Patients compliance in hypertension--the importance of number of tablets.

abstract：AIMS:Case reports and small case series suggest increased central nervous system (CNS) toxicity, especially convulsions, after overdose of mefenamic acid, compared with other nonsteroidal anti-inflammatory drugs (NSAIDs), although comparative epidemiological studies have not been conducted. The current study compared r...

journal_title：British journal of clinical pharmacology

authors： Kamour A,Crichton S,Cooper G,Lupton DJ,Eddleston M,Vale JA,Thompson JP,Thomas SH

更新日期：2017-04-01 00:00:00

abstract：AIMS:Our goal was to evaluate the association between antidepressant use and the risk of coronary heart disease (CHD) among subjects with no history of coronary heart disease. METHODS:A search of Medline, EMBASE, PsycINFO and the Cochrane Library was performed in January 2013. Two authors independently reviewed and se...

journal_title：British journal of clinical pharmacology

authors： Oh SW,Kim J,Myung SK,Hwang SS,Yoon DH

更新日期：2014-10-01 00:00:00

abstract：AIMS:To assess the effect of the calcitonin gene-related peptide (CGRP) receptor antagonist, telcagepant, on the haemodynamic response to sublingual nitroglycerin (NTG). METHODS:Twenty-two healthy male volunteers participated in a randomized, placebo-controlled, double-blind, two-period, crossover study. Subjects rece...

journal_title：British journal of clinical pharmacology

authors： Van der Schueren BJ,Blanchard R,Murphy MG,Palcza J,De Lepeleire I,Van Hecken A,Depré M,de Hoon JN

更新日期：2011-05-01 00:00:00

abstract：:1 A double-blind entry to a trial of an active non-steroidal anti-inflammatory drug, flurbiprofen against placebo was undertaken until 100 patients with classical rheumatoid arthritis had been allocated to each treatment. 2 Each patient was given a long-term supply of drug and was asked to vary their own dosage within...

journal_title：British journal of clinical pharmacology

authors： Rooney PJ,Capell HA,Paterson S,Buchanan WW,Dick WC

更新日期：1978-05-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:• Terutroban is a selective TP receptor antagonist, i.e. a specific antagonist of the thromboxane A(2) and prostaglandin endoperoxide receptors, shown to improve endothelial function after a single administration in patients with coronary artery disease. WHAT THIS STUDY ADDS:• ...

journal_title：British journal of clinical pharmacology

authors： Lesault PF,Boyer L,Pelle G,Covali-Noroc A,Rideau D,Akakpo S,Teiger E,Dubois-Randé JL,Adnot S

更新日期：2011-06-01 00:00:00

abstract：:1. Eight healthy subjects were investigated on four occasions at least 1 week apart when they either ate a standard 3100 kJ cold meal or fasted. One hour earlier, either 50 mg atenolol or placebo was administered. 2. Eating was followed by prominent changes of systolic cardiovascular function: a rise of heart rate (+7...

journal_title：British journal of clinical pharmacology

authors： De Mey C,Enterling D,Meineke I

更新日期：1993-11-01 00:00:00

abstract：AIMS:The aim of this study was to examine the use of potentially inappropriate medication (PIM) in relation to time before death, to explore whether PIMs are discontinued at the end of life, and the factors associated with this discontinuation. METHODS:We conducted a retrospective register-based mortality cohort study...

journal_title：British journal of clinical pharmacology

authors： Paque K,De Schreye R,Elseviers M,Vander Stichele R,Pardon K,Dilles T,Christiaens T,Deliens L,Cohen J

更新日期：2019-04-01 00:00:00

abstract：:Self-poisoning by ingestion or inhalation is common, and it is important to study its various epidemiological manifestations with clear definitions. Data on fatal self-poisonings are recorded nationally within the UK and are codified according to the International Classification of Diseases (ICD) revision relevant at ...

journal_title：British journal of clinical pharmacology

authors： Camidge DR,Wood RJ,Bateman DN

更新日期：2003-12-01 00:00:00

abstract：:The ability of sulindac to modify the weal response to four doses of intradermal bradykinin in subjects given enalapril was tested in a double-blind cross-over study in normal volunteers. The dose-dependent increase in skin thickness after bradykinin was significantly reduced by prior administration of sulindac. Certa...

journal_title：British journal of clinical pharmacology

authors： Ferner RE,Kamali F,Rawlins MD

更新日期：1990-03-01 00:00:00

abstract：AIMS:SNF472 is a calcification inhibitor being developed for the treatment of cardiovascular calcification in haemodialysis (HD) and in calciphylaxis patients. This study investigated the safety, tolerability and pharmacokinetics (PK) of intravenous (IV) SNF472 in healthy volunteers (HV) and HD patients. METHODS:This ...

journal_title：British journal of clinical pharmacology

authors： Perelló J,Joubert PH,Ferrer MD,Canals AZ,Sinha S,Salcedo C

更新日期：2018-12-01 00:00:00

abstract：AIM:To assess the effect of Schisandra sphenanthera extract (SchE) on the pharmacokinetics of tacrolimus in healthy volunteers. METHODS:Twelve healthy male volunteers were orally treated with SchE, three capsules twice daily for 13 days. Pharmacokinetic investigations of oral tacrolimus administration at 2 mg were per...

