当前位置： SCI文献检索 > BRITISH JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Assessment of endothelial function: comparison of the pulse wave response to beta 2-adrenoceptor stimulation with flow mediated dilatation.

Assessment of endothelial function: comparison of the pulse wave response to beta 2-adrenoceptor stimulation with flow mediated dilatation.

Abstract：

AIMS:To assess the reproducibility of the digital pulse wave response to beta(2)-adrenoreceptor stimulation and to determine if an attenuated response to beta(2)-adrenoceptor stimulation is associated with impaired flow mediated dilatation (FMD). METHODS:Subjects (n = 20) with endothelial dysfunction (ED), were compared with healthy control subjects (n = 20). Change in reflection index (Delta RI) of the digital volume pulse in response to salbutamol (SALB, 5 microg min(-1) i.v) and to nitroglycerin (NTG, 5 microg min(-1) i.v) was used to assess endothelium-dependent (Delta RI(SALB)) and endothelium-independent (Delta RI(NTG)) pressure wave reflection. Delta RI(SALB) was assessed on two occasions to examine reproducibility. High resolution ultrasound of the brachial artery was used to measure FMD and also dilation to NTG (NTGD). RESULTS:The mean difference in Delta RI(SALB) between two visits was -0.2%, with SD of the difference 4.9%. Both Delta RI(SALB) and FMD were impaired in subjects with ED compared with values in control subjects (5.0 +/- 0.7 vs. 11.3 +/- 1.2%, mean values +/- SEM, P < 0.01 and 4.2 +/- 0.6 vs. 7.5 +/- 0.8%, P < 0.02 for Delta RI(SALB) and FMD, respectively), whereas Delta RI(NTG) and NTGD were similar in the two groups. Delta RI(SALB) was correlated with FMD (r = 0.44, P < 0.01) and had 88% sensitivity and 79% specificity to detect abnormal (FMD < 4%). CONCLUSIONS:The pulse wave response to a beta(2)-adrenoceptor agonist correlates with FMD and has high sensitivity and specificity in detecting abnormal endothelial function as defined by FMD. However, FMD is the preferred test to detect effects of interventions on endothelial function.

journal_name

Br J Clin Pharmacol

journal_title

British journal of clinical pharmacology

authors

Rambaran C,Jiang B,Ritter JM,Shah A,Kalra L,Chowienczyk PJ

doi

10.1111/j.1365-2125.2007.03006.x

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

238-43

issue

2

eissn

0306-5251

issn

1365-2125

pii

BCP3006

journal_volume

65

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY文献大全
  • Determinants of mercaptopurine toxicity in paediatric acute lymphoblastic leukemia maintenance therapy.

    abstract：AIMS:6-mercaptopurine (6-MP) is used in the treatment of childhood acute lymphoblastic leukaemia (ALL). Its red blood cell (RBC) metabolite concentrations (6-thioguanine [6-TGN] and 6-methylmercaptopurine nucleotides [6-MMPN]) are related to drug response. We investigated the impact of non-genetic covariates and pharma...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.2010.03867.x

    authors： Adam de Beaumais T,Fakhoury M,Medard Y,Azougagh S,Zhang D,Yakouben K,Jacqz-Aigrain E

    更新日期：2011-04-01 00:00:00

  • Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam.

    abstract：:The excretion of diazepam, N-desmethyldiazepam, temazepam and oxazepam in breast milk was studied during withdrawal of a 22-year-old patient from combined high dose diazepam and oxazepam therapy. Concentrations of these benzodiazepines in plasma from both the woman and her nursing infant (1 year old) were also documen...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1990.tb03612.x

    authors： Dusci LJ,Good SM,Hall RW,Ilett KF

    更新日期：1990-01-01 00:00:00

  • The effect on motion sickness and oculomotor function of GR 38032F, a 5-HT3-receptor antagonist with anti-emetic properties.

    abstract：:1. The 5-hydroxytryptamine (5-HT3) receptor antagonist, GR 38032F, which possesses potent anti-emetic properties in vomiting induced by cancer chemotherapeutic drugs, has been tested to determine its value in the prophylaxis of motion sickness induced by cross-coupled stimulation. The double-blind trial compared GR 38...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1989.tb05345.x

    authors： Stott JR,Barnes GR,Wright RJ,Ruddock CJ

    更新日期：1989-02-01 00:00:00

  • The role of epoxyeicosatrienoic acids in the cardiovascular system.

    abstract：:There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of ca...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1111/bcp.12603

    authors： Yang L,Mäki-Petäjä K,Cheriyan J,McEniery C,Wilkinson IB

    更新日期：2015-07-01 00:00:00

  • Comparison of medroxalol and labetalol, drugs with combined alpha- and beta-adrenoceptor antagonist properties.

