Lessons learned from the clinical development of oral peptides.

abstract：:Simultaneous cerebrospinal fluid (CSF), total and free plasma valproic acid (VPA) concentrations were measured in 17 patients receiving two weight-adjusted VPA doses as seizure prophylaxis prior to diagnostic myelography or cisternography. Free drug concentrations were similar when measured by equilibrium dialysis (ED...

journal_title：British journal of clinical pharmacology

authors： Rapeport WG,Mendelow AD,French G,MacPherson P,Teasdale E,Agnew E,Thompson GG,Brodie MJ

更新日期：1983-10-01 00:00:00

abstract：:Voriconazole is an antifungal metabolised by CYP2C19 enzyme, which can be inhibited by proton-pump inhibitors (PPIs). A prospective observational study was carried out to determine the influence of PPIs on voriconazole pharmacokinetic. The 78 patients included were divided into 4 groups: omeprazole (n = 32), pantopraz...

journal_title：British journal of clinical pharmacology

authors： Blanco Dorado S,Maroñas Amigo O,Latorre-Pellicer A,Rodríguez Jato MT,López-Vizcaíno A,Gómez Márquez A,Bardán García B,Belles Medall D,Barbeito Castiñeiras G,Pérez Del Molino Bernal ML,Campos-Toimil M,Otero Espinar F,Blanco Hortas

更新日期：2020-08-01 00:00:00

abstract：AIMS:There is a trend for more flexibility in timing of evidence generation in relation to marketing authorization, including the option to complete phase III trials after authorization or not at all. This paper investigated the relation between phase II and III clinical trial efficacy in oncology. METHODS:All oncolog...

journal_title：British journal of clinical pharmacology

authors： Vreman RA,Belitser SV,Mota ATM,Hövels AM,Goettsch WG,Roes KCB,Leufkens HGM,Mantel-Teeuwisse AK

更新日期：2020-07-01 00:00:00

abstract：AIMS:The study was carried out in order to assess the effects of gender and the use of oral contraceptives (OCs) on CYP2D6 and CYP2C19 activities in healthy volunteers. METHODS:Six hundred and eleven Caucasian volunteers (330 males and 281 females; age range 18-49 years) were phenotyped with respect to CYP2D6 and CYP2...

journal_title：British journal of clinical pharmacology

authors： Hägg S,Spigset O,Dahlqvist R

更新日期：2001-02-01 00:00:00

abstract：:A double-blind, placebo-controlled, cross-over trial of quinine in leg cramps occurring at rest was conducted in 22 elderly cramp sufferers. Despite demonstration of impaired quinine elimination in the elderly, prescription of the traditional dose of 300 mg quinine bisulphate at night failed to produce a significant (...

journal_title：British journal of clinical pharmacology

authors： Warburton A,Royston JP,O'Neill CJ,Nicholson PW,Jee RD,Denham MJ,Dobbs SM,Dobbs RJ

更新日期：1987-04-01 00:00:00

abstract：AIM:To use non-linear mixed effects modelling and simulation techniques to predict whether PF-04878691, a toll-like receptor 7 (TLR7) agonist, would produce sufficient antiviral efficacy while maintaining an acceptable side effect profile in a 'proof of concept' (POC) study in chronic hepatitis C (HCV) patients. METHO...

journal_title：British journal of clinical pharmacology

authors： Jones HM,Chan PL,van der Graaf PH,Webster R

更新日期：2012-01-01 00:00:00

abstract：:1 The effect of an intravenous bolus of labetalol (0.6--1.6 mg/kg body weight) on central and peripheral haemodynamics was studied in nine subjects with essential hypertension and in eleven subjects with chronic renal disease and hypertension. 2 The BP reduction amounting to 20/13 mmHg was entirely due to the lowering...

journal_title：British journal of clinical pharmacology

authors： Bahlmann J,Brod J,Hubrich W,Cachovan M,Pretschner P

更新日期：1979-01-01 00:00:00

abstract：:Oxycodone chloride (0.07 mg kg-1) was given by intravenous bolus to nine young adult surgical patients on the first postoperative day. Plasma was sampled for up to 12 h. Mean values of t1/2z, CL and Vss were 222 min, 0.78 l min-1 and 2.60 l kg-1, respectively. The concentrations of the metabolite noroxycodone was also...

journal_title：British journal of clinical pharmacology

authors： Pöyhiä R,Olkkola KT,Seppälä T,Kalso E

更新日期：1991-10-01 00:00:00

abstract：AIMS:To compare the effects of nabumetone and meloxicam, two cyclo-oxygenase-2 (COX-2) preferential nonsteroidal anti-inflammatory drugs (NSAIDs), on platelet COX-1 activity and platelet function. METHODS:Twelve healthy volunteers (3 male, 9 female, median age 22 years) participated in an open, randomized, cross-over ...

journal_title：British journal of clinical pharmacology

authors： van Kraaij DJ,Hovestad-Witterland AH,de Metz M,Vollaard EJ

更新日期：2002-06-01 00:00:00

abstract：:The antiarrhythmic effects of verapamil were observed before it was appreciated that it was a calcium ion-antagonist. Intravenous verapamil is highly effective in the termination of paroxysmal reciprocating atrioventricular tachycardia, whether associated with preexcitation or involving the atrioventricular node alone...

