Ouabain and responses to endothelium-dependent vasodilators in the human forearm.

abstract：:1 In healthy male volunteers dazoxiben (UK 37248), an inhibitor of thromboxane synthetase, abolished the arterial and venous vasoconstriction produced in the forearm by cold stimulation. 2 Aspirin alone had no effect on this vasoconstriction but negated the effect of dazoxiben. 3 In vitro dazoxiben increased the produ...

journal_title：British journal of clinical pharmacology

authors： Cowley AJ,Jones EW,Hanley SP

更新日期：1983-01-01 00:00:00

abstract：AIMS:Naloxegol, a polyethylene glycol conjugated derivative of the opioid antagonist naloxone, is in clinical development for treatment of opioid-induced constipation (OIC). The aim of the study was to develop a population pharmacokinetic model describing the concentration vs. time profile of orally administered naloxe...

journal_title：British journal of clinical pharmacology

authors： Al-Huniti N,Chapel S,Xu H,Bui KH,Sostek M

更新日期：2016-01-01 00:00:00

abstract：:1. We investigated the effect of the haemostatic agent ethamsylate on aspirin-induced gastric mucosal bleeding. 2. Eighteen healthy subjects were studied three times: at the end of 48 h periods of treatment with (a) placebo, (b) aspirin 600 mg four times daily, (9 doses) and (c) aspirin 600 mg four times daily with ea...

journal_title：British journal of clinical pharmacology

authors： Daneshmend TK,Stein AG,Bhaskar NK,Hawkey CJ

更新日期：1989-07-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Rosiglitazone is able to increase serum adiponectin levels significantly in Type 2 diabetic patients. :The role of genetic factors that determine the marked interindividual variability in glucose-lowering efficacy of rosiglitazone in Chinese patients is not known. The current st...

journal_title：British journal of clinical pharmacology

authors： Sun H,Gong ZC,Yin JY,Liu HL,Liu YZ,Guo ZW,Zhou HH,Wu J,Liu ZQ

更新日期：2008-06-01 00:00:00

abstract：AIM:Amiselimod (MT-1303) is a selective sphingosine 1-phosphate 1 (S1P1 ) receptor modulator which is currently being developed for the treatment of various autoimmune diseases. Unlike some other S1P receptor modulators, amiselimod seemed to show a favourable cardiac safety profile in preclinical, phase I and II studie...

journal_title：British journal of clinical pharmacology

authors： Harada T,Wilbraham D,de La Borderie G,Inoue S,Bush J,Camm AJ

更新日期：2017-05-01 00:00:00

abstract：AIMS:We investigated whether the deterioration in asthma control reported following cessation of theophylline was due to tolerance to theophylline. METHODS:Eighteen subjects with mild stable asthma were given oral theophylline 10 mg kg(-1) day(-1) or placebo for 2 weeks in a double-blind crossover study. FEV1 and PD20...

journal_title：British journal of clinical pharmacology

authors： Bennett JA,Thompson Coon J,Pavord ID,Wilding PJ,Tattersfield AE

更新日期：1998-04-01 00:00:00

abstract：AIM:Pharmacokinetics of small molecule kinase inhibitors (KIs) used in cancer treatment may alter with increasing age, but results are conflicting. This study aims to compare exposure to KIs between older and younger patients (≥70 and <70 years) in clinical practice. METHODS:KI plasma concentrations of routinely treat...

journal_title：British journal of clinical pharmacology

authors： Crombag MBS,van Doremalen JGC,Janssen JM,Rosing H,Schellens JHM,Beijnen JH,Steeghs N,Huitema ADR

更新日期：2018-12-01 00:00:00

abstract：:1 From an understanding of the biological fate and hypotensive effect of debrisoquine (D) we have assessed the relative importance of true drug resistance, inappropriately low dosage and non-compliance as causes of apparent resistance to treatment with this drug. 2 Among 37 hypertensive patients prescribed D, eleven (...

journal_title：British journal of clinical pharmacology

authors： Silas JH,Tucker GT,Smith AJ

更新日期：1980-04-01 00:00:00

abstract：AIMS:To assess the reproducibility of the digital pulse wave response to beta(2)-adrenoreceptor stimulation and to determine if an attenuated response to beta(2)-adrenoceptor stimulation is associated with impaired flow mediated dilatation (FMD). METHODS:Subjects (n = 20) with endothelial dysfunction (ED), were compar...

journal_title：British journal of clinical pharmacology

authors： Rambaran C,Jiang B,Ritter JM,Shah A,Kalra L,Chowienczyk PJ

更新日期：2008-02-01 00:00:00

abstract：AIMS:Korean red ginseng (unskinned Panax ginseng before it is steamed or otherwise heated and subsequently dried) is one of the most widely used herbal remedies. This systematic review evaluates the current evidence for the effectiveness of red ginseng for treating erectile dysfunction. METHODS:Systematic searches wer...

