A double-blind multicentre trial comparing mianserin with imipramine.

abstract：:1 To compare the haemodynamic effects of secondary characteristics of beta-adrenoceptor blockers with an angiotensin converting enzyme inhibitor forty patients with previously untreated mild to moderate hypertension were prescribed either atenolol 50-100 mg day-1, labetalol 200-800 mg day-1, pindolol 10-30 mg day-1 or...

journal_title：British journal of clinical pharmacology

authors： Roberts DH,Tsao Y,Grimmer SF,Winstanley PA,Orme ML,Breckenridge AM

更新日期：1987-08-01 00:00:00

abstract：:The effects of ranitidine on the pharmacokinetics of metoprolol were examined in two studies. In the first study, pharmacokinetics of single doses of metoprolol were examined in six subjects before, during and after ranitidine administration for 1 week. Peak concentrations of metoprolol were increased on ranitidine bu...

journal_title：British journal of clinical pharmacology

authors： Kelly JG,Salem SA,Kinney CD,Shanks RG,McDevitt DG

更新日期：1985-02-01 00:00:00

abstract：AIMS:To investigate the impact of cytochrome P450 2D6 (CYP2D6) on dose-adjusted serum concentrations of flupentixol, haloperidol, perphenazine and zuclopenthixol in a therapeutic drug monitoring (TDM) cohort of psychiatric patients. We also studied the functional impact of CYP2D6*41 on dose-adjusted serum concentration...

journal_title：British journal of clinical pharmacology

authors： Waade RB,Solhaug V,Høiseth G

更新日期：2020-10-28 00:00:00

abstract：AIMS:Paracetamol-containing combination analgesics are widely prescribed but the use of paracetamol/dextropropoxyphene (co-proxamol) is particularly controversial. We aim to examine the prescribing patterns of the paracetamol-containing analgesics in Ireland. METHODS:A national primary care prescribing database was us...

journal_title：British journal of clinical pharmacology

authors： Usher C,Teeling M,Bennett K,McGowan B,Feely J

更新日期：2005-12-01 00:00:00

abstract：:1. Nebivolol, a selective beta 1-adrenoceptor antagonist with antihypertensive effects, has haemodynamic effects suggestive of a direct vasodilator action. 2. The dorsal hand vein technique was used to determine whether nebivolol has venodilator action in vivo in man. 3. Nebivolol and atenolol were infused into the ph...

journal_title：British journal of clinical pharmacology

authors： Bowman AJ,Chen CP,Ford GA

更新日期：1994-09-01 00:00:00

abstract：AIMS:To investigate the impact of the specific red blood cell binding on the pharmacokinetics and pharmacodynamics of the nucleoside transport inhibitor draflazine after i.v. administration at various infusion rates. It was also aimed to relate the red blood cell (RBC) occupancy of draflazine to the ex vivo measured ad...

journal_title：British journal of clinical pharmacology

authors： Snoeck E,Piotrovskij V,Jacqmin P,Van Peer A,Danhof M,Ver Donck K,Woestenborghs R,Van Belle H,Van Bortel L,Van Gool R,Dupont AG,Heykants J

更新日期：1997-06-01 00:00:00

abstract：AIMS:To predict the drug interactions of amiodarone and other drugs, the inhibitory effects and inactivation potential for human cytochrome P450 (CYP) enzymes by amiodarone and its N-dealkylated metabolite, desethylamiodarone were examined. METHODS:The inhibition or inactivation potency of amiodarone and desethylamiod...

journal_title：British journal of clinical pharmacology

authors： Ohyama K,Nakajima M,Suzuki M,Shimada N,Yamazaki H,Yokoi T

更新日期：2000-03-01 00:00:00

abstract：:The importance of number of tablets for patient compliance was investigated in 160 patients with mild-moderate essential hypertension treated with a beta-adrenoceptor blocker and a thiazide diuretic. Mean BP at entry 146 +/- 16/92 +/- 8 mm Hg. All patients were given pindolol 10 mg and clopamide 5 mg in one combinatio...

journal_title：British journal of clinical pharmacology

authors： Asplund J,Danielson M,Ohman P

更新日期：1984-05-01 00:00:00

abstract：:Essential hypertension is an escalating problem for industrialized populations. It is currently seen as a 'complex' genetic trait caused by multiple susceptibility genes the effects of which are modulated by gene-environment and gene-gene interactions. Nevertheless, the success to date in identifying these susceptibil...

journal_title：British journal of clinical pharmacology

authors： O'Shaughnessy KM

更新日期：2001-01-01 00:00:00

abstract：AIMS:Sulfonylureas are recommended as second-line treatment in the management of type 2 diabetes. However, they are still commonly used also as first-line treatment instead of metformin. Given the controversial cardiovascular safety of sulfonylureas, we aimed to determine if their use as first-line treatment is associa...