journal_title：British journal of clinical pharmacology

authors： Krikler DM

更新日期：1986-01-01 00:00:00

abstract：AIMS:Establishing a pharmacological challenge model could yield an important tool to understand the complex role of the nicotinic cholinergic system in cognition and to develop novel compounds acting on the nicotinic acetylcholine receptor. METHODS:This randomized, double-blind, double-dummy, placebo-controlled, four-...

journal_title：British journal of clinical pharmacology

authors： Alvarez-Jimenez R,Hart EP,Prins S,de Kam M,van Gerven JMA,Cohen AF,Groeneveld GJ

更新日期：2018-05-01 00:00:00

abstract：:1. The potential interaction between selective beta 1-adrenoceptor blockers and sulphonylureas or biguanides was studied by comparing the beta 1-adrenoceptor antagonist betaxolol with placebo in 12 normal subjects taking glibenclamide or metformin in a single-blind crossover group study. 2. After a 4 day run-in period...

journal_title：British journal of clinical pharmacology

authors： Sinclair AJ,Davies IB,Warrington SJ

更新日期：1990-11-01 00:00:00

abstract：AIMS:It has been shown that the cellular uptake and cytotoxicity of anthracyclines decrease with increasing cell density in vitro, an event termed 'the inocculum effect'. It is not known whether such an effect occurs in vivo. In this study the relationships between white blood cell (WBC) count, plasma and cellular conc...

journal_title：British journal of clinical pharmacology

authors： Bogason A,Quartino AL,Lafolie P,Masquelier M,Karlsson MO,Paul C,Gruber A,Vitols S

更新日期：2011-04-01 00:00:00

abstract：:1 Soluble aspirin, 600 mg and 1200 mg, and placebo were compared in a double-blind, cross-over study in 12 patients with post-operative pain following removal of impacted lower third molars. 2 Significant analgesia after 600 mg aspirin occurred only at 45 min after administration, whereas significant analgesia after 1...

journal_title：British journal of clinical pharmacology

authors： Seymour RA,Rawlins MD

更新日期：1982-06-01 00:00:00

abstract：:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Reflux oesophagitis is a common clinical disorder associated with significant morbidity. Proton pump inhibitors are the current pharmacotherapy of choice, but not all treated patients achieve symptom relief. Little is known about the efficacy of mosapride, a prokinetic agent wh...

journal_title：British journal of clinical pharmacology

authors： Hsu YC,Yang TH,Hsu WL,Wu HT,Cheng YC,Chiang MF,Wang CS,Lin HJ

更新日期：2010-08-01 00:00:00

abstract：:In a dog model of partial myocardial ischaemia, superimposed ST segment elevations in epicardial ECGs were inhibited by nicardipine over a cumulative i.v. dose range of 1-20 micrograms kg-1. Over the cumulative i.v. dose range of 0.5-166.5 micrograms kg-1, nicardipine had little overall effect on gross cardiac conduct...

journal_title：British journal of clinical pharmacology

authors： Alps BJ,Calder C,Wilson A

更新日期：1985-01-01 00:00:00

abstract：AIMS:BG00010 is a protein in the glial cell line-derived neurotrophic factor (GDNF) family. It is a selective ligand for the GDNF family receptor alpha-3 (GFRα3) co-receptor that normalizes cellular changes resulting from damage or disease, and potentially alleviates neuropathic pain. The main objectives of this study ...

journal_title：British journal of clinical pharmacology

authors： Okkerse P,Hay JL,Versage E,Tang Y,Galluppi G,Ravina B,Verma A,Williams L,Aycardi E,Groeneveld GJ

更新日期：2016-07-01 00:00:00

abstract：:1. The pharmacokinetics of physostigmine were investigated in a three-way cross-over design in six healthy, male volunteers comparing a physostigmine transdermal system (PTS), an oral solution and an i.v. infusion. 2. A single application of the patch over 24 h produced detectable plasma drug concentrations after a me...

journal_title：British journal of clinical pharmacology

authors： Walter K,Müller M,Barkworth MF,Nieciecki AV,Stanislaus F

更新日期：1995-01-01 00:00:00

abstract：:1. Mizolastine, a new benzimidazole derivative with potent selective, non-sedative H1-histamine antagonist activity was compared with terfenadine, cetirizine and loratadine using the histamine-induced wheal and flare model in healthy volunteers. 2. Study design was a five way double-blind crossover design using a sing...

journal_title：British journal of clinical pharmacology

authors： Rosenzweig P,Caplain H,Chaufour S,Ulliac N,Cabanis MJ,Thebault JJ

更新日期：1995-11-01 00:00:00

abstract：:1. Potential therapies for ischaemic stroke include agents to reduce oedema, to improve cerebral perfusion, to reduce excitotoxic damage, to minimise free-radical induced injury and to reduce complications such as deep venous thrombosis. 2. Of the anti-oedema drugs, steroids are ineffective and possibly dangerous; int...

