Inhibition of artificially induced cough in man by bronchodilators.

abstract：:1. This study further examines the quinoline-derivative abanoquil with particular respect to the duration of its alpha 1-adrenoceptor antagonist activity and its concentration-effect relationship following a single intravenous bolus dose of 0.5 micrograms kg-1 in young, normotensive males. 2. alpha 1-adrenoceptor anta...

journal_title：British journal of clinical pharmacology

authors： Schafers RF,Elliott HL,Meredith PA,Miller SH,Reid JL

更新日期：1991-11-01 00:00:00

abstract：AIMS:The objective of this study is to develop a generic model for tacrolimus pharmacokinetics modelling using a meta-analysis approach, that could serve as a first step towards a prediction tool to inform pharmacokinetics-based optimal dosing of tacrolimus in different populations and indications. METHODS:A systemati...

journal_title：British journal of clinical pharmacology

authors： Nanga TM,Doan TTP,Marquet P,Musuamba FT

更新日期：2019-12-01 00:00:00

abstract：:Analysis of human horizontal saccadic eye movements can provide measurements of central nervous system depression and stimulation. Effects on saccadic eye movements have been observed in normal volunteers with barbiturates, benzodiazepines, opiates and related compounds, carbamazepine, amphetamine and ethanol. A suite...

journal_title：British journal of clinical pharmacology

authors： Griffiths AN,Marshall RW,Richens A

更新日期：1984-01-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Desmopressin is a known haemostatic agent and is also being used, albeit at lower doses, during the diagnostic work-up of Cushing's syndrome, a condition characterized by excess cortisol concentrations and frequent thromboembolic events. No study has yet evaluated whether admini...

journal_title：British journal of clinical pharmacology

authors： Pecori Giraldi F,Ambrogio AG,Fatti LM,Rubini V,Cozzi G,Scacchi M,Federici AB,Cavagnini F

更新日期：2011-01-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:The dominant health economic units upon which new treatment funding decisions are made are the incremental cost per life year gained (LYG) or the cost per quality-adjusted life year (QALY) gained. Neither of these units modifies the amount of health gained, by the amount of heal...

journal_title：British journal of clinical pharmacology

authors： Camidge DR,Oliver JJ,Skinner C,Attwood B,Nussey F,Jodrell D,Webb DJ

更新日期：2008-02-01 00:00:00

abstract：:1 Twenty-four healthy male subjects had two consecutive drug nights at 2-week intervals using placebo and 80, 140 and 240 mg doses of phenobarbitone in a double-blind cross-over design. 2 Phenobarbitone produced significant dose-related decreases in sleep latency and number of awakenings, along with increased total sl...

journal_title：British journal of clinical pharmacology

authors： Karacan I,Orr W,Roth T,Kramer M,Thornby J,Bingham S,Kay D

更新日期：1981-09-01 00:00:00

abstract：AIM:This study evaluated the safety and pharmacokinetics (PK) of donepezil HCl and sertraline HCl when administered separately and in combination. METHODS:This was a randomized, open-label, three-period crossover study. In consecutive dosing periods separated by washout periods of > or = 3 weeks, healthy volunteers re...

journal_title：British journal of clinical pharmacology

authors： Nagy CF,Kumar D,Perdomo CA,Wason S,Cullen EI,Pratt RD

更新日期：2004-11-01 00:00:00

abstract：AIMS:Kisangani is an area with intense malaria transmission and sulfadoxine-pyrimethamine resistance. Alternative antimalaria prophylaxis medication and protocols are needed, particularly with pregnant individuals. In this study, we compare the tolerance and effectiveness of mefloquine regimen as a split dose with a me...

journal_title：British journal of clinical pharmacology

authors： Labama Otuli N,Marini Djang'eing'a R,Losimba Likwela J,Bosenge Nguma JD,Maindo Alongo MA,Ahuka Ona Longombe A,Mbutu Mango B,M N Bono D,L Mokili J,Manga Okenge JP

更新日期：2021-01-04 00:00:00

abstract：:The hypertensive disorders of pregnancy (HDP) are a leading cause of maternal mortality and morbidity in both well and under-resourced settings. Maternal, fetal, and neonatal complications of the HDP are concentrated among, but not limited to, women with pre-eclampsia. Pre-eclampsia is a systemic disorder of endotheli...

journal_title：British journal of clinical pharmacology

authors： Magee LA,Abalos E,von Dadelszen P,Sibai B,Easterling T,Walkinshaw S,CHIPS Study Group.

