The effect of sulindac on dermal responses to bradykinin in normal subjects given an angiotensin converting enzyme inhibitor.

abstract：AIMS:The purposes of this work were to: (1) compare pharmacokinetic (PK) parameters for hydroxycarbamide in children receiving their first dose (HCnew ) vs. those receiving chronic therapy (HCchronic ), (2) assess the external validity of a published PK dosing strategy, and (3) explore the accuracy of dosing strategies...

journal_title：British journal of clinical pharmacology

authors： Estepp JH,Wiczling P,Moen J,Kang G,Mack JM,Liem R,Panepinto JA,Garg U,Kearns G,Neville KA

更新日期：2018-07-01 00:00:00

abstract：:1. The effects of chronic dosing with N-acetylcysteine (NAC), on nitrate-induced haemodynamic changes during the acute and chronic treatment of healthy volunteers with glyceryl trinitrate (GTN) patches (Transiderm nitro) has been investigated. 2. Seven volunteers were treated in a double-blind randomised crossover man...

journal_title：British journal of clinical pharmacology

authors： Hogan JC,Lewis MJ,Henderson AH

更新日期：1989-10-01 00:00:00

abstract：:1. Labetalol, a new drug combining alpha-and beta-adrenoceptor blocking properties, has been compared with placebo in a double-blind crossover study of a group of patients with mild to moderate essential hypertension (blood pressure 150/100 to 189/114 mmHg). 2. Labetalol and propranolol lowered blood pressure satisfac...

journal_title：British journal of clinical pharmacology

authors： Pugsley DJ,Nassim M,Armstrong BK,Beilin L

更新日期：1979-01-01 00:00:00

abstract：:At a James Black Conference held in Oxford on 20-22 June 2011, a group of senior clinical pharmacologists and their junior colleagues, other medical specialists, and pharmacists discussed an agenda for UK clinical pharmacology for the next 5 years, addressing the following broad questions. How should UK clinical pharm...

journal_title：British journal of clinical pharmacology

authors： Aronson JK

更新日期：2012-06-01 00:00:00

abstract：:1. The absorption of ciprofloxacin from different regions of the human gastrointestinal tract was investigated in four healthy males using a remote-controlled drug delivery device (hf-capsule). 2. Significant differences in AUC were observed in the control study (oral administration of ciprofloxacin solution without t...

journal_title：British journal of clinical pharmacology

authors： Harder S,Fuhr U,Beermann D,Staib AH

更新日期：1990-07-01 00:00:00

abstract：AIMS:To assess the reproducibility of the digital pulse wave response to beta(2)-adrenoreceptor stimulation and to determine if an attenuated response to beta(2)-adrenoceptor stimulation is associated with impaired flow mediated dilatation (FMD). METHODS:Subjects (n = 20) with endothelial dysfunction (ED), were compar...

journal_title：British journal of clinical pharmacology

authors： Rambaran C,Jiang B,Ritter JM,Shah A,Kalra L,Chowienczyk PJ

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Maraviroc, a noncompetitive antagonist of the CCR5 coreceptor, was recently approved in the USA as a treatment of HIV infection. For antiretroviral agents that target the virus, antiviral effect can be related to some extent to plasma drug concentrations. For CCR5 antagonists that target the host cells, rece...

journal_title：British journal of clinical pharmacology

authors： Rosario MC,Jacqmin P,Dorr P,James I,Jenkins TM,Abel S,van der Ryst E

更新日期：2008-04-01 00:00:00

abstract：:1. Lisinopril and enalapril were administered as 2.5 mg single doses and as eight single daily 2.5 mg doses to separate groups of six patients with chronic renal failure. Patients were receiving regular haemodialysis. 2. In the absence of haemodialysis, the decline in plasma concentrations of lisinopril and enalaprila...

journal_title：British journal of clinical pharmacology

authors： Kelly JG,Doyle GD,Carmody M,Glover DR,Cooper WD

更新日期：1988-12-01 00:00:00

abstract：AIMS:In experimental studies, morphine pharmacokinetics is different in the brain compared with other tissues due to the properties of the blood-brain barrier, including action of efflux pumps. It was hypothesized in this clinical study that active efflux of morphine occurs also in human brain, and that brain injury wo...

journal_title：British journal of clinical pharmacology

authors： Ederoth P,Tunblad K,Bouw R,Lundberg CJ,Ungerstedt U,Nordström CH,Hammarlund-Udenaes M

更新日期：2004-04-01 00:00:00

abstract：:1. The pharmacokinetics, bioavailability and metabolism of nitrendipine were studied in six healthy volunteers (three females, three males) using [13C4]-nitrendipine as a biological internal standard. In the first study the drug was administered simultaneously by the i.v. [13C4] and p.o. (solution) routes and in a sec...

