Effects of MHRA drug safety advice on time trends in prescribing volume and indices of clinical toxicity for quinine.

abstract：:Regulating drugs does not end when market access has been granted. Monitoring drugs over the life cycle has become state of the art, inherent to evolving legislation and societal need. Here, we explore how the drug label could move along in a changing playing-field and become a sustainable label for the future. A dial...

journal_title：British journal of clinical pharmacology

authors： Gispen-de Wied CC,Weemers J,Boon W,Mol PGM,Stolk P

更新日期：2019-10-01 00:00:00

abstract：:1 In an open, randomized cross-over investigation of thirteen patients (nine and four women, aged 37-67 years) with mild or moderate essential hypertension a comparison between atenolol and metoprolol was carried out in order to study the effects of 50, 100 and 200 mg given once daily on blood pressure and heart rate ...

journal_title：British journal of clinical pharmacology

authors： Rasmussen S,Arnung K,Eskildsen PC,Nielsen PE

更新日期：1981-12-01 00:00:00

abstract：:1. The study was performed to determine the sensitivity and short-term and day-to-day variability of a novel technique based on laser interferometry of ocular fundus pulsations and of non-invasive methods for the quantification of haemodynamic drug effects. An additional aim was to assess sex differences in haemodynam...

journal_title：British journal of clinical pharmacology

authors： Wolzt M,Schmetterer L,Rheinberger A,Salomon A,Unfried C,Breiteneder H,Ehringer H,Eichler HG,Fercher AF

更新日期：1995-04-01 00:00:00

abstract：:1. Meals empty more slowly when they contain fat. 2. This study investigated whether an intragastric fat preload in comparison with a water preload affected gastric emptying of a semisolid meal and antral motor activity, and whether cisapride reversed such effects. 3. Twelve healthy subjects were studied under three c...

journal_title：British journal of clinical pharmacology

authors： Stacher G,Bergmann H,Gaupmann G,Schneider C,Kugi A,Höbart J,Binder A,Mittelbach-Steiner G

更新日期：1990-12-01 00:00:00

abstract：:There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of ca...

journal_title：British journal of clinical pharmacology

authors： Yang L,Mäki-Petäjä K,Cheriyan J,McEniery C,Wilkinson IB

更新日期：2015-07-01 00:00:00

abstract：AIM:To evaluate safety, tolerability and pharmacokinetics of oral PF-05190457, an oral ghrelin receptor inverse agonist, in healthy adults. METHODS:Single (SAD) and multiple ascending dose (MAD) studies were randomised, placebo-controlled, double-blind studies. Thirty-five healthy men (age 38.2 ± 10.4 years; body mass...

journal_title：British journal of clinical pharmacology

authors： Denney WS,Sonnenberg GE,Carvajal-Gonzalez S,Tuthill T,Jackson VM

更新日期：2017-02-01 00:00:00

abstract：:1. Effects of 3 h infusions of adrenaline (0.4 nmol kg-1 min-1) or placebo and of mental stress evoked by a colour word test (CWT) on adrenergic receptor function were investigated in healthy men. Responses of heart rate, blood pressure, plasma catecholamines, plasma cyclic AMP and plasma free fatty acids (FFA) were e...

journal_title：British journal of clinical pharmacology

authors： Larsson PT,Martinsson A,Olsson G,Hjemdahl P

更新日期：1989-12-01 00:00:00

abstract：AIMS:Recently, an apparent protective effect of statins against upper gastrointestinal bleeding (UGB) was postulated in a post hoc analysis of a randomized trial. We aimed to evaluate the effect of statin use on acute nonvariceal UGB alone or in combinations with low-dose aspirin and other antithrombotic drugs. METHOD...

journal_title：British journal of clinical pharmacology

authors： Gulmez SE,Lassen AT,Aalykke C,Dall M,Andries A,Andersen BS,Hansen JM,Andersen M,Hallas J

更新日期：2009-04-01 00:00:00

abstract：AIMS:The major objective of the present study was to investigate the effect of imatinib on the pharmacokinetics of paracetamol in patients with chronic myelogenous leukaemia (CML). METHODS:Patients (n = 12) received a single oral dose of acetaminophen 1000 mg on day 1 (control). On days 2-8, imatinib 400 mg was admini...

journal_title：British journal of clinical pharmacology

authors： Kim DW,Tan EY,Jin Y,Park S,Hayes M,Demirhan E,Schran H,Wang Y

更新日期：2011-02-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:• The topical second generation anti-histamine azelastine hydrochloride (AZE) and the potent corticosteroid fluticasone propionate (FP) are well established first-line treatments in allergic rhinitis (AR). • MP29-02, a novel intranasal AZE and FP formulation, has been shown to c...