journal_title：British journal of clinical pharmacology

authors： Jang DJ,Lee MS,Shin BC,Lee YC,Ernst E

更新日期：2008-10-01 00:00:00

abstract：AIMS:Sulfonylureas are recommended as second-line treatment in the management of type 2 diabetes. However, they are still commonly used also as first-line treatment instead of metformin. Given the controversial cardiovascular safety of sulfonylureas, we aimed to determine if their use as first-line treatment is associa...

journal_title：British journal of clinical pharmacology

authors： Filion KB,Douros A,Azoulay L,Yin H,Yu OH,Suissa S

更新日期：2019-10-01 00:00:00

abstract：:A method is described for the simultaneous determination of the carboxylic acid and N-acetyl-derivatives of primaquine, in plasma and urine. After oral administration of 45 mg primaquine, to five healthy volunteers, absorption was rapid, with peak primaquine levels of 153.3 +/- 23.5 ng/ml at 3 +/- 1 h, followed by an ...

journal_title：British journal of clinical pharmacology

authors： Mihaly GW,Ward SA,Edwards G,Orme ML,Breckenridge AM

更新日期：1984-04-01 00:00:00

abstract：:1 A study was carried out to investigate the possible contribution of prostaglandins in captopril-induced hypotension. 2 Healthy volunteers and patients with essential hypertension were given single oral doses of 25 mg and 50 mg captopril respectively before and after cyclo-oxygenase inhibition with indomethacin. 3 Th...

journal_title：British journal of clinical pharmacology

authors： Silberbauer K,Stanek B,Templ H

更新日期：1982-01-01 00:00:00

abstract：:1 Roth et al. (1972) have proposed that within the affective disorders there are two distinct syndromes--anxiety and depression--differentiated by the relative predominance of these symptoms, the presence or absence of premorbid maladaptive traits, and the natural outcome of the disorder. 2 Goldberg (1982) on the othe...

journal_title：British journal of clinical pharmacology

authors： Russell GF,De Silva P

更新日期：1983-01-01 00:00:00

abstract：:1. The cardiovascular responses of mianserin hydrochloride and tricyclic antidepressant drugs were investigated using non-invasive methods of cardiac investigation. A study of the interaction of mianserin and antihypertensive drug therapy is reported. 2. In six normal volunteers, mianserin hydrochloride 20 mg was show...

journal_title：British journal of clinical pharmacology

authors： Burgess CD,Turner P,Wadsworth J

更新日期：1978-01-01 00:00:00

abstract：:1. The absorption of ciprofloxacin from different regions of the human gastrointestinal tract was investigated in four healthy males using a remote-controlled drug delivery device (hf-capsule). 2. Significant differences in AUC were observed in the control study (oral administration of ciprofloxacin solution without t...

journal_title：British journal of clinical pharmacology

authors： Harder S,Fuhr U,Beermann D,Staib AH

更新日期：1990-07-01 00:00:00

abstract：AIM:To develop a semi-mechanistic model, based on glutathione depletion and predict a previously identified intra-individual reduction in busulfan clearance to aid in more precise dosing. METHODS:Busulfan concentration data, measured as part of regular care for allogeneic hematopoietic cell transplantation (HCT) patie...

journal_title：British journal of clinical pharmacology

authors： Langenhorst JB,Boss J,van Kesteren C,Lalmohamed A,Kuball J,Egberts ACG,Boelens JJ,Huitema ADR,van Maarseveen EM

更新日期：2020-08-01 00:00:00

abstract：AIMS:To describe the pharmacokinetic-pharmacodynamic modelling of the psychomotor and mnesic effects of a single 2 mg oral dose of lorazepam in healthy volunteers. METHODS:This was a randomized double-blind, placebo-controlled two-way cross-over study. The effect of lorazepam was examined with the following tasks: cho...

journal_title：British journal of clinical pharmacology

authors： Blin O,Jacquet A,Callamand S,Jouve E,Habib M,Gayraud D,Durand A,Bruguerolle B,Pisano P

更新日期：1999-10-01 00:00:00

abstract：AIMS:The objective of this study is to develop a generic model for tacrolimus pharmacokinetics modelling using a meta-analysis approach, that could serve as a first step towards a prediction tool to inform pharmacokinetics-based optimal dosing of tacrolimus in different populations and indications. METHODS:A systemati...

journal_title：British journal of clinical pharmacology

authors： Nanga TM,Doan TTP,Marquet P,Musuamba FT

更新日期：2019-12-01 00:00:00

abstract：AIMS:In the Swiss heroin substitution trials, patients are treated with self-administered diacetylmorphine (heroin). Intravenous administration is not possible in patients that have venosclerosis. Earlier studies have demonstrated that oral diacetylmorphine may be used, although it is completely converted to morphine p...

