Neuropeptides in hypertension: role of neuropeptide Y and calcitonin gene related peptide.

abstract：:We have traced the historical link between the Law of Mass Action and clinical pharmacology. The Law evolved from the work of the French chemist Claude Louis Berthollet, was first formulated by Cato Guldberg and Peter Waage in 1864 and later clarified by the Dutch chemist Jacobus van 't Hoff in 1877. It has profoundly...

journal_title：British journal of clinical pharmacology

authors： Ferner RE,Aronson JK

更新日期：2016-01-01 00:00:00

abstract：:One hundred different drug advertisements from each of seven leading medical journals have been assessed. Information about drug interactions, adverse reactions, mode of action, absorption, distribution, metabolism, excretion and cost was seldom provided in UK journals. A requirement should exist that drug advertiseme...

journal_title：British journal of clinical pharmacology

authors： Morgan AH,Jeffers TA,Petrie JC,Walker W

更新日期：1976-12-01 00:00:00

abstract：AIMS:Formoterol is a beta2-adrenoceptor agonist marketed as a racemic mixture of the active (R; R)- and inactive (S; S)-enantiomers (rac-formoterol). The drug produces prolonged bronchodilation by inhalation but there is significant interpatient variability in duration of effect. Previous work has shown that in humans ...

journal_title：British journal of clinical pharmacology

authors： Zhang M,Fawcett JP,Kennedy JM,Shaw JP

更新日期：2000-02-01 00:00:00

abstract：:1. Previous studies have demonstrated the presence of antibodies to trifluoroacetylated hepatic proteins (TFA-proteins) in sera from patients with the severe form of halothane-associated hepatitis (halothane hepatitis). The TFA-proteins are produced via cytochrome P450-mediated metabolism of halothane to the reactive ...

journal_title：British journal of clinical pharmacology

authors： Kitteringham NR,Kenna JG,Park BK

更新日期：1995-10-01 00:00:00

abstract：:1 Evidence concerning the convulsant effects of non-monoamine oxidase inhibitor antidepressant drugs has been reviewed. 2 Mianserin is convulsant in therapeutic doses but seizures have not been reported following overdose. 3 The convulsant effects of mianserin are probably no greater than for other non-monoamine oxida...

journal_title：British journal of clinical pharmacology

authors： Richens A,Nawishy S,Trimble M

更新日期：1983-01-01 00:00:00

abstract：:1. In order to assess the prevalence of concurrent use of more than one major psychotropic drug (polypsychopharmacy) in out-patients, a prescription database study was conducted in the Odense area for a period of 2 years. 2. During the index period 5.12% of the inhabitants purchased major psychotropic drugs. Of these,...

journal_title：British journal of clinical pharmacology

authors： Rosholm JU,Hallas J,Gram LF

更新日期：1994-06-01 00:00:00

abstract：:1. Studies using human liver microsomes and six recombinant human CYP isoforms (i.e. CYP1A2, 2A6, 2B6, 2D6, 2E1 and 3A4) were performed to identify the cytochrome P450 (CYP) isoform(s) involved in the ring 4-hydroxylation and side-chain N-desisopropylation of propranolol enantiomers in humans. 2. alpha-Naphthoflavone ...

journal_title：British journal of clinical pharmacology

authors： Yoshimoto K,Echizen H,Chiba K,Tani M,Ishizaki T

更新日期：1995-04-01 00:00:00

abstract：AIMS:The use of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients treated with oral anticoagulants is generally discouraged due to the risk of interactions that could increase the risk of bleeding complications. Available data suggest the NSAID, nabumetone, does not produce such an interaction. We investigated ...

journal_title：British journal of clinical pharmacology

authors： Pardo A,García-Losa M,Fernández-Pavón A,del Castillo S,Pascual-García T,García-Méndez E,Dal-Ré R

更新日期：1999-04-01 00:00:00

abstract：:The effects of bopindolol, a new beta-adrenoceptor blocker, on the exercise tolerance of 12 in-patients, mean age 57 (5 years), with stable angina pectoris and documented coronary artery disease were evaluated. All patients received on 4 different days a single oral dose of bopindolol 0.5 mg, bopindolol 1.0 mg, bopind...

journal_title：British journal of clinical pharmacology

authors： Carboni GP,Scardovi AB,D'Ermo M,Prati PL

更新日期：1991-12-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Desmopressin is a known haemostatic agent and is also being used, albeit at lower doses, during the diagnostic work-up of Cushing's syndrome, a condition characterized by excess cortisol concentrations and frequent thromboembolic events. No study has yet evaluated whether admini...

journal_title：British journal of clinical pharmacology

authors： Pecori Giraldi F,Ambrogio AG,Fatti LM,Rubini V,Cozzi G,Scacchi M,Federici AB,Cavagnini F