journal_title：British journal of clinical pharmacology

authors： Xin HW,Wu XC,Li Q,Yu AR,Zhu M,Shen Y,Su D,Xiong L

更新日期：2007-10-01 00:00:00

abstract：AIMS:Tolcapone is a novel catechol-O-methyltransferase (COMT) inhibitor used as an adjunct to levodopa/carbidopa or levodopa/benserazide therapy to improve treatment of Parkinson's disease. The aim of the current study was to investigate the potential effect of tolcapone on the pharmacokinetics of carbidopa. METHODS:T...

journal_title：British journal of clinical pharmacology

authors： Jorga KM,Nicholl DJ

更新日期：1999-09-01 00:00:00

abstract：:1. The antisecretory responses to pH-feedback controlled (maximum dose 800 mg 24 h-1) and fixed-dose (0.25 mg kg-1 h-1) continuous infusions of ranitidine were compared in a randomised, placebo-controlled, cross-over study in 10 healthy male volunteers. 2. To assess tolerance during repeated dosing with ranitidine, th...

journal_title：British journal of clinical pharmacology

authors： Wilder-Smith CH,Halter F,Häcki W,Merki HS

更新日期：1992-05-01 00:00:00

abstract：:The acute peripheral vascular and diuretic effects of intravenous frusemide 10 mg and 20 mg were compared with those of bumetanide 250 micrograms and 500 micrograms in a group of 10 salt depleted volunteers. Significant reductions in forearm blood flow (FBF) were observed after frusemide 10 mg (-0.77 ml 100 ml-1 min-1...

journal_title：British journal of clinical pharmacology

authors： Johnston GD,Nicholls DP,Kondowe GB,Finch MB

更新日期：1986-04-01 00:00:00

abstract：AIMS:Grapefruit juice inhibits CYP3A4 in the intestinal wall leading to a reduced intestinal first pass metabolism and thereby an increased oral bioavailability of certain drugs. For example, it has been shown that the oral bioavailability of midazolam, a CYP3A4 substrate, increased by 52% in healthy subjects after ing...

journal_title：British journal of clinical pharmacology

authors： Andersen V,Pedersen N,Larsen NE,Sonne J,Larsen S

更新日期：2002-08-01 00:00:00

abstract：:1 The new converting enzyme inhibitor RHC 3659 was tested in 15 male volunteers. The study consisted of two parts: first, the ability of a single oral dose (5, 10, 20, 40 or 80 mg) to inhibit the pressor response to exogenous angiotensin I was tested with blood pressure and heart rate monitored continuously through an...

journal_title：British journal of clinical pharmacology

authors： Burnier M,Turini GA,Brunner HR,Porchet M,Kruithof D,Vukovich RA,Gavras H

更新日期：1981-12-01 00:00:00

abstract：:In a dog model of partial myocardial ischaemia, superimposed ST segment elevations in epicardial ECGs were inhibited by nicardipine over a cumulative i.v. dose range of 1-20 micrograms kg-1. Over the cumulative i.v. dose range of 0.5-166.5 micrograms kg-1, nicardipine had little overall effect on gross cardiac conduct...

journal_title：British journal of clinical pharmacology

authors： Alps BJ,Calder C,Wilson A

更新日期：1985-01-01 00:00:00

abstract：:1. The aromatic 2-hydroxylation of imipramine was studied in microsomes from three human livers. The kinetics were best described by a biphasic enzyme model. The estimated values of Vmax and Km for the high affinity site ranged from 3.2 to 5.7 nmol mg-1 h-1 and from 25 to 31 microM, respectively. 2. Quinidine was a po...

journal_title：British journal of clinical pharmacology

authors： Skjelbo E,Brøsen K

更新日期：1992-09-01 00:00:00

abstract：:1. The pharmacokinetics and pharmacodynamics of intranasal (IN) and oral 1-deamino-8-D-arginine vasopressin (DDAVP) were compared in 10 Chinese adults with central diabetes insipidus previously controlled on IN DDAVP. This was followed by comparison of the acute pharmacodynamics of commonly used oral preparations (con...

journal_title：British journal of clinical pharmacology

authors： Lam KS,Wat MS,Choi KL,Ip TP,Pang RW,Kumana CR

更新日期：1996-09-01 00:00:00

abstract：:1. A bicycle exercise test was used to investigate functional capability and haemodynamics in 30 patients with heart failure (13 NYHA Class II, 17 Class III), before and after i.v. xamoterol (Corwin, Carwin, Corwil, Xamtol, ICI 118,587) 0.2 mg kg-1. 2. Resting heart rate fell from 78 to 74 beats min-1 (P less than 0.0...

journal_title：British journal of clinical pharmacology

authors： Virk SJ,Davies MK

更新日期：1989-01-01 00:00:00

abstract：AIMS:It has been shown that the cellular uptake and cytotoxicity of anthracyclines decrease with increasing cell density in vitro, an event termed 'the inocculum effect'. It is not known whether such an effect occurs in vivo. In this study the relationships between white blood cell (WBC) count, plasma and cellular conc...

