Effect of charcoal-drug ratio on antidotal efficacy of oral activated charcoal in man.

abstract：:1. The effects of simvastatin and pravastatin on measures of central nervous system activity were investigated in a double-blind, placebo-controlled, randomised crossover study. 2. Twenty-five healthy volunteers sequentially took 40 mg day-1 simvastatin, 40 mg day-1 pravastatin or placebo for 4 weeks, separated by a 4...

journal_title：British journal of clinical pharmacology

authors： Harrison RW,Ashton CH

更新日期：1994-03-01 00:00:00

abstract：:Eleven patients with stable rheumatoid disease (RD) who were receiving regular corticosteroid therapy (CS) were investigated to discover the effect on plasma prednisolone levels of additional therapy with the non-steroidal anti-inflammatory (NSAI) drugs, indomethacin and naproxen. There was a highly significant (P les...

journal_title：British journal of clinical pharmacology

authors： Rae SA,Williams IA,English J,Baylis EM

更新日期：1982-09-01 00:00:00

abstract：AIMS:Naloxegol, a polyethylene glycol conjugated derivative of the opioid antagonist naloxone, is in clinical development for treatment of opioid-induced constipation (OIC). The aim of the study was to develop a population pharmacokinetic model describing the concentration vs. time profile of orally administered naloxe...

journal_title：British journal of clinical pharmacology

authors： Al-Huniti N,Chapel S,Xu H,Bui KH,Sostek M

更新日期：2016-01-01 00:00:00

abstract：:We have studied the effects of chlormethiazole and diazepam given orally on the ventilatory and mouth occlusion pressure (P0.1) responses to CO2 in a placebo controlled study in 10 healthy volunteers. Diazepam 10 mg produced a significant reduction in both the ventilatory and P0.1 responses to CO2, and this was not as...

journal_title：British journal of clinical pharmacology

authors： Gilmartin JJ,Corris PA,Stone TN,Veale D,Gibson GJ

更新日期：1988-06-01 00:00:00

abstract：:The effect of anticonvulsant therapy on early morning concentration of cortisol in saliva and plasma was assessed in a group of epileptic patients receiving regular phenytoin medication and the results compared with those obtained from a group of normal subjects not receiving drug therapy. Values of cortisol in matche...

journal_title：British journal of clinical pharmacology

authors： Evans PJ,Walker RF,Peters JR,Dyas J,Riad-Fahmy D,Thomas JP,Rimmer E,Tsanaclis L,Scanlon MF

更新日期：1985-08-01 00:00:00

abstract：:A possible route of metabolism of beta-adrenoceptor stimulating drugs used in obstetrics consists of conjugation by the enzyme phenol sulphotransferase. The substrate specificities of the platelet and the placental enzymes towards these drugs were tested. The specific activities of the beta-adrenoceptor agonists were ...

journal_title：British journal of clinical pharmacology

authors： Sodha RJ,Schneider H

更新日期：1984-01-01 00:00:00

abstract：:The elimination of the cardioselective beta-adrenoceptor antagonist atenolol has been studied in 35 neonates by measuring drug concentration in cord blood and in blood obtained at 24 h by heel stab. Elimination rate was assessed by calculating the slopes of lines joining these two concentration points. The slopes had ...

journal_title：British journal of clinical pharmacology

authors： Rubin PC,Butters L,Reynolds B,Evans J,Sumner D,Low RA,Reid JL

更新日期：1983-12-01 00:00:00

abstract：AIMS:To compare the pharmacokinetics of oseltamivir and oseltamivir carboxylate in hepatically impaired patients and healthy subjects. METHODS:Hepatically impaired patients (n = 11) and healthy subjects (n = 11) were individually paired on the basis of gender, age (+/-10 years) and body weight (+/-20%) and administere...

journal_title：British journal of clinical pharmacology

authors： Snell P,Dave N,Wilson K,Rowell L,Weil A,Galitz L,Robson R

更新日期：2005-05-01 00:00:00

abstract：AIM:In short-term studies, hormonal contraceptives (HC) have been suggested to induce a rise in blood pressure (BP) and urinary albumin excretion (UAE), while the effect of HC in renal function (GFR) is still under debate. Data on long-term and withdrawal effects of HC use on these outcomes are, however, not available....

journal_title：British journal of clinical pharmacology

authors： Atthobari J,Gansevoort RT,Visser ST,de Jong PE,de Jong-van den Berg LT,PREVEND Study Group.

