pharmacology

authors： Rumiantsev DO,Piotrovskii VK,Metelitsa VI,Slastnikova ID,Martsevich SYu,Kokurina EV

更新日期：1989-09-01 00:00:00

abstract：:Mirabegron is used for the treatment of symptoms associated with overactive bladder syndrome. It selectively stimulates the β3 -adrenoreceptor, which relaxes the detrusor muscle. This improves urine storage by distension of the bladder body. ...

journal_title：British journal of clinical pharmacology

authors： Goulooze SC,Cohen AF,Rissmann R

更新日期：2015-10-01 00:00:00

abstract：AIMS:The Transdermal Delivery System (TDS) is a liquid formulation that can be applied to the skin via a metered pump spray to deliver drug to the systemic circulation. The aims of this study were to assess the ability of the TDS preparation to deliver testosterone systemically, and to characterize the pharmacokinetic ...

journal_title：British journal of clinical pharmacology

authors： Chik Z,Johnston A,Tucker AT,Chew SL,Michaels L,Alam CA

更新日期：2006-03-01 00:00:00

abstract：:1. Confusion between the criteria for defining and diagnosing hypertension may have misled the search for the causes of hypertension. 2. The systematic approach of molecular genetics appears to offer the best chance of explaining hypertension, but the attractions are partly offset by the large numbers required, and un...

journal_title：British journal of clinical pharmacology

authors： Brown MJ

更新日期：1996-07-01 00:00:00

abstract：:The in vitro conversion of enalapril (MK421) to enalaprilic acid (MK422) in human autopsy tissues was examined. MK422 was measured by radioimmunoassay. Human cadaver liver was the only tissue in which significant conversion was demonstrated. The esterase activity was stable after post mortem. Autopsy liver tissues fro...

journal_title：British journal of clinical pharmacology

authors： Larmour I,Jackson B,Cubela R,Johnston CI

更新日期：1985-05-01 00:00:00

abstract：:1. The pharmacokinetics of streptokinase (SK) and anistreplase in conventional dosage regimens of 1.5 x 10(6) i.u. of SK infused over 60 min and 30 units of anistreplase over 5 min were studied in 24 consecutive patients presenting with acute myocardial infarction, using a functional bioassay to assess concentrations....

journal_title：British journal of clinical pharmacology

authors： Gemmill JD,Hogg KJ,Burns JM,Rae AP,Dunn FG,Fears R,Ferres H,Standring R,Greenwood H,Pierce D

更新日期：1991-02-01 00:00:00

abstract：:Increasing doses of a slow-release potassium supplement were given to nine hypertensive patients previously treated for at least 18 months with bendrofluazide 10 mg daily. Serum potassium and total body potassium (TBK) were measured after 2 months on each dose. No significant increase in serum potassium or TBK occurre...

journal_title：British journal of clinical pharmacology

authors： Wilkinson PR,Tait C,Hesp R,Raftery EB

更新日期：1982-08-01 00:00:00

abstract：AIMS:This study assessed the effects of the CYP3A inhibitors lopinavir/ritonavir (LPV/r) on the steady-state pharmacokinetics (PK) of aplaviroc (APL), a CYP3A4 substrate, in healthy subjects. METHODS:In Part 1, APL PK was determined in eight subjects who received a single oral 50-mg APL test dose with/without a single...

journal_title：British journal of clinical pharmacology

authors： Adkison KK,Shachoy-Clark A,Fang L,Lou Y,Otto VR,Berrey MM,Piscitelli SC

更新日期：2006-09-01 00:00:00

abstract：:To study the cardioselectivity of xamoterol, eight asthmatic patients took part in a randomised, double-blind, cross-over study, in which xamoterol or saline were infused, followed by four increasing doses of terbutaline i.v. Circulatory studies showed a significant increase of systolic blood pressure after xamoterol ...

journal_title：British journal of clinical pharmacology

authors： Löfdahl CG,Svedmyr N

更新日期：1984-10-01 00:00:00

abstract：:Mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that functions as a key regulator of cell growth, division and survival. Many haematologic malignancies exhibit elevated or aberrant mTOR activation, supporting the launch of numerous clinical trials aimed at evaluating the potential of single agent m...

journal_title：British journal of clinical pharmacology

authors： Lee JS,Vo TT,Fruman DA

更新日期：2016-11-01 00:00:00

abstract：:1 In a double-blind cross-over study, nine healthy male students received placebo, brompheniramine 12 mg), carbinoxamine (12 mg), clemastine (1 mg), and phenylpropanolamine (50 mg) orally. Three doses of each drug were given: at 08.30 h and 21.00 h on the first day of treatment and at 08.30 h on the following day. 2 P...

journal_title：British journal of clinical pharmacology

authors： Seppälä T,Nuotto E,Korttila K

更新日期：1981-08-01 00:00:00

abstract：AIMS:The aims of the present study were to evaluate the pharmacokinetic properties of dihydroartemisinin (DHA) and piperaquine, potential drug-drug interactions with concomitant primaquine treatment, and piperaquine effects on the electrocardiogram in healthy volunteers. METHODS:The population pharmacokinetic properti...

journal_title：British journal of clinical pharmacology

authors： Chotsiri P,Wattanakul T,Hoglund RM,Hanboonkunupakarn B,Pukrittayakamee S,Blessborn D,Jittamala P,White NJ,Day NPJ,Tarning J

更新日期：2017-12-01 00:00:00

abstract：:We have introduced to the course in pharmacology for medical students a simple human experiment that demonstrates the efficacy of activated charcoal in gastrointestinal drug binding. Sixty-one students were given 40 mg frusemide with water, water only, or 40 mg frusemide and 8 g activated charcoal with water either im...

journal_title：British journal of clinical pharmacology

authors： Kivistö KT,Neuvonen PJ

更新日期：1990-09-01 00:00:00

abstract：:Many studies from around the world show a correlation between increasing age and adverse drug reaction (ADR) rate, at least for some medical conditions. More than 80% of ADRs causing admission or occurring in hospital are type A (dose-related) in nature, and thus predictable from the known pharmacology of the drug and...

journal_title：British journal of clinical pharmacology

authors： Routledge PA,O'Mahony MS,Woodhouse KW

更新日期：2004-02-01 00:00:00

abstract：:1. The pharmacokinetics of recombinant erythropoietin, r-Epo, were evaluated after intravenous and subcutaneous administration of 50 u kg-1 to six healthy male volunteers. 2. The calculated mean values (+/- s.d.) for volume of distribution at steady state and clearance after an i.v. dose were 76 (+/- 33) ml kg-1 and 1...

journal_title：British journal of clinical pharmacology

authors： Salmonson T,Danielson BG,Wikström B

更新日期：1990-06-01 00:00:00

abstract：:In a double-blind, placebo-controlled, randomised, cross-over study of six healthy male subjects, the effect of nicardipine (5 mg h-1 for 3 h) on basal and stimulated pituitary hormone release was examined. Statistically significant differences between nicardipine and placebo were seen occasionally for follicle-stimul...

journal_title：British journal of clinical pharmacology

authors： Isles TE,Baty J,Dow RJ

更新日期：1985-01-01 00:00:00