journal_title：British journal of clinical pharmacology

authors： Derendorf H,Munzel U,Petzold U,Maus J,Mascher H,Hermann R,Bousquet J

更新日期：2012-07-01 00:00:00

abstract：AIMS:Breakthrough bleeding or even unwanted pregnancies have been reported in women during concomitant therapy with oral contraceptives and St John's wort extract. The aim of the present study was to investigate the effects of St John's wort extract on oral contraceptive therapy with respect to ovarian activity, breakt...

journal_title：British journal of clinical pharmacology

authors： Pfrunder A,Schiesser M,Gerber S,Haschke M,Bitzer J,Drewe J

更新日期：2003-12-01 00:00:00

abstract：:Widespread use of cocaine and its attendant toxicity has produced a wealth of benchwork studies and small animal investigations that evaluated the effects of cocaine on the cardiovascular system. Despite this wealth of knowledge, very little is known about the frequency or types of arrhythmias in patients with signifi...

journal_title：British journal of clinical pharmacology

authors： Hoffman RS

更新日期：2010-05-01 00:00:00

abstract：:1 Apparent Vmax and Km for phenytoin were estimated in 40 children (aged 8--33 months) and 21 adults (aged 18--66 years). 2 The derived values of Vmax and Km were used to predict the plasma and salivary concentrations of phenytoin following a change in dose. There was a highly significant correlation between observed ...

journal_title：British journal of clinical pharmacology

authors： Blain PG,Mucklow JC,Bacon CJ,Rawlins MD

更新日期：1981-11-01 00:00:00

abstract：:1 Evidence concerning the convulsant effects of non-monoamine oxidase inhibitor antidepressant drugs has been reviewed. 2 Mianserin is convulsant in therapeutic doses but seizures have not been reported following overdose. 3 The convulsant effects of mianserin are probably no greater than for other non-monoamine oxida...

journal_title：British journal of clinical pharmacology

authors： Richens A,Nawishy S,Trimble M

更新日期：1983-01-01 00:00:00

abstract：AIMS:In experimental studies, morphine pharmacokinetics is different in the brain compared with other tissues due to the properties of the blood-brain barrier, including action of efflux pumps. It was hypothesized in this clinical study that active efflux of morphine occurs also in human brain, and that brain injury wo...

journal_title：British journal of clinical pharmacology

authors： Ederoth P,Tunblad K,Bouw R,Lundberg CJ,Ungerstedt U,Nordström CH,Hammarlund-Udenaes M

更新日期：2004-04-01 00:00:00

abstract：AIMS:Several cases of acute non-infectious cholestatic hepatitis recently appeared in Italy following consumption of Curcuma longa-containing dietary supplements. The aim of this research was to describe the Tuscan (Italy) cases of acute hepatitis and to compare them with similar cases of hepatotoxicity published in th...

journal_title：British journal of clinical pharmacology

authors： Lombardi N,Crescioli G,Maggini V,Ippoliti I,Menniti-Ippolito F,Gallo E,Brilli V,Lanzi C,Mannaioni G,Firenzuoli F,Vannacci A

更新日期：2020-07-13 00:00:00

abstract：:1. The effects of the voltage dependent calcium channel blocking agent nifedipine, and of a calcium free bathing medium, on the responses of human blood vessels obtained postmortem to various agonists have been compared with those of the rat aorta. The human vessels studied were digital arteries, basilar arteries and ...

journal_title：British journal of clinical pharmacology

authors： Iwanov V,Moulds RF

更新日期：1991-01-01 00:00:00

abstract：AIMS:Within the new psychoactive substances (NPS) scenario, several hundred different molecules, mostly including synthetic cannabinoids and cathinones, have been identified so far. The aims of the paper were to: (i) identify the number of synthetic cathinones mentioned in a range of psychonaut, NPS-related, online sou...

journal_title：British journal of clinical pharmacology

authors： Schifano F,Napoletano F,Arillotta D,Zangani C,Gilgar L,Guirguis A,Corkery JM,Vento A

更新日期：2020-03-01 00:00:00

abstract：AIMS:To characterize the cytochrome P450 (CYP) enzymes responsible for the N-demethylation of sildenafil to its main metabolite, UK-103 320, to investigate the potential inhibitory effects of sildenafil on CYP enzymes and to evaluate the potential of selected drugs to affect sildenafil metabolism. METHODS:The metaboli...

journal_title：British journal of clinical pharmacology

authors： Hyland R,Roe EG,Jones BC,Smith DA

更新日期：2001-03-01 00:00:00

abstract：:1. Changes in undergraduate medical education will involve the development of a core curriculum of material of essential knowledge and of the skills for self directed learning both as a student and a postgraduate. A survey of departments or individuals teaching clinical pharmacology and therapeutics was conducted to c...

journal_title：British journal of clinical pharmacology

authors： Walley T,Bligh J,Orme M,Breckenridge A

更新日期：1994-02-01 00:00:00

abstract：AIMS:Vancomycin is an important antibiotic for critically ill patients with Gram-positive bacterial infections. Critically ill patients typically have severely altered pathophysiology, which leads to inefficacy or toxicity. Model-informed precision dosing may aid in optimizing the dose, but prospectively validated tool...

