Bioactivation of dapsone to a cytotoxic metabolite: in vitro use of a novel two compartment system which contains human tissues.

abstract：AIMS:To investigate whether the drug-drug interaction between fexofenadine and ketoconazole is localized to efflux transport proteins of the small intestine, and to determine and classify the effective jejunal permeability (Peff) of fexofenadine according to the Biopharmaceutics Classification System (BCS). METHODS:Tw...

journal_title：British journal of clinical pharmacology

authors： Tannergren C,Knutson T,Knutson L,Lennernäs H

更新日期：2003-02-01 00:00:00

abstract：:Voriconazole is an antifungal metabolised by CYP2C19 enzyme, which can be inhibited by proton-pump inhibitors (PPIs). A prospective observational study was carried out to determine the influence of PPIs on voriconazole pharmacokinetic. The 78 patients included were divided into 4 groups: omeprazole (n = 32), pantopraz...

journal_title：British journal of clinical pharmacology

authors： Blanco Dorado S,Maroñas Amigo O,Latorre-Pellicer A,Rodríguez Jato MT,López-Vizcaíno A,Gómez Márquez A,Bardán García B,Belles Medall D,Barbeito Castiñeiras G,Pérez Del Molino Bernal ML,Campos-Toimil M,Otero Espinar F,Blanco Hortas

更新日期：2020-08-01 00:00:00

abstract：AIMS:To assess the duration and consistency of the pharmacological activity of the dihydropyridine calcium antagonist drug, lacidipine. METHODS:Eight healthy normotensive young males participated in a double-blind randomised crossover comparison of single and multiple doses (for 2 weeks) of lacidipine and placebo. The...

journal_title：British journal of clinical pharmacology

authors： Ueda S,Donnelly R,Panfilov V,Morris AD,Elliott HL

更新日期：1998-08-01 00:00:00

abstract：:1 Forty-one patients with essential hypertension, stages I, II, and III, were treated with captopril alone or in combination with hydrochlorothiazide. Forty two percent were responsive to captopril alone, while the remaining 58% also required the diuretic. The need for the diuretic was related to the phase of hyperten...

journal_title：British journal of clinical pharmacology

authors： Rabinad Estrada E,Ingelmo Morin M,Martinez Amenos A,Alsina J,Balcells Gorina A

更新日期：1982-01-01 00:00:00

abstract：AIMS:The cytochrome P-450 2D6 (CYP2D6) gene duplication/multiduplication producing an increase in enzyme activity, and the common Japanese mutation, CYP2D6*10A producing a decrease of enzyme activity were screened in a large number of Japanese psychiatric subjects (n = 111) in order to investigate whether these mutated...

journal_title：British journal of clinical pharmacology

authors： Ohnuma T,Shibata N,Matsubara Y,Arai H

更新日期：2003-09-01 00:00:00

abstract：:1 The effect of drugs acting on beta-adrenoceptors on the absorption and excretion of paracetamol was studied in 26 volunteers and nine patients with mild hypertension, each subject acting as his/her own control. 2 Isoprenaline given 30 min before paracetamol significantly slowed absorption, the effect being dose rela...

journal_title：British journal of clinical pharmacology

authors： Clark RA,Holdsworth CD,Rees MR,Howlett PJ

更新日期：1980-12-01 00:00:00

abstract：AIMS:To characterize the cytochrome P450 (CYP) enzymes responsible for the N-demethylation of sildenafil to its main metabolite, UK-103 320, to investigate the potential inhibitory effects of sildenafil on CYP enzymes and to evaluate the potential of selected drugs to affect sildenafil metabolism. METHODS:The metaboli...

journal_title：British journal of clinical pharmacology

authors： Hyland R,Roe EG,Jones BC,Smith DA

更新日期：2001-03-01 00:00:00

abstract：:Calcium subserves a ubiquitous role in the organisation of cell function. Ca2+ channels which control influx may be modified in disease states. Animal models of cerebral ischaemia do present some problems when investigating potential therapies involving Ca2+ channels. However, it is important not to be too rigid in se...

journal_title：British journal of clinical pharmacology

authors： Alps BJ

更新日期：1992-09-01 00:00:00

abstract：AIMS:5-Fluorouracil (5-FU) is widely used in combination chemotherapy, and literature suggests pharmacokinetic-guided dosing to improve clinical efficacy and reduce toxicity. This study aimed to determine the pharmacokinetic exposure of both 5-FU and its metabolite, 5,6-dihydrofluorouracil (DHFU), in patients with gast...

journal_title：British journal of clinical pharmacology

authors： Jacob J,Mathew SK,Chacko RT,Aruldhas BW,Singh A,Prabha R,Mathew BS

更新日期：2020-06-27 00:00:00

abstract：:1. Hydrochlorothiazide (HCT, 50-75 mg) was administered orally to seven patients with cardiac failure. 2. Plasma levels and urinary concentration of HCT were determined by GLC. 3. The gastrointestinal uptake of the diuretic in three patients was reduced to approximately half that seen in healthy controls. 4. Plasma ha...

