Salbutamol inhibits metabisulphite-induced bronchoconstriction.

Abstract:

:The effect of salbutamol on bronchoconstriction induced by inhaled sodium metabisulphite has been studied in 12 atopic subjects. Salbutamol (200 micrograms, 3.5 x 10(-7) M) and matched placebo were administered by identical metered dose inhaler 15 min before a dose-response to sodium metabisulphite (1.25-100 mg ml-1) was performed. Geometric mean provocative dose of metabisulphite causing a 35% fall in sGaw after placebo pretreatment was 12.8 [5.75-28.1, 95% Cl] mumol, and after salbutamol was 75.9 [46.5-126] mumol. Mean maximum fall in sGaw after placebo pre-treatment was 47.4 [41-53.9]%. At the same metabisulphite concentration mean maximum fall in sGaw after salbutamol was 2.9 [-8.2-14.1]%.

journal_name

Br J Clin Pharmacol

authors

Iredale MJ,Dixon CM,Ind PW

doi

10.1111/j.1365-2125.1991.tb03967.x

subject

Has Abstract

pub_date

1991-11-01 00:00:00

pages

637-8

issue

5

eissn

0306-5251

issn

1365-2125

journal_volume

32

pub_type

临床试验,杂志文章,随机对照试验
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    更新日期:1982-01-01 00:00:00

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  • The measurement of haloperidol and reduced haloperidol in hair as an index of dosage history.

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  • Pharmacokinetics of piroximone after oral and intravenous administration to patients with renal insufficiency.

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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1978-09-01 00:00:00

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    更新日期:2002-02-01 00:00:00

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    journal_title:British journal of clinical pharmacology

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