Abstract:
AIM:To assess the effect of Schisandra sphenanthera extract (SchE) on the pharmacokinetics of tacrolimus in healthy volunteers. METHODS:Twelve healthy male volunteers were orally treated with SchE, three capsules twice daily for 13 days. Pharmacokinetic investigations of oral tacrolimus administration at 2 mg were performed both before and at the end of the SchE treatment period. Whole blood tacrolimus concentrations were determined by enzyme-linked immunosorbent assay. Estimated pharmacokinetic parameters before and with SchE were calculated with noncompartmental techniques. RESULTS:Following administration of SchE, the average percentage increases of individual increases in AUC, AUMC and C(max) of tacrolimus were 164.2% [95% confidence interval (CI) 70.1, 258.4], 133.1% (95% CI 49.5, 261.3) and 227.1% (95% CI 155.8, 298.4), respectively (P < 0.01 or 0.05). On average, there was a 36.8% (95% CI 13.4, 60.2) increase in tacrolimus t(max) (P < 0.01). The average percentage decreases in CL/F and V/F were 49.0% (95% CI 31.1, 66.9) and 53.7% (95% CI 40.1, 67.4), respectively (P < 0.01). CONCLUSIONS:SchE can increase the oral bioavailability of tacrolimus. The results of this study will add important information to the interaction area between drugs and herbal products.
journal_name
Br J Clin Pharmacoljournal_title
British journal of clinical pharmacologyauthors
Xin HW,Wu XC,Li Q,Yu AR,Zhu M,Shen Y,Su D,Xiong Ldoi
10.1111/j.1365-2125.2007.02922.xsubject
Has Abstractpub_date
2007-10-01 00:00:00pages
469-75issue
4eissn
0306-5251issn
1365-2125pii
BCP2922journal_volume
64pub_type
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journal_title:British journal of clinical pharmacology
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journal_title:British journal of clinical pharmacology
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-09-01 00:00:00
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更新日期:1991-09-01 00:00:00
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