Verapamil in arrhythmia.

Abstract:

:The antiarrhythmic effects of verapamil were observed before it was appreciated that it was a calcium ion-antagonist. Intravenous verapamil is highly effective in the termination of paroxysmal reciprocating atrioventricular tachycardia, whether associated with preexcitation or involving the atrioventricular node alone. It consistently slows and regularises the ventricular response in atrial fibrillation, and usually increases the degree of AV-nodal block in atrial flutter though it occasionally induces a return to sinus rhythm. Given orally it is useful for the prophylaxis of atrioventricular reentry tachycardia, and also in modulating the atrioventricular nodal response in atrial fibrillation. Favourable response in ventricular tachycardia is exceptional and then seen in specific benign varieties. Verapamil is the agent of choice for the termination of paroxysmal supraventricular tachycardia.

journal_name

Br J Clin Pharmacol

authors

Krikler DM

doi

10.1111/j.1365-2125.1986.tb02869.x

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

183S-189S

eissn

0306-5251

issn

1365-2125

journal_volume

21 Suppl 2

pub_type

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