Effect of itraconazole and terbinafine on the pharmacokinetics and pharmacodynamics of midazolam in healthy volunteers.

Abstract:

:Twelve healthy volunteers were given orally placebo, itraconazole 100 mg or terbinafine 250 mg for 4 days. Midazolam 7.5 mg was ingested on the fourth day, after which plasma samples were collected and psychomotor performance tests carried out for 17 h. Itraconazole increased the area under the midazolam concentration-time curve six-fold (P < 0.001), the peak concentration 2.5-fold (P < 0.001) and the elimination half-life two-fold (P < 0.001) compared with placebo and terbinafine pretreatments. The pharmacokinetic parameters did not differ between placebo and terbinafine phases. The higher concentrations of midazolam during the itraconazole phase were associated with increased effects. In contrast to itraconazole, terbinafine had no effect on midazolam pharmacokinetics and psychomotor performance tests were unchanged from placebo.

journal_name

Br J Clin Pharmacol

authors

Ahonen J,Olkkola KT,Neuvonen PJ

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

270-2

issue

3

eissn

0306-5251

issn

1365-2125

journal_volume

40

pub_type

临床试验,杂志文章,随机对照试验
  • No relevant pharmacokinetic interaction between pantoprazole and mycophenolate in renal transplant patients: a randomized crossover study.

    abstract:AIMS:Mycophenolic acid (MPA) suppresses lymphocyte proliferation through inosine monophosphate dehydrogenase (IMPDH) inhibition. Two formulations have been approved: mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC-MPS). Pantoprazole (PAN) inhibits gastric acid secretion, which may alter MPA expo...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/bcp.12664

    authors: Rissling O,Glander P,Hambach P,Mai M,Brakemeier S,Klonower D,Halleck F,Singer E,Schrezenmeier EV,Dürr M,Neumayer HH,Budde K

    更新日期:2015-11-01 00:00:00

  • Site of deposition and absorption of an inhaled hydrophilic solute.

    abstract:AIMS:To characterize the absorption kinetics and bioavailability of an inhaled hydrophilic solute deposited at various sites within the airways. METHODS:Nine healthy nonsmokers received one intravenous, one oropharyngeal and two pulmonary doses of technetium-99 m-labelled diethylene triamine pentaacetic acid ((99m)Tc-...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.2006.02835.x

    authors: Bondesson E,Bengtsson T,Nilsson LE,Wollmer P

    更新日期:2007-06-01 00:00:00

  • Effect of the pediatric exclusivity provision on children's access to medicines.

    abstract:AIMS:To determine the paediatric licensing status in the USA, UK, Australia and New Zealand of the 79 medicines granted paediatric exclusivity in the USA, and to assess the importance of those medicines to paediatric practice. METHODS:The medicines granted a patent extension in the USA as of 10 November 2003 were iden...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.2005.02327.x

    authors: Grieve J,Tordoff J,Reith D,Norris P

    更新日期:2005-06-01 00:00:00

  • Effects of dilevalol (R,R-labetalol) compared with nifedipine on heart rate, blood pressure and muscle blood flow at rest and on exercise in hypertensive patients.

    abstract::1. Dilevalol (R,R-labetalol) is a non-selective beta-adrenoceptor antagonist with beta 2-adrenoceptor agonist activity. Its effects after 1 month's administration on heart rate, blood pressure and muscle blood flow were studied in a double-blind crossover comparison with nifedipine in 16 hypertensive patients. 2. Dile...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2125.1993.tb04192.x

    authors: Walley T,Tsao Y,Scott A,Mackay E,Vandenburg M,Breckenridge A

    更新日期:1993-06-01 00:00:00

  • Lipoprotein composition and oxidative modification during therapy with gemfibrozil and lovastatin in patients with combined hyperlipidaemia.

    abstract:AIM:To evaluate the resistance to oxidation of human lipoproteins after hypolipidaemic therapy. METHODS:VLDL and LDL samples were obtained from patients with Familial Combined Hyperlipidaemia included in a randomized, double-blind, cross-over study, with 8 weeks of active treatment (gemfibrozil, 600 mg twice daily, or...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2125.1998.00672.x

    authors: Vázquez M,Zambón D,Hernández Y,Adzet T,Merlos M,Ros E,Laguna JC

    更新日期:1998-03-01 00:00:00

  • Effect of maximal hydration on the renal responses to pretreatment with nonsteroidal anti-inflammatory drugs and probenecid in man.