    abstract：:Medroxalol, a new drug which has been reported to possess both alpha- and beta-adrenoceptor antagonist properties, was compared with labetalol in single dose studies in normotensive males. Oral doses of 400 mg of each drug significantly reduced blood pressure, both supine and erect, without significant changes in hear...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1984.tb02391.x

    authors： Elliott HL,McLean K,Meredith PA,Sumner DJ,Reid JL

    更新日期：1984-05-01 00:00:00

  • Social media and pharmacovigilance: A review of the opportunities and challenges.

    abstract：:Adverse drug reactions come at a considerable cost on society. Social media are a potentially invaluable reservoir of information for pharmacovigilance, yet their true value remains to be fully understood. In order to realize the benefits social media holds, a number of technical, regulatory and ethical challenges rem...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1111/bcp.12717

    authors： Sloane R,Osanlou O,Lewis D,Bollegala D,Maskell S,Pirmohamed M

    更新日期：2015-10-01 00:00:00

  • Vagal activity is increased during intravenous isoprenaline infusion in man.

    abstract：:Eight healthy normal subjects (19-23 years) received graded intravenous isoprenaline infusions PRE- and POST-atropine, 0.04 mg/kg i.v. The adequacy of atropinization was tested with bolus intravenous injections of phenylephrine. PRE-atropine, isoprenaline caused an increase in heart rate and systolic pressure, but a d...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1984.tb02469.x

    authors： Arnold JM,McDevitt DG

    更新日期：1984-09-01 00:00:00

  • Plasma concentrations and protein binding of disopyramide and mono-N-dealkyldisopyramide during chronic oral disopyramide therapy.

    abstract：:1 The plasma levels of disopyramide and mono-N-dealkyldisopyramide were measured from 118 patients, and the protein binding of both drugs from 50 patients during chronic oral disopyramide therapy. 2 No significant correlation was seen between the daily dose of disopyramide and the achieved plasma drug concentration. 3...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1981.tb01134.x

    authors： Aitio ML

    更新日期：1981-04-01 00:00:00

  • A placebo-controlled study of interaction between nabumetone and acenocoumarol.

    abstract：AIMS:The use of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients treated with oral anticoagulants is generally discouraged due to the risk of interactions that could increase the risk of bleeding complications. Available data suggest the NSAID, nabumetone, does not produce such an interaction. We investigated ...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2125.1999.00916.x

    authors： Pardo A,García-Losa M,Fernández-Pavón A,del Castillo S,Pascual-García T,García-Méndez E,Dal-Ré R

    更新日期：1999-04-01 00:00:00

  • The selectivity of the beta-adrenoceptor for ventilation in man.

    abstract：:1 Minute ventilation, alveolar PCO2, CO2 production and heart rate were measured in eight normal subjects before and during infusions of noradrenaline 0.2, 1.0 and 5.0 micrograms min-1 and isoprenaline 0.04, 0.2 and 1.0 microgram min-1. 2 These measurements were repeated after propranolol 3.5 mg, atenolol 8 mg or meto...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1982.tb04961.x

    authors： Butland RJ,Pang JA,Geddes DM

    更新日期：1982-11-01 00:00:00

  • Impaired absorption of paracetamol in vegetarians.

    abstract：:1. The absorption and disposition of paracetamol was investigated in 10 healthy male Thai vegetarians and 10 similar non-vegetarians following an oral dose of 20 mg kg-1. 2. The absorption rate of paracetamol was significantly impaired in the vegetarians compared with the non-vegetarians as shown by a lower mean Cmax ...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1993.tb04223.x

    authors： Prescott LF,Yoovathaworn K,Makarananda K,Saivises R,Sriwatanakul K

    更新日期：1993-09-01 00:00:00

  • Prediction of sustained fetal toxicity induced by ketoprofen based on PK/PD analysis using human placental perfusion and rat toxicity data.

    abstract：AIM:We encountered a case of fetal toxicity due to ductus arteriosus (DA) constriction in a 36-week pregnant woman who had applied multiple ketoprofen patches. The aim of the present study was to present the case and develop a model to predict quantitatively the fetal toxicity risk of transdermal administration of keto...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.13352

    authors： Tanaka S,Kanagawa T,Momma K,Hori S,Satoh H,Nagamatsu T,Fujii T,Kimura T,Sawada Y

    更新日期：2017-11-01 00:00:00

  • A randomized, double-blind, placebo-controlled trial comparing pethidine to metamizol for treatment of post-anaesthetic shivering.