journal_title：British journal of clinical pharmacology

authors： Ter Heine R,Keizer RJ,van Steeg K,Smolders EJ,van Luin M,Derijks HJ,de Jager CPC,Frenzel T,Brüggemann R

更新日期：2020-12-01 00:00:00

abstract：:1. Quinidine is a potent inhibitor of the genetically-determined debrisoquine 4-hydroxylation. Oxidation reactions of several other drugs, including the 5-hydroxylation of the new antiarrhythmic drug propafenone, depend on the isozyme responsible for debrisoquine 4-hydroxylation. 2. The effect of quinidine on the debr...

journal_title：British journal of clinical pharmacology

authors： Funck-Brentano C,Kroemer HK,Pavlou H,Woosley RL,Roden DM

更新日期：1989-04-01 00:00:00

abstract：AIM:To investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of the highly selective oral p38alpha/beta mitogen-activated protein (MAP) kinase inhibitor Org 48,775-0 in a first-in-human study. METHODS:In the single ascending dosing (SAD) study, an oral dose of Org 48,775-0 (0.3-600 mg) was evalua...

journal_title：British journal of clinical pharmacology

authors： Moerland M,Kales AJ,Broekhuizen K,Nässander U,Nelissen R,de Kam ML,Peeters PAM,Burggraaf J

更新日期：2020-11-17 00:00:00

abstract：AIMS:We investigated whether the deterioration in asthma control reported following cessation of theophylline was due to tolerance to theophylline. METHODS:Eighteen subjects with mild stable asthma were given oral theophylline 10 mg kg(-1) day(-1) or placebo for 2 weeks in a double-blind crossover study. FEV1 and PD20...

journal_title：British journal of clinical pharmacology

authors： Bennett JA,Thompson Coon J,Pavord ID,Wilding PJ,Tattersfield AE

更新日期：1998-04-01 00:00:00

abstract：:1. The 5-hydroxytryptamine (5-HT3) receptor antagonist, GR 38032F, which possesses potent anti-emetic properties in vomiting induced by cancer chemotherapeutic drugs, has been tested to determine its value in the prophylaxis of motion sickness induced by cross-coupled stimulation. The double-blind trial compared GR 38...

journal_title：British journal of clinical pharmacology

authors： Stott JR,Barnes GR,Wright RJ,Ruddock CJ

更新日期：1989-02-01 00:00:00

abstract：:The renal response to a challenge of maximal water diuresis has been studied in seven subjects pretreated over 48 h with either placebo, probenecid, indomethacin or piroxicam. Probenecid did not alter the excretion of water and sodium chloride when compared with placebo responses, but increased both phosphate and urat...

journal_title：British journal of clinical pharmacology

authors： Dixey JJ,Noormohamed FH,Lant AF,Brewerton DA

更新日期：1988-05-01 00:00:00

abstract：:1 The effect of an intravenous bolus of labetalol (0.6--1.6 mg/kg body weight) on central and peripheral haemodynamics was studied in nine subjects with essential hypertension and in eleven subjects with chronic renal disease and hypertension. 2 The BP reduction amounting to 20/13 mmHg was entirely due to the lowering...

journal_title：British journal of clinical pharmacology

authors： Bahlmann J,Brod J,Hubrich W,Cachovan M,Pretschner P

更新日期：1979-01-01 00:00:00

abstract：AIMS:Post licensing, the evaluation of drug safety relies heavily on the collation of sporadic, spontaneous reports on adverse effects. The aim was to assess the potential utility of a more systematic approach to the detection of adverse events that utilizes routinely collected clinical data from a large primary care p...

journal_title：British journal of clinical pharmacology

authors： Grosso A,Douglas I,Hingorani A,MacAllister R,Smeeth L

更新日期：2008-11-01 00:00:00

abstract：:The effects of intravenous boluses of adenosine on respiration and heart rate were compared in young and elderly individuals. Respiratory stimulation and biphasic changes in heart rate were confirmed. The dose-response relationship for the effects of adenosine on respiration and heart-rate did not differ significantly...

journal_title：British journal of clinical pharmacology

authors： Watt AH,Bayer A,Routledge PA,Swift CG

更新日期：1989-02-01 00:00:00

abstract：:The pharmacokinetics and metabolism of an intravenous dose (500 mg) of paracetamol were studied in a group of non-insulin dependent diabetic patients (n = 10) and in a group of healthy control subjects (n = 9). Paracetamol clearance, half-life and the partial clearance to paracetamol glucuronide were not significantly...

journal_title：British journal of clinical pharmacology

authors： Kamali F,Thomas SH,Ferner RE

更新日期：1993-01-01 00:00:00