Effect of maximal hydration on the renal responses to pretreatment with nonsteroidal anti-inflammatory drugs and probenecid in man.

abstract：:For people seeking treatment, the course of heroin addiction tends to be chronic and relapsing, and longer duration of treatment is associated with better outcomes. Heroin addiction is strongly associated with deviant behaviour and crime, and the objectives in treating heroin addiction have been a blend of humane supp...

journal_title：British journal of clinical pharmacology

authors： Bell J

更新日期：2014-02-01 00:00:00

abstract：:1 A study was carried out to investigate the possible contribution of prostaglandins in captopril-induced hypotension. 2 Healthy volunteers and patients with essential hypertension were given single oral doses of 25 mg and 50 mg captopril respectively before and after cyclo-oxygenase inhibition with indomethacin. 3 Th...

journal_title：British journal of clinical pharmacology

authors： Silberbauer K,Stanek B,Templ H

更新日期：1982-01-01 00:00:00

abstract：:A double-blind, placebo-controlled, cross-over trial of quinine in leg cramps occurring at rest was conducted in 22 elderly cramp sufferers. Despite demonstration of impaired quinine elimination in the elderly, prescription of the traditional dose of 300 mg quinine bisulphate at night failed to produce a significant (...

journal_title：British journal of clinical pharmacology

authors： Warburton A,Royston JP,O'Neill CJ,Nicholson PW,Jee RD,Denham MJ,Dobbs SM,Dobbs RJ

更新日期：1987-04-01 00:00:00

abstract：AIM:To evaluate safety, tolerability and pharmacokinetics of oral PF-05190457, an oral ghrelin receptor inverse agonist, in healthy adults. METHODS:Single (SAD) and multiple ascending dose (MAD) studies were randomised, placebo-controlled, double-blind studies. Thirty-five healthy men (age 38.2 ± 10.4 years; body mass...

journal_title：British journal of clinical pharmacology

authors： Denney WS,Sonnenberg GE,Carvajal-Gonzalez S,Tuthill T,Jackson VM

更新日期：2017-02-01 00:00:00

abstract：:Six patients received 10 mg of midazolam intravenously during the anhepatic period of liver transplantation. Arterial blood was sampled during this time and for a similar period following revascularisation. The plasma was analysed using gas chromatography and electron capture detection (GC-ECD) for midazolam alpha-hyd...

journal_title：British journal of clinical pharmacology

authors： Park GR,Manara AR,Dawling S

更新日期：1989-05-01 00:00:00

abstract：AIMS:The cytochrome P-450 2D6 (CYP2D6) gene duplication/multiduplication producing an increase in enzyme activity, and the common Japanese mutation, CYP2D6*10A producing a decrease of enzyme activity were screened in a large number of Japanese psychiatric subjects (n = 111) in order to investigate whether these mutated...

journal_title：British journal of clinical pharmacology

authors： Ohnuma T,Shibata N,Matsubara Y,Arai H

更新日期：2003-09-01 00:00:00

abstract：AIMS:The inhaled allergen challenge model has been used previously to investigate the effects of novel anti-inflammatory drugs in inhaled corticosteroid (ICS)-naïve asthmatics. The aim of this study was to characterize high- and low-dose allergen challenges in asthmatic patients using ICS. METHODS:Twenty-eight asthmat...

journal_title：British journal of clinical pharmacology

authors： Lee WY,Southworth T,Booth S,Singh D

更新日期：2015-03-01 00:00:00

abstract：:The safe use of Chinese materia medica (CMM) and products in traditional Chinese medicine (TCM) practice conventionally relies on correct pharmacognostic identification, good agricultural and manufacturing practices based on pharmacopoeia standards and rational/correct CMM combinations with TCM-guided clinical prescri...

journal_title：British journal of clinical pharmacology

authors： Chan K,Zhang H,Lin ZX

更新日期：2015-10-01 00:00:00

abstract：:The effects of omeprazole on cytochrome P-450 mediated 7-ethoxycoumarin deethylation were studied in human liver microsomes. Omeprazole inhibited both the high and low affinity components of deethylation, with an estimated Ki of 0.03 mM for the high affinity component. The results are further evidence that the previou...

journal_title：British journal of clinical pharmacology

authors： Jensen JC,Gugler R

更新日期：1986-03-01 00:00:00

abstract：AIMS:This paper describes the pharmacokinetics and effects of propofol in short-term sedated paediatric patients. METHODS:Six mechanically ventilated children aged 1-5 years received a 6 h continuous infusion of propofol 6% at the rate of 2 or 3 mg kg-1 h-1 for sedation following cardiac surgery. A total of seven arte...

journal_title：British journal of clinical pharmacology

authors： Knibbe CA,Melenhorst-de Jong G,Mestrom M,Rademaker CM,Reijnvaan AF,Zuideveld KP,Kuks PF,van Vught H,Danhof M

