Bioavailability of the antiemetic metopimazine given as a microenema.

abstract：:Ouabain inhibits endothelium-dependent vascular relaxation in vitro, but has not been studied in this regard in vivo. We have therefore measured blood flow responses to carbachol, bradykinin and sodium nitroprusside (endothelium-dependent and endothelium-independent vasodilators) infused into the brachial artery with ...

journal_title：British journal of clinical pharmacology

authors： Woolfson RG,Benjamin N,Todd SD,Poston L,Ritter JM

更新日期：1991-12-01 00:00:00

abstract：:1. Relative rates of absorption of enteric and non-enteric preparations of prednisolone were measured in five renal transplant recipients. 2. The absorption of the enteric coated preparation is delayed and the peak plasma concentration is much lower than that attained using the same dose of the uncoated material. 3. T...

journal_title：British journal of clinical pharmacology

authors： Hulme B,James VH,Rault R

更新日期：1975-08-01 00:00:00

abstract：:The airway and cardiovascular effects of intravenous neurokinin A (NKA) and substance P (SP) were compared in six normal subjects. Both SP and NKA increased skin temperature (SkT) and heart rate (HR), but SP was more potent than NKA by factors of 6 and 20 respectively. No change in systolic blood pressure (BP) occurre...

journal_title：British journal of clinical pharmacology

authors： Evans TW,Dixon CM,Clarke B,Conradson TB,Barnes PJ

更新日期：1988-02-01 00:00:00

abstract：AIMS:Roux-en-Y gastric bypass (RYGB) alters the anatomical structure of the gastrointestinal tract, which can result in alterations in drug disposition. The aim of the present study was to evaluate the oral disposition of two compounds belonging to the Biopharmaceutical Classification System Class II - fenofibrate (bil...

journal_title：British journal of clinical pharmacology

authors： Gesquiere I,Hens B,Van der Schueren B,Mols R,de Hoon J,Lannoo M,Matthys C,Foulon V,Augustijns P

更新日期：2016-11-01 00:00:00

abstract：:The pharmacokinetics of intravenous and oral propranolol have been compared in six obese and six normal subjects matched for age and sex. After intravenous administration there was no difference in plasma clearance but the volume of distribution was greater (V = 339 l vs 198 l) and the half-life was longer (t1/2 = 5.0...

journal_title：British journal of clinical pharmacology

authors： Bowman SL,Hudson SA,Simpson G,Munro JF,Clements JA

更新日期：1986-05-01 00:00:00

abstract：:Three hypothalamic regulatory hormones, thyrotrophin-releasing hormone (TRH), luteinizing hormone/follicle-stimulating hormone-releasing hormone (LH/FSH-RH) and growth hormone-release inhibiting hormone (GH-RIH) given intravenously had no effect on the electroencephalographic response known as the contingent negative ...

journal_title：British journal of clinical pharmacology

authors： Ashton H,Millman JE,Telford R,Thompson JW,Davies TF,Hall R

更新日期：1976-08-01 00:00:00

abstract：:The pharmacokinetics of piroximone (PI) were determined in patients with renal failure (inulin clearance less than 50 ml min-1 per 1.73 m2) using two protocols: (a) 10 patients received a single i.v. infusion of 0.5 mg kg-1 PI and the data were compared with those from seven healthy subjects receiving the same regimen...

journal_title：British journal of clinical pharmacology

authors： Fauvel JP,Bernard N,Laville M,Pozet N,Sassard J,Zech PY

更新日期：1995-02-01 00:00:00

abstract：:1. Preliminary results are reported from a long-term study aimed at recording the concentrations of serum lipids and lipoproteins at 6, 12 and 24 months of treatment with pindolol in young/middle-aged males with moderate hypertension. 2. Seventy-three patients have been recruited, of whom 47 have completed 6 months tr...

journal_title：British journal of clinical pharmacology

authors： Carlson LA,Ribacke M,Terent A

更新日期：1987-01-01 00:00:00

abstract：AIMS:The aim of this study was to determine the potential influence of variables such as the cell content in the fluid, and serum levels, on the concentrations of ceftibuten, cefixime and azithromycin in the middle ear fluid of patients suffering from acute otitis media. METHODS:This randomized, open study compared th...

journal_title：British journal of clinical pharmacology

authors： Scaglione F,Demartini G,Dugnani S,Arcidiacono MM,Pintucci JP,Fraschini F

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to determine the risk of myopathy in older people receiving statin therapy. METHODS:Eligible studies were identified searching Ovid Medline, EMBASE, Scopus, CINAHL, Cochrane and PSYCHINFO databases (1987 to July 2014). The selection criteria comprised randomized controlled st...

journal_title：British journal of clinical pharmacology

authors： Iwere RB,Hewitt J

更新日期：2015-09-01 00:00:00

abstract：:Eleven HIV-infected men participated in a randomized, two-treatment, two-period crossover study to determine the effect of a 25 g protein meal on zidovudine pharmacokinetics. On two separate occasions, 1 week apart, each patient received 200 mg zidovudine in a fasting state or immediately following the protein meal. A...

