Pharmacovigilance in children: detecting adverse drug reactions in routine electronic healthcare records. A systematic review.

abstract：AIMS:To examine the impact on heart rate variability (HRV), of agonism or antagonism at the cardiac beta2-adrenoceptor in healthy volunteers, using standard time-domain summary statistics and non-linear methods (scatterplot and quadrant analysis). METHODS:Under double-blind and randomised conditions (Latin square desi...

journal_title：British journal of clinical pharmacology

authors： Hanratty CG,Silke B,Riddell JG

更新日期：1999-02-01 00:00:00

abstract：:Serum free fractions of nifedipine, verapamil and some of their metabolites were measured in patients with ischaemic heart disease receiving single oral dose and chronic monotherapy and were compared with those obtained in vitro. The percentages of unbound nifedipine and verapamil in vitro (concentration range 50-200 ...

journal_title：British journal of clinical pharmacology

authors： Rumiantsev DO,Piotrovskii VK,Metelitsa VI,Slastnikova ID,Martsevich SYu,Kokurina EV

更新日期：1989-09-01 00:00:00

abstract：AIMS:The aim of this study was to examine the use of potentially inappropriate medication (PIM) in relation to time before death, to explore whether PIMs are discontinued at the end of life, and the factors associated with this discontinuation. METHODS:We conducted a retrospective register-based mortality cohort study...

journal_title：British journal of clinical pharmacology

authors： Paque K,De Schreye R,Elseviers M,Vander Stichele R,Pardon K,Dilles T,Christiaens T,Deliens L,Cohen J

更新日期：2019-04-01 00:00:00

abstract：:1 The disposition of prazosin following oral and intravenous administration has been studied in seven young and seven elderly men, all of whom were in good health and living independently in the community. 2 The elimination half-life (min) of prazosin was 123 +/- 19.4 (s.d.) in the young and 194 +/- 36 in the elderly ...

journal_title：British journal of clinical pharmacology

authors： Rubin PC,Scott PJ,Reid JL

更新日期：1981-09-01 00:00:00

abstract：AIMS:Brentuximab vedotin, an antibody-drug conjugate (ADC), selectively delivers the microtubule-disrupting agent monomethyl auristatin E (MMAE) into CD30-expressing cells. The pharmacokinetics of brentuximab vedotin have been characterized in patients with CD30-positive haematologic malignancies. The primary objective...

journal_title：British journal of clinical pharmacology

authors： Zhao B,Chen R,O'Connor OA,Gopal AK,Ramchandren R,Goy A,Matous JV,Fasanmade AA,Manley TJ,Han TH

更新日期：2016-09-01 00:00:00

abstract：AIM:Sunitinib is an oral tyrosine kinase inhibitor approved for the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST). Because of the large interpatient pharmacokinetic variability and established exposure-response and exposure-toxicity relationships in clinical trial patients, therapeut...

journal_title：British journal of clinical pharmacology

authors： Westerdijk K,Krens SD,van der Graaf WTA,Mulder SF,van Herpen CML,Smilde T,van Erp NP,Desar IME

更新日期：2020-05-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:• The topical second generation anti-histamine azelastine hydrochloride (AZE) and the potent corticosteroid fluticasone propionate (FP) are well established first-line treatments in allergic rhinitis (AR). • MP29-02, a novel intranasal AZE and FP formulation, has been shown to c...

journal_title：British journal of clinical pharmacology

authors： Derendorf H,Munzel U,Petzold U,Maus J,Mascher H,Hermann R,Bousquet J

更新日期：2012-07-01 00:00:00

abstract：:1 In a preliminary double-blind trial the effects of ephedrine and pseudoephedrine on the blood pressure and heart rate of resting healthy volunteers were compared. Ephedrine 60 or 90 mg were required to raise the diastolic blood pressure above 90 mmHg, whereas 210 or 240 mg pseudoephedrine were required to produce th...

journal_title：British journal of clinical pharmacology

authors： Drew CD,Knight GT,Hughes DT,Bush M

更新日期：1978-09-01 00:00:00

abstract：:The effects of the proton pump inhibitor lansoprazole on the bioavailability of a low-dose oral contraceptive (OC), containing 0.03 mg ethinyloestradiol (EE) and 0.15 mg levonorgestrel (LNG), were investigated. Twenty-four healthy females (aged 19-35 years; weight 60.6 +/- 7.1 kg) participated in a multiple-dose, plac...

journal_title：British journal of clinical pharmacology

authors： Fuchs W,Sennewald R,Klotz U

更新日期：1994-10-01 00:00:00

abstract：:1 The potency of single doses of the aldosterone antagonist SC8109 relative to spironolactone in reversing the urinary electrolyte effects of fludrocortisone was examined in a double-blind, balanced, crossover study in six healthy volunteers. 2 For the urinary ratio log10 10Na/K, the relative potency of SC8109; spiron...