更新日期：2002-10-01 00:00:00

abstract：:1 Norfenfluramine is thought to be the major active metabolite of fenfluramine in man. Therefore its in vitro effect on lipogenesis in human adipose tissue from twelve patients was investigated. 2 Although inhibition of lipogenesis was demonstrated, the concentrations of norfenfluramine necessary (>1 mM) were much hig...

journal_title：British journal of clinical pharmacology

authors： Ashwell M

更新日期：1974-10-01 00:00:00

abstract：:To study the cardioselectivity of xamoterol, eight asthmatic patients took part in a randomised, double-blind, cross-over study, in which xamoterol or saline were infused, followed by four increasing doses of terbutaline i.v. Circulatory studies showed a significant increase of systolic blood pressure after xamoterol ...

journal_title：British journal of clinical pharmacology

authors： Löfdahl CG,Svedmyr N

更新日期：1984-10-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Oxycodone is an opioid analgesic that is metabolized mainly in the liver by cytochrome P450 (CYP) 2D6 and 3A4 enzymes. So far, the effects of CYP2D6 or CYP3A4 inhibitors on the pharmacokinetics of oxycodone in humans have not been systematically studied. WHAT THIS STUDY ADDS:Dr...

journal_title：British journal of clinical pharmacology

authors： Grönlund J,Saari TI,Hagelberg NM,Neuvonen PJ,Olkkola KT,Laine K

更新日期：2010-07-01 00:00:00

abstract：AIMS:Rifampicin profoundly reduces lopinavir concentrations. Doubled doses of lopinavir/ritonavir compensate for the effect of rifampicin in adults, but fail to provide adequate lopinavir concentrations in young children on rifampicin-based antituberculosis therapy. The objective of this study was to develop a populati...

journal_title：British journal of clinical pharmacology

authors： Zhang C,Denti P,Decloedt EH,Ren Y,Karlsson MO,McIlleron H

更新日期：2013-11-01 00:00:00

abstract：AIMS:Naloxegol, a polyethylene glycol conjugated derivative of the opioid antagonist naloxone, is in clinical development for treatment of opioid-induced constipation (OIC). The aim of the study was to develop a population pharmacokinetic model describing the concentration vs. time profile of orally administered naloxe...

journal_title：British journal of clinical pharmacology

authors： Al-Huniti N,Chapel S,Xu H,Bui KH,Sostek M

更新日期：2016-01-01 00:00:00

abstract：:1. Relative rates of absorption of enteric and non-enteric preparations of prednisolone were measured in five renal transplant recipients. 2. The absorption of the enteric coated preparation is delayed and the peak plasma concentration is much lower than that attained using the same dose of the uncoated material. 3. T...

journal_title：British journal of clinical pharmacology

authors： Hulme B,James VH,Rault R

更新日期：1975-08-01 00:00:00

abstract：:The plasma concentrations of sodium cromoglycate were measured for 4 h following a single dose of 20 mg given by inhalation to six normal volunteers. A series of forced expiratory manoeuvres was performed 2 h after the dose, which resulted in a rapid and marked increase in the plasma concentrations of the drug. A simi...

journal_title：British journal of clinical pharmacology

authors： Richards R,Fowler C,Simpson SF,Renwick AG,Holgate ST

更新日期：1989-06-01 00:00:00

abstract：AIMS:5-hydroxytryptamine3 receptor antagonists act antiemetically and slow colonic transit. This study evaluated effects of the high-affinity 5-HT3 antagonist, cilansetron, on fasting, meal-and anticholinesterase-stimulated phasic contractile activity of the human sigmoid colon as well as on bowel habits and stool cons...

journal_title：British journal of clinical pharmacology

authors： Stacher G,Weber U,Stacher-Janotta G,Bauer P,Huber K,Holzäpfel A,Krause G,Steinborn C

更新日期：2000-05-01 00:00:00

abstract：AIM:The combination of ephedrine and caffeine has been used in herbal products for weight loss and athletic performance-enhancement, but the pharmacokinetic profiles of these compounds have not been well characterized. This study aimed to develop a mechanistic model describing ephedrine, norephedrine, and caffeine phar...

journal_title：British journal of clinical pharmacology

authors： Csajka C,Haller CA,Benowitz NL,Verotta D

更新日期：2005-03-01 00:00:00

abstract：:Ipratropium bromide (0.5 mg) and fenoterol (2 mg) produced equivalent peak bronchodilatation between 1 and 2 h after administration to eight patients with chronic partially reversible airways obstruction. The duration of action compared with saline was 6 h for ipratropium and 4 h for fenoterol. Both drugs in combinati...