更新日期：2007-02-01 00:00:00

abstract：:1 Data from a comprehensive drug surveillance programme are analysed to provide details of procainamide use and toxicity in medical wards of teaching hospitals in five countries. 2 Out of a total of 488 recipients 9.2% had one or more adverse effect attributed to the drug; common effects being arrhythmias, gastro-inte...

journal_title：British journal of clinical pharmacology

authors： Lawson DH,Jick H

更新日期：1977-10-01 00:00:00

abstract：:1 Forty-one patients with essential hypertension, stages I, II, and III, were treated with captopril alone or in combination with hydrochlorothiazide. Forty two percent were responsive to captopril alone, while the remaining 58% also required the diuretic. The need for the diuretic was related to the phase of hyperten...

journal_title：British journal of clinical pharmacology

authors： Rabinad Estrada E,Ingelmo Morin M,Martinez Amenos A,Alsina J,Balcells Gorina A

更新日期：1982-01-01 00:00:00

abstract：:1 Improvement in physical performance, based on exercise tolerance, self-assessed work and physician-rated functional capacities, is proposed as a measure of efficacy of anti-anginal therapy in the rehabilitation of the cardiac patient. 2 Improved physical performance parallels changes in frequency of anginal attacks ...

journal_title：British journal of clinical pharmacology

authors： Ling AS,Groel JT

更新日期：1979-01-01 00:00:00

abstract：AIMS:The objectives were to investigate the pharmacokinetics, pharmacodynamics and safety of ilaprazole infusion in healthy subjects and patients with esomeprazole as positive control, and then recommend the dosage regimen for Phase 2b/3 studies. METHODS:Three clinical studies were performed. First, 16 healthy subject...

journal_title：British journal of clinical pharmacology

authors： Wang H,Shao F,Liu X,Xu W,Ou N,Qin X,Liu F,Hou X,Hu H,Jiang J

更新日期：2019-11-01 00:00:00

abstract：:The effects of separate 7 day pretreatments with sulphinpyrazone (800 mg daily) and cimetidine (1 g daily) on the disposition of (+/-)-verapamil have been examined in eight healthy volunteers (four male, four female). Each subject received single oral (80 mg) and intravenous (0.15 mg/kg) doses of verapamil on differen...

journal_title：British journal of clinical pharmacology

authors： Wing LM,Miners JO,Lillywhite KJ

更新日期：1985-03-01 00:00:00

abstract：AIM:To describe the time to clinical events (death, disability, cognitive impairment and depression) in Parkinson's disease using the time course of disease status and treatment as explanatory variables. METHODS:Disease status based on the Unified Parkinson's Disease Rating Scale (UPDRS) and the time to clinical outco...

journal_title：British journal of clinical pharmacology

authors： Vu TC,Nutt JG,Holford NH

更新日期：2012-08-01 00:00:00

abstract：:Analysis of human horizontal saccadic eye movements can provide measurements of central nervous system depression and stimulation. Effects on saccadic eye movements have been observed in normal volunteers with barbiturates, benzodiazepines, opiates and related compounds, carbamazepine, amphetamine and ethanol. A suite...

journal_title：British journal of clinical pharmacology

authors： Griffiths AN,Marshall RW,Richens A

更新日期：1984-01-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the effects of a single green tea (GT), administered concomitantly or 1 hour before nadolol intake on nadolol pharmacokinetics. METHODS:In a randomized 3-phase crossover study, 11 healthy volunteers received an oral administration of nadolol with, or 1 hour after preingest...

journal_title：British journal of clinical pharmacology

authors： Misaka S,Abe O,Ono T,Ono Y,Ogata H,Miura I,Shikama Y,Fromm MF,Yabe H,Shimomura K

更新日期：2020-11-01 00:00:00

abstract：AIMS:The aim of the present study was to evaluate the disposition of metoprolol after oral administration of an immediate and controlled-release formulation before and after Roux-en-Y gastric bypass (RYGB) surgery in the same individuals and to validate a physiologically based pharmacokinetic (PBPK) model for predictin...

journal_title：British journal of clinical pharmacology

authors： Gesquiere I,Darwich AS,Van der Schueren B,de Hoon J,Lannoo M,Matthys C,Rostami A,Foulon V,Augustijns P

更新日期：2015-11-01 00:00:00

abstract：:1. The antitussive properties of bronchodilators were evaluated in a total of 47 normal volunteers. 2. Cough was induced by inhalation of ultrasonically nebulized solutions of distilled water and hypotonic saline. 3. Inhaled fenoterol hydrobromide (360 micrograms; 20 volunteers) and inhaled ipratropium bromide (72 mic...

journal_title：British journal of clinical pharmacology

authors： Lowry R,Higenbottam T,Johnson T,Godden D

更新日期：1987-10-01 00:00:00

abstract：AIM:Our aim was to compare the practicability of six different potentially inappropriate medication (PIM) criteria in geriatric outpatients with polypharmacy. METHODS:We analysed baseline data from the Medication Safety Review Clinic in Taiwanese Elders (MSRC-Taiwan) study. The prevalence and correlates of PIMs were d...