journal_title：British journal of clinical pharmacology

authors： Lees KR

更新日期：1992-12-01 00:00:00

abstract：:1 Roth et al. (1972) have proposed that within the affective disorders there are two distinct syndromes--anxiety and depression--differentiated by the relative predominance of these symptoms, the presence or absence of premorbid maladaptive traits, and the natural outcome of the disorder. 2 Goldberg (1982) on the othe...

journal_title：British journal of clinical pharmacology

authors： Russell GF,De Silva P

更新日期：1983-01-01 00:00:00

abstract：AIMS:Generic products can be regarded as therapeutically equivalent and switchable with the reference product. However, switchability between generics is unknown, as direct comparisons between generics are not performed. The aim of this study was to investigate the bioequivalence between generic clopidogrel products by...

journal_title：British journal of clinical pharmacology

authors： Pejčić Z,Vučićević K,García-Arieta A,Miljković B

更新日期：2019-09-01 00:00:00

abstract：AIMS:Angiotensin receptor blockers (ARBs) are renoprotective and targeted to blood pressure. However, ARBs have multiple other (off-target) effects which may affect renal outcome. It is unknown whether on-target and off-target effects are congruent within individuals. If not, this variation in short term effects may ha...

journal_title：British journal of clinical pharmacology

authors： Schievink B,de Zeeuw D,Parving HH,Rossing P,Lambers Heerspink HJ

更新日期：2015-10-01 00:00:00

abstract：:To study the cardioselectivity of xamoterol, eight asthmatic patients took part in a randomised, double-blind, cross-over study, in which xamoterol or saline were infused, followed by four increasing doses of terbutaline i.v. Circulatory studies showed a significant increase of systolic blood pressure after xamoterol ...

journal_title：British journal of clinical pharmacology

authors： Löfdahl CG,Svedmyr N

更新日期：1984-10-01 00:00:00

abstract：:1. Using human mononuclear leucocytes as target cells, we have investigated the bioactivation of dapsone (DDS) to a cytotoxic metabolite in the presence of microsomes from nine human livers. Values for NADPH dependent toxicity ranged from 8.8-27% (15.8 +/- 5.9%) and were similar to those for microsomes from control mi...

journal_title：British journal of clinical pharmacology

authors： Coleman MD,Breckenridge AM,Park BK

更新日期：1989-10-01 00:00:00

abstract：AIMS:To develop and evaluate a feasible, authentic pharmacist-led prescribing feedback intervention for doctors-in-training, to reduce prescribing errors. METHODS:This was a mixed methods study. Sixteen postgraduate doctors-in training, rotating though the surgical assessment unit of 1 UK hospital, were filmed taking ...

journal_title：British journal of clinical pharmacology

authors： Parker H,Farrell O,Bethune R,Hodgetts A,Mattick K

更新日期：2019-10-01 00:00:00

abstract：AIMS:Endothelins (ETs) may play a role in the pathogenesis of a variety of cardiovascular diseases. The present study was designed to investigate the pharmacokinetic and pharmacodynamic effects of the orally active ETA selective receptor antagonist ABT-627 in healthy humans. METHODS:Healthy volunteers were included in...

journal_title：British journal of clinical pharmacology

authors： Verhaar MC,Grahn AY,Van Weerdt AW,Honing ML,Morrison PJ,Yang YP,Padley RJ,Rabelink TJ

更新日期：2000-06-01 00:00:00

abstract：:1 This study was designed to compare in a double-blind randomized crossover trial, atenolol, labetalol, metoprolol and pindolol. Considerable differences in dose (atenolol 138 +/- 13 mg daily; labetalol 308 +/- 34 mg daily; metoprolol 234 +/- 22 mg daily; and pindolol 24 +/-2 mg daily were required to produce similar ...

journal_title：British journal of clinical pharmacology

authors： McNeil JJ,Louis WJ

更新日期：1979-04-01 00:00:00

abstract：:1. We compare the sensitivity and specificity of chosen outcome criteria in a placebo-controlled, randomised cross-over study of the efficacy of maintenance therapy with the levodopa/carbidopa combination (Sinemet Plus) alone. Patients were characterised by having idiopathic Parkinsonism with no overt fluctuations in ...

journal_title：British journal of clinical pharmacology

authors： Bowes SG,Clark PK,Charlett A,O'Neill CJ,Leeman AL,Weller C,Nicholson PW,Deshmukh AA,Dobbs SM,Dobbs RJ

更新日期：1991-03-01 00:00:00

abstract：:1 Prolactin levels in response to sulpiride were studied in healthy volunteers. 2 Oral doses of 1 mg-50 mg sulpiride or placebo were given. 3 A 3 mg sulpiride dose produced similar levels to those achieved with both 10 mg and 50 mg. 4 Circadian effects were studied showing no significant differences in the prolactin r...

journal_title：British journal of clinical pharmacology

authors： McMurdo ME,Howie PW,Lewis M,Marnie M,McEwen J,McNeilly AS

更新日期：1987-08-01 00:00:00