journal_title：British journal of clinical pharmacology

authors： Sahai J,Gallicano K,Garber G,McGilveray I,Hawley-Foss N,Turgeon N,Cameron DW

更新日期：1992-06-01 00:00:00

abstract：AIMS:To evaluate the electroencephalographic (EEG) effects, blood concentrations, vehicle irritation and dose-effect relationships for diazepam administered nasally. METHODS:The study had a cross-over design with eight healthy volunteers (one drop out). It consisted of four legs with four different administrations: in...

journal_title：British journal of clinical pharmacology

authors： Lindhardt K,Gizurarson S,Stefánsson SB,Olafsson DR,Bechgaard E

更新日期：2001-11-01 00:00:00

abstract：:1 In a double-blind cross-over study, nine healthy male students received placebo, brompheniramine 12 mg), carbinoxamine (12 mg), clemastine (1 mg), and phenylpropanolamine (50 mg) orally. Three doses of each drug were given: at 08.30 h and 21.00 h on the first day of treatment and at 08.30 h on the following day. 2 P...

journal_title：British journal of clinical pharmacology

authors： Seppälä T,Nuotto E,Korttila K

更新日期：1981-08-01 00:00:00

abstract：:1 The pharmacodynamic profile of single oral doses of prorenoate potassium (40 mg) and spironolactone (100 mg), as judged by reversal of the effects of fludrocostisone on the urinary electrolyte composition, was compared to that of placebo in a double-blind crossover study in six healthy subjects. 2 Both drugs showed ...

journal_title：British journal of clinical pharmacology

authors： Ramsay LE,Shelton JR,Tidd MJ

更新日期：1976-06-01 00:00:00

abstract：:1. Ten healthy subjects received two treatments: a single 1 g oral dose of nalidixic acid (NA) followed 1 h later by either an infinitesimal dilution of the drug (NA 7CH) or by succussed water which served as placebo. The study was repeated 18 months later in 10 different subjects. 2. A further 10 healthy subjects rec...

journal_title：British journal of clinical pharmacology

authors： Ferry N,Bernard N,Pozet N,Gardes E,Bruguier M,Cuisinaud G,Sassard J

更新日期：1991-07-01 00:00:00

abstract：:The effects of separate 7 day pretreatments with sulphinpyrazone (800 mg daily) and cimetidine (1 g daily) on the disposition of (+/-)-verapamil have been examined in eight healthy volunteers (four male, four female). Each subject received single oral (80 mg) and intravenous (0.15 mg/kg) doses of verapamil on differen...

journal_title：British journal of clinical pharmacology

authors： Wing LM,Miners JO,Lillywhite KJ

更新日期：1985-03-01 00:00:00

abstract：:1. Quinidine is a potent inhibitor of the genetically-determined debrisoquine 4-hydroxylation. Oxidation reactions of several other drugs, including the 5-hydroxylation of the new antiarrhythmic drug propafenone, depend on the isozyme responsible for debrisoquine 4-hydroxylation. 2. The effect of quinidine on the debr...

journal_title：British journal of clinical pharmacology

authors： Funck-Brentano C,Kroemer HK,Pavlou H,Woosley RL,Roden DM

更新日期：1989-04-01 00:00:00

abstract：:Ipratropium bromide (0.5 mg) and fenoterol (2 mg) produced equivalent peak bronchodilatation between 1 and 2 h after administration to eight patients with chronic partially reversible airways obstruction. The duration of action compared with saline was 6 h for ipratropium and 4 h for fenoterol. Both drugs in combinati...

journal_title：British journal of clinical pharmacology

authors： Jenkins CR,Chow CM,Fisher BL,Marlin GE

更新日期：1982-07-01 00:00:00

abstract：:1. We attempted to collect information on the metabolism and production of angiotensins (ANG) in different vascular beds in humans by constant i.v. infusion of mono-iodinated [125I]-ANG I into subjects with essential hypertension, at the time of renal vein catheterization as part of the diagnostic work-up for renovasc...

journal_title：British journal of clinical pharmacology

authors： Schalekamp MA,Admiraal PJ,Derkx FH

更新日期：1989-01-01 00:00:00

abstract：AIMS:Intravenous formulations of busulfan have recently become available. Although busulfan is used frequently in children as part of a myeloablative regimen prior to bone marrow transplantation, pharmacokinetic data on intravenous busulfan in children are scarce. The aim was to investigate intravenous busulfan pharmac...

journal_title：British journal of clinical pharmacology

authors： Cremers S,Schoemaker R,Bredius R,den Hartigh J,Ball L,Twiss I,Vermeij P,Vossen J