journal_title：British journal of clinical pharmacology

authors： Beermann B,Groschinsky-Grind M

更新日期：1979-06-01 00:00:00

abstract：:People who are 60 years old and older have the highest incidence of developing new-onset epilepsy. The increase of the ageing population has resulted in a greater number of patients with new-onset epilepsy or at risk of developing the condition. Previously published review articles regarding epilepsy in older patients...

journal_title：British journal of clinical pharmacology

authors： Vu LC,Piccenna L,Kwan P,O'Brien TJ

更新日期：2018-10-01 00:00:00

abstract：:1. The pharmacokinetics of butorphanol were evaluated in 18 female volunteers with varying degrees of renal function following a single, 1 mg transnasal dose of butorphanol tartrate. The creatinine clearance (CLCR) values for subjects in the normal (NOR), moderately impaired (MI), and severely impaired (SI) groups wer...

journal_title：British journal of clinical pharmacology

authors： Shyu WC,Morgenthien EA,Barbhaiya RH

更新日期：1996-05-01 00:00:00

abstract：AIMS:To investigate the impact of the specific red blood cell binding on the pharmacokinetics and pharmacodynamics of the nucleoside transport inhibitor draflazine after i.v. administration at various infusion rates. It was also aimed to relate the red blood cell (RBC) occupancy of draflazine to the ex vivo measured ad...

journal_title：British journal of clinical pharmacology

authors： Snoeck E,Piotrovskij V,Jacqmin P,Van Peer A,Danhof M,Ver Donck K,Woestenborghs R,Van Belle H,Van Bortel L,Van Gool R,Dupont AG,Heykants J

更新日期：1997-06-01 00:00:00

abstract：:Herbal medicines and products derived from them are a diverse group of products for which different (and often limited) levels of evidence are available. As importantly, such products generally vary in their composition and are at the end of an often poorly understood value chain, which often links producers in biodiv...

journal_title：British journal of clinical pharmacology

authors： Heinrich M

更新日期：2015-07-01 00:00:00

abstract：:1. The relative bioavailability of cyclosporin was studied in 11 healthy volunteers after single oral capsule doses of cyclosporin on three separate occasions; fasting, with breakfast and with breakfast together with bile acid tablets (400 mg of cholic acid and 100 mg of dehydrocholic acid). 2. There was a significant...

journal_title：British journal of clinical pharmacology

authors： Lindholm A,Henricsson S,Dahlqvist R

更新日期：1990-05-01 00:00:00

abstract：:The effect of salbutamol on bronchoconstriction induced by inhaled sodium metabisulphite has been studied in 12 atopic subjects. Salbutamol (200 micrograms, 3.5 x 10(-7) M) and matched placebo were administered by identical metered dose inhaler 15 min before a dose-response to sodium metabisulphite (1.25-100 mg ml-1) ...

journal_title：British journal of clinical pharmacology

authors： Iredale MJ,Dixon CM,Ind PW

更新日期：1991-11-01 00:00:00

abstract：AIMS:To develop a population pharmacokinetic model for mycophenolic acid (MPA) in children with idiopathic nephrotic syndrome (INS) treated with mycophenolate mofetil (MMF), identify covariates that explain variability and determine the Bayesian estimator of the area under the concentration-time curve over 12 h (AUC(0-...

journal_title：British journal of clinical pharmacology

authors： Zhao W,Elie V,Baudouin V,Bensman A,André JL,Brochard K,Broux F,Cailliez M,Loirat C,Jacqz-Aigrain E

更新日期：2010-04-01 00:00:00

abstract：AIMS:Previous pharmacokinetic characterization of a transporter probe cocktail containing digoxin (P-gp), furosemide (OAT1, OAT3), metformin (OCT2, MATE1, MATE2-K) and rosuvastatin (OATP1B1, OATP1B3, BCRP) in healthy subjects showed increases in rosuvastatin systemic exposure compared to rosuvastatin alone. In this tri...

journal_title：British journal of clinical pharmacology

authors： Stopfer P,Giessmann T,Hohl K,Hutzel S,Schmidt S,Gansser D,Ishiguro N,Taub ME,Sharma A,Ebner T,Müller F

更新日期：2018-09-01 00:00:00

abstract：:1. The effects of the voltage dependent calcium channel blocking agent nifedipine, and of a calcium free bathing medium, on the responses of human blood vessels obtained postmortem to various agonists have been compared with those of the rat aorta. The human vessels studied were digital arteries, basilar arteries and ...

journal_title：British journal of clinical pharmacology

authors： Iwanov V,Moulds RF

更新日期：1991-01-01 00:00:00

abstract：AIMS:Health Canada has developed a pathway to approve drugs that have limited efficacy and safety data, the Notice of Compliance with conditions (NOC/c) policy. Increased safety reporting is required for these drugs but there has not been any systematic review of their post-market safety. This study compares safety war...