journal_title：British journal of clinical pharmacology

authors： Filion KB,Douros A,Azoulay L,Yin H,Yu OH,Suissa S

更新日期：2019-10-01 00:00:00

abstract：:1 A total of three hundred and nineteen new chemical entities (NCEs) were investigated in man for the first time between 1964 and 1985 by seven UK-owned pharmaceutical companies. The majority (96.2%), were self-originated by the UK company or one of its overseas subsidiaries. 2 There was an increase in the number of N...

journal_title：British journal of clinical pharmacology

authors： Prentis RA,Lis Y,Walker SR

更新日期：1988-03-01 00:00:00

abstract：AIMS:Variability in responsiveness to clopidogrel is a clinical problem in secondary prevention after cerebral ischaemia which has been suggested to be linked to competitive metabolization of clopidogrel and cytochrome P450 (CYP) 3A4-oxidated statins such as simvastatin. We assessed the hypothesis that simvastatin, in ...

journal_title：British journal of clinical pharmacology

authors： Siepmann T,Heinke D,Kepplinger J,Barlinn K,Gehrisch S,Grählert X,Schwanebeck U,Reichmann H,Puetz V,Bodechtel U,Gahn G

更新日期：2014-11-01 00:00:00

abstract：AIM:To construct a population pharmacokinetic model for methadone enantiomers in the setting of methadone maintenance treatment for opioid dependence. METHODS:A population pharmacokinetic model was developed using P-Pharm software for rac-, (R)- and (S)-methadone using data (8-13 plasma samples per subject) obtained f...

journal_title：British journal of clinical pharmacology

authors： Foster DJ,Somogyi AA,White JM,Bochner F

更新日期：2004-06-01 00:00:00

abstract：AIMS:To characterize the pharmacokinetics (PK) of moxetumomab pasudotox, an anti-CD22 recombinant immunotoxin, in adults with relapsed or refractory hairy cell leukaemia, we examined data from a phase 1 study (Study 1001; n = 49) and from the pivotal clinical study (Study 1053; n = 74). METHODS:Data from both studies ...

journal_title：British journal of clinical pharmacology

authors： Kuruvilla D,Chia YL,Balic K,Yao NS,Kreitman RJ,Pastan I,Li X,Standifer N,Liang M,Tseng CM,Faggioni R,Roskos L

更新日期：2020-07-01 00:00:00

abstract：AIMS:Using human liver microsomes from donors of the CYP2D6 poor and extensive metabolizer genotypes, the role of individual cytochromes P-450 in the oxidative metabolism of dihydrocodeine was investigated. METHODS:The kinetics of formation of N- and O-demethylated metabolites, nordihydrocodeine and dihydromorphine, w...

journal_title：British journal of clinical pharmacology

authors： Kirkwood LC,Nation RL,Somogyi AA

更新日期：1997-12-01 00:00:00

abstract：:Cytochrome P450 3A is the main enzyme subfamily involved in the metabolism of a variety of marketed medicines. It is generally believed that the substrate specificity of polymorphic P450 3A5 is similar to that of the predominant P450 3A4 isoform, although some differences in catalytic properties have been found. It ha...

journal_title：British journal of clinical pharmacology

authors： Yamazaki H,Nakamoto M,Shimizu M,Murayama N,Niwa T

更新日期：2010-06-01 00:00:00

abstract：:1. The three dimensional requirements for inhibition of ACE (angiotensin converting enzyme) were investigated in order to facilitate design of a more potent and selective antihypertensive agent. 2. All compounds designed possessed a bicyclic unit incorporating carboxylate and amidic carbonyl groups together with a thi...

journal_title：British journal of clinical pharmacology

authors： Attwood MR

更新日期：1989-01-01 00:00:00

abstract：:1 Theories linking 5-hydroxytryptamine (5-HT) with depression are briefly reviewed. The various experimental strategies adopted to investigate this relationship, examination of autopsy data, CSF metabolite data, 5-HT re-uptake patterns in human blood platelets and imipramine binding studies in human platelets, are dis...

journal_title：British journal of clinical pharmacology

authors： Goodwin FK,Post RM

更新日期：1983-01-01 00:00:00

abstract：:1 Roth et al. (1972) have proposed that within the affective disorders there are two distinct syndromes--anxiety and depression--differentiated by the relative predominance of these symptoms, the presence or absence of premorbid maladaptive traits, and the natural outcome of the disorder. 2 Goldberg (1982) on the othe...

journal_title：British journal of clinical pharmacology

authors： Russell GF,De Silva P

更新日期：1983-01-01 00:00:00

abstract：:1. We report a method for measuring the concentrations of haloperidol (HL) and its major active metabolite, reduced haloperidol (RHL), in human scalp hair. 2. Hair samples were obtained from 59 patients who had been taking HL at fixed daily doses for more than 4 months and whose compliance was good. A morning pre-dose...