journal_title：British journal of clinical pharmacology

authors： Mikus G,Fischer C,Heuer B,Langen C,Eichelbaum M

更新日期：1987-11-01 00:00:00

abstract：AIM:To evaluate a context-learning pharmacotherapy programme for approximately 750 2nd, 3rd and 4th year preclinical medical students with respect to mastering cognitive pharmacotherapeutic skills, i.e. choosing a (drug) treatment and determining patient information. METHODS:The context-learning pharmacotherapy progra...

journal_title：British journal of clinical pharmacology

authors： Vollebregt JA,van Oldenrijk J,Kox D,van Galen SR,Sturm B,Metz JC,Richir MC,de Haan M,Hugtenburg JG,de Vries TP

更新日期：2006-12-01 00:00:00

abstract：:1 The effect of pregnancy on the binding of phenytoin and phenobarbitone to serum proteins was studied in normal women and in drug treated epileptic women. 2 The binding of both drugs was reduced during pregnancy. The reduction correlated positively with the gestational age and negatively with the serum albumin concen...

journal_title：British journal of clinical pharmacology

authors： Chen SS,Perucca E,Lee JN,Richens A

更新日期：1982-04-01 00:00:00

abstract：AIMS:Continuous noninvasive blood pressure measurement by photoplethysmography has been regularly used in the experimental paradigm of angiotensin challenges, applied to the phase I clinical testing of angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists. This work aims to evaluate the performa...

journal_title：British journal of clinical pharmacology

authors： Buclin T,Buchwalder-Csajka C,Brunner HR,Biollaz J

更新日期：1999-10-01 00:00:00

abstract：AIMS:The aim of this work is to understand the process of drug administration and identify points in the workflow that resulted in interventions by clinical information systems in order to improve patient safety. METHODS:To identify a generic way to structure the drug administration process we performed peer-group dis...

journal_title：British journal of clinical pharmacology

authors： Seidling HM,Lampert A,Lohmann K,Schiele JT,Send AJ,Witticke D,Haefeli WE

更新日期：2013-09-01 00:00:00

abstract：:1. Endogenous dopamine, acting through specific receptors on blood vessels, renal tubules and adrenal cortical cells, may play a role in the development and maintenance of the hypertensive state. 2. In hypertensive patients, activation of the DA1-receptor with intravenous fenoldopam produces a rapid and sustained redu...

journal_title：British journal of clinical pharmacology

authors： Hieble JP,Eden RJ,de Mey C

更新日期：1990-01-01 00:00:00

abstract：AIMS:Pupillography is a noninvasive and cost-effective method to determine autonomic nerve activity. Genetic variants in cytochrome P450 (CYP), dopamine receptor (DRD2, DRD3), serotonin receptor (HTR2A, HTR2C) and ATP-binding cassette subfamily B (ABCB1) genes, among others, were previously associated with the pharmaco...

journal_title：British journal of clinical pharmacology

authors： Koller D,Saiz-Rodríguez M,Zubiaur P,Ochoa D,Almenara S,Román M,Romero-Palacián D,de Miguel-Cáceres A,Martín S,Navares-Gómez M,Mejía G,Wojnicz A,Abad-Santos F

更新日期：2020-10-01 00:00:00

abstract：:Many studies from around the world show a correlation between increasing age and adverse drug reaction (ADR) rate, at least for some medical conditions. More than 80% of ADRs causing admission or occurring in hospital are type A (dose-related) in nature, and thus predictable from the known pharmacology of the drug and...

journal_title：British journal of clinical pharmacology

authors： Routledge PA,O'Mahony MS,Woodhouse KW

更新日期：2004-02-01 00:00:00

abstract：:The pharmacokinetics of intravenous and oral propranolol have been compared in six obese and six normal subjects matched for age and sex. After intravenous administration there was no difference in plasma clearance but the volume of distribution was greater (V = 339 l vs 198 l) and the half-life was longer (t1/2 = 5.0...

journal_title：British journal of clinical pharmacology

authors： Bowman SL,Hudson SA,Simpson G,Munro JF,Clements JA

更新日期：1986-05-01 00:00:00

abstract：:A single oral dose of lamotrigine was administered to seven volunteers with Gilbert's Syndrome (unconjugated hyperbilirubinaemia). Plasma samples were assayed by high performance liquid chromatography (h.p.l.c.) and pharmacokinetic parameters were compared with those of a group of nine normal volunteers. In the subjec...

journal_title：British journal of clinical pharmacology

authors： Posner J,Cohen AF,Land G,Winton C,Peck AW

更新日期：1989-07-01 00:00:00

abstract：:1 Quadruple chemotherapy with cytotoxic drugs in advanced (Stage IIIB) Hodgkin's disease causes a fall in the blood lymphocyte count with recovery 1 month after stopping treatment. 2 No selective effect on the T or B lymphocyte populations was shown. ...

journal_title：British journal of clinical pharmacology

authors： Clay A,Swain A,Trounce JR

更新日期：1977-08-01 00:00:00

abstract：AIMS:The pharmacokinetics (PK) of fluconazole and micafungin differ in neonates compared with children and adults. Dosing instructions in product labels appear to be inconsistent with the emerging scientific evidence. Limited information is available on the safety profile of these agents in neonates. Our objective was ...

journal_title：British journal of clinical pharmacology

authors： Leroux S,Jacqz-Aigrain E,Elie V,Legrand F,Barin-Le Guellec C,Aurich B,Biran V,Dusang B,Goudjil S,Coopman S,Garcia Sanchez R,Zhao W,Manzoni P,FP7 TINN (Treat Infections in NeoNates) consortium.