journal_title：British journal of clinical pharmacology

authors： McInnes GT,Harrison IR,Shelton JR,Perkins RM

更新日期：1981-11-01 00:00:00

abstract：:1 As part of a prospective study on the use of digoxin in a general practice, plasma digoxin concentrations were measured in all patients receiving the drug. 2 A low mean plasma digoxin concentration was observed, suggesting a cautious approach to digitalization. 3 The correlation between plasma digoxin concentration ...

journal_title：British journal of clinical pharmacology

authors： Holt DW,Williamson JD,Volans GN

更新日期：1977-06-01 00:00:00

abstract：:Ipratropium bromide (0.5 mg) and fenoterol (2 mg) produced equivalent peak bronchodilatation between 1 and 2 h after administration to eight patients with chronic partially reversible airways obstruction. The duration of action compared with saline was 6 h for ipratropium and 4 h for fenoterol. Both drugs in combinati...

journal_title：British journal of clinical pharmacology

authors： Jenkins CR,Chow CM,Fisher BL,Marlin GE

更新日期：1982-07-01 00:00:00

abstract：:Ten volunteers carried a 10 mg 24 h -1 transdermal glyceryl trinitrate (GTN) patch for 24 h before moderate exercise. Plasma GTN-concentration increased significantly (P less than 0.05) by 19% to peak value at 15 min. Two hours after patch renewal repeat exercise increased GTN concentration by 56% (P less than 0.001)....

journal_title：British journal of clinical pharmacology

authors： Gjesdal K,Klemsdal TO,Rykke EO,Bredesen JE

更新日期：1991-05-01 00:00:00

abstract：AIMS:Pupillography is a noninvasive and cost-effective method to determine autonomic nerve activity. Genetic variants in cytochrome P450 (CYP), dopamine receptor (DRD2, DRD3), serotonin receptor (HTR2A, HTR2C) and ATP-binding cassette subfamily B (ABCB1) genes, among others, were previously associated with the pharmaco...

journal_title：British journal of clinical pharmacology

authors： Koller D,Saiz-Rodríguez M,Zubiaur P,Ochoa D,Almenara S,Román M,Romero-Palacián D,de Miguel-Cáceres A,Martín S,Navares-Gómez M,Mejía G,Wojnicz A,Abad-Santos F

更新日期：2020-10-01 00:00:00

abstract：AIMS:The administration of omeprazole may interfere with the absorption of orally administered drugs by reducing gastric pH and hence tablet dissolution. The aim of this study was to investigate the effects of a 5 day administration of omeprazole on the pharmacokinetics of furazolidone. METHODS:Eighteen healthy (nine ...

journal_title：British journal of clinical pharmacology

authors： Calafatti SA,Ortiz RA,Deguer M,Martinez M,Pedrazzoli J Jr

更新日期：2001-08-01 00:00:00

abstract：AIMS:We investigated the effect of angiotensin converting enzyme inhibitors (ACEIs) on postsynaptic adrenoceptor sensitivity and compared the effect of the lipophilic ACEI, quinapril, and that of hydrophilic agent, enalapril in human vessels. METHODS:Alpha-adrenoceptor sensitivity was evaluated using the dorsal hand v...

journal_title：British journal of clinical pharmacology

authors： Kimura M,Umemura K,Kosuge K,Nishimoto M,Ohashi K,Nakashima M

更新日期：1998-12-01 00:00:00

abstract：:1. The primary action of the converting enzyme inhibitors to prevent the formation of angiotensin II can explain a decrease in peripheral vascular resistance in patients with elevated, but not in those with normal or reduced plasma renin levels. 2. The inhibition of the breakdown of bradykinin will potentiate the vaso...

journal_title：British journal of clinical pharmacology

authors： Vanhoutte PM,Auch-Schwelk W,Biondi ML,Lorenz RR,Schini VB,Vidal MJ

更新日期：1989-01-01 00:00:00

abstract：:1. Recently, some cases have been reported where intravenous use of omeprazole was followed by loss of vision. We followed up a cohort of close to 140,000 persons during periods of treatment and non-treatment with five anti-ulcer drugs. 2. The relative risk of vascular disorders of the eye during use of omeprazole com...

journal_title：British journal of clinical pharmacology

authors： García Rodríguez LA,Mannino S,Wallander MA,Lindblom B

更新日期：1996-08-01 00:00:00

abstract：AIM:To assess the relative contribution of intestinal and hepatic CYP3A inhibition to the interaction between the prototypic CYP3A substrate midazolam and clarithromycin in the elderly. METHODS:On day 1, 16 volunteers (eight male, eight female) aged 65-75 years weighing 59-112 kg received simultaneous doses of midazol...

journal_title：British journal of clinical pharmacology

authors： Quinney SK,Haehner BD,Rhoades MB,Lin Z,Gorski JC,Hall SD

更新日期：2008-01-01 00:00:00

abstract：AIMS:Major bleeding complications with low-molecular-weight heparin (LMWH) treatment have been reported both in clinical studies and during postmarketing surveillance. Monitoring of antifactor Xa (anti-Xa) activities is therefore recommended in special populations often predisposed to renal impairment. The PROPHRE.75 s...

journal_title：British journal of clinical pharmacology

authors： Berges A,Laporte S,Epinat M,Zufferey P,Alamartine E,Tranchand B,Decousus H,Mismetti P,PROPHRE.75 Study Group.

