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Ciprofloxacin absorption in different regions of the human gastrointestinal tract. Investigations with the hf-capsule.

Abstract：

:1. The absorption of ciprofloxacin from different regions of the human gastrointestinal tract was investigated in four healthy males using a remote-controlled drug delivery device (hf-capsule). 2. Significant differences in AUC were observed in the control study (oral administration of ciprofloxacin solution without the hf-capsule = 100%) and after release of ciprofloxacin in the jejunum (geometric mean: 37%), the ileum (mean: 23%), the ascending colon (mean: 7%) and the descending colon (mean: 5%), whereas tmax showed no difference for any of the absorption sites. Ciprofloxacin release in the stomach resulted in the greatest AUC (mean: 140%). Thus, it is concluded that the main absorption site of ciprofloxacin is the upper gastrointestinal tract, up to the jejunum. 3. Differences in presystemic metabolism of known drug metabolites along the gut could be excluded, as the pattern of urinary recovery of desethylene-, sulpho-, and oxo-ciprofloxacin and the parent compound was similar for all drug release sites.

journal_name

Br J Clin Pharmacol

journal_title

British journal of clinical pharmacology

authors

Harder S,Fuhr U,Beermann D,Staib AH

doi

10.1111/j.1365-2125.1990.tb03740.x

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

35-9

issue

1

eissn

0306-5251

issn

1365-2125

journal_volume

30

pub_type

杂志文章

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