当前位置： SCI文献检索 > BRITISH JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Pharmacokinetics of piroximone after oral and intravenous administration to patients with renal insufficiency.

Pharmacokinetics of piroximone after oral and intravenous administration to patients with renal insufficiency.

Abstract：

:The pharmacokinetics of piroximone (PI) were determined in patients with renal failure (inulin clearance less than 50 ml min-1 per 1.73 m2) using two protocols: (a) 10 patients received a single i.v. infusion of 0.5 mg kg-1 PI and the data were compared with those from seven healthy subjects receiving the same regimen; (b), a single oral dose of either 25 or 50 mg PI was given to 20 patients. PI concentrations were assayed by h.p.l.c. in plasma and urine over 48 h. After i.v. administration to healthy subjects PI was distributed rapidly and eliminated with a mean half-life of 1.3 +/- 0.2 h. The urinary recovery of unchanged PI was 64% of the dose. In the patients the extent of renal elimination of PI was decreased (-78%) in relation to the degree of renal insufficiency as assessed by inulin clearance (r = 0.97, P < 0.0001). Mean Cmax, AUC and t1/2,z values after i.v. infusion were increased by 47%, 127% and 77%, respectively, in comparison with healthy subjects. Similar results were obtained after oral administration. Until chronic dosing studies are undertaken, PI dosage should be adapted in relation to renal function.

journal_name

Br J Clin Pharmacol

journal_title

British journal of clinical pharmacology

authors

Fauvel JP,Bernard N,Laville M,Pozet N,Sassard J,Zech PY

doi

10.1111/j.1365-2125.1995.tb04429.x

subject

Has Abstract

pub_date

1995-02-01 00:00:00

pages

187-9

issue

2

eissn

0306-5251

issn

1365-2125

journal_volume

39

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY文献大全
  • Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions.

    abstract：AIMS:Previous isobolographic analysis revealed that coadministration of morphine and oxycodone produces synergistic antinociception in laboratory rodents. As both opioids can produce ventilatory depression, this study was designed to determine whether their ventilatory effects were synergistic when coadministered to he...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.2005.02368.x

    authors： Ladd LA,Kam PC,Williams DB,Wright AW,Smith MT,Mather LE

    更新日期：2005-05-01 00:00:00

  • Pharmacokinetic and clinical profile of a novel formulation of bosentan in children with pulmonary arterial hypertension: the FUTURE-1 study.

    abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:* Exposure to bosentan was lower in paediatric pulmonary arterial hypertension (PAH) patients treated with the marketed adult formulation at a dose of about 2 mg kg(-1) when compared with adult PAH patients. * In healthy adult subjects, bosentan pharmacokinetics are less than do...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1111/j.1365-2125.2009.03532.x

    authors： Beghetti M,Haworth SG,Bonnet D,Barst RJ,Acar P,Fraisse A,Ivy DD,Jais X,Schulze-Neick I,Galiè N,Morganti A,Dingemanse J,Kusic-Pajic A,Berger RM

    更新日期：2009-12-01 00:00:00

  • Debrisoquine and mephenytoin oxidation in Sinhalese: a population study.

    abstract：:The frequency distributions of the 0-8 h urinary metabolic ratios of debrisoquine and mephenytoin were measured in 111 healthy, unrelated Sinhalese resident in Sri Lanka. Blood samples were taken from 77 of these subjects for CYP2D6 genotyping. Bimodality in the distribution of the log10 debrisoquine/4-hydroxydebrisoq...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1994.tb04384.x

    authors： Weerasuriya K,Jayakody RL,Smith CA,Wolf CR,Tucker GT,Lennard MS

    更新日期：1994-11-01 00:00:00

  • Bioavailability and disposition of azelastine and fluticasone propionate when delivered by MP29-02, a novel aqueous nasal spray.

    abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:• The topical second generation anti-histamine azelastine hydrochloride (AZE) and the potent corticosteroid fluticasone propionate (FP) are well established first-line treatments in allergic rhinitis (AR). • MP29-02, a novel intranasal AZE and FP formulation, has been shown to c...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.2012.04222.x

    authors： Derendorf H,Munzel U,Petzold U,Maus J,Mascher H,Hermann R,Bousquet J

    更新日期：2012-07-01 00:00:00

  • The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine.

    abstract：AIMS:Clozapine (CLZ), an atypical neuroleptic with a high risk of causing agranulocytosis, is metabolized in the liver to desmethylclozapine (DCLZ) and clozapine N-oxide (CLZ-NO). This study investigated the involvement of different CYP isoforms in the formation of these two metabolites. METHODS:Human liver microsomal...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2125.1997.t01-1-00605.x

    authors： Eiermann B,Engel G,Johansson I,Zanger UM,Bertilsson L

    更新日期：1997-11-01 00:00:00

  • Hydroxycarbamide in children with sickle cell anaemia after first-dose vs. chronic therapy: pharmacokinetics and predictive models for drug exposure.

    abstract：AIMS:The purposes of this work were to: (1) compare pharmacokinetic (PK) parameters for hydroxycarbamide in children receiving their first dose (HCnew ) vs. those receiving chronic therapy (HCchronic ), (2) assess the external validity of a published PK dosing strategy, and (3) explore the accuracy of dosing strategies...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1111/bcp.13426

    authors： Estepp JH,Wiczling P,Moen J,Kang G,Mack JM,Liem R,Panepinto JA,Garg U,Kearns G,Neville KA

    更新日期：2018-07-01 00:00:00

  • Relation between changes in blood pressure and serum ACE activity after a single dose of enalapril and ACE genotype in healthy subjects.

    abstract：:1. The effects of a single oral dose of enalapril 10 mg on serum ACE activity and blood pressure in relation to the ACE genotype were studied in 27 healthy men, n = 9 each of genotype DD, ID and II, in a parallel group study design. 2. Before treatment serum ACE activity differed significantly between the genotypes, w...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1995.tb04419.x

    authors： Todd GP,Chadwick IG,Higgins KS,Yeo WW,Jackson PR,Ramsay LE

    更新日期：1995-02-01 00:00:00

  • Development of anti-migraine therapeutics using the capsaicin-induced dermal blood flow model.

    abstract：:The efficacy of calcitonin gene-related peptide (receptor) (CGRP-(R)) blocking therapeutics in the treatment of acute migraine headache provided proof-of-concept for the involvement of CGRP in the pathophysiology of this disorder. One of the major hurdles for the development of any class of drugs, including CGRP block...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1111/bcp.12704

    authors： Buntinx L,Vermeersch S,de Hoon J

    更新日期：2015-11-01 00:00:00

  • Flecainide: single and multiple oral dose kinetics, absolute bioavailability and effect of food and antacid in man.

    abstract：:The kinetics of flecainide after single intravenous (2 mg kg-1) and oral (200 mg) dosing, absolute bioavailability, effects of food and aluminium hydroxide on flecainide absorption and steady-state kinetics following twice daily oral dosing (200 mg) have been evaluated in ten healthy subjects. Absolute bioavailability...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1986.tb02892.x

    authors： Tjandra-Maga TB,Verbesselt R,Van Hecken A,Mullie A,De Schepper PJ

    更新日期：1986-09-01 00:00:00

  • Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans.

    abstract：AIMS:To assess the utility of human hepatic microsomes for predicting in vivo intrinsic clearance (CLint ) via the use of four cytochrome P450 2C9 substrates: phenytoin, tolbutamide (S)-ibuprofen (two pathways) and diclofenac, and to examine the role of exogenous albumin within the microsomal incubation. METHODS:V max...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2125.1999.00935.x

    authors： Carlile DJ,Hakooz N,Bayliss MK,Houston JB

    更新日期：1999-06-01 00:00:00

  • The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion technique.