更新日期：2007-10-01 00:00:00

abstract：:1. Fifty-four depressive in-patients aged 18-45 yr, were treated at random, in double-blind conditions, with mianserin 60 mg daily or imipramine 150 mg daily in three divided doses for 4 weeks. Nitrazepam and diazepam were also allowed if necessary. 2. There was no significant difference in antidepressant efficacy bet...

journal_title：British journal of clinical pharmacology

authors： Pichot P,Dreyfus JF,Pull C

更新日期：1978-01-01 00:00:00

abstract：AIMS:To compare the effects of nabumetone and meloxicam, two cyclo-oxygenase-2 (COX-2) preferential nonsteroidal anti-inflammatory drugs (NSAIDs), on platelet COX-1 activity and platelet function. METHODS:Twelve healthy volunteers (3 male, 9 female, median age 22 years) participated in an open, randomized, cross-over ...

journal_title：British journal of clinical pharmacology

authors： van Kraaij DJ,Hovestad-Witterland AH,de Metz M,Vollaard EJ

更新日期：2002-06-01 00:00:00

abstract：AIMS:To evaluate the effect of a 3-day regimen of ibuprofen 600 mg x 4 on acute postoperative swelling and pain and other inflammatory events after third molar surgery compared with a traditional regimen of paracetamol 1000 mg x 4. METHODS:A controlled, randomized, double-blind, cross-over study where 36 patients (26 ...

journal_title：British journal of clinical pharmacology

authors： Bjørnsson GA,Haanaes HR,Skoglund LA

更新日期：2003-04-01 00:00:00

abstract：:1. The pharmacokinetics of didanosine, trimethoprim, and sulphamethoxazole were evaluated in ten HIV seropositive asymptomatic patients as single agents and upon coadministration of single doses. 2. Using a randomized, balanced incomplete block crossover study with at least a 1-week washout period between successive t...

journal_title：British journal of clinical pharmacology

authors： Srinivas NR,Knupp CA,Batteiger B,Smith RA,Barbhaiya RH

更新日期：1996-03-01 00:00:00

abstract：:The degrees of interactions between the H2-receptor antagonists, cimetidine and ranitidine, and several beta-adrenoceptor blockers were investigated in healthy volunteers following 7 days of oral monotherapy with penbutolol, propranolol, metoprolol, pindolol and atenolol, and after co-administration with each of the H...

journal_title：British journal of clinical pharmacology

authors： Mutschler E,Spahn H,Kirch W

更新日期：1984-01-01 00:00:00

abstract：:The concentration of chloroquine (CQ), dapsone (DDS) and pyrimethamine (PYR) in plasma and milk were measured following the coadministration of a single dose of chloroquine and Maloprim to lactating women. The milk to plasma area under the concentration-time curve (AUC) ratio ranged from 1.96 to 4.26 for CQ, 0.22 to 0...

journal_title：British journal of clinical pharmacology

authors： Edstein MD,Veenendaal JR,Newman K,Hyslop R

更新日期：1986-12-01 00:00:00

abstract：:1. The inhibitory effect of sufotidine, a new histamine H2-receptor antagonist, on gastric secretion of acid and pepsin was studied in six healthy male volunteers. This was a three-way, cross-over, randomized, double-blind study. On each of 3 study days, the drug in a dose of 600 mg, or placebo, was administered eithe...

journal_title：British journal of clinical pharmacology

authors： Johnston DA,Wormsley KG

更新日期：1989-10-01 00:00:00

abstract：:1. An open-label, randomised study was performed to assess the effect of tenidap sodium on the pharmacodynamics and plasma protein binding of warfarin. 2. Fourteen healthy male volunteers received either a single oral dose of 120 mg tenidap sodium or matching placebo capsules from days 11 to 36. A single oral dose of ...

journal_title：British journal of clinical pharmacology

authors： Apseloff G,Wilner KD,Gerber N

更新日期：1995-01-01 00:00:00

abstract：:1. The effects of simvastatin and pravastatin on measures of central nervous system activity were investigated in a double-blind, placebo-controlled, randomised crossover study. 2. Twenty-five healthy volunteers sequentially took 40 mg day-1 simvastatin, 40 mg day-1 pravastatin or placebo for 4 weeks, separated by a 4...

journal_title：British journal of clinical pharmacology

authors： Harrison RW,Ashton CH

更新日期：1994-03-01 00:00:00

abstract：:The absorption of the antiemetic metopimazine (MPZ) given as a single dose of (a) 40 mg microenema, (b) 40 mg orally and (c) 10 mg as a 60 min i.v. continuous infusion was investigated in six healthy volunteers. Blood samples were drawn and the serum concentrations of MPZ and its acid metabolite were measured. The bio...

journal_title：British journal of clinical pharmacology

authors： Herrstedt J,Jørgensen M,Angelo HR,Rassing MR,Møller-Sonnergaard J,Dombernowsky P

更新日期：1996-06-01 00:00:00