A simple collection method for saliva in children: potential for home monitoring of carbamazepine therapy.

abstract：:1 Cimetidine has been reported to reduce serum calcium and parathyroid hormone (PTH) levels in primary hyperparathyroidism, but some studies have reported negative findings. 2 A double-blind, controlled trial of cimetidine in this condition was, therefore, conducted. Eight patients were given cimetidine and placebo fo...

journal_title：British journal of clinical pharmacology

authors： Fisken RA,Wilkinson R,Heath DA

更新日期：1982-11-01 00:00:00

abstract：AIMS:To characterize the pharmacokinetics (PK) of moxetumomab pasudotox, an anti-CD22 recombinant immunotoxin, in adults with relapsed or refractory hairy cell leukaemia, we examined data from a phase 1 study (Study 1001; n = 49) and from the pivotal clinical study (Study 1053; n = 74). METHODS:Data from both studies ...

journal_title：British journal of clinical pharmacology

authors： Kuruvilla D,Chia YL,Balic K,Yao NS,Kreitman RJ,Pastan I,Li X,Standifer N,Liang M,Tseng CM,Faggioni R,Roskos L

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Benzodiazepines and "Z drugs" are often prescribed in residents of nursing homes (NH) despite their well-known deleterious effects. We aimed to investigate if a general intervention on quality of care led to discontinuation of benzodiazepine, and to examine which NH-related factors were associated in change ...

journal_title：British journal of clinical pharmacology

authors： de Souto Barreto P,Lapeyre-Mestre M,Cestac P,Vellas B,Rolland Y

更新日期：2016-04-01 00:00:00

abstract：AIMS:To determine whether topical ocular chloramphenicol increases the risk of aplastic anaemia and to estimate the magnitude of this risk, if any. METHODS:Population-based prospective case-control surveillance of aplastic anaemia in a community of 4.2 million inhabitants from 1980 to 1995 (67.2 million person-years) ...

journal_title：British journal of clinical pharmacology

authors： Laporte JR,Vidal X,Ballarín E,Ibáñez L

更新日期：1998-08-01 00:00:00

abstract：:Analysis of human horizontal saccadic eye movements can provide measurements of central nervous system depression and stimulation. Effects on saccadic eye movements have been observed in normal volunteers with barbiturates, benzodiazepines, opiates and related compounds, carbamazepine, amphetamine and ethanol. A suite...

journal_title：British journal of clinical pharmacology

authors： Griffiths AN,Marshall RW,Richens A

更新日期：1984-01-01 00:00:00

abstract：:1. The pharmacokinetics and pharmacodynamics of a single dose of trandolapril, an angiotensin converting enzyme (ACE) inhibitor with an active metabolite, trandolaprilat, which is in part further metabolised prior to renal elimination, were evaluated in 31 subjects with a wide range of renal function (creatinine clear...

journal_title：British journal of clinical pharmacology

authors： Bevan EG,McInnes GT,Aldigier JC,Conte JJ,Grunfeld JP,Harper SJ,Meyer BH,Pauly N,Wilkinson R

更新日期：1993-02-01 00:00:00

abstract：:Calcium subserves a ubiquitous role in the organisation of cell function. Ca2+ channels which control influx may be modified in disease states. Animal models of cerebral ischaemia do present some problems when investigating potential therapies involving Ca2+ channels. However, it is important not to be too rigid in se...

journal_title：British journal of clinical pharmacology

authors： Alps BJ

更新日期：1992-09-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the effect of policosanol on the susceptibility of LDL-C to in vitro lipid peroxidation in human healthy volunteers. METHODS:The effect of policosanol (5 and 10 mg day(-1) on LDL-C oxidation was studied in a double-blind, randomized, placebo-controlled trial conducted in 6...

journal_title：British journal of clinical pharmacology

authors： Menéndez R,Más R,Amor AM,González RM,Fernández JC,Rodeiro I,Zayas M,Jiménez S

更新日期：2000-09-01 00:00:00

abstract：:1. A bicycle exercise test was used to investigate functional capability and haemodynamics in 30 patients with heart failure (13 NYHA Class II, 17 Class III), before and after i.v. xamoterol (Corwin, Carwin, Corwil, Xamtol, ICI 118,587) 0.2 mg kg-1. 2. Resting heart rate fell from 78 to 74 beats min-1 (P less than 0.0...

journal_title：British journal of clinical pharmacology

authors： Virk SJ,Davies MK

更新日期：1989-01-01 00:00:00

abstract：AIMS:To evaluate putative associations between drugs and dilated cardiomyopathy. METHODS:We used the case/noncase method in the French PharmacoVigilance Database (FPVD). Cases were all the observations with dilated cardiomyopathy registered into the FPVD between 1 January 1990 and 30 June 2007. Noncases were all other...

journal_title：British journal of clinical pharmacology

authors： Montastruc G,Favreliere S,Sommet A,Pathak A,Lapeyre-Mestre M,Perault-Pochat MC,Montastruc JL,French Association of Regional PharmacoVigilance Centres.

