Extra-hepatic metabolism of midazolam.

abstract：:1 The effect of acebutolol, a relatively selective beta-adrenoceptor blocking drug and propranolol, a non-selective one, on the hypoglycaemic action of glibenclamide after an oral glucose load has been investigated in a group of maturity-onset diabetic patients. 2 Glibenclamide significantly reduced the blood glucose ...

journal_title：British journal of clinical pharmacology

authors： Zaman R,Kendall MJ,Biggs PI

更新日期：1982-04-01 00:00:00

abstract：:1 Apparent Vmax and Km for phenytoin were estimated in 40 children (aged 8--33 months) and 21 adults (aged 18--66 years). 2 The derived values of Vmax and Km were used to predict the plasma and salivary concentrations of phenytoin following a change in dose. There was a highly significant correlation between observed ...

journal_title：British journal of clinical pharmacology

authors： Blain PG,Mucklow JC,Bacon CJ,Rawlins MD

更新日期：1981-11-01 00:00:00

abstract：AIMS:To assess the reproducibility of the digital pulse wave response to beta(2)-adrenoreceptor stimulation and to determine if an attenuated response to beta(2)-adrenoceptor stimulation is associated with impaired flow mediated dilatation (FMD). METHODS:Subjects (n = 20) with endothelial dysfunction (ED), were compar...

journal_title：British journal of clinical pharmacology

authors： Rambaran C,Jiang B,Ritter JM,Shah A,Kalra L,Chowienczyk PJ

更新日期：2008-02-01 00:00:00

abstract：:The hypertensive disorders of pregnancy (HDP) are a leading cause of maternal mortality and morbidity in both well and under-resourced settings. Maternal, fetal, and neonatal complications of the HDP are concentrated among, but not limited to, women with pre-eclampsia. Pre-eclampsia is a systemic disorder of endotheli...

journal_title：British journal of clinical pharmacology

authors： Magee LA,Abalos E,von Dadelszen P,Sibai B,Easterling T,Walkinshaw S,CHIPS Study Group.

更新日期：2011-09-01 00:00:00

abstract：AIMS:To assess the age-associated changes over time of plasma paraxanthine/caffeine (PAX/CAF) ratios used as a probe for CYP1A2 activity. METHODS:Intraindividual and interindividual variabilities in PAX/CAF ratio were compared by phenotyping with caffeine, 16 young and 16 elderly healthy subjects on five occasions. R...

journal_title：British journal of clinical pharmacology

authors： Simon T,Becquemont L,Hamon B,Nouyrigat E,Chodjania Y,Poirier JM,Funck-Brentano C,Jaillon P

更新日期：2001-11-01 00:00:00

abstract：:Scientific advice (SA) is an important tool offered by regulators to help developers generate robust evidence on a medicine's benefits and risks. Drawing on accumulated experience and looking at the SA provided by the European Medicines Agency in 2018 to advanced therapy medicinal products originally developed by publ...

journal_title：British journal of clinical pharmacology

authors： Tavridou A,Rogers D,Bonelli M,Schiel A,Hidalgo-Simon A

更新日期：2020-11-25 00:00:00

abstract：:Paracetamol overdose prior to the introduction of acetylcysteine was associated with significant morbidity. Acetylcysteine is now the mainstay of treatment for paracetamol poisoning and has effectively reduced rates of hepatotoxicity and death. The current three-bag intravenous regimen with an initial high loading dos...

journal_title：British journal of clinical pharmacology

authors： Chiew AL,Isbister GK,Duffull SB,Buckley NA

更新日期：2016-03-01 00:00:00

abstract：:1 Cimetidine has been reported to reduce serum calcium and parathyroid hormone (PTH) levels in primary hyperparathyroidism, but some studies have reported negative findings. 2 A double-blind, controlled trial of cimetidine in this condition was, therefore, conducted. Eight patients were given cimetidine and placebo fo...

journal_title：British journal of clinical pharmacology

authors： Fisken RA,Wilkinson R,Heath DA

更新日期：1982-11-01 00:00:00

abstract：AIMS:Naloxegol, a polyethylene glycol conjugated derivative of the opioid antagonist naloxone, is in clinical development for treatment of opioid-induced constipation (OIC). The aim of the study was to develop a population pharmacokinetic model describing the concentration vs. time profile of orally administered naloxe...

journal_title：British journal of clinical pharmacology

authors： Al-Huniti N,Chapel S,Xu H,Bui KH,Sostek M

更新日期：2016-01-01 00:00:00

abstract：AIM:To evaluate cases of deep vein thrombosis (DVT) and pulmonary embolism (PE) reported in a prescription event monitoring study of Yasmin, an oral contraceptive. METHODS:Reports of DVT/PE and events suggestive of DVT/PE were followed up by questionnaire. RESULTS:Thirteen cases (DVT five; PE eight), each with possib...

