Population pharmacokinetics, efficacy, and safety of moxetumomab pasudotox in patients with relapsed or refractory hairy cell leukaemia.

abstract：:Medroxalol, a new drug which has been reported to possess both alpha- and beta-adrenoceptor antagonist properties, was compared with labetalol in single dose studies in normotensive males. Oral doses of 400 mg of each drug significantly reduced blood pressure, both supine and erect, without significant changes in hear...

journal_title：British journal of clinical pharmacology

authors： Elliott HL,McLean K,Meredith PA,Sumner DJ,Reid JL

更新日期：1984-05-01 00:00:00

abstract：:Renal clearance of lithium has been used as a marker of proximal tubular function in man. Recently, lithium pre-treatment has been shown to interfere with the natriuretic actions of some natriuretic agents in man. We have therefore investigated the effects of oral lithium carbonate (500 mg) on the natriuretic response...

journal_title：British journal of clinical pharmacology

authors： Lang CC,Rahman AR,Struthers AD

更新日期：1991-06-01 00:00:00

abstract：:Analysis of human horizontal saccadic eye movements can provide measurements of central nervous system depression and stimulation. Effects on saccadic eye movements have been observed in normal volunteers with barbiturates, benzodiazepines, opiates and related compounds, carbamazepine, amphetamine and ethanol. A suite...

journal_title：British journal of clinical pharmacology

authors： Griffiths AN,Marshall RW,Richens A

更新日期：1984-01-01 00:00:00

abstract：AIMS:The pharmacokinetics and dose proportionality of rizatriptan single oral doses from 2.5 to 15 mg administered as solutions to healthy volunteers were studied. METHODS:In a randomized, crossover study with four periods, twenty-four healthy volunteers (12 males and 12 females) took single oral doses of 2.5, 5, 10, ...

journal_title：British journal of clinical pharmacology

authors： Lee Y,Conroy JA,Stepanavage ME,Mendel CM,Somers G,McLoughlin DA,Olah TV,De Smet M,Keymeulen B,Rogers JD

更新日期：1999-04-01 00:00:00

abstract：:1. Quinidine is a potent inhibitor of the genetically-determined debrisoquine 4-hydroxylation. Oxidation reactions of several other drugs, including the 5-hydroxylation of the new antiarrhythmic drug propafenone, depend on the isozyme responsible for debrisoquine 4-hydroxylation. 2. The effect of quinidine on the debr...

journal_title：British journal of clinical pharmacology

authors： Funck-Brentano C,Kroemer HK,Pavlou H,Woosley RL,Roden DM

更新日期：1989-04-01 00:00:00

abstract：:This study investigated the effects of placebo, 1 mg, 3 mg, 10 mg and 30 mg ritanserin and 10 mg diazepam on human sleep. Twelve normal volunteers participated in this randomized, double-blind, placebo-controlled cross-over sleep study. A clear dose-response relationship was found for ritanserin with higher doses evok...

journal_title：British journal of clinical pharmacology

authors： Idzikowski C,Mills FJ,James RJ

更新日期：1991-02-01 00:00:00

abstract：:1. Fifty-four depressive in-patients aged 18-45 yr, were treated at random, in double-blind conditions, with mianserin 60 mg daily or imipramine 150 mg daily in three divided doses for 4 weeks. Nitrazepam and diazepam were also allowed if necessary. 2. There was no significant difference in antidepressant efficacy bet...

journal_title：British journal of clinical pharmacology

authors： Pichot P,Dreyfus JF,Pull C

更新日期：1978-01-01 00:00:00

abstract：:1. The phenotyping parameters for dextromethorphan and mephenytoin were assessed in 48 normal male volunteers following administration of each metabolic probe drug on separate occasions and together according to a randomized 3-way crossover design. 2. Neither the urinary S-/R-mephenytoin ratio nor the dextromethorphan...

journal_title：British journal of clinical pharmacology

authors： Guttendorf RJ,Britto M,Blouin RA,Foster TS,John W,Pittman KA,Wedlund PJ

更新日期：1990-04-01 00:00:00

abstract：:1. The inhibitory effect of sufotidine, a new histamine H2-receptor antagonist, on gastric secretion of acid and pepsin was studied in six healthy male volunteers. This was a three-way, cross-over, randomized, double-blind study. On each of 3 study days, the drug in a dose of 600 mg, or placebo, was administered eithe...

journal_title：British journal of clinical pharmacology

authors： Johnston DA,Wormsley KG

更新日期：1989-10-01 00:00:00

abstract：:The ability of sulindac to modify the weal response to four doses of intradermal bradykinin in subjects given enalapril was tested in a double-blind cross-over study in normal volunteers. The dose-dependent increase in skin thickness after bradykinin was significantly reduced by prior administration of sulindac. Certa...

