Inhibition of human liver cytochrome P-450 by omeprazole.

abstract：:1. The oral kinetics of oxazepam after a single 15 mg oral dose was investigated in six healthy volunteers before and during concomitant administration of the beta-adrenoceptor antagonists propranolol (80 mg) and labetalol (200 mg) (racemates). 2. A possible pharmacodynamic interaction between oxazepam and the beta-ad...

journal_title：British journal of clinical pharmacology

authors： Sonne J,Døssing M,Loft S,Olesen KL,Vollmer-Larsen A,Victor MA,Hamberg O,Thyssen H

更新日期：1990-01-01 00:00:00

abstract：AIMS:To investigate the relationships between pretreatment folate concentrations, MTX pharmacokinetics and acute toxicities following high dose methotrexate (HD MTX) therapy. METHODS:MTX and its major extracellular metabolite 7-OH-MTX were measured in eight serum samples per HD MTX cycle in 65 consecutive osteosarcoma...

journal_title：British journal of clinical pharmacology

authors： Holmboe L,Andersen AM,Mørkrid L,Slørdal L,Hall KS

更新日期：2012-01-01 00:00:00

abstract：AIMS:To investigate the driving forces behind increasing utilization of cardiovascular drugs. METHODS:Using register data, all Danish residents as of 1 January 1996 were followed until 2006. Cohort members were censored at death or emigration. Cardiovascular drug utilization on the individual level was traced, applyin...

journal_title：British journal of clinical pharmacology

authors： Kildemoes HW,Støvring H,Andersen M

更新日期：2008-12-01 00:00:00

abstract：AIMS:To assess safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity of CNTO 7160, an anti-interleukin-33 receptor (IL-33R) monoclonal antibody, in healthy subjects and patients with asthma or atopic dermatitis (AD). METHODS:In Part 1 of this Phase I, randomized, double-blind, placebo-c...

journal_title：British journal of clinical pharmacology

authors： Nnane I,Frederick B,Yao Z,Raible D,Shu C,Badorrek P,van den Boer M,Branigan P,Duffy K,Baribaud F,Fink D,Yang TY,Xu Z

更新日期：2020-12-01 00:00:00

abstract：:1. The influence of food on the absorption of frusemide and bumetanide was compared in two separate randomized crossover studies. 2. On three separate occasions frusemide 40 mg was administered to eight healthy male volunteers intravenously, orally in the fasting state and orally after a standard breakfast. Blood and ...

journal_title：British journal of clinical pharmacology

authors： McCrindle JL,Li Kam Wa TC,Barron W,Prescott LF

更新日期：1996-12-01 00:00:00

abstract：AIMS:To characterize the pharmacokinetics of the dual 5alpha-reductase inhibitor GI198745 (dutasteride) to allow for more accurate predictions of GI198745 concentrations after different dosing schedules. METHODS:In this randomized, single-blind, parallel group study, 32 healthy male volunteers received single oral dos...

journal_title：British journal of clinical pharmacology

authors： Gisleskog PO,Hermann D,Hammarlund-Udenaes M,Karlsson MO

更新日期：1999-01-01 00:00:00

abstract：AIMS:The aims of this study were to determine the effects of the nonsteroidal, selective aromatase inhibitor, anastrozole, at steady-state concentrations, on the pharmacokinetics and pharmacodynamics of warfarin, and to assess whether or not anastrozole alone has any anticoagulant activity. METHODS:This was a randomiz...

journal_title：British journal of clinical pharmacology

authors： Yates RA,Wong J,Seiberling M,Merz M,März W,Nauck M

更新日期：2001-05-01 00:00:00

abstract：:Oxycodone chloride (0.07 mg kg-1) was given by intravenous bolus to nine young adult surgical patients on the first postoperative day. Plasma was sampled for up to 12 h. Mean values of t1/2z, CL and Vss were 222 min, 0.78 l min-1 and 2.60 l kg-1, respectively. The concentrations of the metabolite noroxycodone was also...

journal_title：British journal of clinical pharmacology

authors： Pöyhiä R,Olkkola KT,Seppälä T,Kalso E

更新日期：1991-10-01 00:00:00

abstract：:1. Dilevalol (R,R-labetalol) is a non-selective beta-adrenoceptor antagonist with beta 2-adrenoceptor agonist activity. Its effects after 1 month's administration on heart rate, blood pressure and muscle blood flow were studied in a double-blind crossover comparison with nifedipine in 16 hypertensive patients. 2. Dile...

journal_title：British journal of clinical pharmacology

authors： Walley T,Tsao Y,Scott A,Mackay E,Vandenburg M,Breckenridge A

更新日期：1993-06-01 00:00:00

abstract：AIMS:In man a neurokinin-1 (NK1) receptor antagonist has previously been shown to be ineffective in the prevention of motion-induced nausea. The antiemetic efficacy of NK1 receptor antagonists against chemotherapy-induced emesis is, however, enhanced when combined with a 5-HT3 receptor antagonist. Hence the efficacy of...

