Observations on the relationship between anxiety and depressive symptoms during the course of depressive illnesses.

abstract：:1. The antihypertensive efficacy and tolerability of a low dose combination of the angiotensin converting enzyme inhibitor ramipril (2.5 mg) and the extended release formulation of the dihydropyridine calcium channel antagonist felodipine (5 mg) were assessed in a double-blind, double dummy placebo controlled, randomi...

journal_title：British journal of clinical pharmacology

authors： Bainbridge AD,Macfadyen RJ,Stark S,Lees KR,Reid JL

更新日期：1993-10-01 00:00:00

abstract：:The pharmacokinetics of CGP 15 210 G, a new 5-HT uptake inhibitor in poor and extensive metabolisers of debrisoquine, give indirect evidence of an association between its metabolism and polymorphic hydroxylation of the debrisoquine type. ...

journal_title：British journal of clinical pharmacology

authors： Gleiter CH,Aichele G,Nilsson E,Hengen N,Antonin KH,Bieck PR

更新日期：1985-07-01 00:00:00

abstract：AIMS:5-Fluorouracil (5-FU) is widely used in combination chemotherapy, and literature suggests pharmacokinetic-guided dosing to improve clinical efficacy and reduce toxicity. This study aimed to determine the pharmacokinetic exposure of both 5-FU and its metabolite, 5,6-dihydrofluorouracil (DHFU), in patients with gast...

journal_title：British journal of clinical pharmacology

authors： Jacob J,Mathew SK,Chacko RT,Aruldhas BW,Singh A,Prabha R,Mathew BS

更新日期：2020-06-27 00:00:00

abstract：:The degrees of interactions between the H2-receptor antagonists, cimetidine and ranitidine, and several beta-adrenoceptor blockers were investigated in healthy volunteers following 7 days of oral monotherapy with penbutolol, propranolol, metoprolol, pindolol and atenolol, and after co-administration with each of the H...

journal_title：British journal of clinical pharmacology

authors： Mutschler E,Spahn H,Kirch W

更新日期：1984-01-01 00:00:00

abstract：AIMS:The objectives were to investigate the pharmacokinetics, pharmacodynamics and safety of ilaprazole infusion in healthy subjects and patients with esomeprazole as positive control, and then recommend the dosage regimen for Phase 2b/3 studies. METHODS:Three clinical studies were performed. First, 16 healthy subject...

journal_title：British journal of clinical pharmacology

authors： Wang H,Shao F,Liu X,Xu W,Ou N,Qin X,Liu F,Hou X,Hu H,Jiang J

更新日期：2019-11-01 00:00:00

abstract：AIMS:Data regarding the cardiac toxicity of cabozantinib lacks. The aim of our study was to assess the risk of cabozantinib-related cardiotoxicity in mRCC patients. METHODS:We performed a multicentre prospective study on mRCC patients treated with cabozantinib between October 2016 and November 2017. Transthoracic echo...

journal_title：British journal of clinical pharmacology

authors： Iacovelli R,Ciccarese C,Fornarini G,Massari F,Bimbatti D,Mosillo C,Rebuzzi SE,Di Nunno V,Grassi M,Fantinel E,Ardizzoni A,Tortora G

更新日期：2019-06-01 00:00:00

abstract：AIMS:To examine the feasibility of using the human iris in vivo for the assessment of the interaction between tyramine and monoamine oxidase (MAO) inhibitors. To examine the relative roles of the two forms of MAO in terminating the response to sympathomimetic amines in the iris, by comparing the effects of single oral ...

journal_title：British journal of clinical pharmacology

authors： Bitsios P,Langley RW,Tavernor S,Pyykkö K,Scheinin M,Szabadi E,Bradshaw CM

更新日期：1998-06-01 00:00:00

abstract：AIMS:Probenecid influences transport processes of drugs at several sites in the body and decreases elimination of several quinolones. We sought to explore extent, time course, and mechanism of the interaction between ciprofloxacin and probenecid at renal and nonrenal sites. METHODS:A randomized, two-way crossover stud...

journal_title：British journal of clinical pharmacology

authors： Landersdorfer CB,Kirkpatrick CM,Kinzig M,Bulitta JB,Holzgrabe U,Jaehde U,Reiter A,Naber KG,Rodamer M,Sörgel F

更新日期：2010-02-01 00:00:00

abstract：:The thermogenic beta 3-adrenoceptor agonist BRL 26830A has been shown to increase weight loss in dieting subjects but tremor was a frequent adverse effect. We have investigated the magnitude and nature of this tremor after a single oral dose in 18 subjects. Two complementary techniques were used to attach the recordin...

journal_title：British journal of clinical pharmacology

authors： Connacher AA,Lakie M,Powers N,Elton RA,Walsh EG,Jung RT

更新日期：1990-10-01 00:00:00

abstract：:1 The disposition of prazosin following oral and intravenous administration has been studied in seven young and seven elderly men, all of whom were in good health and living independently in the community. 2 The elimination half-life (min) of prazosin was 123 +/- 19.4 (s.d.) in the young and 194 +/- 36 in the elderly ...