    abstract::The renal response to a challenge of maximal water diuresis has been studied in seven subjects pretreated over 48 h with either placebo, probenecid, indomethacin or piroxicam. Probenecid did not alter the excretion of water and sodium chloride when compared with placebo responses, but increased both phosphate and urat...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2125.1988.tb03355.x

    authors: Dixey JJ,Noormohamed FH,Lant AF,Brewerton DA

    更新日期:1988-05-01 00:00:00

  • Charcoal haemoperfusion for paracetamol overdose.

    abstract::1 A controlled trial of charcoal haemoperfusion as an early treatment for paracetamol overdose showed no benefit. 2 The plasma clearances of paracetamol by the charcoal column were variable and disappointingly small (range 4-119 ml/minute). The cumulative amounts removed were also low, mean 1.4 g (range 0.2-5.2 g). 3 ...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.1974.tb00249.x

    authors: Gazzard BG,Willison RA,Weston MJ,Thompson RP,Williams R

    更新日期:1974-06-01 00:00:00

  • The clinical pharmacology of a herbal asthma cigarette.

    abstract::1 Herbal preparations containing atropine-like alkaloids are marketed as proprietory asthma remedies, typically in the form of cigarettes. 2 This randomised, cross-over study compares in six healthy volunteers the pharmacological effects caused by smoking a standard, medium tar, tobacco cigarette or a herbal cigarette...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2125.1980.tb01793.x

    authors: Elliott HL,Reid JL

    更新日期:1980-11-01 00:00:00

  • Tremor and the anti-obesity drug BRL 26830A.

    abstract::The thermogenic beta 3-adrenoceptor agonist BRL 26830A has been shown to increase weight loss in dieting subjects but tremor was a frequent adverse effect. We have investigated the magnitude and nature of this tremor after a single oral dose in 18 subjects. Two complementary techniques were used to attach the recordin...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.1990.tb03821.x

    authors: Connacher AA,Lakie M,Powers N,Elton RA,Walsh EG,Jung RT

    更新日期:1990-10-01 00:00:00

  • The effect of the beta-adrenoceptor antagonist pindolol on exercise performance.

    abstract::1 Fifty-two patients who had been treated for essential hypertension for at least 5 years with once-a-day pindolol alone or in combination with a diuretic participated in a strenuous exercise programme. The 24 h antihypertensive efficacy of once-a-day pindolol was shown in blood pressure readings made before the intak...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.1982.tb01443.x

    authors: Dhatariya RC,Blowers AJ

    更新日期:1982-05-01 00:00:00

  • Usage of paracetamol-containing combination analgesics remains high in primary care.

    abstract:AIMS:Paracetamol-containing combination analgesics are widely prescribed but the use of paracetamol/dextropropoxyphene (co-proxamol) is particularly controversial. We aim to examine the prescribing patterns of the paracetamol-containing analgesics in Ireland. METHODS:A national primary care prescribing database was us...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2125.2005.02500.x

    authors: Usher C,Teeling M,Bennett K,McGowan B,Feely J

    更新日期:2005-12-01 00:00:00

  • Impact of citrus soft drinks relative to grapefruit juice on ciclosporin disposition.

    abstract:AIMS:A recent case report had suggested a citrus soft drink (Sun Drop) may have caused clinically relevant elevations in ciclosporin levels through a grapefruit juice-like mechanism via inactivation of intestinal cytochrome P450 3A4 (CYP3A4). This study was conducted to investigate the effect of grapefruit juice and ci...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2125.2005.02519.x

    authors: Schwarz UI,Johnston PE,Bailey DG,Kim RB,Mayo G,Milstone A

    更新日期:2006-10-01 00:00:00

  • Some considerations on the role of benzodiazepines in the treatment of depression.

    abstract::1 Benzodiazepines are regarded as pure anxiolytics, and their value in the treatment of depression is controversial. Nevertheless, symptoms of anxiety and depression coexist in patients with endogenous or neurotic depression, and clinical trials indicate that depressed patients respond better to a benzodiazepine-tricy...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.1981.tb01835.x

    authors: Cassano GB,Conti L

    更新日期:1981-01-01 00:00:00

  • Plasma nitrendipine concentrations in elderly hypertensive patients after single and multiple dosing.

    abstract::Twenty-three elderly hypertensive subjects received nitrendipine 10mg daily by mouth for 8 days. Plasma nitrendipine concentrations were measured after the first and last dose. There was no significant difference in plasma concentrations at any time point between the two days nor in derived pharmacokinetic measurement...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.1988.tb05283.x

    authors: Crome P,Baksi A,MacMahon D,Pandita-Gunawardena ND,Edwards J,Marley J

    更新日期:1988-09-01 00:00:00

  • Quality of requests for serum digoxin concentrations: experience from an Australian regional health service.