更新日期：2010-03-01 00:00:00

abstract：:It is recognised that randomised controlled trials are not feasible for capturing rare adverse events. There is an increasing trend towards observational research methodologies using large population-based health databases. These databases offer more scope for adequate sample sizes, allowing for comprehensive patient ...

journal_title：British journal of clinical pharmacology

authors： Chan EW,Liu KQ,Chui CS,Sing CW,Wong LY,Wong IC

更新日期：2015-10-01 00:00:00

abstract：AIMS:The aim of this study was to compare the effects of aspirin on platelet function as measured by the 'classical' template bleeding time with a new ex vivo method measuring closure times using the PFA-100 machine. Platelet aggregation in response to arachidonic acid was also measured ex vivo. METHODS:The trial was ...

journal_title：British journal of clinical pharmacology

authors： Marshall PW,Williams AJ,Dixon RM,Growcott JW,Warburton S,Armstrong J,Moores J

更新日期：1997-08-01 00:00:00

abstract：:1. The objective of this study was to investigate the efficacy of home-medicated non-steroidal anti-inflammatory (NSAID) analgesics, using an electronic patient diary. Single doses of ketoprofen 25 mg and ketoprofen 50 mg were compared with ibuprofen 200 mg and placebo in the treatment of a single occasion of episodic...

journal_title：British journal of clinical pharmacology

authors： van Gerven JM,Schoemaker RC,Jacobs LD,Reints A,Ouwersloot-van der Meij MJ,Hoedemaker HG,Cohen AF

更新日期：1996-10-01 00:00:00

abstract：:The acute peripheral vascular and diuretic effects of intravenous frusemide 10 mg and 20 mg were compared with those of bumetanide 250 micrograms and 500 micrograms in a group of 10 salt depleted volunteers. Significant reductions in forearm blood flow (FBF) were observed after frusemide 10 mg (-0.77 ml 100 ml-1 min-1...

journal_title：British journal of clinical pharmacology

authors： Johnston GD,Nicholls DP,Kondowe GB,Finch MB

更新日期：1986-04-01 00:00:00

abstract：:1 A study was carried out to investigate the possible contribution of prostaglandins in captopril-induced hypotension. 2 Healthy volunteers and patients with essential hypertension were given single oral doses of 25 mg and 50 mg captopril respectively before and after cyclo-oxygenase inhibition with indomethacin. 3 Th...

journal_title：British journal of clinical pharmacology

authors： Silberbauer K,Stanek B,Templ H

更新日期：1982-01-01 00:00:00

abstract：AIMS:Korean red ginseng (unskinned Panax ginseng before it is steamed or otherwise heated and subsequently dried) is one of the most widely used herbal remedies. This systematic review evaluates the current evidence for the effectiveness of red ginseng for treating erectile dysfunction. METHODS:Systematic searches wer...

journal_title：British journal of clinical pharmacology

authors： Jang DJ,Lee MS,Shin BC,Lee YC,Ernst E

更新日期：2008-10-01 00:00:00

abstract：:1 The anti-hypertensive effect of labetalol given twice or three times daily was evaluated in ambulant subjects with essential hypertension by recording blood pressure directly for 24 h before and after 15 d of labetalol administration (daily dose 600-1800 mg). 2 Labetalol reduced 24 h systolic and diastolic blood pre...

journal_title：British journal of clinical pharmacology

authors： Mancia G,Pomidossi G,Parati G,Bertinieri G,Grassi G,Navone F,Ferrari A,Gregorini L,Zanchetti A

更新日期：1982-06-01 00:00:00

abstract：:The oral delivery of peptides and proteins has been hampered by an array of obstacles. However, several promising novel oral delivery systems have been developed. This paper reviews the most advanced oral formulation technologies, and highlights key lessons and implications from studies undertaken to date with these o...

journal_title：British journal of clinical pharmacology

authors： Karsdal MA,Riis BJ,Mehta N,Stern W,Arbit E,Christiansen C,Henriksen K

更新日期：2015-05-01 00:00:00

abstract：:1. The purpose of this study was to evaluate possible changes in brain morphology and evoked potentials associated with daily administration of 300 mg kg-1 vigabatrin in dogs. 2. Somatosensory evoked potentials (SEP) and auditory evoked potentials (AEP) were recorded at baseline and weekly for 12 weeks of treatment an...

journal_title：British journal of clinical pharmacology

authors： Arezzo JC,Schroeder CE,Litwak MS,Steward DL

更新日期：1989-01-01 00:00:00

abstract：AIMS:To investigate whether the drug-drug interaction between fexofenadine and ketoconazole is localized to efflux transport proteins of the small intestine, and to determine and classify the effective jejunal permeability (Peff) of fexofenadine according to the Biopharmaceutics Classification System (BCS). METHODS:Tw...