journal_title：British journal of clinical pharmacology

authors： Rubin PC,Scott PJ,Reid JL

更新日期：1981-09-01 00:00:00

abstract：:1 A 'low-dose' combined oral contraceptive steroid (OCS) preparation containing 30 microgram ethinylo-estradiol and 150 microgram levonorgestrel was found to reduce significantly antipyrine clearance in a group of women acting as their own controls. 2 An OCS preparation containing only a progestogen (75 microgram norg...

journal_title：British journal of clinical pharmacology

authors： Chambers DM,Jefferson GC,Chambers M,Loudon NB

更新日期：1982-02-01 00:00:00

abstract：:1. This study further examines the quinoline-derivative abanoquil with particular respect to the duration of its alpha 1-adrenoceptor antagonist activity and its concentration-effect relationship following a single intravenous bolus dose of 0.5 micrograms kg-1 in young, normotensive males. 2. alpha 1-adrenoceptor anta...

journal_title：British journal of clinical pharmacology

authors： Schafers RF,Elliott HL,Meredith PA,Miller SH,Reid JL

更新日期：1991-11-01 00:00:00

abstract：:1 A new osmotic pressure mediated delivery system for metoprolol (Lopresor Oros) has been evaluated by measuring the haemodynamic effects and pharmacokinetics after single and multiple oral dosing in young healthy volunteers. 2 Similar studies have been carried out in the same group using equivalent single and multipl...

journal_title：British journal of clinical pharmacology

authors： Kendall MJ,Jack DB,Woods KL,Laugher SJ,Quarterman CP,John VA

更新日期：1982-03-01 00:00:00

abstract：:The influence of cimetidine pretreatment on the pharmacokinetics of 5-fluorouracil (5FU) has been studied in 15 ambulant patients with carcinoma. Neither pretreatment with a single dose of cimetidine (400 mg) nor with daily treatment at 1000 mg for 1 week altered 5FU pharmacokinetics. Pretreatment with cimetidine for ...

journal_title：British journal of clinical pharmacology

authors： Harvey VJ,Slevin ML,Dilloway MR,Clark PI,Johnston A,Lant AF

更新日期：1984-09-01 00:00:00

abstract：:The renal response to a challenge of maximal water diuresis has been studied in seven subjects pretreated over 48 h with either placebo, probenecid, indomethacin or piroxicam. Probenecid did not alter the excretion of water and sodium chloride when compared with placebo responses, but increased both phosphate and urat...

journal_title：British journal of clinical pharmacology

authors： Dixey JJ,Noormohamed FH,Lant AF,Brewerton DA

更新日期：1988-05-01 00:00:00

abstract：AIM:This study aims to investigate the clinical and demographic factors influencing gentamicin pharmacokinetics in a large cohort of unselected premature and term newborns and to evaluate optimal regimens in this population. METHODS:All gentamicin concentration data, along with clinical and demographic characteristics...

journal_title：British journal of clinical pharmacology

authors： Fuchs A,Guidi M,Giannoni E,Werner D,Buclin T,Widmer N,Csajka C

更新日期：2014-11-01 00:00:00

abstract：:Phenytoin drug reaction with eosinophilia and systemic symptoms (DRESS) in 3 Aboriginal Australians positive for HLA-B*56:02 has been previously reported. We report the allele frequency of HLA-B*56:02 in 2 South Australian populations, 1 Aboriginal (4.8%, 95% confidence interval 2.4-7.8%) and the other European (0%). ...

journal_title：British journal of clinical pharmacology

authors： Somogyi AA,Barratt DT,Phillips EJ,Moore K,Ilyas F,Gabb GM

更新日期：2019-09-01 00:00:00

abstract：AIMS:To assess the prevalence of potentially inappropriate medications (PIMs) use in a population of community-based multicompartment compliance aid (MCA) users in north-east Scotland. METHODS:Data for MCAs dispensed by 48 of the 50 community pharmacies in Aberdeen City between 1st June to 31st October 2014, together ...

journal_title：British journal of clinical pharmacology

authors： Counter D,Stewart D,MacLeod J,McLay JS

更新日期：2017-07-01 00:00:00

abstract：:The plasma concentrations of the tetracyclic antidepressant maprotiline and its effect on histamine-induced bronchoconstriction were measured after single (50 mg) and multiple (50 mg twice daily) oral doses in healthy subjects. Histamine-induced bronchoconstriction was abolished after a single dose of maprotiline and ...

journal_title：British journal of clinical pharmacology

authors： Firkusny L,Gleiter CH

更新日期：1994-04-01 00:00:00

abstract：AIMS:(i) To model the effects of the monoclonal antibody ATM-027 on the number of target cells and on the receptor density on the cell surface as measured by Fluorescence Activated Cell Sorter analysis, (ii) to investigate the effects of categorizing a continuous scale, and (iii) to simulate a phase II trial from phase...