journal_title：British journal of clinical pharmacology

authors： Chang CB,Chen JH,Wen CJ,Kuo HK,Lu IS,Chiu LS,Wu SC,Chan DC

更新日期：2011-09-01 00:00:00

abstract：AIMS:To assess whether frequency of placebo administration is associated with duodenal ulcer healing. METHODS:A systematic literature review of randomized clinical trials was undertaken. 79 of 80 trials that met the inclusion criteria. The pooled 4 week placebo healing rate of all duodenal ulcer trials that employed a...

journal_title：British journal of clinical pharmacology

authors： de Craen AJ,Moerman DE,Heisterkamp SH,Tytgat GN,Tijssen JG,Kleijnen J

更新日期：1999-12-01 00:00:00

abstract：:1. In 48 patients with chronic asthma who had been receiving treatment with beclomethasone dipropionate aerosol (BDA) at a daily dose of 400 microgram for several years, observations were made on the effect of increasing the dose to 800 microgram daily for 6 months. 2. There was subjective improvement in 37 of the 48 ...

journal_title：British journal of clinical pharmacology

authors： Chatterjee SS

更新日期：1977-01-01 00:00:00

abstract：AIMS:To analyse clinical outcomes with direct oral anticoagulants in patients with atrial fibrillation according to geographic region. METHODS:We systematically searched MEDLINE, CENTRAL, websites of regulatory agencies, clinical trials registers and conference proceedings for randomized controlled trials of direct or...

journal_title：British journal of clinical pharmacology

authors： Gómez-Outes A,Terleira-Fernández AI,Calvo-Rojas G,Suárez-Gea ML,Vargas-Castrillón E

更新日期：2016-09-01 00:00:00

abstract：:1 The pharmacokinetics of diazepam following intravenous administration have been investigated in six normal volunteers and nine epileptic patients receiving chronic antiepileptic drug therapy. 2 After intravenous administration, serum diazepam levels declined biexponentially in all subjects. The elimination half-life...

journal_title：British journal of clinical pharmacology

authors： Dhillon S,Richens A

更新日期：1981-12-01 00:00:00

abstract：AIMS:A systematic review of the literature published in English over 10 years was undertaken in order to describe the use of electronic healthcare data in the identification of potential adverse drug reactions (ADRs) in children. METHODS:MEDLINE and EMBASE were searched using MESH headings and text words. Titles, keyw...

journal_title：British journal of clinical pharmacology

authors： Black C,Tagiyeva-Milne N,Helms P,Moir D

更新日期：2015-10-01 00:00:00

abstract：AIMS:High plasma cholesterol concentration and increased platelet activity are two major risk factors for atherosclerosis. Lovastatin, the lipophilic drug was shown to inhibit platelet aggregation whereas pravastatin, the hydrophilic drug had no such effect. Analysis of the effect of fluvastatin which is both a lipophi...

journal_title：British journal of clinical pharmacology

authors： Osamah H,Mira R,Sorina S,Shlomo K,Michael A

更新日期：1997-07-01 00:00:00

abstract：:1. The antisecretory responses to pH-feedback controlled (maximum dose 800 mg 24 h-1) and fixed-dose (0.25 mg kg-1 h-1) continuous infusions of ranitidine were compared in a randomised, placebo-controlled, cross-over study in 10 healthy male volunteers. 2. To assess tolerance during repeated dosing with ranitidine, th...

journal_title：British journal of clinical pharmacology

authors： Wilder-Smith CH,Halter F,Häcki W,Merki HS

更新日期：1992-05-01 00:00:00

abstract：:1 As part of a prospective study on the use of digoxin in a general practice, plasma digoxin concentrations were measured in all patients receiving the drug. 2 A low mean plasma digoxin concentration was observed, suggesting a cautious approach to digitalization. 3 The correlation between plasma digoxin concentration ...

journal_title：British journal of clinical pharmacology

authors： Holt DW,Williamson JD,Volans GN

更新日期：1977-06-01 00:00:00

abstract：AIMS:To compare the effects of two long-acting calcium antagonists of different types on cardiovascular stress responses in hypertension. METHODS:One-hundred and forty-five patients with mild to moderate hypertension and a mean (+/- s.e.mean) age of 51 +/- 0.9 years received for 8 weeks the phenylalkylamine verapamil ...

journal_title：British journal of clinical pharmacology

authors： Lefrandt JD,Heitmann J,Sevre K,Castellano M,Hausberg M,Fallon M,Urbigkeit A,Rostrup M,Agabiti-Rosei E,Rahn KH,Murphy M,Zannad F,de Kam PJ,Smit AJ

更新日期：2001-12-01 00:00:00

abstract：:The renal response to a challenge of maximal water diuresis has been studied in seven subjects pretreated over 48 h with either placebo, probenecid, indomethacin or piroxicam. Probenecid did not alter the excretion of water and sodium chloride when compared with placebo responses, but increased both phosphate and urat...

journal_title：British journal of clinical pharmacology

authors： Dixey JJ,Noormohamed FH,Lant AF,Brewerton DA

更新日期：1988-05-01 00:00:00