Atenolol elimination in the neonate.

abstract：:Paracetamol overdose prior to the introduction of acetylcysteine was associated with significant morbidity. Acetylcysteine is now the mainstay of treatment for paracetamol poisoning and has effectively reduced rates of hepatotoxicity and death. The current three-bag intravenous regimen with an initial high loading dos...

journal_title：British journal of clinical pharmacology

authors： Chiew AL,Isbister GK,Duffull SB,Buckley NA

更新日期：2016-03-01 00:00:00

abstract：AIMS:Dexloxiglumide is a new CCK(1) receptor antagonist under investigation for treatment of functional gastrointestinal disorders and is metabolized by CYP3A4 and CYP2C9. The objectives of these two separate randomized, two-period, two-treatment crossover studies were to investigate the effects of steady-state ketocon...

journal_title：British journal of clinical pharmacology

authors： Jakate AS,Roy P,Patel A,Abramowitz W,Persiani S,Wangsa J,Kapil R

更新日期：2005-11-01 00:00:00

abstract：:Three calcium antagonists, diltiazem, flunarizine and verapamil stimulated human sperm motility in vitro. Among them, diltiazem induced the largest amplitude of motility increase. The concentration-response curve of diltiazem was similar in shape to those of calcium chelators. EGTA, a calcium chelator, potentiated the...

journal_title：British journal of clinical pharmacology

authors： Hong CY,Chiang BN,Ku J,Wei YH,Fong JC

更新日期：1985-01-01 00:00:00

abstract：AIMS:To describe the pharmacokinetic-pharmacodynamic modelling of the psychomotor and mnesic effects of a single 2 mg oral dose of lorazepam in healthy volunteers. METHODS:This was a randomized double-blind, placebo-controlled two-way cross-over study. The effect of lorazepam was examined with the following tasks: cho...

journal_title：British journal of clinical pharmacology

authors： Blin O,Jacquet A,Callamand S,Jouve E,Habib M,Gayraud D,Durand A,Bruguerolle B,Pisano P

更新日期：1999-10-01 00:00:00

abstract：:A potential kinetic interaction between cimetidine and flecainide has been studied in eight healthy males receiving flecainide (200 mg) orally on three occasions: before any treatment and on day 2 and day 7 of 8 days' cimetidine maintenance treatment at 1 g daily. Six days pretreatment with cimetidine induced the foll...

journal_title：British journal of clinical pharmacology

authors： Tjandra-Maga TB,van Hecken A,van Melle P,Verbesselt R,de Schepper PJ

更新日期：1986-07-01 00:00:00

abstract：AIM:To review the literature on adverse drug reactions (ADRs) in children with respect to occurrence, seriousness, type, therapeutic group, age and gender of the child and category of reporter. METHODS:Medline and Embase databases were searched from origin and updated until February 2010. We included empirically based...

journal_title：British journal of clinical pharmacology

authors： Aagaard L,Christensen A,Hansen EH

更新日期：2010-10-01 00:00:00

abstract：:The rise in plasma adenosine-3',5'-monophosphate occurring in response to insulin induced hypoglycaemia in normal human subjects, was abolished by non-selective beta-adrenoceptor blockade but unaffected by selective beta 1-adrenoceptor blockade. This implies that the rise is secondary to beta 2-adrenoceptor stimulatio...

journal_title：British journal of clinical pharmacology

authors： Armitstead JG,Lightman SL,Brown MJ,Causon RC,Vaughan NJ

更新日期：1983-12-01 00:00:00

abstract：AIM:To characterize the romiplostim dose-response in subjects with low or intermediate-1 risk myelodysplastic syndromes (MDS) receiving subcutaneous romiplostim. METHODS:Data from 44 MDS subjects receiving subcutaneous romiplostim (dose range 300-1500 μg week(-1) ) were used to develop a pharmacodynamic model consisti...

journal_title：British journal of clinical pharmacology

authors： Perez Ruixo JJ,Doshi S,Wang YM,Mould DR

更新日期：2013-06-01 00:00:00

abstract：:1 Benzodiazepines are regarded as pure anxiolytics, and their value in the treatment of depression is controversial. Nevertheless, symptoms of anxiety and depression coexist in patients with endogenous or neurotic depression, and clinical trials indicate that depressed patients respond better to a benzodiazepine-tricy...

journal_title：British journal of clinical pharmacology

authors： Cassano GB,Conti L

更新日期：1981-01-01 00:00:00

abstract：AIM:Amiselimod (MT-1303) is a selective sphingosine 1-phosphate 1 (S1P1 ) receptor modulator which is currently being developed for the treatment of various autoimmune diseases. Unlike some other S1P receptor modulators, amiselimod seemed to show a favourable cardiac safety profile in preclinical, phase I and II studie...

