Betaxolol and glucose-insulin relationships: studies in normal subjects taking glibenclamide or metformin.

abstract：:The renal response to a challenge of maximal water diuresis has been studied in seven subjects pretreated over 48 h with either placebo, probenecid, indomethacin or piroxicam. Probenecid did not alter the excretion of water and sodium chloride when compared with placebo responses, but increased both phosphate and urat...

journal_title：British journal of clinical pharmacology

authors： Dixey JJ,Noormohamed FH,Lant AF,Brewerton DA

更新日期：1988-05-01 00:00:00

abstract：:Thiol compounds have been reported to abolish hypoxanthine/xanthine oxidase induced luminol chemiluminescence and this effect has been attributed to scavenging of superoxide (O2-)/(H2O2) produced from hypoxanthine/xanthine oxidase. Yet other workers have reported that thiol compounds have shown little, if any, reactiv...

journal_title：British journal of clinical pharmacology

authors： Clapperton M,McMurray J,Fisher AC,Dargie HJ

更新日期：1995-06-01 00:00:00

abstract：:Both empirical epidemiological data on the causes of traffic accidents and conceptual models of skilled human performance stress the central role of perception and cognition. This paper examines the effects of drugs on two major components of cognitive perceptual performance, namely, concentrated attention or vigilanc...

journal_title：British journal of clinical pharmacology

authors： Moskowitz H

更新日期：1984-01-01 00:00:00

abstract：:1 A total of three hundred and nineteen new chemical entities (NCEs) were investigated in man for the first time between 1964 and 1985 by seven UK-owned pharmaceutical companies. The majority (96.2%), were self-originated by the UK company or one of its overseas subsidiaries. 2 There was an increase in the number of N...

journal_title：British journal of clinical pharmacology

authors： Prentis RA,Lis Y,Walker SR

更新日期：1988-03-01 00:00:00

abstract：AIM:To investigate the effect of the P-glycoprotein inhibitor verapamil on the pharmacokinetics and pharmacodynamics of dabigatran etexilate (DE). METHOD:In this two part multiple crossover trial in 40 healthy subjects, DE 150 mg was given alone or with verapamil at different doses, duration of treatment (single vs. m...

journal_title：British journal of clinical pharmacology

authors： Härtter S,Sennewald R,Nehmiz G,Reilly P

更新日期：2013-04-01 00:00:00

abstract：:1. The beta-adrenergic blocking potencies of practolol, ICI 66082, tolamolol, acebutolol, H 93/26, H 87/07, pindolol and Ro 3-4787 were compared with that of propranolol, on human and rat adipocytes. 2. A good correlation was found between the potencies on adipocytes of the two species but not between our results and ...

journal_title：British journal of clinical pharmacology

authors： Harms HH,Van der Meer J

更新日期：1975-08-01 00:00:00

abstract：AIMS:To predict the drug interactions of amiodarone and other drugs, the inhibitory effects and inactivation potential for human cytochrome P450 (CYP) enzymes by amiodarone and its N-dealkylated metabolite, desethylamiodarone were examined. METHODS:The inhibition or inactivation potency of amiodarone and desethylamiod...

journal_title：British journal of clinical pharmacology

authors： Ohyama K,Nakajima M,Suzuki M,Shimada N,Yamazaki H,Yokoi T

更新日期：2000-03-01 00:00:00

abstract：:The effect of isotonic bicycle exercise on beta 2-adrenoceptors and cAMP production in lymphocytes was studied. The origin of the newly exposed receptors was studied by measuring radioligand binding in the presence of hydrophylic or lipophylic 'cold' ligands. During exercise beta 2-adrenoceptor density increased from ...

journal_title：British journal of clinical pharmacology

authors： Graafsma SJ,van Tits LJ,Willems PH,Hectors MP,Rodrigues de Miranda JF,De Pont JJ,Thien T

更新日期：1990-01-01 00:00:00

abstract：:A free lignocaine index was developed on the basis of measurements of plasma lignocaine and its principle binding protein, alpha 1-acid glycoprotein (AAG) in 80 samples from 16 patients admitted to the coronary care unit and given prophylactic lignocaine therapy. The free drug fraction, fu, of lignocaine was determine...

journal_title：British journal of clinical pharmacology

authors： Routledge PA,Lazar JD,Barchowsky A,Stargel WW,Wagner GS,Shand DG

更新日期：1985-12-01 00:00:00

abstract：:1. The pharmacokinetics of didanosine, trimethoprim, and sulphamethoxazole were evaluated in ten HIV seropositive asymptomatic patients as single agents and upon coadministration of single doses. 2. Using a randomized, balanced incomplete block crossover study with at least a 1-week washout period between successive t...