journal_title：British journal of clinical pharmacology

authors： Ferner RE,Kamali F,Rawlins MD

更新日期：1990-03-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Recently, we have shown that the plasma concentration of R-fexofenadine is greater than that of the S-enantiomer. Although itraconazole co-administration is known to increase the bioavailability of a racemic mixture of fexofenadine, little is known about the stereoselective inhi...

journal_title：British journal of clinical pharmacology

authors： Tateishi T,Miura M,Suzuki T,Uno T

更新日期：2008-05-01 00:00:00

abstract：AIMS:To develop a population pharmacokinetic model for lopinavir in combination with ritonavir, in which the interaction between both drugs was characterized, and in which relationships between patient characteristics and pharmacokinetics were identified. METHODS:The pharmacokinetics of lopinavir in combination with r...

journal_title：British journal of clinical pharmacology

authors： Crommentuyn KM,Kappelhoff BS,Mulder JW,Mairuhu AT,van Gorp EC,Meenhorst PL,Huitema AD,Beijnen JH

更新日期：2005-10-01 00:00:00

abstract：:The effects of two single oral doses of ibopamine (150 and 600 mg) on heart rate, blood pressure, urine flow, sodium, potassium and creatinine excretion were studied in normal volunteers. No significant change was observed in urine flow, sodium, potassium or creatinine excretion at either dose. No significant change w...

journal_title：British journal of clinical pharmacology

authors： Harvey JN,Worth DP,Brown J,Lee MR

更新日期：1984-06-01 00:00:00

abstract：AIMS:Health Canada has developed a pathway to approve drugs that have limited efficacy and safety data, the Notice of Compliance with conditions (NOC/c) policy. Increased safety reporting is required for these drugs but there has not been any systematic review of their post-market safety. This study compares safety war...

journal_title：British journal of clinical pharmacology

authors： Lexchin J

更新日期：2015-05-01 00:00:00

abstract：:Theophylline clearance was studied in normal healthy volunteers before and after chronic oral dosing. Oral theophylline clearance showed a significant decrease (P less than 0.001) from 59.3 +/- 6.48 ml/min (mean +/- s.e. mean, n = 10) to 48.0 +/- 6.4 ml/min. Steady-state intravenous clearance decreased by 26 +/- 2% fr...

journal_title：British journal of clinical pharmacology

authors： Efthimiou H,Morgan DJ,Ioannides-Demos L,Raymond K,McLean AJ

更新日期：1984-05-01 00:00:00

abstract：:Paracetamol disposition was studied in groups of pregnant and non-pregnant women of comparable age. Paracetamol apparent oral clearance was 58% higher and elimination half-life was 28% lower in the pregnant women compared to the control group. The higher clearance in the pregnant women was due to increased activity of...

journal_title：British journal of clinical pharmacology

authors： Miners JO,Robson RA,Birkett DJ

更新日期：1986-09-01 00:00:00

abstract：:Cytochrome P450 3A is the main enzyme subfamily involved in the metabolism of a variety of marketed medicines. It is generally believed that the substrate specificity of polymorphic P450 3A5 is similar to that of the predominant P450 3A4 isoform, although some differences in catalytic properties have been found. It ha...

journal_title：British journal of clinical pharmacology

authors： Yamazaki H,Nakamoto M,Shimizu M,Murayama N,Niwa T

更新日期：2010-06-01 00:00:00

abstract：:Highly active antiretroviral therapy is recommended for HIV-infected pregnant women to prevent mother-to-child transmission. The specific physiological background induced by pregnancy leads to significant changes in maternal pharmacokinetics, suggesting potential variability in plasma concentrations of antiretrovirals...

journal_title：British journal of clinical pharmacology

authors： Roustit M,Jlaiel M,Leclercq P,Stanke-Labesque F

更新日期：2008-08-01 00:00:00

abstract：AIMS:The goal of this study was to determine the frequencies of important allelic variants in the TPMT, NAT2, GST, SULT1A1 and MDR-1 genes in the Egyptian population and compare them with the frequencies in other ethnic populations. METHODS:Genotyping was carried out in a total of 200 unrelated Egyptian subjects. TPMT...

journal_title：British journal of clinical pharmacology

authors： Hamdy SI,Hiratsuka M,Narahara K,Endo N,El-Enany M,Moursi N,Ahmed MS,Mizugaki M

更新日期：2003-06-01 00:00:00

abstract：:1. Meals empty more slowly when they contain fat. 2. This study investigated whether an intragastric fat preload in comparison with a water preload affected gastric emptying of a semisolid meal and antral motor activity, and whether cisapride reversed such effects. 3. Twelve healthy subjects were studied under three c...

journal_title：British journal of clinical pharmacology

authors： Stacher G,Bergmann H,Gaupmann G,Schneider C,Kugi A,Höbart J,Binder A,Mittelbach-Steiner G

