The pharmacokinetics of dapsone after oral administration to healthy volunteers.

abstract：AIMS:To develop and evaluate a feasible, authentic pharmacist-led prescribing feedback intervention for doctors-in-training, to reduce prescribing errors. METHODS:This was a mixed methods study. Sixteen postgraduate doctors-in training, rotating though the surgical assessment unit of 1 UK hospital, were filmed taking ...

journal_title：British journal of clinical pharmacology

authors： Parker H,Farrell O,Bethune R,Hodgetts A,Mattick K

更新日期：2019-10-01 00:00:00

abstract：:1 Theories linking 5-hydroxytryptamine (5-HT) with depression are briefly reviewed. The various experimental strategies adopted to investigate this relationship, examination of autopsy data, CSF metabolite data, 5-HT re-uptake patterns in human blood platelets and imipramine binding studies in human platelets, are dis...

journal_title：British journal of clinical pharmacology

authors： Goodwin FK,Post RM

更新日期：1983-01-01 00:00:00

abstract：:The effect of liver cirrhosis on plasma clearance and metabolite profile of i.v. administered antipyrine was studied in 23 patients with alcoholic liver cirrhosis (age 37-70 years) and 17 healthy subjects (age 28-55 years). Liver volume was also measured and was found to be larger in patients than in controls, mean va...

journal_title：British journal of clinical pharmacology

authors： Teunissen MW,Spoelstra P,Koch CW,Weeda B,van Duyn W,Janssens AR,Breimer DD

更新日期：1984-11-01 00:00:00

abstract：:A potential kinetic interaction between cimetidine and flecainide has been studied in eight healthy males receiving flecainide (200 mg) orally on three occasions: before any treatment and on day 2 and day 7 of 8 days' cimetidine maintenance treatment at 1 g daily. Six days pretreatment with cimetidine induced the foll...

journal_title：British journal of clinical pharmacology

authors： Tjandra-Maga TB,van Hecken A,van Melle P,Verbesselt R,de Schepper PJ

更新日期：1986-07-01 00:00:00

abstract：AIMS:To determine role of CYP2D6 activity in the pharmacokinetics of propafenone (PPF) enantiomers in native Chinese subjects. METHODS:Sixteen extensive metabolizers (EMs) and one poor metabolizer (PM), whose phenotype had been previously assessed with dextromethorphan metabolic phenotyping, were enrolled. Blood sampl...

journal_title：British journal of clinical pharmacology

authors： Cai WM,Chen B,Cai MH,Chen Y,Zhang YD

更新日期：1999-05-01 00:00:00

abstract：:A single oral dose of lamotrigine was administered to seven volunteers with Gilbert's Syndrome (unconjugated hyperbilirubinaemia). Plasma samples were assayed by high performance liquid chromatography (h.p.l.c.) and pharmacokinetic parameters were compared with those of a group of nine normal volunteers. In the subjec...

journal_title：British journal of clinical pharmacology

authors： Posner J,Cohen AF,Land G,Winton C,Peck AW

更新日期：1989-07-01 00:00:00

abstract：:1 A controlled trial of charcoal haemoperfusion as an early treatment for paracetamol overdose showed no benefit. 2 The plasma clearances of paracetamol by the charcoal column were variable and disappointingly small (range 4-119 ml/minute). The cumulative amounts removed were also low, mean 1.4 g (range 0.2-5.2 g). 3 ...

journal_title：British journal of clinical pharmacology

authors： Gazzard BG,Willison RA,Weston MJ,Thompson RP,Williams R

更新日期：1974-06-01 00:00:00

abstract：:1 The effect of low dose steady state warfarin (0.2 mg and 1 mg daily) on clotting factor activity and vitamin K1 metabolism was studied in seven healthy volunteers. 2 Steady state plasma warfarin concentrations were 41-99 ng ml-1 for the 0.2 mg dose and 157-292 ng ml-1 for the 1 mg dose. 3 There was a significant pro...

journal_title：British journal of clinical pharmacology

authors： Choonara IA,Malia RG,Haynes BP,Hay CR,Cholerton S,Breckenridge AM,Preston FE,Park BK

更新日期：1988-01-01 00:00:00

abstract：:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The population pharmacokinetics and limited sampling strategies for ciclosporin monitoring have been extensively studied in renal and liver transplant recipients. Little is known about the pharmacokinetics of ciclosporin in patients undergoing haematopoietic allogeneic stem c...

journal_title：British journal of clinical pharmacology

authors： Wilhelm AJ,de Graaf P,Veldkamp AI,Janssen JJ,Huijgens PC,Swart EL

更新日期：2012-04-01 00:00:00

abstract：:Responses of human bronchial strip preparations to contractile and relaxant agonists were measured in preparations from non-diseased and from asthmatic lung obtained 3-15 h post-mortem. The potencies of carbachol and histamine were approximately two times less in asthmatic than in non-diseased bronchi. This was statis...