journal_title：British journal of clinical pharmacology

authors： Lexchin J

更新日期：2015-05-01 00:00:00

abstract：:The importance of number of tablets for patient compliance was investigated in 160 patients with mild-moderate essential hypertension treated with a beta-adrenoceptor blocker and a thiazide diuretic. Mean BP at entry 146 +/- 16/92 +/- 8 mm Hg. All patients were given pindolol 10 mg and clopamide 5 mg in one combinatio...

journal_title：British journal of clinical pharmacology

authors： Asplund J,Danielson M,Ohman P

更新日期：1984-05-01 00:00:00

abstract：:1 A study was carried out to investigate the possible contribution of prostaglandins in captopril-induced hypotension. 2 Healthy volunteers and patients with essential hypertension were given single oral doses of 25 mg and 50 mg captopril respectively before and after cyclo-oxygenase inhibition with indomethacin. 3 Th...

journal_title：British journal of clinical pharmacology

authors： Silberbauer K,Stanek B,Templ H

更新日期：1982-01-01 00:00:00

abstract：AIMS:In order to evaluate a hypothesized protective effect of the use of HMG Co-A reductase inhibitors (statins) on the development of Type 2 diabetes, we conducted a nested case-control study based on data from the UK-based General Practice Research Database (GPRD). METHODS:We identified a population of adults 30-79 ...

journal_title：British journal of clinical pharmacology

authors： Jick SS,Bradbury BD

更新日期：2004-09-01 00:00:00

abstract：:The kinetics of clobazam taken 3 h before, during, and 3 h after a standard hospital meal were studied in six healthy volunteers. Peak plasma levels were significantly lower when the drug was taken with or after meals suggesting that the rate of absorption was reduced by food. The mean area under the concentration vs ...

journal_title：British journal of clinical pharmacology

authors： Cenraud B,Guyot M,Levy RH,Brachet-Liermain A,Morselli PL,Moreland TA,Loiseau P

更新日期：1983-12-01 00:00:00

abstract：AIMS:Data regarding the cardiac toxicity of cabozantinib lacks. The aim of our study was to assess the risk of cabozantinib-related cardiotoxicity in mRCC patients. METHODS:We performed a multicentre prospective study on mRCC patients treated with cabozantinib between October 2016 and November 2017. Transthoracic echo...

journal_title：British journal of clinical pharmacology

authors： Iacovelli R,Ciccarese C,Fornarini G,Massari F,Bimbatti D,Mosillo C,Rebuzzi SE,Di Nunno V,Grassi M,Fantinel E,Ardizzoni A,Tortora G

更新日期：2019-06-01 00:00:00

abstract：AIMS:Smoking is a major risk factor for developing atherosclerosis. In order to understand the vascular abnormalities observed in smokers, we investigated vascular responsiveness in cigarette smokers. METHODS:We performed two consecutive matched group comparative studies to investigate vascular responsiveness using ve...

journal_title：British journal of clinical pharmacology

authors： Butler R,Morris AD,Struthers AD

更新日期：2001-08-01 00:00:00

abstract：:The effects of two single oral doses of ibopamine (150 and 600 mg) on heart rate, blood pressure, urine flow, sodium, potassium and creatinine excretion were studied in normal volunteers. No significant change was observed in urine flow, sodium, potassium or creatinine excretion at either dose. No significant change w...

journal_title：British journal of clinical pharmacology

authors： Harvey JN,Worth DP,Brown J,Lee MR

更新日期：1984-06-01 00:00:00

abstract：:1. We studied the effects of pre-treatment with oral indomethacin (25 mg four times daily for 3 days) on the pharmacokinetics, haemodynamics and diuretic properties of oral felodipine (10 mg single dose) in 12 healthy male volunteers using a placebo controlled double-blind four-way crossover protocol. 2. Felodipine wi...

journal_title：British journal of clinical pharmacology

authors： Hardy BG,Bartle WR,Myers M,Bailey DG,Edgar B

更新日期：1988-11-01 00:00:00

abstract：:1 Six previously untreated emergency admissions to hospital with severe hypertension were given oral treatment with labetalol. 2 Pre-treatment diastolic BP exceeded 130 mmHg, and clinical evidence of either accelerated hypertension or encephalopathy was present. 3 Hypotensive response after treatment followed two patt...

journal_title：British journal of clinical pharmacology

authors： Ghose RR

更新日期：1979-01-01 00:00:00

abstract：AIMS:There is a trend for more flexibility in timing of evidence generation in relation to marketing authorization, including the option to complete phase III trials after authorization or not at all. This paper investigated the relation between phase II and III clinical trial efficacy in oncology. METHODS:All oncolog...

journal_title：British journal of clinical pharmacology

authors： Vreman RA,Belitser SV,Mota ATM,Hövels AM,Goettsch WG,Roes KCB,Leufkens HGM,Mantel-Teeuwisse AK

更新日期：2020-07-01 00:00:00