journal_title：British journal of clinical pharmacology

authors： Matsuno H,Uematsu T,Nakashima M

更新日期：1990-02-01 00:00:00

abstract：:1. The single dose pharmacokinetics of orally administered nimodipine (60 mg) were investigated in normal subjects and in two groups of epileptic patients receiving chronic treatment with hepatic microsomal enzyme-inducing anticonvulsants (carbamazepine, phenobarbitone or phenytoin) and sodium valproate, respectively....

journal_title：British journal of clinical pharmacology

authors： Tartara A,Galimberti CA,Manni R,Parietti L,Zucca C,Baasch H,Caresia L,Mück W,Barzaghi N,Gatti G

更新日期：1991-09-01 00:00:00

abstract：AIMS:Inflammation reduces hepatic clearance of many drugs with unknown therapeutic consequences. This study was carried out to examine the effect of rheumatoid arthritis (RA) on the pharmacokinetics and pharmacodynamics of verapamil. METHODS:Eight RA patients were age- and sex-matched with eight healthy volunteers. Th...

journal_title：British journal of clinical pharmacology

authors： Mayo PR,Skeith K,Russell AS,Jamali F

更新日期：2000-12-01 00:00:00

abstract：AIMS:To characterize determinants of the elimination of methotrexate (MTX) and 7-hydroxy-methotrexate (7-OH-MTX) in patients receiving high-dose MTX therapy (HDMTX). METHODS:24 and 48-h blood samples from 76 patients receiving HDMTX (dose range 300 mg m-2 to 12 g m-2) were analysed, and concentration-time data were su...

journal_title：British journal of clinical pharmacology

authors： Joerger M,Huitema AD,van den Bongard HJ,Baas P,Schornagel JH,Schellens JH,Beijnen JH

更新日期：2006-07-01 00:00:00

abstract：AIMS:Ward physicians hold key positions in the course of efforts to reduce drug expenditures in hospitals. This study evaluated the knowledge of German hospital physicians with respect to the daily therapeutic costs of 21 frequently used drugs. METHODS:A questionnaire survey was carried out among 168 ward physicians f...

journal_title：British journal of clinical pharmacology

authors： Schnurrer JU,Stichtenoth DO,Troost R,Frölich JC

更新日期：2001-04-01 00:00:00

abstract：:Plasma melatonin was used to determine overall beta-adrenergic transmission through pineal neuro-effector junctions during desmethylimipramine (DMI) treatment in 10 normal subjects. Changes in plasma melatonin indicated that an initial increase in noradrenaline (NA) transmission produced by DMI was counteracted by ada...

journal_title：British journal of clinical pharmacology

authors： Cowen PJ,Green AR,Grahame-Smith DG,Braddock LE

更新日期：1985-06-01 00:00:00

abstract：:Scientific advice (SA) is an important tool offered by regulators to help developers generate robust evidence on a medicine's benefits and risks. Drawing on accumulated experience and looking at the SA provided by the European Medicines Agency in 2018 to advanced therapy medicinal products originally developed by publ...

journal_title：British journal of clinical pharmacology

authors： Tavridou A,Rogers D,Bonelli M,Schiel A,Hidalgo-Simon A

更新日期：2020-11-25 00:00:00

abstract：AIMS:AT9283 is used to treat patients with solid tumours and patients with leukaemia. However, the maximum tolerated dose (MTD) for children with leukaemia remains unknown due to early termination of the Phase I trial. The aim of this study was to develop a population model of AT9283 to describe the pharmacokinetics in...

journal_title：British journal of clinical pharmacology

authors： Duong JK,Griffin MJ,Hargrave D,Vormoor J,Edwards D,Boddy AV

更新日期：2017-08-01 00:00:00

abstract：AIMS:To assess the prevalence of potentially inappropriate medications (PIMs) use in a population of community-based multicompartment compliance aid (MCA) users in north-east Scotland. METHODS:Data for MCAs dispensed by 48 of the 50 community pharmacies in Aberdeen City between 1st June to 31st October 2014, together ...

journal_title：British journal of clinical pharmacology

authors： Counter D,Stewart D,MacLeod J,McLay JS

更新日期：2017-07-01 00:00:00

abstract：:For people seeking treatment, the course of heroin addiction tends to be chronic and relapsing, and longer duration of treatment is associated with better outcomes. Heroin addiction is strongly associated with deviant behaviour and crime, and the objectives in treating heroin addiction have been a blend of humane supp...

journal_title：British journal of clinical pharmacology

authors： Bell J

更新日期：2014-02-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Performance-enhancing dietary supplements have not been clinically tested for safety or efficacy. In clinical trials performed under resting conditions, performance-enhancing supplements raise blood pressure and affect glucose homeostasis. The effect of exercise on the pharmacok...

journal_title：British journal of clinical pharmacology

authors： Haller CA,Duan M,Jacob P 3rd,Benowitz N

更新日期：2008-06-01 00:00:00