journal_title：British journal of clinical pharmacology

authors： Tannergren C,Knutson T,Knutson L,Lennernäs H

更新日期：2003-02-01 00:00:00

abstract：:The pharmacokinetics of piretanide, a new loop diuretic, were studied in four patients with GFR 4.7-14.8 ml/min. An oral dose of piretanide 18 mg was given at 08.00 h in two patients and at 08.00 h and 14.00 h in two. Blood samples were drawn after 0.5, 1, 2, 3, 4, 6, 8, 10, 12 and 24 h. Serum concentrations of pireta...

journal_title：British journal of clinical pharmacology

authors： Berg KJ,Walstad RA,Bergh K

更新日期：1983-03-01 00:00:00

abstract：AIMS:The inhaled allergen challenge model has been used previously to investigate the effects of novel anti-inflammatory drugs in inhaled corticosteroid (ICS)-naïve asthmatics. The aim of this study was to characterize high- and low-dose allergen challenges in asthmatic patients using ICS. METHODS:Twenty-eight asthmat...

journal_title：British journal of clinical pharmacology

authors： Lee WY,Southworth T,Booth S,Singh D

更新日期：2015-03-01 00:00:00

abstract：AIMS:The role of CYP pharmacogenetics in the bioactivation of cyclophosphamide is still controversial. Recent clinical studies have suggested a role for either CYP2C19 or CYP2B6. The aim of this study was to clarify the role of these pharmacogenes. METHODS:We used a combined in vitro-in vivo approach to determine the ...

journal_title：British journal of clinical pharmacology

authors： Helsby NA,Hui CY,Goldthorpe MA,Coller JK,Soh MC,Gow PJ,De Zoysa JZ,Tingle MD

更新日期：2010-12-01 00:00:00

abstract：:1 Study I evaluated the absorption of oxprenolol in the ileum, compared to jejunum, in healthy volunteers by an intestinal perfusion technique. Around 80 mg of drug were delivered as a saline solution directly in the small bowel. 2 Samples taken 30 cm distally to the site of perfusion showed that 63% of perfused oxpre...

journal_title：British journal of clinical pharmacology

authors： Godbillon J,Vidon N,Palma R,Pfeiffer A,Franchisseur C,Bovet M,Gosset G,Bernier JJ,Hirtz J

更新日期：1987-09-01 00:00:00

abstract：:The pharmacokinetics of antipyrine were studied in 12 healthy volunteers and 10 patients of Kenya African origin with Hodgkin's lymphoma. The half-life of antipyrine was 12.2 +/- 1.3 h (mean + s.d.), while the apparent volume of distribution (V) was 0.67 +/- 0.11 l kg-1 (mean +/- s.d.) and the total body clearance was...

journal_title：British journal of clinical pharmacology

authors： Juma FD

更新日期：1987-12-01 00:00:00

abstract：:1. The cardiovascular responses of mianserin hydrochloride and tricyclic antidepressant drugs were investigated using non-invasive methods of cardiac investigation. A study of the interaction of mianserin and antihypertensive drug therapy is reported. 2. In six normal volunteers, mianserin hydrochloride 20 mg was show...

journal_title：British journal of clinical pharmacology

authors： Burgess CD,Turner P,Wadsworth J

更新日期：1978-01-01 00:00:00

abstract：:1 beta-adrenoceptor blockade with metoprolol provoked, both at rest and during exercise, a decrease of 'active' renin and angiotensin II together with an increase of 'inactive' renin and unchanged 'total' renin. The significant exercise-provoked increases in angiotensin II, plasma renin activity and 'active', 'inactiv...

journal_title：British journal of clinical pharmacology

authors： Lijnen PJ,Amery AK,Fagard RH,Reybrouck TM,Moerman EJ,De Schaepdryver AF

更新日期：1979-02-01 00:00:00

abstract：:Small GTPases of the Rho family and their down-stream effectors Rho associated kinases (ROCKs) are the molecules that converge a spectrum of pathophysiological signals triggered by the diabetic milieu and represent promising molecular targets for nephroprotective treatment in diabetes. The review discusses recent stud...

journal_title：British journal of clinical pharmacology

authors： Komers R

更新日期：2013-10-01 00:00:00

abstract：:Activation of mu opioid receptors on sensory nerves in the lung represents an attractive mechanism for reducing cough and reflex bronchoconstriction. We have examined the effect of the peptide 443C81, a peripherally acting mu opioid agonist, on the cough and reflex increase in respiratory resistance (Rrs) produced by ...

journal_title：British journal of clinical pharmacology

authors： Choudry NB,Gray SJ,Posner J,Fuller RW

更新日期：1991-11-01 00:00:00

abstract：:To study the cardioselectivity of xamoterol, eight asthmatic patients took part in a randomised, double-blind, cross-over study, in which xamoterol or saline were infused, followed by four increasing doses of terbutaline i.v. Circulatory studies showed a significant increase of systolic blood pressure after xamoterol ...

journal_title：British journal of clinical pharmacology

authors： Löfdahl CG,Svedmyr N

更新日期：1984-10-01 00:00:00