    abstract:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:* Therapeutic drug monitoring of serum digoxin concentrations (SDC) is considered useful in enhancing the therapeutic benefits of digoxin and minimizing the incidence of adverse drug reactions. * The quality of requests for SDC has been reported to be generally unsatisfactory. H...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.2006.02802.x

    authors: Ellington C,Grgurinovich N,Miners JO,Mangoni AA

    更新日期:2007-05-01 00:00:00

  • Non-invasive measurement of the haemodynamic effects of inhaled salbutamol, intravenous L-arginine and sublingual nitroglycerin.

    abstract:AIMS:To examine the effects of salbutamol and L-arginine, two compounds acting largely on the endothelium, and the endothelium-independent agent nitroglycerin on blood pressure, arterial compliance, cardiac function and vascular resistance. METHODS:Continuous radial pulse wave analysis, whole-body impedance cardiograp...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.2009.03434.x

    authors: Tahvanainen A,Leskinen M,Koskela J,Ilveskoski E,Alanko J,Kähönen M,Kööbi T,Lehtimäki L,Moilanen E,Mustonen J,Pörsti I

    更新日期:2009-07-01 00:00:00

  • Metabolic effects of low-dose fluconazole in healthy female users and non-users of oral contraceptives.

    abstract::1. Azole antifungal agents such as ketoconazole act by inhibiting cytochrome P-450 mediated sterol synthesis in the fungal cell membrane and thus have the potential to interfere with mammalian steroidogenesis. Fluconazole is a novel orally-effective antifungal triazole which has been reported to have more specific eff...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2125.1989.tb03449.x

    authors: Devenport MH,Crook D,Wynn V,Lees LJ

    更新日期:1989-06-01 00:00:00

  • The metabolism of mexiletine in relation to the debrisoquine/sparteine-type polymorphism of drug oxidation.

    abstract::1. The relationship between the metabolism of the antiarrhythmic drug mexiletine and the debrisoquine/sparteine-type polymorphism was studied in vitro, using microsomes from six human livers, and in vivo, in nine healthy drug-free volunteers with wide variation in their ability to hydroxylate debrisoquine. 2. There wa...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.1991.tb03931.x

    authors: Broly F,Vandamme N,Libersa C,Lhermitte M

    更新日期:1991-10-01 00:00:00

  • A review of controlled studies with nomifensine, performed outside the UK.

    abstract::1. Double-blind controlled comparisons of nomifensine with placebo, imipramine, desipramine, viloxazine, nortriptyline, a combination of amitriptyline and chlordiazepoxide, and diazepam have been carried out in various parts of the world. 2. Dosage ranged from 50-225 mg daily, and treatment lasted from 2-26 weeks. 3. ...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,评审

    doi:10.1111/j.1365-2125.1977.tb05759.x

    authors: Habermann W

    更新日期:1977-01-01 00:00:00

  • The pharmacokinetics of nortriptyline in patients with chronic renal failure.

    abstract::1 The pharmacokinetics of single oral doses of nortriptyline were studied in twenty patients with chronic renal failure, eight of whom were receiving treatment with haemodialysis. 2 The median nortriptyline half-life was 25.2 h (range 14.5-140.0 h) and the median nortriptyline clearance was 32.3 l/h (range 8.1-122.0 l...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.1981.tb01852.x

    authors: Dawlilng S,Lynn K,Rosser R,Braithwaite R

    更新日期:1981-07-01 00:00:00

  • Assessing efficacy of non-opioid analgesics in experimental pain models in healthy volunteers: an updated review.

    abstract:AIM:Experimental pain models may help to evaluate the mechanisms of analgesics and target the clinical indications for their use. This review, the second in a series of two, addresses how the efficacy of non-opioid analgesics have been assessed in human volunteers using experimental pain models. METHODS:A literature s...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2125.2009.03433.x

    authors: Staahl C,Olesen AE,Andresen T,Arendt-Nielsen L,Drewes AM

    更新日期:2009-09-01 00:00:00

  • Experience with labetalol in hypertension.

    abstract::1 The effect of labetalol has been assessed in an open clinical trial in 19 patients with sub-optimal control of blood pressure on other therapy, and in a placebo-controlled cross-over study. Most patients were taking a diuretic before the trial and they continued to do so during the trial. 2 In the open trial, labeta...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Bolli P,Waal-Manning J,Wood AJ,Simpson FO