    abstract：:1. Shivering is frequent during the post-anaesthetic recovery period, and there is no clear consensus about the best strategy for its treatment. We tested the efficacy of two commonly used analgesic drugs, pethidine and metamizol. 2. A randomized, double-blind, placebo-controlled clinical trial was performed, includin...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2125.1996.04124.x

    authors： Monsó A,Riudeubas J,Barbal F,Laporte JR,Arnau JM

    更新日期：1996-09-01 00:00:00

  • A comparative study of atenolol and metoprolol in the treatment of hypertension.

    abstract：:1 In an open, randomized cross-over investigation of thirteen patients (nine and four women, aged 37-67 years) with mild or moderate essential hypertension a comparison between atenolol and metoprolol was carried out in order to study the effects of 50, 100 and 200 mg given once daily on blood pressure and heart rate ...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-2125.1981.tb01326.x

    authors： Rasmussen S,Arnung K,Eskildsen PC,Nielsen PE

    更新日期：1981-12-01 00:00:00

  • Observations on the relationship between anxiety and depressive symptoms during the course of depressive illnesses.

    abstract：:1 Roth et al. (1972) have proposed that within the affective disorders there are two distinct syndromes--anxiety and depression--differentiated by the relative predominance of these symptoms, the presence or absence of premorbid maladaptive traits, and the natural outcome of the disorder. 2 Goldberg (1982) on the othe...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1983.tb05859.x

    authors： Russell GF,De Silva P

    更新日期：1983-01-01 00:00:00

  • Fixed-dose combination antibiotics: The search for evidence using the example of ampicillin-cloxacillin.

    abstract：:High consumption of irrational fixed-dose combination (FDC) antibiotics may pose a threat of antimicrobial resistance. In India, ampicillin-cloxacillin was the second highest sold FDC antibiotic behind amoxicillin and clavulanic acid. There remain, however, questions about its efficacy and safety and a lack of regulat...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.14711

    authors： Sayer B,Bortone B,Sharland M,Hsia Y

    更新日期：2020-12-23 00:00:00

  • Ouabain and responses to endothelium-dependent vasodilators in the human forearm.

    abstract：:Ouabain inhibits endothelium-dependent vascular relaxation in vitro, but has not been studied in this regard in vivo. We have therefore measured blood flow responses to carbachol, bradykinin and sodium nitroprusside (endothelium-dependent and endothelium-independent vasodilators) infused into the brachial artery with ...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：

    authors： Woolfson RG,Benjamin N,Todd SD,Poston L,Ritter JM

    更新日期：1991-12-01 00:00:00

  • Improved physical performance as a therapeutic objective in patients with angina.

    abstract：:1 Improvement in physical performance, based on exercise tolerance, self-assessed work and physician-rated functional capacities, is proposed as a measure of efficacy of anti-anginal therapy in the rehabilitation of the cardiac patient. 2 Improved physical performance parallels changes in frequency of anginal attacks ...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1979.tb04686.x

    authors： Ling AS,Groel JT

    更新日期：1979-01-01 00:00:00

  • Effects of azapropazone on pain-related brain activity in human subjects.

    abstract：:1. The dose-related effects of azapropazone on (i) event-related and spontaneous EEG-activity and (ii) the subjects' pain ratings were investigated using an experimental human pain model based on both chemo-somatosensory event-related potentials (CSSERP) and subjects' pain ratings. 2. Healthy subjects (n = 20) partici...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1995.tb05799.x

    authors： Lötsch J,Mohammadian P,Hummel T,Florin S,Brune K,Geisslinger G,Kobal G

    更新日期：1995-12-01 00:00:00

  • The effects of cimetidine on serum calcium and parathyroid hormone levels in primary hyperparathyroidism.

    abstract：:1 Cimetidine has been reported to reduce serum calcium and parathyroid hormone (PTH) levels in primary hyperparathyroidism, but some studies have reported negative findings. 2 A double-blind, controlled trial of cimetidine in this condition was, therefore, conducted. Eight patients were given cimetidine and placebo fo...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1982.tb04960.x

    authors： Fisken RA,Wilkinson R,Heath DA

    更新日期：1982-11-01 00:00:00

  • Attention tasks as skills performance measures of drug effects.

    abstract：:Both empirical epidemiological data on the causes of traffic accidents and conceptual models of skilled human performance stress the central role of perception and cognition. This paper examines the effects of drugs on two major components of cognitive perceptual performance, namely, concentrated attention or vigilanc...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1984.tb02582.x

    authors： Moskowitz H

    更新日期：1984-01-01 00:00:00

  • The effect of propranolol on paracetamol metabolism in man.

    abstract：:Ten healthy volunteers were treated for 4 days with 160 mg propranolol HCl and placebo in random order. At the end of each treatment salivary antipyrine kinetics and the plasma kinetics and urinary excretion of paracetamol and its major metabolites were measured following a 1500 mg oral dose. Propranolol prolonged the...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1990.tb03631.x

    authors： Baraka OZ,Truman CA,Ford JM,Roberts CJ

    更新日期：1990-02-01 00:00:00

  • Neuropeptides in hypertension: role of neuropeptide Y and calcitonin gene related peptide.