    abstract：AIMS:To investigate whether the drug-drug interaction between fexofenadine and ketoconazole is localized to efflux transport proteins of the small intestine, and to determine and classify the effective jejunal permeability (Peff) of fexofenadine according to the Biopharmaceutics Classification System (BCS). METHODS:Tw...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2125.2003.01722.x

    authors： Tannergren C,Knutson T,Knutson L,Lennernäs H

    更新日期：2003-02-01 00:00:00

  • The gastrointestinal passage and release of beclomethasone dipropionate from oral delivery systems in ileostomy volunteers.

    abstract：AIMS:To study the delivery of 15 mg beclomethasone 17,21-dipropionate (BDP) to the distal part of the small bowel for three oral sustained-release formulations (I-III) and a reference capsule in volunteer ileostomists, and to compare these findings with the in vitro dissolution profiles. METHODS:Two groups of nine ile...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2125.1998.00782.x

    authors： Burggraaf J,van Haarst AD,Fockens P,Schoemaker HC,Krauwinkel WJ,Cohen AF

    更新日期：1998-09-01 00:00:00

  • Lack of inhibitory effect of metronidazole on theophylline disposition in healthy subjects.

    abstract：:The effect of metronidazole, at a dose of 1.2 g daily, on theophylline disposition was studied in 10 healthy adult volunteers. Neither theophylline half-life, volume of distribution nor total body clearance was altered by the anti-microbial. It is concluded that metronidazole does not impair theophylline metabolism de...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1987.tb03146.x

    authors： Adebayo GI,Mabadeje AF

    更新日期：1987-07-01 00:00:00

  • Pharmacovigilance in children: detecting adverse drug reactions in routine electronic healthcare records. A systematic review.

    abstract：AIMS:A systematic review of the literature published in English over 10 years was undertaken in order to describe the use of electronic healthcare data in the identification of potential adverse drug reactions (ADRs) in children. METHODS:MEDLINE and EMBASE were searched using MESH headings and text words. Titles, keyw...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1111/bcp.12645

    authors： Black C,Tagiyeva-Milne N,Helms P,Moir D

    更新日期：2015-10-01 00:00:00

  • Non-invasive measurement of the haemodynamic effects of inhaled salbutamol, intravenous L-arginine and sublingual nitroglycerin.

    abstract：AIMS:To examine the effects of salbutamol and L-arginine, two compounds acting largely on the endothelium, and the endothelium-independent agent nitroglycerin on blood pressure, arterial compliance, cardiac function and vascular resistance. METHODS:Continuous radial pulse wave analysis, whole-body impedance cardiograp...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.2009.03434.x

    authors： Tahvanainen A,Leskinen M,Koskela J,Ilveskoski E,Alanko J,Kähönen M,Kööbi T,Lehtimäki L,Moilanen E,Mustonen J,Pörsti I

    更新日期：2009-07-01 00:00:00

  • Lisinopril and nifedipine: no acute interaction in normotensives.

    abstract：:1. A double-blind, four period crossover study was undertaken to test for an interaction between single oral doses of nifedipine retard (20 mg) and lisinopril (20 mg) in normal subjects. 2. Side effects with both drugs were mild and the incidence was additive. 3. Blood pressure (BP) was lowered by nifedipine for 4 h, ...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-2125.1988.tb03308.x

    authors： Lees KR,Reid JL

    更新日期：1988-03-01 00:00:00

  • Chenodeoxycholic acid therapy for hypertriglyceridaemia in men.

    abstract：:1 Ten consecutive patients with hypertriglyceridaemia who adhered to a low carbohydrate diet without complete control of serum triglycerides were started on chenodeoxycholic acid 750 mg daily and followed monthly for 6 months. Nine of these patients were then followed for a further month on placebo capsules and therea...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-2125.1978.tb01632.x

    authors： Bateson MC,Maclean D,Evans JR,Bouchier IA

    更新日期：1978-03-01 00:00:00

  • Concurrent administration of donepezil HCl and sertraline HCl in healthy volunteers: assessment of pharmacokinetic changes and safety following single and multiple oral doses.