journal_title：British journal of clinical pharmacology

authors： Reid K,Palmer JL,Wright RJ,Clemes SA,Troakes C,Somal HS,House F,Stott JR

更新日期：2000-07-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Recently, we have shown that the plasma concentration of R-fexofenadine is greater than that of the S-enantiomer. Although itraconazole co-administration is known to increase the bioavailability of a racemic mixture of fexofenadine, little is known about the stereoselective inhi...

journal_title：British journal of clinical pharmacology

authors： Tateishi T,Miura M,Suzuki T,Uno T

更新日期：2008-05-01 00:00:00

abstract：AIM:This study aims to investigate the clinical and demographic factors influencing gentamicin pharmacokinetics in a large cohort of unselected premature and term newborns and to evaluate optimal regimens in this population. METHODS:All gentamicin concentration data, along with clinical and demographic characteristics...

journal_title：British journal of clinical pharmacology

authors： Fuchs A,Guidi M,Giannoni E,Werner D,Buclin T,Widmer N,Csajka C

更新日期：2014-11-01 00:00:00

abstract：AIMS:To investigate the extent of dose-related off-label antibiotic paediatric prescribing in primary care and to identify any potential clinical effects, particularly of lower than recommended dose prescribing. METHODS:Assessment of antibiotic prescribing in 168 396 children aged 0-16 years for the year 1999-2000 fro...

journal_title：British journal of clinical pharmacology

authors： Ekins-Daukes S,McLay JS,Taylor MW,Simpson CR,Helms PJ

更新日期：2003-07-01 00:00:00

abstract：AIMS:The pharmacokinetics of voriconazole show a nonlinear dose-exposure relationship caused by inhibition of its own CYP3A-dependent metabolism. Because the magnitude of autoinhibition also depends on voriconazole concentrations, infusion rate might modulate voriconazole exposure. The impact of four different infusion...

journal_title：British journal of clinical pharmacology

authors： Hohmann N,Kreuter R,Blank A,Weiss J,Burhenne J,Haefeli WE,Mikus G

更新日期：2017-09-01 00:00:00

abstract：:Renal clearance of lithium has been used as a marker of proximal tubular function in man. Recently, lithium pre-treatment has been shown to interfere with the natriuretic actions of some natriuretic agents in man. We have therefore investigated the effects of oral lithium carbonate (500 mg) on the natriuretic response...

journal_title：British journal of clinical pharmacology

authors： Lang CC,Rahman AR,Struthers AD

更新日期：1991-06-01 00:00:00

abstract：:The effect of urinary pH on flecainide excretion has been evaluated in six healthy subjects after a single oral dose of 300 mg flecainide administered as the acetate salt. The cumulative urinary excretion of unchanged flecainide under acidic conditions (134.0 +/- 16.1 mg; mean +/- s.e. mean) was significantly higher t...

journal_title：British journal of clinical pharmacology

authors： Muhiddin KA,Johnston A,Turner P

更新日期：1984-04-01 00:00:00

abstract：AIMS:To assess the duration and consistency of the pharmacological activity of the dihydropyridine calcium antagonist drug, lacidipine. METHODS:Eight healthy normotensive young males participated in a double-blind randomised crossover comparison of single and multiple doses (for 2 weeks) of lacidipine and placebo. The...

journal_title：British journal of clinical pharmacology

authors： Ueda S,Donnelly R,Panfilov V,Morris AD,Elliott HL

更新日期：1998-08-01 00:00:00

abstract：:Darunavir is an efficacious drug; however, pharmacokinetic variability has been reported. The objective of this study was to find predisposing factors for low darunavir plasma concentrations in patients starting the once- or twice-daily dosage. Darunavir plasma concentrations from January 2010 till December 2014 of hu...

journal_title：British journal of clinical pharmacology

authors： Daskapan A,Stienstra Y,Kosterink JGW,Bierman WFW,van der Werf TS,Touw DJ,Alffenaar JC

更新日期：2018-03-01 00:00:00

abstract：:After oral administration of 100 mg dapsone (DDS) to 25 healthy volunteers peak serum DDS concentrations between 1.10 and 2.33 mg l-1 were reached within 0.5 to 4 h. AUCs varied from 20.3 to 75.4 mg l-1 h, while the elimination half-lives ranged from 11.5 to 29.2 h. The apparent volumes of distribution were 0.84 to 1....

journal_title：British journal of clinical pharmacology

authors： Pieters FA,Zuidema J

更新日期：1986-10-01 00:00:00

abstract：:The effects of single doses of anhydrous caffeine (250 mg and 500 mg) and placebo on physiological, psychological measures and subjective feelings were studied in a double-blind, cross-over study in nine healthy subjects who had abstained from caffeine-containing beverages for 24 h before each occasion. Caffeine and c...

