Abstract:
AIMS:Several studies have reported the under-representation of women in clinical trials, thereby challenging the external validity of the benefit/risk assessments of launched drugs. Our aim was to determine the extent to which women have been included in clinical trials used for drug registration and to analyse the fraction of women participating in phases I, II and III. METHODS:We conducted cross-sectional, structured research into publicly available registration dossiers of Food and Drug Administration (FDA)-approved drugs that are prescribed frequently. Furthermore, we analysed compounds with high hepatic clearance and a known gender-related difference in drug response. In a sensitivity analysis, we compared figures with US disease prevalence data. RESULTS:For 38 of the initial 137 drugs (28%), sufficient data were reported and publicly available. For these drugs, 185 479 trial participants were included, of whom 47% were female and 44% were male; gender was not reported for 9% of participants. However, the number of female participants varied with the phase of the trial, with 22% females in phase I trials vs. 48% and 49%, respectively, in phase II and III trials. When compared with US disease prevalence data, 10 drugs (26%) had a greater than 20% difference between the proportion of females affected with the disease compared with representation in clinical trials. CONCLUSIONS:From these publicly available data, there was no evidence of any systematic under-representation of women in clinical trials.
journal_name
Br J Clin Pharmacoljournal_title
British journal of clinical pharmacologyauthors
Labots G,Jones A,de Visser SJ,Rissmann R,Burggraaf Jdoi
10.1111/bcp.13497subject
Has Abstractpub_date
2018-04-01 00:00:00pages
700-707issue
4eissn
0306-5251issn
1365-2125journal_volume
84pub_type
杂志文章abstract:AIMS:In order to evaluate a hypothesized protective effect of the use of HMG Co-A reductase inhibitors (statins) on the development of Type 2 diabetes, we conducted a nested case-control study based on data from the UK-based General Practice Research Database (GPRD). METHODS:We identified a population of adults 30-79 ...
journal_title:British journal of clinical pharmacology
pub_type: 杂志文章
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更新日期:2004-09-01 00:00:00
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journal_title:British journal of clinical pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-08-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-11-01 00:00:00
abstract::1. Dilevalol (R,R-labetalol) is a non-selective beta-adrenoceptor antagonist with beta 2-adrenoceptor agonist activity. Its effects after 1 month's administration on heart rate, blood pressure and muscle blood flow were studied in a double-blind crossover comparison with nifedipine in 16 hypertensive patients. 2. Dile...
journal_title:British journal of clinical pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-2125.1993.tb04192.x
更新日期:1993-06-01 00:00:00
abstract::Adopted guidelines reflect a harmonised European approach to a specific scientific issue and should reflect the most recent scientific knowledge. However, whilst EU regulations are mandatory for all member states and EU directives must be followed by national laws in line with the directive, EMA guidelines do not have...
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abstract::We have developed a method of monitoring plasma concentrations of antiepileptic drugs which uses salivary samples, and is suitable for home monitoring in children. To validate the method, paired plasma and saliva samples from 39 children aged between 2 and 15 years were assayed for carbamazepine and its active metabol...
journal_title:British journal of clinical pharmacology
pub_type: 杂志文章
doi:10.1111/j.1365-2125.1993.tb05700.x
更新日期:1993-03-01 00:00:00
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journal_title:British journal of clinical pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-2125.1987.tb03211.x
更新日期:1987-10-01 00:00:00
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doi:10.1111/j.1365-2125.1982.tb02010.x
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doi:10.1111/j.1365-2125.1981.tb01281.x
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journal_title:British journal of clinical pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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doi:10.1111/j.1365-2125.1982.tb01975.x
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journal_title:British journal of clinical pharmacology
pub_type: 杂志文章
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更新日期:1995-03-01 00:00:00
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doi:10.1111/j.1365-2125.2012.04216.x
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pub_type: 杂志文章
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journal_title:British journal of clinical pharmacology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:British journal of clinical pharmacology
pub_type: 杂志文章
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journal_title:British journal of clinical pharmacology
pub_type: 杂志文章
doi:10.1111/j.1365-2125.1986.tb05193.x
更新日期:1986-03-01 00:00:00
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journal_title:British journal of clinical pharmacology
pub_type: 杂志文章
doi:10.1111/j.1365-2125.1981.tb01266.x
更新日期:1981-10-01 00:00:00
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更新日期:2010-10-01 00:00:00
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journal_title:British journal of clinical pharmacology
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更新日期:1984-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:British journal of clinical pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:British journal of clinical pharmacology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-2125.1982.tb02028.x
更新日期:1982-10-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1989-12-01 00:00:00