journal_title：British journal of clinical pharmacology

authors： Pearce HM,Layton D,Wilton LV,Shakir SA

更新日期：2005-07-01 00:00:00

abstract：:1. A 1.25 mg dose of cilazapril, a new angiotensin-converting enzyme (ACE) inhibitor, was administered orally to two groups of hypertensive patients, five with normal renal function (NRF) and seven with impaired renal function (IRF), once daily for 5 or 8 consecutive days. Blood pressure, heart rate and serum ACE acti...

journal_title：British journal of clinical pharmacology

authors： Shionoiri H,Gotoh E,Sugimoto K,Takasaki I,Minamisawa K,Ishii M

更新日期：1989-01-01 00:00:00

abstract：AIMS:Voriconazole is a novel triazole with broad-spectrum antifungal activity. It is likely that some patients receiving voriconazole may also require treatment with the anticoagulant warfarin. Cytochrome P450 isoenzymes are important in the metabolism of both these drugs. This study investigated the effect of voricona...

journal_title：British journal of clinical pharmacology

authors： Purkins L,Wood N,Kleinermans D,Nichols D

更新日期：2003-12-01 00:00:00

abstract：AIMS:The cytochrome P-450 2D6 (CYP2D6) gene duplication/multiduplication producing an increase in enzyme activity, and the common Japanese mutation, CYP2D6*10A producing a decrease of enzyme activity were screened in a large number of Japanese psychiatric subjects (n = 111) in order to investigate whether these mutated...

journal_title：British journal of clinical pharmacology

authors： Ohnuma T,Shibata N,Matsubara Y,Arai H

更新日期：2003-09-01 00:00:00

abstract：:In a double-blind trial the effects on ventilatory function (FEV1), heart rate and blood pressure of oral pirbuterol and oral salbutamol in various single doses were studied in ten patients with chronic asthma. Pirbuterol (15 mg) and salbutamol (4 mg) produced equal peak levels of bronchodilatation. There was no signi...

journal_title：British journal of clinical pharmacology

authors： Willey RF,Grant IW,Pocock SJ

更新日期：1976-08-01 00:00:00

abstract：AIMS:Paracetamol is frequently involved in intended self-poisoning, and concomitant overdosing of other drugs is commonly reported. The purpose of the study was to investigate further concomitant drug overdose in patients with paracetamol poisoning and to evaluate its effects on the outcome of the paracetamol intoxicat...

journal_title：British journal of clinical pharmacology

authors： Schmidt LE,Dalhoff K

更新日期：2002-05-01 00:00:00

abstract：AIM:We aimed to establish a method to assess systemic and pre-systemic cytochrome P450 (CYP) 3A activity using ineffective microgram doses of midazolam. METHODS:In an open, one sequence, crossover study, 16 healthy participants received intravenous and oral midazolam at microgram (0.001 mg intravenous and 0.003 mg ora...

journal_title：British journal of clinical pharmacology

authors： Hohmann N,Kocheise F,Carls A,Burhenne J,Haefeli WE,Mikus G

更新日期：2015-02-01 00:00:00

abstract：AIMS:The pharmacokinetics of voriconazole show a nonlinear dose-exposure relationship caused by inhibition of its own CYP3A-dependent metabolism. Because the magnitude of autoinhibition also depends on voriconazole concentrations, infusion rate might modulate voriconazole exposure. The impact of four different infusion...

journal_title：British journal of clinical pharmacology

authors： Hohmann N,Kreuter R,Blank A,Weiss J,Burhenne J,Haefeli WE,Mikus G

更新日期：2017-09-01 00:00:00

abstract：AIMS:We investigated the effect of angiotensin converting enzyme inhibitors (ACEIs) on postsynaptic adrenoceptor sensitivity and compared the effect of the lipophilic ACEI, quinapril, and that of hydrophilic agent, enalapril in human vessels. METHODS:Alpha-adrenoceptor sensitivity was evaluated using the dorsal hand v...

journal_title：British journal of clinical pharmacology

authors： Kimura M,Umemura K,Kosuge K,Nishimoto M,Ohashi K,Nakashima M

更新日期：1998-12-01 00:00:00

abstract：:A single oral dose of lamotrigine was administered to seven volunteers with Gilbert's Syndrome (unconjugated hyperbilirubinaemia). Plasma samples were assayed by high performance liquid chromatography (h.p.l.c.) and pharmacokinetic parameters were compared with those of a group of nine normal volunteers. In the subjec...

journal_title：British journal of clinical pharmacology

authors： Posner J,Cohen AF,Land G,Winton C,Peck AW

更新日期：1989-07-01 00:00:00

abstract：AIMS:(i) To model the effects of the monoclonal antibody ATM-027 on the number of target cells and on the receptor density on the cell surface as measured by Fluorescence Activated Cell Sorter analysis, (ii) to investigate the effects of categorizing a continuous scale, and (iii) to simulate a phase II trial from phase...