journal_title：British journal of clinical pharmacology

authors： Srinivas NR,Knupp CA,Batteiger B,Smith RA,Barbhaiya RH

更新日期：1996-03-01 00:00:00

abstract：AIMS:Probenecid influences transport processes of drugs at several sites in the body and decreases elimination of several quinolones. We sought to explore extent, time course, and mechanism of the interaction between ciprofloxacin and probenecid at renal and nonrenal sites. METHODS:A randomized, two-way crossover stud...

journal_title：British journal of clinical pharmacology

authors： Landersdorfer CB,Kirkpatrick CM,Kinzig M,Bulitta JB,Holzgrabe U,Jaehde U,Reiter A,Naber KG,Rodamer M,Sörgel F

更新日期：2010-02-01 00:00:00

abstract：AIMS:There are insufficient direct comparative studies addressing the impact of the type of statin on their respective efficacy in heart failure (HF). The aim of the current study was to compare the effects of lipophilic (atorvastatin) vs hydrophilic (rosuvastatin) on left ventricular function, inflammatory and fibrosi...

journal_title：British journal of clinical pharmacology

authors： El Said NO,El Wakeel LM,Khorshid H,Darweesh EAG,Ahmed MA

更新日期：2020-12-08 00:00:00

abstract：AIMS:Nicotine nasal spray and transdermal nicotine are effective aids to smoking cessation, and are being evaluated for treatment of other medical diseases. Wide variation in levels of nicotine and its metabolite, cotinine, have been observed with such therapies. This study aimed primarily to assess sources of individu...

journal_title：British journal of clinical pharmacology

authors： Benowitz NL,Zevin S,Jacob P 3rd

更新日期：1997-03-01 00:00:00

abstract：:1 A controlled trial of charcoal haemoperfusion as an early treatment for paracetamol overdose showed no benefit. 2 The plasma clearances of paracetamol by the charcoal column were variable and disappointingly small (range 4-119 ml/minute). The cumulative amounts removed were also low, mean 1.4 g (range 0.2-5.2 g). 3 ...

journal_title：British journal of clinical pharmacology

authors： Gazzard BG,Willison RA,Weston MJ,Thompson RP,Williams R

更新日期：1974-06-01 00:00:00

abstract：:1 The effect of pregnancy on the binding of phenytoin and phenobarbitone to serum proteins was studied in normal women and in drug treated epileptic women. 2 The binding of both drugs was reduced during pregnancy. The reduction correlated positively with the gestational age and negatively with the serum albumin concen...

journal_title：British journal of clinical pharmacology

authors： Chen SS,Perucca E,Lee JN,Richens A

更新日期：1982-04-01 00:00:00

abstract：AIM:Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase and are an important group of hypolipidaemic drugs, widely used in the treatment of hypercholesterolaemia and cardiovascular disease. Some studies have shown that statins are able to modulate inflammation and alveolar bone loss. METHODS:In o...

journal_title：British journal of clinical pharmacology

authors： Estanislau IM,Terceiro IR,Lisboa MR,Teles Pde B,Carvalho Rde S,Martins RS,Moreira MM

更新日期：2015-06-01 00:00:00

abstract：:In order to elucidate the mechanisms by which beta-adrenoceptor blockade leads to a reduction in portal pressure, we have measured portal pressure, heart rate and cardiac index in 17 patients with cirrhosis and portal hypertension following the oral administration of the selective beta 2-adrenoceptor blocking agent, I...

journal_title：British journal of clinical pharmacology

authors： Bihari D,Westaby D,Gimson A,Crossley I,Harry J,Williams R

更新日期：1984-06-01 00:00:00

abstract：:1 Mianserin does not affect the uptake of biogenic amines into rat brain, in contrast to tricyclic antidepressants which block amine uptake. 2 Mianserin increases the turnover of noradrenaline (NA) in rat brain after acute or chronic administration, whereas tricyclic antidepressants reduce turnover of NA and 5-hydroxy...

journal_title：British journal of clinical pharmacology

authors： Leonard BE

更新日期：1978-01-01 00:00:00

abstract：:1. The study was performed to determine the sensitivity and short-term and day-to-day variability of a novel technique based on laser interferometry of ocular fundus pulsations and of non-invasive methods for the quantification of haemodynamic drug effects. An additional aim was to assess sex differences in haemodynam...

journal_title：British journal of clinical pharmacology

authors： Wolzt M,Schmetterer L,Rheinberger A,Salomon A,Unfried C,Breiteneder H,Ehringer H,Eichler HG,Fercher AF

更新日期：1995-04-01 00:00:00

abstract：:Plasma and synovial fluid concentrations of the enantiomers of flurbiprofen were measured in 15 rheumatoid patients receiving 100 mg racemic flurbiprofen twice daily. Pharmacokinetic parameters showed considerable variability within the group of patients, although differences in S(+)/R(-) plasma concentration ratios w...