journal_title：British journal of clinical pharmacology

authors： Harada T,Wilbraham D,de La Borderie G,Inoue S,Bush J,Camm AJ

更新日期：2017-05-01 00:00:00

abstract：AIMS:To evaluate the electroencephalographic (EEG) effects, blood concentrations, vehicle irritation and dose-effect relationships for diazepam administered nasally. METHODS:The study had a cross-over design with eight healthy volunteers (one drop out). It consisted of four legs with four different administrations: in...

journal_title：British journal of clinical pharmacology

authors： Lindhardt K,Gizurarson S,Stefánsson SB,Olafsson DR,Bechgaard E

更新日期：2001-11-01 00:00:00

abstract：AIMS:6-mercaptopurine (6-MP) is used in the treatment of childhood acute lymphoblastic leukaemia (ALL). Its red blood cell (RBC) metabolite concentrations (6-thioguanine [6-TGN] and 6-methylmercaptopurine nucleotides [6-MMPN]) are related to drug response. We investigated the impact of non-genetic covariates and pharma...

journal_title：British journal of clinical pharmacology

authors： Adam de Beaumais T,Fakhoury M,Medard Y,Azougagh S,Zhang D,Yakouben K,Jacqz-Aigrain E

更新日期：2011-04-01 00:00:00

abstract：AIMS:Genetic factors, notably CYP2B6 516G→T [rs3745274] and 983T→C [rs28399499], explain much of the interindividual variability in efavirenz pharmacokinetics, but data from Africa are limited. We characterized relationships between genetic polymorphisms and plasma efavirenz concentrations in HIV-infected Black South A...

journal_title：British journal of clinical pharmacology

authors： Sinxadi PZ,Leger PD,McIlleron HM,Smith PJ,Dave JA,Levitt NS,Maartens G,Haas DW

更新日期：2015-07-01 00:00:00

abstract：:A double-blind, crossover study was carried out on the acceptability of three doses of brotizolam (0.125, 0.25 and 0.5 mg) in chronic insomniacs aged between 21 and 75 years (33 men: 42 women). Patients reported a shorter time to fall asleep and less nocturnal awakenings. Improvement in sleep was evident during the fi...

journal_title：British journal of clinical pharmacology

authors： Fritz-Osner A,Arias-Ortiz JL,Dorantes JF,Rabago-Sánchez J,Rodríguez-Tenorio A,Sánchez-Martinez J

更新日期：1983-01-01 00:00:00

abstract：:The safe use of Chinese materia medica (CMM) and products in traditional Chinese medicine (TCM) practice conventionally relies on correct pharmacognostic identification, good agricultural and manufacturing practices based on pharmacopoeia standards and rational/correct CMM combinations with TCM-guided clinical prescri...

journal_title：British journal of clinical pharmacology

authors： Chan K,Zhang H,Lin ZX

更新日期：2015-10-01 00:00:00

abstract：:Clinical studies comparing the response and side effects of various opioids have not been able to show robust differences between drugs. Hence, recommendations of the regulatory authorities have been driven by costs with a general tendency in many countries to restrict physician's use of opioids to morphine. Although ...

journal_title：British journal of clinical pharmacology

authors： Drewes AM,Jensen RD,Nielsen LM,Droney J,Christrup LL,Arendt-Nielsen L,Riley J,Dahan A

更新日期：2013-01-01 00:00:00

abstract：:The effects of separate 7 day pretreatments with sulphinpyrazone (800 mg daily) and cimetidine (1 g daily) on the disposition of (+/-)-verapamil have been examined in eight healthy volunteers (four male, four female). Each subject received single oral (80 mg) and intravenous (0.15 mg/kg) doses of verapamil on differen...

journal_title：British journal of clinical pharmacology

authors： Wing LM,Miners JO,Lillywhite KJ

更新日期：1985-03-01 00:00:00

abstract：:Eight psoriatic patients were treated with etretinate (50 mg daily) for 6 weeks. Skin chamber exudates from involved and uninvolved skin were assayed for arachidonic acid, 12-HETE, PGE2 and for neutrophil chemokinetic activity co-chromatographing with leukotriene B4, before and at weekly intervals during therapy. Pre-...

journal_title：British journal of clinical pharmacology

authors： Wong E,Barr RM,Brain SD,Greaves MW,Olins LA,Mallet AI

更新日期：1984-10-01 00:00:00

abstract：AIMS:To evaluate the potential ethnic differences in the pharmacokinetics (PK) and pharmacodynamics (PD) of evolocumab in Caucasian and Asian populations using population PK/PD modelling analysis. METHODS:Data from different ethnic groups in 5 Phase I clinical trials, including two American studies, one Japanese study...

journal_title：British journal of clinical pharmacology

authors： Wang C,Zheng Q,Zhang M,Lu H

更新日期：2019-01-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:* Exposure to bosentan was lower in paediatric pulmonary arterial hypertension (PAH) patients treated with the marketed adult formulation at a dose of about 2 mg kg(-1) when compared with adult PAH patients. * In healthy adult subjects, bosentan pharmacokinetics are less than do...