更新日期：1990-12-01 00:00:00

abstract：:1 Fifty-two patients who had been treated for essential hypertension for at least 5 years with once-a-day pindolol alone or in combination with a diuretic participated in a strenuous exercise programme. The 24 h antihypertensive efficacy of once-a-day pindolol was shown in blood pressure readings made before the intak...

journal_title：British journal of clinical pharmacology

authors： Dhatariya RC,Blowers AJ

更新日期：1982-05-01 00:00:00

abstract：AIMS:To assess the duration and consistency of the pharmacological activity of the dihydropyridine calcium antagonist drug, lacidipine. METHODS:Eight healthy normotensive young males participated in a double-blind randomised crossover comparison of single and multiple doses (for 2 weeks) of lacidipine and placebo. The...

journal_title：British journal of clinical pharmacology

authors： Ueda S,Donnelly R,Panfilov V,Morris AD,Elliott HL

更新日期：1998-08-01 00:00:00

abstract：AIMS:This study aimed to analyse the effects of genetic polymorphisms in drug transporters and metabolizing enzymes, and clinical laboratory data on the pharmacokinetic parameters of apixaban. METHODS:Data were collected from 81 Japanese patients with atrial fibrillation. Pharmacogenomic data were stratified by ABCB1,...

journal_title：British journal of clinical pharmacology

authors： Ueshima S,Hira D,Kimura Y,Fujii R,Tomitsuka C,Yamane T,Tabuchi Y,Ozawa T,Itoh H,Ohno S,Horie M,Terada T,Katsura T

更新日期：2018-06-01 00:00:00

abstract：:To study the cardioselectivity of xamoterol, eight asthmatic patients took part in a randomised, double-blind, cross-over study, in which xamoterol or saline were infused, followed by four increasing doses of terbutaline i.v. Circulatory studies showed a significant increase of systolic blood pressure after xamoterol ...

journal_title：British journal of clinical pharmacology

authors： Löfdahl CG,Svedmyr N

更新日期：1984-10-01 00:00:00

abstract：:Twenty-three elderly hypertensive subjects received nitrendipine 10mg daily by mouth for 8 days. Plasma nitrendipine concentrations were measured after the first and last dose. There was no significant difference in plasma concentrations at any time point between the two days nor in derived pharmacokinetic measurement...

journal_title：British journal of clinical pharmacology

authors： Crome P,Baksi A,MacMahon D,Pandita-Gunawardena ND,Edwards J,Marley J

更新日期：1988-09-01 00:00:00

abstract：:1 Roth et al. (1972) have proposed that within the affective disorders there are two distinct syndromes--anxiety and depression--differentiated by the relative predominance of these symptoms, the presence or absence of premorbid maladaptive traits, and the natural outcome of the disorder. 2 Goldberg (1982) on the othe...

journal_title：British journal of clinical pharmacology

authors： Russell GF,De Silva P

更新日期：1983-01-01 00:00:00

abstract：AIM:Propylene glycol (PG) is often applied as an excipient in drug formulations. As these formulations may also be used in neonates, the aim of this study was to characterize the pharmacokinetics of propylene glycol, co-administered intravenously with paracetamol (800 mg PG/1000 mg paracetamol) or phenobarbital (700 mg...

journal_title：British journal of clinical pharmacology

authors： De Cock RF,Knibbe CA,Kulo A,de Hoon J,Verbesselt R,Danhof M,Allegaert K

更新日期：2013-01-01 00:00:00

abstract：AIMS:Continuous noninvasive blood pressure measurement by photoplethysmography has been regularly used in the experimental paradigm of angiotensin challenges, applied to the phase I clinical testing of angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists. This work aims to evaluate the performa...

journal_title：British journal of clinical pharmacology

authors： Buclin T,Buchwalder-Csajka C,Brunner HR,Biollaz J

更新日期：1999-10-01 00:00:00

abstract：:1 The effect of an intravenous bolus of labetalol (0.6--1.6 mg/kg body weight) on central and peripheral haemodynamics was studied in nine subjects with essential hypertension and in eleven subjects with chronic renal disease and hypertension. 2 The BP reduction amounting to 20/13 mmHg was entirely due to the lowering...

journal_title：British journal of clinical pharmacology

authors： Bahlmann J,Brod J,Hubrich W,Cachovan M,Pretschner P

更新日期：1979-01-01 00:00:00

abstract：AIMS:Homeopathic medicines are frequently purchased over the counter (OTC). Respiratory complaints are the most frequent reason for such purchases. Children with upper respiratory tract infection (URTI) are frequent users of homeopathy. This study investigates the effect of self treatment with one of three self selecte...

journal_title：British journal of clinical pharmacology

authors： Steinsbekk A,Bentzen N,Fønnebø V,Lewith G

更新日期：2005-04-01 00:00:00