更新日期：2018-09-01 00:00:00

abstract：:1. The population pharmacokinetics of lisinopril were investigated using data collected from two multicentre trials of lisinopril in the treatment of hypertension in elderly patients (n = 40) and patients with renal disease (n = 20). 2. Lisinopril was started at doses of 2.5-5 mg daily and increased at 2-4 weekly inte...

journal_title：British journal of clinical pharmacology

authors： Thomson AH,Kelly JG,Whiting B

更新日期：1989-01-01 00:00:00

abstract：:1 The disposition in urine of debrisoquine and its hydroxylated metabolites has been studied in subjects of the 'extensive metabolizer' (EM; n = 5) and 'poor metabolizer' (PM; n = 5) phenotypes. The 4-hydroxylation of debrisoquine by PM subjects following a 10 mg oral dose was capacity-limited and displayed significan...

journal_title：British journal of clinical pharmacology

authors： Sloan TP,Lancaster R,Shah RR,Idle JR,Smith RL

更新日期：1983-04-01 00:00:00

abstract：AIMS:In order to evaluate a hypothesized protective effect of the use of HMG Co-A reductase inhibitors (statins) on the development of Type 2 diabetes, we conducted a nested case-control study based on data from the UK-based General Practice Research Database (GPRD). METHODS:We identified a population of adults 30-79 ...

journal_title：British journal of clinical pharmacology

authors： Jick SS,Bradbury BD

更新日期：2004-09-01 00:00:00

abstract：AIMS:To assess safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity of CNTO 7160, an anti-interleukin-33 receptor (IL-33R) monoclonal antibody, in healthy subjects and patients with asthma or atopic dermatitis (AD). METHODS:In Part 1 of this Phase I, randomized, double-blind, placebo-c...

journal_title：British journal of clinical pharmacology

authors： Nnane I,Frederick B,Yao Z,Raible D,Shu C,Badorrek P,van den Boer M,Branigan P,Duffy K,Baribaud F,Fink D,Yang TY,Xu Z

更新日期：2020-12-01 00:00:00

abstract：:The effects of high and low urine flow rates on the urinary metabolic ratios for paracetamol glucuronidation, sulphation and oxidation were determined at steady-state in seven healthy young adult volunteers. Metabolic partial clearances were unaffected by urine flow rate, but individual paracetamol metabolic ratios va...

journal_title：British journal of clinical pharmacology

authors： Miners JO,Osborne NJ,Tonkin AL,Birkett DJ

更新日期：1992-10-01 00:00:00

abstract：:Six patients received 10 mg of midazolam intravenously during the anhepatic period of liver transplantation. Arterial blood was sampled during this time and for a similar period following revascularisation. The plasma was analysed using gas chromatography and electron capture detection (GC-ECD) for midazolam alpha-hyd...

journal_title：British journal of clinical pharmacology

authors： Park GR,Manara AR,Dawling S

更新日期：1989-05-01 00:00:00

abstract：AIMS:The major objective of the present study was to investigate the effect of imatinib on the pharmacokinetics of paracetamol in patients with chronic myelogenous leukaemia (CML). METHODS:Patients (n = 12) received a single oral dose of acetaminophen 1000 mg on day 1 (control). On days 2-8, imatinib 400 mg was admini...

journal_title：British journal of clinical pharmacology

authors： Kim DW,Tan EY,Jin Y,Park S,Hayes M,Demirhan E,Schran H,Wang Y

更新日期：2011-02-01 00:00:00

abstract：:1 Five normal subjects received pre-treatment with cimetidine 200 mg three times daily and 400 mg at night for 6 days, or matching placebo. 2 Caffeine (300 mg) was given orally before any treatment and at the beginning of the last day of each treatment course. Treatments were randomly allocated and separated by at lea...

journal_title：British journal of clinical pharmacology

authors： Broughton LJ,Rogers HJ

更新日期：1981-08-01 00:00:00

abstract：:1 The clinical pharmacokinetics of the many benzodiazepines used to treat numerous and varied clinical conditions can be influenced by many factors. 2 Combinations of drugs efficacious in the central nervous system can change the onset, intensity and duration of effect as a result of pharmacological, physiological and...

journal_title：British journal of clinical pharmacology

authors： van der Kleijn E,Vree TB,Baars AM,Wijsman R,Edmunds LC,Knop HJ

更新日期：1981-01-01 00:00:00