journal_title：British journal of clinical pharmacology

authors： Beghetti M,Haworth SG,Bonnet D,Barst RJ,Acar P,Fraisse A,Ivy DD,Jais X,Schulze-Neick I,Galiè N,Morganti A,Dingemanse J,Kusic-Pajic A,Berger RM

更新日期：2009-12-01 00:00:00

abstract：:Calcium subserves a ubiquitous role in the organisation of cell function. Ca2+ channels which control influx may be modified in disease states. Animal models of cerebral ischaemia do present some problems when investigating potential therapies involving Ca2+ channels. However, it is important not to be too rigid in se...

journal_title：British journal of clinical pharmacology

authors： Alps BJ

更新日期：1992-09-01 00:00:00

abstract：:We define a me-too drug as a pharmacologically active compound that is structurally related to a first-in-class compound, regarded as belonging to the same therapeutic class as the original compound, and used for the same therapeutic purposes, but which may differ in some respects, such as specificity of pharmacologic...

journal_title：British journal of clinical pharmacology

authors： Aronson JK,Green AR

更新日期：2020-11-01 00:00:00

abstract：:1. The influence of food on the absorption of frusemide and bumetanide was compared in two separate randomized crossover studies. 2. On three separate occasions frusemide 40 mg was administered to eight healthy male volunteers intravenously, orally in the fasting state and orally after a standard breakfast. Blood and ...

journal_title：British journal of clinical pharmacology

authors： McCrindle JL,Li Kam Wa TC,Barron W,Prescott LF

更新日期：1996-12-01 00:00:00

abstract：AIMS:Inherited polymorphisms of codons 16, 27, and 164 of the beta2-adrenergic receptor (B2AR) gene may result in significantly changed functions of this receptor. The aim of the present study was to investigate the frequencies of the main mutations of the B2AR gene in Turks. METHODS:A group of 104 unrelated Turkish s...

journal_title：British journal of clinical pharmacology

authors： Aynacioglu AS,Cascorbi I,Güngör K,Ozkur M,Bekir N,Roots I,Brockmöller J

更新日期：1999-11-01 00:00:00

abstract：AIMS:5-Fluorouracil (5-FU) is widely used in combination chemotherapy, and literature suggests pharmacokinetic-guided dosing to improve clinical efficacy and reduce toxicity. This study aimed to determine the pharmacokinetic exposure of both 5-FU and its metabolite, 5,6-dihydrofluorouracil (DHFU), in patients with gast...

journal_title：British journal of clinical pharmacology

authors： Jacob J,Mathew SK,Chacko RT,Aruldhas BW,Singh A,Prabha R,Mathew BS

更新日期：2020-06-27 00:00:00

abstract：:There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of ca...

journal_title：British journal of clinical pharmacology

authors： Yang L,Mäki-Petäjä K,Cheriyan J,McEniery C,Wilkinson IB

更新日期：2015-07-01 00:00:00

abstract：:Self-poisoning by ingestion or inhalation is common, and it is important to study its various epidemiological manifestations with clear definitions. Data on fatal self-poisonings are recorded nationally within the UK and are codified according to the International Classification of Diseases (ICD) revision relevant at ...

journal_title：British journal of clinical pharmacology

authors： Camidge DR,Wood RJ,Bateman DN

更新日期：2003-12-01 00:00:00

abstract：AIMS:The CYP3A metric 4β-hydroxycholesterol (4βOHC) has been shown to correlate with tacrolimus steady-state apparent oral clearance (CL/F). Recently, pretransplant 4βOHC was shown not to predict tacrolimus CL/F after transplantation in a cohort of renal recipients (n = 79). The goal of the current study was determine ...

journal_title：British journal of clinical pharmacology

authors： Vanhove T,Hasan M,Annaert P,Oswald S,Kuypers DRJ

更新日期：2017-11-01 00:00:00

abstract：AIM:To describe the time to clinical events (death, disability, cognitive impairment and depression) in Parkinson's disease using the time course of disease status and treatment as explanatory variables. METHODS:Disease status based on the Unified Parkinson's Disease Rating Scale (UPDRS) and the time to clinical outco...

journal_title：British journal of clinical pharmacology

authors： Vu TC,Nutt JG,Holford NH

更新日期：2012-08-01 00:00:00

abstract：:1 Aspirin is partly hydrolyzed to salicylic acid during absorption. Absorbed aspirin is rapidly hydrolyzed systemically. Salicylic acid elimination kinetics are dependent on drug concentration due to the limited capacity of two major biotransformation pathways: formation of salicyluric acid and of salicylphenolic gluc...

journal_title：British journal of clinical pharmacology

authors： Levy G

更新日期：1980-10-01 00:00:00