    abstract：AIM:This study evaluated the safety and pharmacokinetics (PK) of donepezil HCl and sertraline HCl when administered separately and in combination. METHODS:This was a randomized, open-label, three-period crossover study. In consecutive dosing periods separated by washout periods of > or = 3 weeks, healthy volunteers re...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.2004.01801.x

    authors： Nagy CF,Kumar D,Perdomo CA,Wason S,Cullen EI,Pratt RD

    更新日期：2004-11-01 00:00:00

  • Population pharmacokinetics of ciclosporin in haematopoietic allogeneic stem cell transplantation with emphasis on limited sampling strategy.

    abstract：:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The population pharmacokinetics and limited sampling strategies for ciclosporin monitoring have been extensively studied in renal and liver transplant recipients. Little is known about the pharmacokinetics of ciclosporin in patients undergoing haematopoietic allogeneic stem c...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.2011.04116.x

    authors： Wilhelm AJ,de Graaf P,Veldkamp AI,Janssen JJ,Huijgens PC,Swart EL

    更新日期：2012-04-01 00:00:00

  • Intrinsic heart rate on exercise and the measurement of beta-adrenoceptor blockade.

    abstract：:Methods of expressing the effects of beta-adrenoceptor blocking drugs on exercise heart rate have been evaluated using a standardised exercise test. In six normal subjects given atropine (0.04 mg/kg) on two separate occasions, the mean +/- s.e. mean exercise heart rate rose by 10.3 +/- 1.8 beats/min and by 11.0 +/- 1....

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1976.tb00348.x

    authors： Carruthers SG,Shanks RG,McDevitt DG

    更新日期：1976-12-01 00:00:00

  • Protein binding of non-steroidal anti-inflammatory drugs in plasma and synovial fluid of arthritic patients.

    abstract：:1 The protein binding of seven non-steroidal anti-inflammatory drugs (indomethacin, tolmetin, salicylic acid, ibuprofen, flurbiprofen, naproxen and GP53,633) and warfarin was investigated by equilibrium dialysis in simultaneous samples of synovial fluid and plasma from 12 arthritic patients. 2 The protein binding of a...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1983.tb01469.x

    authors： Wanwimolruk S,Brooks PM,Birkett DJ

    更新日期：1983-01-01 00:00:00

  • The antitussive effect of dextromethorphan in relation to CYP2D6 activity.

    abstract：AIMS:To test the hypothesis that inhibition of cytochrome P450 2D6 (CYP2D6) by quinidine increases the antitussive effect of dextromethorphan (DEX) in an induced cough model. METHODS:Twenty-two healthy extensive metaboliser phenotypes for CYP2D6 were studied according to a double-blind, randomised cross-over design af...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2125.1999.00029.x

    authors： Abdul Manap R,Wright CE,Gregory A,Rostami-Hodjegan A,Meller ST,Kelm GR,Lennard MS,Tucker GT,Morice AH

    更新日期：1999-09-01 00:00:00

  • Direct oral anticoagulants for stroke prevention in patients with atrial fibrillation: meta-analysis by geographic region with a focus on European patients.

    abstract：AIMS:To analyse clinical outcomes with direct oral anticoagulants in patients with atrial fibrillation according to geographic region. METHODS:We systematically searched MEDLINE, CENTRAL, websites of regulatory agencies, clinical trials registers and conference proceedings for randomized controlled trials of direct or...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1111/bcp.13005

    authors： Gómez-Outes A,Terleira-Fernández AI,Calvo-Rojas G,Suárez-Gea ML,Vargas-Castrillón E