更新日期：2002-04-01 00:00:00

abstract：:1. Previous studies have demonstrated the presence of antibodies to trifluoroacetylated hepatic proteins (TFA-proteins) in sera from patients with the severe form of halothane-associated hepatitis (halothane hepatitis). The TFA-proteins are produced via cytochrome P450-mediated metabolism of halothane to the reactive ...

journal_title：British journal of clinical pharmacology

authors： Kitteringham NR,Kenna JG,Park BK

更新日期：1995-10-01 00:00:00

abstract：AIMS:Our study aimed to evaluate the impacts of the cytochrome P450 (CYP) 2B6-G516T and CYP2D6 genetic polymorphisms on pharmacokinetic and clinical parameters in patients receiving methadone maintenance treatment. METHODS:Opioid PhArmacoLogy (OPAL) was a clinical survey of the sociodemographic characteristics, histor...

journal_title：British journal of clinical pharmacology

authors： Victorri-Vigneau C,Verstuyft C,Bouquié R,Laforgue EJ,Hardouin JB,Leboucher J,Le Geay B,Dano C,Challet-Bouju G,Grall-Bronnec M

更新日期：2019-07-01 00:00:00

abstract：AIMS:To assess the effect of the calcitonin gene-related peptide (CGRP) receptor antagonist, telcagepant, on the haemodynamic response to sublingual nitroglycerin (NTG). METHODS:Twenty-two healthy male volunteers participated in a randomized, placebo-controlled, double-blind, two-period, crossover study. Subjects rece...

journal_title：British journal of clinical pharmacology

authors： Van der Schueren BJ,Blanchard R,Murphy MG,Palcza J,De Lepeleire I,Van Hecken A,Depré M,de Hoon JN

更新日期：2011-05-01 00:00:00

abstract：:The pharmacokinetics of antipyrine were studied in 12 healthy volunteers and 10 patients of Kenya African origin with Hodgkin's lymphoma. The half-life of antipyrine was 12.2 +/- 1.3 h (mean + s.d.), while the apparent volume of distribution (V) was 0.67 +/- 0.11 l kg-1 (mean +/- s.d.) and the total body clearance was...

journal_title：British journal of clinical pharmacology

authors： Juma FD

更新日期：1987-12-01 00:00:00

abstract：:A 12-week double-blind study was performed to compare the safety and efficacy of doxazosin, prazosin and placebo in 172 patients with essential hypertension. According to response, patients received doxazosin 1-16 mg once daily, prazosin 0.5-10 mg twice daily, or placebo. Mean final daily doses were doxazosin 11.3 mg ...

journal_title：British journal of clinical pharmacology

authors： Torvik D,Madsbu HP

更新日期：1986-01-01 00:00:00

abstract：AIMS:The study was designed to evaluate the relative bioavailability of diclofenac in plasma, subcutaneous adipose and skeletal muscle tissue after repeated topical administration using MIKA Diclofenac Spray Gel (4%), a novel formulation, and after oral dosing using VOLTAREN 50 mg enteric coated tablets. METHODS:Diclo...

journal_title：British journal of clinical pharmacology

authors： Brunner M,Dehghanyar P,Seigfried B,Martin W,Menke G,Müller M

更新日期：2005-11-01 00:00:00

abstract：AIMS:The aim of the present study was to investigate whether differences in total and peak drug exposure upon generic substitution are due to differences between formulations or to intrasubject pharmacokinetic variability of the active substance. METHODS:The study was designed as a retrospective reanalysis of existing...

journal_title：British journal of clinical pharmacology

authors： Yu Y,Teerenstra S,Neef C,Burger D,Maliepaard M

更新日期：2016-04-01 00:00:00

abstract：AIMS:To quantify usage of COX-2 inhibitors compared with nonselective NSAIDs and to determine their impact (including financial) on the co-prescription of antipeptic ulcer (anti-PU) drugs. METHODS:The Irish General Medical Services prescription database (covering 1.2 million people) was examined for NSAID prescription...

journal_title：British journal of clinical pharmacology

authors： Teeling M,Bennett K,Feely J

更新日期：2004-03-01 00:00:00

abstract：:Cost-containment measures in healthcare provision include the implementation of therapeutic and generic drug substitution strategies in patients whose condition is already well controlled with pharmacotherapy. Treatment for hypertension is frequently targeted for such measures. However, drug acquisition costs are only...

journal_title：British journal of clinical pharmacology

authors： Johnston A,Stafylas P,Stergiou GS

更新日期：2010-09-01 00:00:00

abstract：AIMS:SNF472 is a calcification inhibitor being developed for the treatment of cardiovascular calcification in haemodialysis (HD) and in calciphylaxis patients. This study investigated the safety, tolerability and pharmacokinetics (PK) of intravenous (IV) SNF472 in healthy volunteers (HV) and HD patients. METHODS:This ...

journal_title：British journal of clinical pharmacology

authors： Perelló J,Joubert PH,Ferrer MD,Canals AZ,Sinha S,Salcedo C

更新日期：2018-12-01 00:00:00