    abstract：:1. The effect of neuropeptide Y (NPY) on cardiovascular function at three levels of the noradrenergic axis where the peptide is known to co-exist with noradrenaline (NA) and or adrenaline (A) was studied in normotensive Sprague-Dawley (SD), Wistar-Kyoto (WKY) or spontaneously hypertensive rats (SHR). 2. In the perfuse...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1990.tb05472.x

    authors： Westfall TC,Han SP,Knuepfer M,Martin J,Chen XL,del Valle K,Ciarleglio A,Naes L

    更新日期：1990-01-01 00:00:00

  • Population pharmacokinetics of levamisole in children with steroid-sensitive nephrotic syndrome.

    abstract：AIM:The aim was to investigate the population pharmacokinetics of levamisole in children with steroid-sensitive nephrotic syndrome. METHODS:Non-linear mixed effects modelling was performed on samples collected during a randomized controlled trial. Samples were collected from children who were receiving 2.5 mg kg(-1) l...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.12607

    authors： Kreeftmeijer-Vegter AR,Dorlo TP,Gruppen MP,de Boer A,de Vries PJ

    更新日期：2015-08-01 00:00:00

  • Post-marketing assessment of the safety of strontium ranelate; a novel case-only approach to the early detection of adverse drug reactions.

    abstract：AIMS:Post licensing, the evaluation of drug safety relies heavily on the collation of sporadic, spontaneous reports on adverse effects. The aim was to assess the potential utility of a more systematic approach to the detection of adverse events that utilizes routinely collected clinical data from a large primary care p...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.2008.03273.x

    authors： Grosso A,Douglas I,Hingorani A,MacAllister R,Smeeth L

    更新日期：2008-11-01 00:00:00

  • Effects of a geriatric intervention aiming to improve quality care in nursing homes on benzodiazepine use and discontinuation.

    abstract：BACKGROUND:Benzodiazepines and "Z drugs" are often prescribed in residents of nursing homes (NH) despite their well-known deleterious effects. We aimed to investigate if a general intervention on quality of care led to discontinuation of benzodiazepine, and to examine which NH-related factors were associated in change ...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.12847

    authors： de Souto Barreto P,Lapeyre-Mestre M,Cestac P,Vellas B,Rolland Y

    更新日期：2016-04-01 00:00:00

  • Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil.

    abstract：AIMS:To characterize the cytochrome P450 (CYP) enzymes responsible for the N-demethylation of sildenafil to its main metabolite, UK-103 320, to investigate the potential inhibitory effects of sildenafil on CYP enzymes and to evaluate the potential of selected drugs to affect sildenafil metabolism. METHODS:The metaboli...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2125.2001.00318.x

    authors： Hyland R,Roe EG,Jones BC,Smith DA

    更新日期：2001-03-01 00:00:00

  • Assay and characterisation of debrisoquine 4-hydroxylase activity of microsomal fractions of human liver.

    abstract：:1 A method for the assay of debrisoquine 4-hydroxylase activity in vitro by microsomal fractions of human liver is described. The assay utilises gas chromatography-mass spectrometry with d9-4-hydroxydebrisoquine as internal standard. 2 The limit of detection of 4-hydroxydebrisoquine was 2 ng ml -1 and the coefficient ...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1982.tb01430.x

    authors： Kahn GC,Boobis AR,Murray S,Brodie MJ,Davies DS

    更新日期：1982-05-01 00:00:00

  • Duloxetine pharmacokinetics are similar in Japanese and Caucasian subjects.

    abstract：AIMS:To compare single- and multiple-dose duloxetine pharmacokinetics between healthy Japanese and Caucasians. METHODS:Twenty-four subjects of each race were given single oral doses of duloxetine (20, 40 and 60 mg) in a randomized, double-blind study. Another 20 subjects of each race received 20, 40 mg or placebo (2 :...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.2006.02770.x

    authors： Chan C,Yeo KP,Pan AX,Lim M,Knadler MP,Small DS

    更新日期：2007-03-01 00:00:00

  • The influence of age, liver size and enantiomer concentrations on warfarin requirements.

    abstract：:1. We have tested the hypothesis that the fall in hepatic mass with age influences the age related increase in sensitivity to warfarin. In 39 otherwise healthy outpatients, aged 50-87 years, stabilised on warfarin for prophylaxis of thromboembolism, age, mean International Normalised Ratio (INR), and mean warfarin dos...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：

    authors： Wynne H,Cope L,Kelly P,Whittingham T,Edwards C,Kamali F

    更新日期：1995-09-01 00:00:00