    更新日期：2016-09-01 00:00:00

  • Impact of lipophilic vs hydrophilic statins on the clinical outcome and biomarkers of remodelling in heart failure patients: A prospective comparative randomized study.

    abstract：AIMS:There are insufficient direct comparative studies addressing the impact of the type of statin on their respective efficacy in heart failure (HF). The aim of the current study was to compare the effects of lipophilic (atorvastatin) vs hydrophilic (rosuvastatin) on left ventricular function, inflammatory and fibrosi...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.14695

    authors： El Said NO,El Wakeel LM,Khorshid H,Darweesh EAG,Ahmed MA

    更新日期：2020-12-08 00:00:00

  • Interpretation of middle ear fluid concentrations of antibiotics: comparison between ceftibuten, cefixime and azithromycin.

    abstract：AIMS:The aim of this study was to determine the potential influence of variables such as the cell content in the fluid, and serum levels, on the concentrations of ceftibuten, cefixime and azithromycin in the middle ear fluid of patients suffering from acute otitis media. METHODS:This randomized, open study compared th...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2125.1999.00887.x

    authors： Scaglione F,Demartini G,Dugnani S,Arcidiacono MM,Pintucci JP,Fraschini F

    更新日期：1999-03-01 00:00:00

  • The effect of rectal ozone on the portal vein oxygenation and pharmacokinetics of propranolol in liver cirrhosis (a preliminary human study).

    abstract：AIM:The aim of this study was to investigate the effect of rectal ozone on portal vein oxygenation and the pharmacokinetic changes of propranolol in patients with liver cirrhosis. METHODS:Fifteen patients with liver cirrhosis were included They were given a fixed oral dose of propranolol 80mg on the morning of day 1 a...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.2010.03851.x

    authors： Zaky S,Fouad EA,Kotb HI

    更新日期：2011-03-01 00:00:00

  • What influences persistence with medicines? A multinational discrete choice experiment of 2549 patients.

    abstract：AIM:The aim was to examine patients' stated preferences to persist with medicines and to explore the influence of psychosocial and sociocognitive factors. METHODS:Community-dwelling, hypertensive patients recruited from nine European countries were invited to complete a discrete choice experiment (DCE) with attributes...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.12971

    authors： Holmes EA,Morrison VL,Hughes DA

    更新日期：2016-08-01 00:00:00

  • Bioactivity of enoxaparin in critically ill patients with normal renal function.

    abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Venous thromboembolism is a frequent complication in critically ill patients that has a negative impact on patient outcomes. Critically ill patients have significantly lower plasma anti-factor-Xa activity levels compared with control patients after administration of subcutaneous...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.2012.04285.x

    authors： Gouya G,Palkovits S,Kapiotis S,Madl C,Locker G,Stella A,Wolzt M,Heinz G

    更新日期：2012-11-01 00:00:00

  • Cefuroxime plasma and tissue concentrations in patients undergoing elective cardiac surgery: Continuous vs bolus application. A pilot study.

    abstract：AIMS:Surgical site infections contribute to morbidity and mortality after surgery. The authors hypothesized that higher antibiotic tissue concentrations can be reached for a prolonged time span by continuous administration of prophylactic cefuroxime compared to bolus administration. METHODS:Twelve patients undergoing ...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.13865

    authors： Skhirtladze-Dworschak K,Hutschala D,Reining G,Dittrich P,Bartunek A,Dworschak M,Tschernko EM

    更新日期：2019-04-01 00:00:00

  • Future of the drug label: Perspectives from a multistakeholder dialogue.

    abstract：:Regulating drugs does not end when market access has been granted. Monitoring drugs over the life cycle has become state of the art, inherent to evolving legislation and societal need. Here, we explore how the drug label could move along in a changing playing-field and become a sustainable label for the future. A dial...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.14070

    authors： Gispen-de Wied CC,Weemers J,Boon W,Mol PGM,Stolk P

    更新日期：2019-10-01 00:00:00