journal_title：British journal of clinical pharmacology

authors： Bruce M,Scott N,Lader M,Marks V

更新日期：1986-07-01 00:00:00

abstract：:1 The heart rate responses to increasing doses of isoprenaline (n = 6) (during infusion with atropine 0.5 mg/min i.v.) and noradrenaline (n = 5), (during infusion with phentolamine 160 mg/h i.v.) were recorded before and after the intravenous administration of propranolol (15 mg) or metoprolol (15 mg). 2 In the doses ...

journal_title：British journal of clinical pharmacology

authors： Bonelli J

更新日期：1982-01-01 00:00:00

abstract：:Voriconazole is an antifungal metabolised by CYP2C19 enzyme, which can be inhibited by proton-pump inhibitors (PPIs). A prospective observational study was carried out to determine the influence of PPIs on voriconazole pharmacokinetic. The 78 patients included were divided into 4 groups: omeprazole (n = 32), pantopraz...

journal_title：British journal of clinical pharmacology

authors： Blanco Dorado S,Maroñas Amigo O,Latorre-Pellicer A,Rodríguez Jato MT,López-Vizcaíno A,Gómez Márquez A,Bardán García B,Belles Medall D,Barbeito Castiñeiras G,Pérez Del Molino Bernal ML,Campos-Toimil M,Otero Espinar F,Blanco Hortas

更新日期：2020-08-01 00:00:00

abstract：:A method is described for the simultaneous determination of the carboxylic acid and N-acetyl-derivatives of primaquine, in plasma and urine. After oral administration of 45 mg primaquine, to five healthy volunteers, absorption was rapid, with peak primaquine levels of 153.3 +/- 23.5 ng/ml at 3 +/- 1 h, followed by an ...

journal_title：British journal of clinical pharmacology

authors： Mihaly GW,Ward SA,Edwards G,Orme ML,Breckenridge AM

更新日期：1984-04-01 00:00:00

abstract：:The pharmacokinetic behaviour and the bioavailability of midazolam were investigated in six volunteers after intravenous (0.15 mg/kg) and oral administration (10, 20 and 40 mg). Following rapid intravenous injection of midazolam, the plasma concentration of the substance decreased to approximately 10% within 2 h owing...

journal_title：British journal of clinical pharmacology

authors： Heizmann P,Eckert M,Ziegler WH

更新日期：1983-01-01 00:00:00

abstract：:The efficacy of calcitonin gene-related peptide (receptor) (CGRP-(R)) blocking therapeutics in the treatment of acute migraine headache provided proof-of-concept for the involvement of CGRP in the pathophysiology of this disorder. One of the major hurdles for the development of any class of drugs, including CGRP block...

journal_title：British journal of clinical pharmacology

authors： Buntinx L,Vermeersch S,de Hoon J

更新日期：2015-11-01 00:00:00

abstract：:Cytochrome P450 3A is the main enzyme subfamily involved in the metabolism of a variety of marketed medicines. It is generally believed that the substrate specificity of polymorphic P450 3A5 is similar to that of the predominant P450 3A4 isoform, although some differences in catalytic properties have been found. It ha...

journal_title：British journal of clinical pharmacology

authors： Yamazaki H,Nakamoto M,Shimizu M,Murayama N,Niwa T

更新日期：2010-06-01 00:00:00

abstract：:1 Six previously untreated emergency admissions to hospital with severe hypertension were given oral treatment with labetalol. 2 Pre-treatment diastolic BP exceeded 130 mmHg, and clinical evidence of either accelerated hypertension or encephalopathy was present. 3 Hypotensive response after treatment followed two patt...

journal_title：British journal of clinical pharmacology

authors： Ghose RR

更新日期：1979-01-01 00:00:00

abstract：:1 Fifty-two patients who had been treated for essential hypertension for at least 5 years with once-a-day pindolol alone or in combination with a diuretic participated in a strenuous exercise programme. The 24 h antihypertensive efficacy of once-a-day pindolol was shown in blood pressure readings made before the intak...

journal_title：British journal of clinical pharmacology

authors： Dhatariya RC,Blowers AJ

更新日期：1982-05-01 00:00:00

abstract：:The oxidative O-de-ethylation and aromatic 2-hydroxylation of phenacetin have been investigated in panels of extensive (EM, n = 13) and poor (PM, n = 10) metabolizers of debrisoquine. The EM group excreted in the urine significantly more paracetamol (EM: 40.8 +/- 14.9% dose/0-8 h; PM: 29.2 +/- 8.7% dose/0-8 h, 2P less...

journal_title：British journal of clinical pharmacology

authors： Devonshire HW,Kong I,Cooper M,Sloan TP,Idle JR,Smith RL

更新日期：1983-08-01 00:00:00

abstract：:1 The relationship between serum quinidine levels and rate-corrected QT (QTc) interval after administration of single identical doses of quinidine was assessed. Quinidine concentrations were determined by a modification of Hamfelt & Malers' (1963) method. The significance and clinical application of our findings is di...

journal_title：British journal of clinical pharmacology

authors： Edwards IR,Hancock BW,Saynor R

更新日期：1974-12-01 00:00:00