更新日期：2011-09-01 00:00:00

abstract：:Cyclophosphamide is an alkylating agent used in the treatment of solid and haematological malignancies and as an immunosuppressive agent. As a prodrug, it is dependent on bioactivation to the active phosphoramide mustard metabolite to elicit its therapeutic effect. This focused review will highlight the evidence for t...

journal_title：British journal of clinical pharmacology

authors： Helsby NA,Yong M,van Kan M,de Zoysa JR,Burns KE

更新日期：2019-09-01 00:00:00

abstract：AIMS:Spirometry, plethysmography and impulse oscillometry (IOS) measure different aspects of lung function. These methods have not been compared for their ability to assess long- and short-acting anticholinergic agents. We therefore performed a double-blind, placebo-controlled, four-way cross-over study in 30 healthy s...

journal_title：British journal of clinical pharmacology

authors： Singh D,Tal-Singer R,Faiferman I,Lasenby S,Henderson A,Wessels D,Goosen A,Dallow N,Vessey R,Goldman M

更新日期：2006-04-01 00:00:00

abstract：:1. Six healthy volunteers received single doses of either nomifensine 100 mg, nomifensine 50 mg or placebo at weekly intervals in a randomized double-blind crossover study. 2. Subjects were subjected to a simulated test of car driving at night. 3. Testing lasted about 1.5 h and consisted of measuring responses to ligh...

journal_title：British journal of clinical pharmacology

authors： Hindmarch I

更新日期：1977-01-01 00:00:00

abstract：AIMS:To test the feasibility of a novel rivastigmine nasal spray as prospective treatment for dementia. METHODS:A single dose, crossover absolute bioavailability and safety study was conducted with rivastigmine intravenous solution (1 mg) and nasal spray (3.126 mg) in eight healthy elderly individuals, aged 58-75 year...

journal_title：British journal of clinical pharmacology

authors： Morgan TM,Soh B

更新日期：2017-03-01 00:00:00

abstract：:The safe use of Chinese materia medica (CMM) and products in traditional Chinese medicine (TCM) practice conventionally relies on correct pharmacognostic identification, good agricultural and manufacturing practices based on pharmacopoeia standards and rational/correct CMM combinations with TCM-guided clinical prescri...

journal_title：British journal of clinical pharmacology

authors： Chan K,Zhang H,Lin ZX

更新日期：2015-10-01 00:00:00

abstract：AIM:We compared the pharmacokinetic (PK) profiles of co-crystal of tramadol-celecoxib (CTC) vs. each reference product (alone and in open combination) after single (first dose) and multiple dosing. METHODS:Healthy adults aged 18-50 years received, under fasted conditions, 15 twice-daily doses of the following treatmen...

journal_title：British journal of clinical pharmacology

authors： Videla S,Lahjou M,Vaqué A,Sust M,Escriche M,Soler L,Sans A,Sicard E,Gascón N,Encina G,Plata-Salamán C

更新日期：2018-01-01 00:00:00

abstract：AIMS:Breakthrough bleeding or even unwanted pregnancies have been reported in women during concomitant therapy with oral contraceptives and St John's wort extract. The aim of the present study was to investigate the effects of St John's wort extract on oral contraceptive therapy with respect to ovarian activity, breakt...

journal_title：British journal of clinical pharmacology

authors： Pfrunder A,Schiesser M,Gerber S,Haschke M,Bitzer J,Drewe J

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Benzodiazepines and "Z drugs" are often prescribed in residents of nursing homes (NH) despite their well-known deleterious effects. We aimed to investigate if a general intervention on quality of care led to discontinuation of benzodiazepine, and to examine which NH-related factors were associated in change ...

journal_title：British journal of clinical pharmacology

authors： de Souto Barreto P,Lapeyre-Mestre M,Cestac P,Vellas B,Rolland Y

更新日期：2016-04-01 00:00:00

abstract：:A method is described for the simultaneous determination of the carboxylic acid and N-acetyl-derivatives of primaquine, in plasma and urine. After oral administration of 45 mg primaquine, to five healthy volunteers, absorption was rapid, with peak primaquine levels of 153.3 +/- 23.5 ng/ml at 3 +/- 1 h, followed by an ...

journal_title：British journal of clinical pharmacology

authors： Mihaly GW,Ward SA,Edwards G,Orme ML,Breckenridge AM

更新日期：1984-04-01 00:00:00

abstract：:1 Fifty-two patients who had been treated for essential hypertension for at least 5 years with once-a-day pindolol alone or in combination with a diuretic participated in a strenuous exercise programme. The 24 h antihypertensive efficacy of once-a-day pindolol was shown in blood pressure readings made before the intak...

journal_title：British journal of clinical pharmacology

authors： Dhatariya RC,Blowers AJ

更新日期：1982-05-01 00:00:00

abstract：AIMS:To study the effect of eprosartan, a nonbiphenyl tetrazole angiotensin II receptor antagonist, on digoxin pharmacokinetics in a randomized, open-label, two period, period balanced crossover study in 12 healthy men. METHODS:Each subject received a single 0.6 mg oral dose of digoxin (Lanoxicaps 0.2 mg/capsule, Glax...