journal_title：British journal of clinical pharmacology

authors： Zingmark PH,Edenius C,Karlsson MO

更新日期：2004-10-01 00:00:00

abstract：:1. The study was performed to determine the sensitivity and short-term and day-to-day variability of a novel technique based on laser interferometry of ocular fundus pulsations and of non-invasive methods for the quantification of haemodynamic drug effects. An additional aim was to assess sex differences in haemodynam...

journal_title：British journal of clinical pharmacology

authors： Wolzt M,Schmetterer L,Rheinberger A,Salomon A,Unfried C,Breiteneder H,Ehringer H,Eichler HG,Fercher AF

更新日期：1995-04-01 00:00:00

abstract：AIMS:The therapeutic action of tricyclic agents may be accompanied by unwanted effects on the cardiovascular system. The evidence for the effects on vascular and nonvascular smooth muscle comes from animal studies. Whether these studies can be extrapolated to human vessels remains to be determined. Therefore, the prese...

journal_title：British journal of clinical pharmacology

authors： Vila JM,Medina P,Segarra G,Lluch P,Pallardó F,Flor B,Lluch S

更新日期：1999-08-01 00:00:00

abstract：:Clinical studies comparing the response and side effects of various opioids have not been able to show robust differences between drugs. Hence, recommendations of the regulatory authorities have been driven by costs with a general tendency in many countries to restrict physician's use of opioids to morphine. Although ...

journal_title：British journal of clinical pharmacology

authors： Drewes AM,Jensen RD,Nielsen LM,Droney J,Christrup LL,Arendt-Nielsen L,Riley J,Dahan A

更新日期：2013-01-01 00:00:00

abstract：:Children are not small adults. However, the main thesis of this review will be that children's responses to drugs have much in common with the responses in adults and indeed in other mammals. Often, it is assumed that drug effects differ in children but in reality this perception often arises because the drugs have no...

journal_title：British journal of clinical pharmacology

authors： Stephenson T

更新日期：2005-06-01 00:00:00

abstract：:We have traced the historical link between the Law of Mass Action and clinical pharmacology. The Law evolved from the work of the French chemist Claude Louis Berthollet, was first formulated by Cato Guldberg and Peter Waage in 1864 and later clarified by the Dutch chemist Jacobus van 't Hoff in 1877. It has profoundly...

journal_title：British journal of clinical pharmacology

authors： Ferner RE,Aronson JK

更新日期：2016-01-01 00:00:00

abstract：:A double-blind, placebo-controlled, cross-over trial of quinine in leg cramps occurring at rest was conducted in 22 elderly cramp sufferers. Despite demonstration of impaired quinine elimination in the elderly, prescription of the traditional dose of 300 mg quinine bisulphate at night failed to produce a significant (...

journal_title：British journal of clinical pharmacology

authors： Warburton A,Royston JP,O'Neill CJ,Nicholson PW,Jee RD,Denham MJ,Dobbs SM,Dobbs RJ

更新日期：1987-04-01 00:00:00

abstract：:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Reflux oesophagitis is a common clinical disorder associated with significant morbidity. Proton pump inhibitors are the current pharmacotherapy of choice, but not all treated patients achieve symptom relief. Little is known about the efficacy of mosapride, a prokinetic agent wh...

journal_title：British journal of clinical pharmacology

authors： Hsu YC,Yang TH,Hsu WL,Wu HT,Cheng YC,Chiang MF,Wang CS,Lin HJ

更新日期：2010-08-01 00:00:00

abstract：AIMS:Spirometry, plethysmography and impulse oscillometry (IOS) measure different aspects of lung function. These methods have not been compared for their ability to assess long- and short-acting anticholinergic agents. We therefore performed a double-blind, placebo-controlled, four-way cross-over study in 30 healthy s...

journal_title：British journal of clinical pharmacology

authors： Singh D,Tal-Singer R,Faiferman I,Lasenby S,Henderson A,Wessels D,Goosen A,Dallow N,Vessey R,Goldman M

更新日期：2006-04-01 00:00:00

abstract：:The kinetics of clobazam taken 3 h before, during, and 3 h after a standard hospital meal were studied in six healthy volunteers. Peak plasma levels were significantly lower when the drug was taken with or after meals suggesting that the rate of absorption was reduced by food. The mean area under the concentration vs ...

journal_title：British journal of clinical pharmacology

authors： Cenraud B,Guyot M,Levy RH,Brachet-Liermain A,Morselli PL,Moreland TA,Loiseau P

更新日期：1983-12-01 00:00:00

abstract：:1 The effects of the thromboxane synthetase inhibitor dazoxiben (UK 37248) on haemodynamics, blood gases, thromboxane and prostacyclin release and on arrhythmias were examined in anaesthetised greyhounds subject to acute coronary artery occlusion and reperfusion. 2 Ten minutes after the administration of UK 37248 2 mg...

journal_title：British journal of clinical pharmacology

authors： Coker SJ,Parratt JR

更新日期：1983-01-01 00:00:00