journal_title：British journal of clinical pharmacology

authors： Goldie RG,Spina D,Henry PJ,Lulich KM,Paterson JW

更新日期：1986-12-01 00:00:00

abstract：:1. We have investigated the effect of repeated s.c. Org 10172 (a low molecular weight heparinoid; Lomoparan) treatment (1000 anti-Xa units twice daily for 5 days) on antipyrine (500 mg orally) metabolism, and the effect of enzyme induction by pentobarbitone (100 mg for 12 days) on the pharmacokinetics and pharmacodyna...

journal_title：British journal of clinical pharmacology

authors： De Boer A,Stiekema JC,Danhof M,Breimer DD

更新日期：1991-07-01 00:00:00

abstract：:Studies were done to examine the influence of the menstrual cycle on the elimination kinetics of paracetamol. Salivary concentrations of paracetamol were determined after oral administration of 1 g of paracetamol on day 3, 10, 14, 20 and 25 of the menstrual cycle in normal healthy women volunteers with regular menstru...

journal_title：British journal of clinical pharmacology

authors： Somaja L,Thangam J

更新日期：1987-03-01 00:00:00

abstract：:1. A rapid intravenous bolus injection of 4.0 g Magnapen (which contains 2.0 g of ampicillin and 2.0 g of flucloxacillin) was to seven patients undergoing total hip replacement immediatly before induction of general anesthesia. Postoperatively the patients patients received 2.0 g Magnapen by intramuscular injection ev...

journal_title：British journal of clinical pharmacology

authors： Parsons RL,Beavis JP,Laurence M,David JA,Paddock GM,Trounce JR

更新日期：1978-08-01 00:00:00

abstract：AIMS:To explore longitudinal changes in the number and type of medicines used among older people who experience polypharmacy. METHODS:We used pharmaceutical claims for a 10% sample of Australian Pharmaceutical Benefits Scheme beneficiaries to identify people aged 70 years and older who were exposed to 5 or more medici...

journal_title：British journal of clinical pharmacology

authors： Falster MO,Charrier R,Pearson SA,Buckley NA,Daniels B

更新日期：2020-07-31 00:00:00

abstract：:The effect of charcoal-drug ratio on the antidotal efficacy of oral activated charcoal was studied in six healthy volunteers in a randomized cross-over study and compared with the adsorption capacity of activated charcoal in vitro. Aminosalicylic acid (PAS) 1 g and 5 g were ingested on an empty stomach in 30 ml of wat...

journal_title：British journal of clinical pharmacology

authors： Olkkola KT

更新日期：1985-06-01 00:00:00

abstract：:The effects of separate 7 day pretreatments with sulphinpyrazone (800 mg daily) and cimetidine (1 g daily) on the disposition of (+/-)-verapamil have been examined in eight healthy volunteers (four male, four female). Each subject received single oral (80 mg) and intravenous (0.15 mg/kg) doses of verapamil on differen...

journal_title：British journal of clinical pharmacology

authors： Wing LM,Miners JO,Lillywhite KJ

更新日期：1985-03-01 00:00:00

abstract：AIMS:Aprepitant and fosaprepitant, commonly used for the prevention of chemotherapy-induced nausea and vomiting, alter cytochrome P450 activity. This systematic review evaluates clinically significant pharmacokinetic drug interactions with aprepitant and fosaprepitant and describes adverse events ascribed to drug inter...

journal_title：British journal of clinical pharmacology

authors： Patel P,Leeder JS,Piquette-Miller M,Dupuis LL

更新日期：2017-10-01 00:00:00

abstract：AIMS:Whereas cortical EEG effects of benzodiazepines are well characterized, information about benzodiazepine effects in other areas of the central nervous system is sparse. This study investigated the action of midazolam and its active metabolite alpha-hydroxy-midazolam on different parts of the auditory pathway in si...

journal_title：British journal of clinical pharmacology

authors： Hotz MA,Ritz R,Linder L,Scollo-Lavizzari G,Haefeli WE

更新日期：2000-01-01 00:00:00

abstract：AIMS:Several studies have reported the under-representation of women in clinical trials, thereby challenging the external validity of the benefit/risk assessments of launched drugs. Our aim was to determine the extent to which women have been included in clinical trials used for drug registration and to analyse the fra...

journal_title：British journal of clinical pharmacology

authors： Labots G,Jones A,de Visser SJ,Rissmann R,Burggraaf J

更新日期：2018-04-01 00:00:00

abstract：AIMS:To compare the effects of two long-acting calcium antagonists of different types on cardiovascular stress responses in hypertension. METHODS:One-hundred and forty-five patients with mild to moderate hypertension and a mean (+/- s.e.mean) age of 51 +/- 0.9 years received for 8 weeks the phenylalkylamine verapamil ...

journal_title：British journal of clinical pharmacology

authors： Lefrandt JD,Heitmann J,Sevre K,Castellano M,Hausberg M,Fallon M,Urbigkeit A,Rostrup M,Agabiti-Rosei E,Rahn KH,Murphy M,Zannad F,de Kam PJ,Smit AJ