journal_title：British journal of clinical pharmacology

authors： Zingmark PH,Edenius C,Karlsson MO

更新日期：2004-10-01 00:00:00

abstract：:1 Improvement in physical performance, based on exercise tolerance, self-assessed work and physician-rated functional capacities, is proposed as a measure of efficacy of anti-anginal therapy in the rehabilitation of the cardiac patient. 2 Improved physical performance parallels changes in frequency of anginal attacks ...

journal_title：British journal of clinical pharmacology

authors： Ling AS,Groel JT

更新日期：1979-01-01 00:00:00

abstract：:1. In 48 patients with chronic asthma who had been receiving treatment with beclomethasone dipropionate aerosol (BDA) at a daily dose of 400 microgram for several years, observations were made on the effect of increasing the dose to 800 microgram daily for 6 months. 2. There was subjective improvement in 37 of the 48 ...

journal_title：British journal of clinical pharmacology

authors： Chatterjee SS

更新日期：1977-01-01 00:00:00

abstract：:1 Daily treatment of two-kidney clipped renal hypertensive rats with hydrallazine, hydrochlorothiazide (HCTZ) and a new orally active inhibitor of the angiotensin-converting enzyme, captopril (SQ14,225), was correlated with survival rates for up to 9 months. 2 The groups of rats given captopril alone or captopril plus...

journal_title：British journal of clinical pharmacology

authors： Horovitz ZP,Antonaccio MJ,Rubin B,Panasevich RE

更新日期：1979-01-01 00:00:00

abstract：:The effect of fatty degeneration of liver parenchyma on drug metabolism was investigated in 21 obese non-insulin-dependent diabetic subjects by measuring plasma antipyrine kinetics, hepatic cytochrome P-450, liver size and the extent of fatty infiltration. The hepatic drug metabolising capacity, as measured by total a...

journal_title：British journal of clinical pharmacology

authors： Pirttiaho HI,Salmela PI,Sotaniemi EA,Pelkonen RO,Pitkänen U,Luoma PV

更新日期：1984-12-01 00:00:00

abstract：AIMS:Drug disposition in children may vary from adults due to age-related variation in drug metabolism. Microdose studies present an innovation to study pharmacokinetics (PK) in paediatrics; however, they should be used only when the PK is dose linear. We aimed to assess dose linearity of a [14 C]midazolam microdose, b...

journal_title：British journal of clinical pharmacology

authors： van Groen BD,Vaes WH,Park BK,Krekels EHJ,van Duijn E,Kõrgvee LT,Maruszak W,Grynkiewicz G,Garner RC,Knibbe CAJ,Tibboel D,de Wildt SN,Turner MA

更新日期：2019-10-01 00:00:00

abstract：AIM:To investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of the highly selective oral p38alpha/beta mitogen-activated protein (MAP) kinase inhibitor Org 48,775-0 in a first-in-human study. METHODS:In the single ascending dosing (SAD) study, an oral dose of Org 48,775-0 (0.3-600 mg) was evalua...

journal_title：British journal of clinical pharmacology

authors： Moerland M,Kales AJ,Broekhuizen K,Nässander U,Nelissen R,de Kam ML,Peeters PAM,Burggraaf J

更新日期：2020-11-17 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Human pregnane X receptor (PXR/NR1I2) is a key regulator of cytochrome P450 3A4. To date, there are 198 reported SNPs for the human PXR/NR1I2 gene. Some of these SNPs are found to affect the inducing ability of PXR to CYP3A4. WHAT THIS STUDY ADDS:This study, for the first time,...

journal_title：British journal of clinical pharmacology

authors： Wang XD,Li JL,Su QB,Guan S,Chen J,Du J,He YW,Zeng J,Zhang JX,Chen X,Huang M,Zhou SF

更新日期：2009-02-01 00:00:00

abstract：AIMS:The present pharmacokinetic study was undertaken to determine the dose proportionality of three different doses of budesonide-400 microg, 800 microg or 1600 microg administered twice daily by a dry-powder inhaler (Turbuhaler ) in adult patients with mild asthma. METHODS:A total of 38 patients received budesonide ...

journal_title：British journal of clinical pharmacology

authors： Kaiser H,Aaronson D,Dockhorn R,Edsbäcker S,Korenblat P,Källén A

更新日期：1999-09-01 00:00:00

abstract：AIMS:To examine the hypothesis that sildenafil, a phosphodiesterase type 5 inhibitor that inhibits cGMP breakdown, could enhance nitric oxide-mediated vasodilation and reverse endothelial dysfunction in chronic smokers. METHODS:Flow-mediated dilation of the brachial artery and forearm postischemic reactive hyperemia (...

journal_title：British journal of clinical pharmacology

authors： Dishy V,Harris PA,Pierce R,Prasad HC,Sofowora G,Bonar HL,Wood AJ,Stein CM

更新日期：2004-02-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:* The interindividual variability of the pharmacokinetic parameters of cilostazol is relatively large. * Cilostazol undergoes extensive hepatic metabolism via the P450 enzymes, primarily CYP3A and, to a lesser extent, CYP2C19. * Indeed, <1% of the administered dose of cilostazol...

journal_title：British journal of clinical pharmacology

authors： Yoo HD,Cho HY,Lee YB

更新日期：2010-01-01 00:00:00