journal_title：British journal of clinical pharmacology

authors： Bogason A,Quartino AL,Lafolie P,Masquelier M,Karlsson MO,Paul C,Gruber A,Vitols S

更新日期：2011-04-01 00:00:00

abstract：:1 The clinical pharmacokinetics of the many benzodiazepines used to treat numerous and varied clinical conditions can be influenced by many factors. 2 Combinations of drugs efficacious in the central nervous system can change the onset, intensity and duration of effect as a result of pharmacological, physiological and...

journal_title：British journal of clinical pharmacology

authors： van der Kleijn E,Vree TB,Baars AM,Wijsman R,Edmunds LC,Knop HJ

更新日期：1981-01-01 00:00:00

abstract：AIMS:Pupillography is a noninvasive and cost-effective method to determine autonomic nerve activity. Genetic variants in cytochrome P450 (CYP), dopamine receptor (DRD2, DRD3), serotonin receptor (HTR2A, HTR2C) and ATP-binding cassette subfamily B (ABCB1) genes, among others, were previously associated with the pharmaco...

journal_title：British journal of clinical pharmacology

authors： Koller D,Saiz-Rodríguez M,Zubiaur P,Ochoa D,Almenara S,Román M,Romero-Palacián D,de Miguel-Cáceres A,Martín S,Navares-Gómez M,Mejía G,Wojnicz A,Abad-Santos F

更新日期：2020-10-01 00:00:00

abstract：:Phenytoin drug reaction with eosinophilia and systemic symptoms (DRESS) in 3 Aboriginal Australians positive for HLA-B*56:02 has been previously reported. We report the allele frequency of HLA-B*56:02 in 2 South Australian populations, 1 Aboriginal (4.8%, 95% confidence interval 2.4-7.8%) and the other European (0%). ...

journal_title：British journal of clinical pharmacology

authors： Somogyi AA,Barratt DT,Phillips EJ,Moore K,Ilyas F,Gabb GM

更新日期：2019-09-01 00:00:00

abstract：:1 The effect of the addition of probenecid to oral and rectal regimes of indomethacin was studied in three groups of rheumatoid arthritic patients. 2 The addition of probenecid increases plasma levels of indomethacin given both orally and rectally and significantly reduces the clinical parameters of joint inflammation...

journal_title：British journal of clinical pharmacology

authors： Brooks PM,Bell MA,Sturrock RD,Famaey JP,Dick WC

更新日期：1974-08-01 00:00:00

abstract：UNLABELLED:What is already known about this subject? The naturally occurring interlukin-1 receptor antagonist (IL-1RA) markedly protects rodents against ischaemic, excitotoxic and traumatic brain injury, suggesting it may be of therapeutic value. When administered intravenously to patients soon after stroke, IL-1RA is ...

journal_title：British journal of clinical pharmacology

authors： Gueorguieva I,Clark SR,McMahon CJ,Scarth S,Rothwell NJ,Tyrrell PJ,Hopkins SJ,Rowland M

更新日期：2008-03-01 00:00:00

abstract：:1 Theories linking 5-hydroxytryptamine (5-HT) with depression are briefly reviewed. The various experimental strategies adopted to investigate this relationship, examination of autopsy data, CSF metabolite data, 5-HT re-uptake patterns in human blood platelets and imipramine binding studies in human platelets, are dis...

journal_title：British journal of clinical pharmacology

authors： Goodwin FK,Post RM

更新日期：1983-01-01 00:00:00

abstract：AIM:To investigate the effect of sepsis upon the volume of distribution (Vd) of gentamicin in neonates. METHODS:A retrospective chart review was conducted of neonates admitted to Dunedin Hospital who had gentamicin concentrations performed between 1st January 2000 and 30th October 2003. Data from 277 neonates, includi...

journal_title：British journal of clinical pharmacology

authors： Lingvall M,Reith D,Broadbent R

更新日期：2005-01-01 00:00:00

abstract：:1. The 5-hydroxytryptamine (5-HT3) receptor antagonist, GR 38032F, which possesses potent anti-emetic properties in vomiting induced by cancer chemotherapeutic drugs, has been tested to determine its value in the prophylaxis of motion sickness induced by cross-coupled stimulation. The double-blind trial compared GR 38...

journal_title：British journal of clinical pharmacology

authors： Stott JR,Barnes GR,Wright RJ,Ruddock CJ

更新日期：1989-02-01 00:00:00

abstract：:1. The pharmacokinetics, bioavailability and metabolism of nitrendipine were studied in six healthy volunteers (three females, three males) using [13C4]-nitrendipine as a biological internal standard. In the first study the drug was administered simultaneously by the i.v. [13C4] and p.o. (solution) routes and in a sec...

journal_title：British journal of clinical pharmacology

authors： Mikus G,Fischer C,Heuer B,Langen C,Eichelbaum M

更新日期：1987-11-01 00:00:00