更新日期：2011-01-01 00:00:00

abstract：:In a double-blind, placebo-controlled, randomised, cross-over study of six healthy male subjects, the effect of nicardipine (5 mg h-1 for 3 h) on basal and stimulated pituitary hormone release was examined. Statistically significant differences between nicardipine and placebo were seen occasionally for follicle-stimul...

journal_title：British journal of clinical pharmacology

authors： Isles TE,Baty J,Dow RJ

更新日期：1985-01-01 00:00:00

abstract：:Medroxalol, a new drug which has been reported to possess both alpha- and beta-adrenoceptor antagonist properties, was compared with labetalol in single dose studies in normotensive males. Oral doses of 400 mg of each drug significantly reduced blood pressure, both supine and erect, without significant changes in hear...

journal_title：British journal of clinical pharmacology

authors： Elliott HL,McLean K,Meredith PA,Sumner DJ,Reid JL

更新日期：1984-05-01 00:00:00

abstract：:1. The kinetics and effects of ebastine 10 and 50 mg were studied after oral dosing in healthy subjects. 2. The parent drug was extensively metabolised during the first pass to its carboxylic acid derivative, carebastine. 3. The pharmacokinetics of carebastine were linear over the dose range studied and the terminal e...

journal_title：British journal of clinical pharmacology

authors： Vincent J,Liminana R,Meredith PA,Reid JL

更新日期：1988-11-01 00:00:00

abstract：AIMS:To develop a polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP)-based assay to genotype for hepatic CYP3A5 expression and to use this assay to study a British population. METHODS:CYP3A5-specific primers were designed with one including a base-pair mismatch to create a RsaI site in sam...

journal_title：British journal of clinical pharmacology

authors： King BP,Leathart JB,Mutch E,Williams FM,Daly AK

更新日期：2003-06-01 00:00:00

abstract：:In a randomised crossover study in volunteers plasma midazolam levels were estimated for 24 h following 15 mg by mouth, either preceded by no medication or following 24 h therapy with ranitidine. Administration of the H2-receptor blocker significantly increased bioavailability of the benzodiazepine and resulted in hig...

journal_title：British journal of clinical pharmacology

authors： Elwood RJ,Hildebrand PJ,Dundee JW,Collier PS

更新日期：1983-06-01 00:00:00

abstract：AIMS:To obtain in vivo evidence for the involvement of cytochrome P450 (CYP) 3A4 in the metabolism of brotizolam. METHODS:Fourteen healthy male volunteers received erythromycin 1200 mg day(-1) or placebo for 7 days in a double-blind randomized crossover manner. On the 6th day they received a single oral 0.5-mg dose of...

journal_title：British journal of clinical pharmacology

authors： Tokairin T,Fukasawa T,Yasui-Furukori N,Aoshima T,Suzuki A,Inoue Y,Tateishi T,Otani K

更新日期：2005-08-01 00:00:00

abstract：AIMS:Generic products can be regarded as therapeutically equivalent and switchable with the reference product. However, switchability between generics is unknown, as direct comparisons between generics are not performed. The aim of this study was to investigate the bioequivalence between generic clopidogrel products by...

journal_title：British journal of clinical pharmacology

authors： Pejčić Z,Vučićević K,García-Arieta A,Miljković B

更新日期：2019-09-01 00:00:00

abstract：AIMS:It is estimated that two-thirds of cancer patients will at some point during their illness experience breakthrough pain. In this study, the pharmacokinetics of a novel sublingual dosage form of fentanyl developed for breakthrough pain was evaluated. METHODS:Eleven Caucasian patients (seven male and 4 female, aged...

journal_title：British journal of clinical pharmacology

authors： Lennernäs B,Hedner T,Holmberg M,Bredenberg S,Nyström C,Lennernäs H

更新日期：2005-02-01 00:00:00

abstract：:We have studied the effects of chlormethiazole and diazepam given orally on the ventilatory and mouth occlusion pressure (P0.1) responses to CO2 in a placebo controlled study in 10 healthy volunteers. Diazepam 10 mg produced a significant reduction in both the ventilatory and P0.1 responses to CO2, and this was not as...

journal_title：British journal of clinical pharmacology

authors： Gilmartin JJ,Corris PA,Stone TN,Veale D,Gibson GJ

更新日期：1988-06-01 00:00:00

abstract：:1 The effect of the addition of probenecid to oral and rectal regimes of indomethacin was studied in three groups of rheumatoid arthritic patients. 2 The addition of probenecid increases plasma levels of indomethacin given both orally and rectally and significantly reduces the clinical parameters of joint inflammation...

journal_title：British journal of clinical pharmacology

authors： Brooks PM,Bell MA,Sturrock RD,Famaey JP,Dick WC

更新日期：1974-08-01 00:00:00

abstract：:The pharmacokinetics of CGP 15 210 G, a new 5-HT uptake inhibitor in poor and extensive metabolisers of debrisoquine, give indirect evidence of an association between its metabolism and polymorphic hydroxylation of the debrisoquine type. ...