    更新日期:1976-08-01 00:00:00

  • Duloxetine pharmacokinetics are similar in Japanese and Caucasian subjects.

    abstract:AIMS:To compare single- and multiple-dose duloxetine pharmacokinetics between healthy Japanese and Caucasians. METHODS:Twenty-four subjects of each race were given single oral doses of duloxetine (20, 40 and 60 mg) in a randomized, double-blind study. Another 20 subjects of each race received 20, 40 mg or placebo (2 :...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2125.2006.02770.x

    authors: Chan C,Yeo KP,Pan AX,Lim M,Knadler MP,Small DS

    更新日期:2007-03-01 00:00:00

  • A comparison of the effects of propranolol and oxprenolol on forearm blood flow and skin temperature.

    abstract::1 The effects of oxprenolol 80 mg and propranolol 80 mg on resting forearm blood flow (RFBF) and skin temperature were compared in seven normotensive subjects, for 4 h after an oral dose. 2 There was a significant fall of RFBF after propranolol (mean +/- s.e. mean 0.74 +/- 0.24 ml 100 g-1 min-1) compared to a smaller ...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2125.1981.tb01154.x

    authors: Vandenburg MJ,Conlon C,Ledingham JM

    更新日期:1981-05-01 00:00:00

  • Human subcutaneous tissue distribution of fluconazole: comparison of microdialysis and suction blister techniques.

    abstract:AIMS:To investigate uptake of fluconazole into the interstitial fluid of human subcutaneous tissue using the microdialysis and suction blister techniques. METHODS:A sterile microdialysis probe (CMA/60) was inserted subcutaneously into the upper arm of five healthy volunteers following an overnight fast. Blisters were ...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2125.2003.01930.x

    authors: Sasongko L,Williams KM,Day RO,McLachlan AJ

    更新日期:2003-11-01 00:00:00

  • Pharmacodynamic monitoring during acute intervention in ischaemic heart disease using a new echo-Doppler device.

    abstract::1. We have utilised a new non-imaging echo-Doppler cardiac output device, using the principle of attenuated compensated volume flow (ACVF), to assess the cardiovascular effects of atenolol and buccal nitroglycerin (NTG) in a placebo-controlled study of 30 patients with coronary disease. 2. Atenolol (4 mg i.v.) reduced...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2125.1990.tb03696.x

    authors: Silke B,Verma SP,Taylor SH

    更新日期:1990-06-01 00:00:00

  • Lisinopril population pharmacokinetics in elderly and renal disease patients with hypertension.

    abstract::1. The population pharmacokinetics of lisinopril were investigated using data collected from two multicentre trials of lisinopril in the treatment of hypertension in elderly patients (n = 40) and patients with renal disease (n = 20). 2. Lisinopril was started at doses of 2.5-5 mg daily and increased at 2-4 weekly inte...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.1989.tb05335.x

    authors: Thomson AH,Kelly JG,Whiting B

    更新日期:1989-01-01 00:00:00

  • Attention tasks as skills performance measures of drug effects.

    abstract::Both empirical epidemiological data on the causes of traffic accidents and conceptual models of skilled human performance stress the central role of perception and cognition. This paper examines the effects of drugs on two major components of cognitive perceptual performance, namely, concentrated attention or vigilanc...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.1984.tb02582.x

    authors: Moskowitz H

    更新日期:1984-01-01 00:00:00

  • Population pharmacokinetics of (R)-, (S)- and rac-methadone in methadone maintenance patients.

    abstract:AIM:To construct a population pharmacokinetic model for methadone enantiomers in the setting of methadone maintenance treatment for opioid dependence. METHODS:A population pharmacokinetic model was developed using P-Pharm software for rac-, (R)- and (S)-methadone using data (8-13 plasma samples per subject) obtained f...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2125.2004.02079.x

    authors: Foster DJ,Somogyi AA,White JM,Bochner F

    更新日期:2004-06-01 00:00:00

  • Marketing medicines: charting the rise of modern therapeutics through a systematic review of adverts in UK medical journals (1950-1980).

    abstract:AIMS:To examine how pharmaceutical products that were first marketed between 1950 and 1980 were promoted to physicians through advertisements and briefly review advertising regulations and accuracy of the advertisements in the light of modern knowledge. METHODS:We systematically reviewed advertisements promoting drugs...

    journal_title:British journal of clinical pharmacology

    pub_type: 历史文章,杂志文章

    doi:10.1111/bcp.13549

    authors: Green AR,Haddad PM,Aronson JK

    更新日期:2018-08-01 00:00:00