journal_title：British journal of clinical pharmacology

authors： Halbsguth U,Rentsch KM,Eich-Höchli D,Diterich I,Fattinger K

更新日期：2008-12-01 00:00:00

abstract：AIMS:Nicotine nasal spray and transdermal nicotine are effective aids to smoking cessation, and are being evaluated for treatment of other medical diseases. Wide variation in levels of nicotine and its metabolite, cotinine, have been observed with such therapies. This study aimed primarily to assess sources of individu...

journal_title：British journal of clinical pharmacology

authors： Benowitz NL,Zevin S,Jacob P 3rd

更新日期：1997-03-01 00:00:00

abstract：AIMS:The pharmacokinetics of voriconazole show a nonlinear dose-exposure relationship caused by inhibition of its own CYP3A-dependent metabolism. Because the magnitude of autoinhibition also depends on voriconazole concentrations, infusion rate might modulate voriconazole exposure. The impact of four different infusion...

journal_title：British journal of clinical pharmacology

authors： Hohmann N,Kreuter R,Blank A,Weiss J,Burhenne J,Haefeli WE,Mikus G

更新日期：2017-09-01 00:00:00

abstract：:1 The effect of pregnancy on the binding of phenytoin and phenobarbitone to serum proteins was studied in normal women and in drug treated epileptic women. 2 The binding of both drugs was reduced during pregnancy. The reduction correlated positively with the gestational age and negatively with the serum albumin concen...

journal_title：British journal of clinical pharmacology

authors： Chen SS,Perucca E,Lee JN,Richens A

更新日期：1982-04-01 00:00:00

abstract：:Twelve healthy volunteers were given orally placebo, itraconazole 100 mg or terbinafine 250 mg for 4 days. Midazolam 7.5 mg was ingested on the fourth day, after which plasma samples were collected and psychomotor performance tests carried out for 17 h. Itraconazole increased the area under the midazolam concentration...

journal_title：British journal of clinical pharmacology

authors： Ahonen J,Olkkola KT,Neuvonen PJ

更新日期：1995-09-01 00:00:00

abstract：AIM:To construct a population pharmacokinetic model for methadone enantiomers in the setting of methadone maintenance treatment for opioid dependence. METHODS:A population pharmacokinetic model was developed using P-Pharm software for rac-, (R)- and (S)-methadone using data (8-13 plasma samples per subject) obtained f...

journal_title：British journal of clinical pharmacology

authors： Foster DJ,Somogyi AA,White JM,Bochner F

更新日期：2004-06-01 00:00:00

abstract：:Mirabegron is used for the treatment of symptoms associated with overactive bladder syndrome. It selectively stimulates the β3 -adrenoreceptor, which relaxes the detrusor muscle. This improves urine storage by distension of the bladder body. ...

journal_title：British journal of clinical pharmacology

authors： Goulooze SC,Cohen AF,Rissmann R

更新日期：2015-10-01 00:00:00

abstract：:Aims We investigated whether venoconstriction by α-adrenoceptor stimulation, and venodilation by β-adrenoceptor stimulation and nitroglycerin are altered in patients with diabetes mellitus (DM). Methods Eight male patients with non insulin-dependent DM and eight age-matched control subjects were included. The patients...

journal_title：British journal of clinical pharmacology

authors： Harada K,Ohmori M,Kitoh Y,Sugimoto KI,Fujimura A

更新日期：1999-04-01 00:00:00

abstract：:1 Data from a comprehensive drug surveillance programme are analysed to provide details of procainamide use and toxicity in medical wards of teaching hospitals in five countries. 2 Out of a total of 488 recipients 9.2% had one or more adverse effect attributed to the drug; common effects being arrhythmias, gastro-inte...

journal_title：British journal of clinical pharmacology

authors： Lawson DH,Jick H

更新日期：1977-10-01 00:00:00

abstract：:The safe use of Chinese materia medica (CMM) and products in traditional Chinese medicine (TCM) practice conventionally relies on correct pharmacognostic identification, good agricultural and manufacturing practices based on pharmacopoeia standards and rational/correct CMM combinations with TCM-guided clinical prescri...

journal_title：British journal of clinical pharmacology

authors： Chan K,Zhang H,Lin ZX

更新日期：2015-10-01 00:00:00

abstract：:1 Self-poisoning with a selective weedkiller containing 2,4-D and mecoprop in a 39 year old man resulted in prolonged deep coma, pyrexia, hyperventilation, hypoxaemia, myotonia, skeletal muscle damage and electrocardiographic changes consistent with cardiomyopathy. 2 The admission plasma concentrations of 2,4-D and me...

journal_title：British journal of clinical pharmacology

authors： Prescott LF,Park J,Darrien I

更新日期：1979-01-01 00:00:00