journal_title：British journal of clinical pharmacology

authors： Jenkins CR,Chow CM,Fisher BL,Marlin GE

更新日期：1982-07-01 00:00:00

abstract：:Using a variety of radioimmunoassay methods, plasma digoxin concentrations were measured in two patients before and after the administration of ovine Fab antibody fragments to remove the effects of digoxin. Gross method-dependent anomalies in the results due to in vitro drug interaction were observed. More widespread ...

journal_title：British journal of clinical pharmacology

authors： Gibb I,Adams PC,Parnham AJ,Jennings K

更新日期：1983-10-01 00:00:00

abstract：:1. The pharmacokinetics of streptokinase (SK) and anistreplase in conventional dosage regimens of 1.5 x 10(6) i.u. of SK infused over 60 min and 30 units of anistreplase over 5 min were studied in 24 consecutive patients presenting with acute myocardial infarction, using a functional bioassay to assess concentrations....

journal_title：British journal of clinical pharmacology

authors： Gemmill JD,Hogg KJ,Burns JM,Rae AP,Dunn FG,Fears R,Ferres H,Standring R,Greenwood H,Pierce D

更新日期：1991-02-01 00:00:00

abstract：:Paracetamol overdose prior to the introduction of acetylcysteine was associated with significant morbidity. Acetylcysteine is now the mainstay of treatment for paracetamol poisoning and has effectively reduced rates of hepatotoxicity and death. The current three-bag intravenous regimen with an initial high loading dos...

journal_title：British journal of clinical pharmacology

authors： Chiew AL,Isbister GK,Duffull SB,Buckley NA

更新日期：2016-03-01 00:00:00

abstract：:Twelve healthy habitual cigarette smokers and eight non-smokers participated in a double-blind placebo controlled study to determine the effect of smoking on the pharmacokinetics and pharmacodynamics of the H2-receptor antagonist famotidine. In smokers, cigarette smoking was standardised and started 1 h before (A), or...

journal_title：British journal of clinical pharmacology

authors： Baak LC,Ganesh S,Jansen JB,Lamers CB

更新日期：1992-02-01 00:00:00

abstract：AIMS:Little is known about the effects of comorbidities and patient characteristics on treatment initiation of lipid-lowering drugs (LLDs), which can be helpful in the evaluation of the risks and benefits of LLDs. METHODS:Baseline characteristics among subjects who received their first ever-recorded LLD prescription i...

journal_title：British journal of clinical pharmacology

authors： Yang CC,Jick SS,Testa MA

更新日期：2003-03-01 00:00:00

abstract：AIMS:The aim of this study was to compare the effects of the ACE-inhibitor lisinopril and the angiotensin II receptor antagonist losartan on insulin sensitivity in the treatment of non diabetic hypertensives. METHODS:Twenty-five non diabetic subjects with mild to moderate hypertension, 11 females and 14 males, aged 44...

journal_title：British journal of clinical pharmacology

authors： Fogari R,Zoppi A,Corradi L,Lazzari P,Mugellini A,Lusardi P

更新日期：1998-11-01 00:00:00

abstract：AIM:Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase and are an important group of hypolipidaemic drugs, widely used in the treatment of hypercholesterolaemia and cardiovascular disease. Some studies have shown that statins are able to modulate inflammation and alveolar bone loss. METHODS:In o...

journal_title：British journal of clinical pharmacology

authors： Estanislau IM,Terceiro IR,Lisboa MR,Teles Pde B,Carvalho Rde S,Martins RS,Moreira MM

更新日期：2015-06-01 00:00:00

abstract：:This double-blind study in 60 hospitalized female patients comparing midazolam 15 mg, oxazepam 15 mg and placebo, demonstrated an inter-group difference in favour of midazolam with regard to efficacy. The sleep parameters of onset latency and duration were improved by midazolam. All three compounds were very well tole...

journal_title：British journal of clinical pharmacology

authors： Fischbach R

更新日期：1983-01-01 00:00:00

abstract：:1. The potential interaction between selective beta 1-adrenoceptor blockers and sulphonylureas or biguanides was studied by comparing the beta 1-adrenoceptor antagonist betaxolol with placebo in 12 normal subjects taking glibenclamide or metformin in a single-blind crossover group study. 2. After a 4 day run-in period...

journal_title：British journal of clinical pharmacology

authors： Sinclair AJ,Davies IB,Warrington SJ

更新日期：1990-11-01 00:00:00

abstract：AIM:In short-term studies, hormonal contraceptives (HC) have been suggested to induce a rise in blood pressure (BP) and urinary albumin excretion (UAE), while the effect of HC in renal function (GFR) is still under debate. Data on long-term and withdrawal effects of HC use on these outcomes are, however, not available....

journal_title：British journal of clinical pharmacology

authors： Atthobari J,Gansevoort RT,Visser ST,de Jong PE,de Jong-van den Berg LT,PREVEND Study Group.

更新日期：2007-02-01 00:00:00