更新日期：2001-12-01 00:00:00

abstract：AIMS:Our study aimed to evaluate the impacts of the cytochrome P450 (CYP) 2B6-G516T and CYP2D6 genetic polymorphisms on pharmacokinetic and clinical parameters in patients receiving methadone maintenance treatment. METHODS:Opioid PhArmacoLogy (OPAL) was a clinical survey of the sociodemographic characteristics, histor...

journal_title：British journal of clinical pharmacology

authors： Victorri-Vigneau C,Verstuyft C,Bouquié R,Laforgue EJ,Hardouin JB,Leboucher J,Le Geay B,Dano C,Challet-Bouju G,Grall-Bronnec M

更新日期：2019-07-01 00:00:00

abstract：:In order to elucidate the mechanisms by which beta-adrenoceptor blockade leads to a reduction in portal pressure, we have measured portal pressure, heart rate and cardiac index in 17 patients with cirrhosis and portal hypertension following the oral administration of the selective beta 2-adrenoceptor blocking agent, I...

journal_title：British journal of clinical pharmacology

authors： Bihari D,Westaby D,Gimson A,Crossley I,Harry J,Williams R

更新日期：1984-06-01 00:00:00

abstract：:1 The effect of the addition of probenecid to oral and rectal regimes of indomethacin was studied in three groups of rheumatoid arthritic patients. 2 The addition of probenecid increases plasma levels of indomethacin given both orally and rectally and significantly reduces the clinical parameters of joint inflammation...

journal_title：British journal of clinical pharmacology

authors： Brooks PM,Bell MA,Sturrock RD,Famaey JP,Dick WC

更新日期：1974-08-01 00:00:00

abstract：:1. Double-blind controlled comparisons of nomifensine with placebo, imipramine, desipramine, viloxazine, nortriptyline, a combination of amitriptyline and chlordiazepoxide, and diazepam have been carried out in various parts of the world. 2. Dosage ranged from 50-225 mg daily, and treatment lasted from 2-26 weeks. 3. ...

journal_title：British journal of clinical pharmacology

authors： Habermann W

更新日期：1977-01-01 00:00:00

abstract：:1 The disposition in urine of debrisoquine and its hydroxylated metabolites has been studied in subjects of the 'extensive metabolizer' (EM; n = 5) and 'poor metabolizer' (PM; n = 5) phenotypes. The 4-hydroxylation of debrisoquine by PM subjects following a 10 mg oral dose was capacity-limited and displayed significan...

journal_title：British journal of clinical pharmacology

authors： Sloan TP,Lancaster R,Shah RR,Idle JR,Smith RL

更新日期：1983-04-01 00:00:00

abstract：AIMS:Antihistamines make up the first line of treatments against motion-sickness. Still, their efficacy and specific mechanism have come into question. The aim of this study was to investigate the effect of meclizine on motion-sensitivity. METHODS:This study was carried out as a triple-blinded randomized trial involvi...

journal_title：British journal of clinical pharmacology

authors： Wibble T,Engström J,Verrecchia L,Pansell T

更新日期：2020-08-01 00:00:00

abstract：:The effect of fatty degeneration of liver parenchyma on drug metabolism was investigated in 21 obese non-insulin-dependent diabetic subjects by measuring plasma antipyrine kinetics, hepatic cytochrome P-450, liver size and the extent of fatty infiltration. The hepatic drug metabolising capacity, as measured by total a...

journal_title：British journal of clinical pharmacology

authors： Pirttiaho HI,Salmela PI,Sotaniemi EA,Pelkonen RO,Pitkänen U,Luoma PV

更新日期：1984-12-01 00:00:00

abstract：AIMS:To characterize milk/plasma (M/P) ratio and infant dose, for venlafaxine (V) and its O-desmethyl metabolite (ODV), in breastfeeding women taking venlafaxine for the treatment of depression, and to determine the plasma concentration and effects of these drugs in their infants. METHODS:Six women (mean age 34.5 year...

journal_title：British journal of clinical pharmacology

authors： Ilett KF,Kristensen JH,Hackett LP,Paech M,Kohan R,Rampono J

更新日期：2002-01-01 00:00:00

abstract：AIMS:To assess the age-associated changes over time of plasma paraxanthine/caffeine (PAX/CAF) ratios used as a probe for CYP1A2 activity. METHODS:Intraindividual and interindividual variabilities in PAX/CAF ratio were compared by phenotyping with caffeine, 16 young and 16 elderly healthy subjects on five occasions. R...

journal_title：British journal of clinical pharmacology

authors： Simon T,Becquemont L,Hamon B,Nouyrigat E,Chodjania Y,Poirier JM,Funck-Brentano C,Jaillon P

更新日期：2001-11-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:• Terutroban is a selective TP receptor antagonist, i.e. a specific antagonist of the thromboxane A(2) and prostaglandin endoperoxide receptors, shown to improve endothelial function after a single administration in patients with coronary artery disease. WHAT THIS STUDY ADDS:• ...

journal_title：British journal of clinical pharmacology

authors： Lesault PF,Boyer L,Pelle G,Covali-Noroc A,Rideau D,Akakpo S,Teiger E,Dubois-Randé JL,Adnot S

更新日期：2011-06-01 00:00:00