journal_title：British journal of clinical pharmacology

authors： Martin DE,Tompson D,Boike SC,Tenero D,Ilson B,Citerone D,Jorkasky DK

更新日期：1997-06-01 00:00:00

abstract：:1. Eight healthy subjects were investigated on four occasions at least 1 week apart when they either ate a standard 3100 kJ cold meal or fasted. One hour earlier, either 50 mg atenolol or placebo was administered. 2. Eating was followed by prominent changes of systolic cardiovascular function: a rise of heart rate (+7...

journal_title：British journal of clinical pharmacology

authors： De Mey C,Enterling D,Meineke I

更新日期：1993-11-01 00:00:00

abstract：:1. The influence of food on the absorption of frusemide and bumetanide was compared in two separate randomized crossover studies. 2. On three separate occasions frusemide 40 mg was administered to eight healthy male volunteers intravenously, orally in the fasting state and orally after a standard breakfast. Blood and ...

journal_title：British journal of clinical pharmacology

authors： McCrindle JL,Li Kam Wa TC,Barron W,Prescott LF

更新日期：1996-12-01 00:00:00

abstract：:1 Comparison of phenytoin clearance showed a marked increase in people over 65 years of age compared with people under 45 years of age. 2 This difference was apparent if phenytoin was given orally or intravenously. 3 Phenytoin clearance correlated inversely with phenytoin binding and plasma albumin, both of which were...

journal_title：British journal of clinical pharmacology

authors： Hayes MJ,Langman MJ,Short AH

更新日期：1975-02-01 00:00:00

abstract：:1. The pharmacokinetics and pharmacodynamics of intranasal (IN) and oral 1-deamino-8-D-arginine vasopressin (DDAVP) were compared in 10 Chinese adults with central diabetes insipidus previously controlled on IN DDAVP. This was followed by comparison of the acute pharmacodynamics of commonly used oral preparations (con...

journal_title：British journal of clinical pharmacology

authors： Lam KS,Wat MS,Choi KL,Ip TP,Pang RW,Kumana CR

更新日期：1996-09-01 00:00:00

abstract：:1 The pharmacodynamic profile of single oral doses of prorenoate potassium (40 mg) and spironolactone (100 mg), as judged by reversal of the effects of fludrocostisone on the urinary electrolyte composition, was compared to that of placebo in a double-blind crossover study in six healthy subjects. 2 Both drugs showed ...

journal_title：British journal of clinical pharmacology

authors： Ramsay LE,Shelton JR,Tidd MJ

更新日期：1976-06-01 00:00:00

abstract：:1 Human common palmar digital arteries and dorsal metacarpal veins have been studied in vitro to investigate the responses of arterial and venous muscle to hydrallazine, diazoxide, nitroprusside and sodium nitrite. 2 Tissues were removed at autopsy, cut into helical strips and suspended in organ baths under identical ...

journal_title：British journal of clinical pharmacology

authors： Moulds RF,Jauernig RA,Shaw J

更新日期：1981-01-01 00:00:00

abstract：:1. The primary action of the converting enzyme inhibitors to prevent the formation of angiotensin II can explain a decrease in peripheral vascular resistance in patients with elevated, but not in those with normal or reduced plasma renin levels. 2. The inhibition of the breakdown of bradykinin will potentiate the vaso...

journal_title：British journal of clinical pharmacology

authors： Vanhoutte PM,Auch-Schwelk W,Biondi ML,Lorenz RR,Schini VB,Vidal MJ

更新日期：1989-01-01 00:00:00

abstract：:The airway and cardiovascular effects of intravenous neurokinin A (NKA) and substance P (SP) were compared in six normal subjects. Both SP and NKA increased skin temperature (SkT) and heart rate (HR), but SP was more potent than NKA by factors of 6 and 20 respectively. No change in systolic blood pressure (BP) occurre...

journal_title：British journal of clinical pharmacology

authors： Evans TW,Dixon CM,Clarke B,Conradson TB,Barnes PJ

更新日期：1988-02-01 00:00:00

abstract：:There is concern in the UK about nonmedical use (NMU) of alprazolam (Xanax). We investigated the epidemiology of alprazolam NMU compared with diazepam using data from the Survey of Non-Medical Use of Prescription Drugs (NMURx) programme (collected 28 September-1 December 2017). The survey included 10 019 respondents a...

journal_title：British journal of clinical pharmacology

authors： Hockenhull J,Amioka E,Black JC,Haynes CM,Dargan PI,Dart RC,Wood DM

更新日期：2019-08-01 00:00:00

abstract：AIMS:Surgical site infections contribute to morbidity and mortality after surgery. The authors hypothesized that higher antibiotic tissue concentrations can be reached for a prolonged time span by continuous administration of prophylactic cefuroxime compared to bolus administration. METHODS:Twelve patients undergoing ...

journal_title：British journal of clinical pharmacology

authors： Skhirtladze-Dworschak K,Hutschala D,Reining G,Dittrich P,Bartunek A,Dworschak M,Tschernko EM

更新日期：2019-04-01 00:00:00