journal_title：British journal of clinical pharmacology

authors： Young MA,Aarons L,Toon S

更新日期：1991-01-01 00:00:00

abstract：AIMS:There is a trend for more flexibility in timing of evidence generation in relation to marketing authorization, including the option to complete phase III trials after authorization or not at all. This paper investigated the relation between phase II and III clinical trial efficacy in oncology. METHODS:All oncolog...

journal_title：British journal of clinical pharmacology

authors： Vreman RA,Belitser SV,Mota ATM,Hövels AM,Goettsch WG,Roes KCB,Leufkens HGM,Mantel-Teeuwisse AK

更新日期：2020-07-01 00:00:00

abstract：:Six human volunteers were each given single oral doses of aspirin (ASA) ranging from 300-1,500 mg. The unchanged ASA excreted in the urine was proportional to dose and urinary pH. The mean percent (+/- s.d.) of dose excreted was 1.9 +/- 0.67. The clearance for ASA was 1.42 +/- 0.28 1/h. The rate of in vitro hydrolysis...

journal_title：British journal of clinical pharmacology

authors： Elliot Cham B,Dykman JH,Bochner F

更新日期：1982-10-01 00:00:00

abstract：:Cytochrome P450 3A is the main enzyme subfamily involved in the metabolism of a variety of marketed medicines. It is generally believed that the substrate specificity of polymorphic P450 3A5 is similar to that of the predominant P450 3A4 isoform, although some differences in catalytic properties have been found. It ha...

journal_title：British journal of clinical pharmacology

authors： Yamazaki H,Nakamoto M,Shimizu M,Murayama N,Niwa T

更新日期：2010-06-01 00:00:00

abstract：:1. The N-acetylation of dapsone (DDS) was studied in 182 unrelated healthy Japanese subjects. The frequency of slow acetylators determined using the plasma monoacetyldapsone (MADDS) to DDS ratio (MADDS/DDS, slow acetylators less than 0.30 and rapid acetylators greater than 0.35) at 3 h after an oral dose of DDS (100 m...

journal_title：British journal of clinical pharmacology

authors： Horai Y,Ishizaki T

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Maraviroc, a noncompetitive antagonist of the CCR5 coreceptor, was recently approved in the USA as a treatment of HIV infection. For antiretroviral agents that target the virus, antiviral effect can be related to some extent to plasma drug concentrations. For CCR5 antagonists that target the host cells, rece...

journal_title：British journal of clinical pharmacology

authors： Rosario MC,Jacqmin P,Dorr P,James I,Jenkins TM,Abel S,van der Ryst E

更新日期：2008-04-01 00:00:00

abstract：AIMS:The objective of this study is to develop a generic model for tacrolimus pharmacokinetics modelling using a meta-analysis approach, that could serve as a first step towards a prediction tool to inform pharmacokinetics-based optimal dosing of tacrolimus in different populations and indications. METHODS:A systemati...

journal_title：British journal of clinical pharmacology

authors： Nanga TM,Doan TTP,Marquet P,Musuamba FT

更新日期：2019-12-01 00:00:00

abstract：:1. A survey has been conducted amongst 459 members of the Clinical Section of the British Pharmacological Society to ascertain facts about the administration of drugs to healthy volunteers over the period October 1986 to September 1987. 2. A response rate of 87.1% was obtained with 114 individuals being involved in he...

journal_title：British journal of clinical pharmacology

authors： Orme M,Harry J,Routledge P,Hobson S

更新日期：1989-02-01 00:00:00

abstract：:1 Fourteen hypertensive patients were studied by intra-arterial BP monitoring to quantify the effects of standardized physiological stresses: Valsalva manoeuvre, isometric, treadmill and bicycle exercise, and 60 degree tilting before and after labetalol treatment. 2 The dose of labetalol ranged from 100--600 mg three ...

journal_title：British journal of clinical pharmacology

authors： Balasubramanian V,Mann S,Millar-Craig MW,Raftery EB

更新日期：1979-01-01 00:00:00

abstract：AIMS:Spirometry, plethysmography and impulse oscillometry (IOS) measure different aspects of lung function. These methods have not been compared for their ability to assess long- and short-acting anticholinergic agents. We therefore performed a double-blind, placebo-controlled, four-way cross-over study in 30 healthy s...

journal_title：British journal of clinical pharmacology

authors： Singh D,Tal-Singer R,Faiferman I,Lasenby S,Henderson A,Wessels D,Goosen A,Dallow N,Vessey R,Goldman M

更新日期：2006-04-01 00:00:00

abstract：:1. A double-blind placebo-controlled study was conducted on the effects of oral terbutaline (beta 2-adrenoceptor agonist) and propranolol (beta 1 beta 2-adrenoceptor antagonist) on basal heat production of skeletal muscle, measured ex vivo by direct microcalorimetry. Terbutaline slow-release 7.5 mg, propranolol 80 mg,...

journal_title：British journal of clinical pharmacology

authors： Fagher B,Liedholm H,Sjögren A,Monti M

更新日期：1993-06-01 00:00:00