journal_title：British journal of clinical pharmacology

authors： Gleiter CH,Aichele G,Nilsson E,Hengen N,Antonin KH,Bieck PR

更新日期：1985-07-01 00:00:00

abstract：:1 The cardiac effects of disopyramide (D) and lignocaine (L) were measured and compared in normal volunteers (D n=4; L n=3) following the establishment of a series of three steady-state drug plasma concentrations spanning the therapeutic range (1.5-5 micrograms base ml-1). 2 During control and steady-state periods mul...

journal_title：British journal of clinical pharmacology

authors： Martin MA,Bax ND,Tucker GT,Ward JW

更新日期：1980-09-01 00:00:00

abstract：AIM:To evaluate safety, tolerability and pharmacokinetics of oral PF-05190457, an oral ghrelin receptor inverse agonist, in healthy adults. METHODS:Single (SAD) and multiple ascending dose (MAD) studies were randomised, placebo-controlled, double-blind studies. Thirty-five healthy men (age 38.2 ± 10.4 years; body mass...

journal_title：British journal of clinical pharmacology

authors： Denney WS,Sonnenberg GE,Carvajal-Gonzalez S,Tuthill T,Jackson VM

更新日期：2017-02-01 00:00:00

abstract：:1 A method for the assay of debrisoquine 4-hydroxylase activity in vitro by microsomal fractions of human liver is described. The assay utilises gas chromatography-mass spectrometry with d9-4-hydroxydebrisoquine as internal standard. 2 The limit of detection of 4-hydroxydebrisoquine was 2 ng ml -1 and the coefficient ...

journal_title：British journal of clinical pharmacology

authors： Kahn GC,Boobis AR,Murray S,Brodie MJ,Davies DS

更新日期：1982-05-01 00:00:00

abstract：:1. We have compared acute gastric bleeding caused by a new slow release preparation of indomethacin (indomethacin Continus) with that caused by aspirin and other indomethacin preparations. 2. In a randomized crossover study, blood loss into timed gastric aspirates was determined in 20 healthy volunteers after receivin...

journal_title：British journal of clinical pharmacology

authors： Prichard PJ,Poniatowska TJ,Willars JE,Ravenscroft AT,Hawkey CJ

更新日期：1988-08-01 00:00:00

abstract：:1 Daily treatment of two-kidney clipped renal hypertensive rats with hydrallazine, hydrochlorothiazide (HCTZ) and a new orally active inhibitor of the angiotensin-converting enzyme, captopril (SQ14,225), was correlated with survival rates for up to 9 months. 2 The groups of rats given captopril alone or captopril plus...

journal_title：British journal of clinical pharmacology

authors： Horovitz ZP,Antonaccio MJ,Rubin B,Panasevich RE

更新日期：1979-01-01 00:00:00

abstract：:This study compared the efficacy of 8 mg controlled release (CR) salbutamol tablets twice daily with standard 4 mg salbutamol tablets four times daily in patients with chronic obstructive airways disease. There was significant bronchodilation in both treatment groups as measured by standard spirometry (P less than 0.0...

journal_title：British journal of clinical pharmacology

authors： Milroy R,Carter R,Carlyle D,Boyd G

更新日期：1990-05-01 00:00:00

abstract：AIMS:We investigated the effect of angiotensin converting enzyme inhibitors (ACEIs) on postsynaptic adrenoceptor sensitivity and compared the effect of the lipophilic ACEI, quinapril, and that of hydrophilic agent, enalapril in human vessels. METHODS:Alpha-adrenoceptor sensitivity was evaluated using the dorsal hand v...

journal_title：British journal of clinical pharmacology

authors： Kimura M,Umemura K,Kosuge K,Nishimoto M,Ohashi K,Nakashima M

更新日期：1998-12-01 00:00:00

abstract：:1 The relationship between serum quinidine levels and rate-corrected QT (QTc) interval after administration of single identical doses of quinidine was assessed. Quinidine concentrations were determined by a modification of Hamfelt & Malers' (1963) method. The significance and clinical application of our findings is di...

journal_title：British journal of clinical pharmacology

authors： Edwards IR,Hancock BW,Saynor R

更新日期：1974-12-01 00:00:00

abstract：AIMS:This study aimed to investigate possible effects of ABCB1 genotype on fluvastatin, pravastatin, lovastatin, and rosuvastatin pharmacokinetics. METHODS:In a fixed-order crossover study, 10 healthy volunteers with the ABCB1 c.1236C/C-c.2677G/G-c.3435C/C (CGC/CGC) genotype and 10 with the c.1236T/T-c.2677T/T-c.3435T...

journal_title：British journal of clinical pharmacology

authors： Keskitalo JE,Kurkinen KJ,Neuvonen M,Backman JT,Neuvonen PJ,Niemi M

更新日期：2009-08-01 00:00:00