The effect of infinitesimal drug dilutions on the pharmacokinetics of nalidixic acid and atenolol.

abstract：:1. Azole antifungal agents such as ketoconazole act by inhibiting cytochrome P-450 mediated sterol synthesis in the fungal cell membrane and thus have the potential to interfere with mammalian steroidogenesis. Fluconazole is a novel orally-effective antifungal triazole which has been reported to have more specific eff...

journal_title：British journal of clinical pharmacology

authors： Devenport MH,Crook D,Wynn V,Lees LJ

更新日期：1989-06-01 00:00:00

abstract：AIMS:To assess the utility of human hepatic microsomes for predicting in vivo intrinsic clearance (CLint ) via the use of four cytochrome P450 2C9 substrates: phenytoin, tolbutamide (S)-ibuprofen (two pathways) and diclofenac, and to examine the role of exogenous albumin within the microsomal incubation. METHODS:V max...

journal_title：British journal of clinical pharmacology

authors： Carlile DJ,Hakooz N,Bayliss MK,Houston JB

更新日期：1999-06-01 00:00:00

abstract：AIMS:Breakthrough bleeding or even unwanted pregnancies have been reported in women during concomitant therapy with oral contraceptives and St John's wort extract. The aim of the present study was to investigate the effects of St John's wort extract on oral contraceptive therapy with respect to ovarian activity, breakt...

journal_title：British journal of clinical pharmacology

authors： Pfrunder A,Schiesser M,Gerber S,Haschke M,Bitzer J,Drewe J

更新日期：2003-12-01 00:00:00

abstract：:In order to clarify the characteristics of absorption of 5-aminosalicylic acid (5-ASA) from the colon, a neutral solution was instilled into the right part of the colon and the rectum, respectively, in six volunteers. A laxative (bisacodyl) and liquid meals were given prior to each instillation. No significant differe...

journal_title：British journal of clinical pharmacology

authors： Bondesen S,Schou JB,Pedersen V,Rafiolsadat Z,Hansen SH,Hvidberg EF

更新日期：1988-02-01 00:00:00

abstract：AIMS:Antihistamines make up the first line of treatments against motion-sickness. Still, their efficacy and specific mechanism have come into question. The aim of this study was to investigate the effect of meclizine on motion-sensitivity. METHODS:This study was carried out as a triple-blinded randomized trial involvi...

journal_title：British journal of clinical pharmacology

authors： Wibble T,Engström J,Verrecchia L,Pansell T

更新日期：2020-08-01 00:00:00

abstract：AIMS:Prescribing errors are common and inadequate preparation of prescribers appears to contribute. A junior doctor-led prescribing tutorial programme has been developed for Edinburgh final year medical students to increase exposure to common prescribing tasks. The aim of this study was to assess the impact of these tu...

journal_title：British journal of clinical pharmacology

authors： Gibson KR,Qureshi ZU,Ross MT,Maxwell SR

更新日期：2014-01-01 00:00:00

abstract：AIM:To assess the effect of Schisandra sphenanthera extract (SchE) on the pharmacokinetics of tacrolimus in healthy volunteers. METHODS:Twelve healthy male volunteers were orally treated with SchE, three capsules twice daily for 13 days. Pharmacokinetic investigations of oral tacrolimus administration at 2 mg were per...

journal_title：British journal of clinical pharmacology

authors： Xin HW,Wu XC,Li Q,Yu AR,Zhu M,Shen Y,Su D,Xiong L

更新日期：2007-10-01 00:00:00

abstract：AIMS:Formoterol is a beta2-adrenoceptor agonist marketed as a racemic mixture of the active (R; R)- and inactive (S; S)-enantiomers (rac-formoterol). The drug produces prolonged bronchodilation by inhalation but there is significant interpatient variability in duration of effect. Previous work has shown that in humans ...

journal_title：British journal of clinical pharmacology

authors： Zhang M,Fawcett JP,Kennedy JM,Shaw JP

更新日期：2000-02-01 00:00:00

abstract：AIMS:This study assessed the effects of the CYP3A inhibitors lopinavir/ritonavir (LPV/r) on the steady-state pharmacokinetics (PK) of aplaviroc (APL), a CYP3A4 substrate, in healthy subjects. METHODS:In Part 1, APL PK was determined in eight subjects who received a single oral 50-mg APL test dose with/without a single...

journal_title：British journal of clinical pharmacology

authors： Adkison KK,Shachoy-Clark A,Fang L,Lou Y,Otto VR,Berrey MM,Piscitelli SC

更新日期：2006-09-01 00:00:00

abstract：:Plasma and synovial fluid concentrations of the enantiomers of flurbiprofen were measured in 15 rheumatoid patients receiving 100 mg racemic flurbiprofen twice daily. Pharmacokinetic parameters showed considerable variability within the group of patients, although differences in S(+)/R(-) plasma concentration ratios w...

journal_title：British journal of clinical pharmacology

authors： Young MA,Aarons L,Toon S

更新日期：1991-01-01 00:00:00

abstract：:1. In order to assess the prevalence of concurrent use of more than one major psychotropic drug (polypsychopharmacy) in out-patients, a prescription database study was conducted in the Odense area for a period of 2 years. 2. During the index period 5.12% of the inhabitants purchased major psychotropic drugs. Of these,...

journal_title：British journal of clinical pharmacology

authors： Rosholm JU,Hallas J,Gram LF

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Benzodiazepines and "Z drugs" are often prescribed in residents of nursing homes (NH) despite their well-known deleterious effects. We aimed to investigate if a general intervention on quality of care led to discontinuation of benzodiazepine, and to examine which NH-related factors were associated in change ...

journal_title：British journal of clinical pharmacology

authors： de Souto Barreto P,Lapeyre-Mestre M,Cestac P,Vellas B,Rolland Y

更新日期：2016-04-01 00:00:00

abstract：AIMS:Dapagliflozin is a sodium-glucose co-transporter 2 inhibitor that has been developed as oral glucose lowering drug. The original dosefinding studies focused on optimal glycaemic effects. However, dapagliflozin also affects various cardiorenal risk markers and provides cardiorenal protection. To evaluate whether th...

journal_title：British journal of clinical pharmacology

authors： Koomen JV,Stevens J,Heerspink HJL

更新日期：2020-11-01 00:00:00

abstract：AIMS:Our study aimed to evaluate the impacts of the cytochrome P450 (CYP) 2B6-G516T and CYP2D6 genetic polymorphisms on pharmacokinetic and clinical parameters in patients receiving methadone maintenance treatment. METHODS:Opioid PhArmacoLogy (OPAL) was a clinical survey of the sociodemographic characteristics, histor...

journal_title：British journal of clinical pharmacology

authors： Victorri-Vigneau C,Verstuyft C,Bouquié R,Laforgue EJ,Hardouin JB,Leboucher J,Le Geay B,Dano C,Challet-Bouju G,Grall-Bronnec M

更新日期：2019-07-01 00:00:00

abstract：:1. A survey has been conducted amongst 459 members of the Clinical Section of the British Pharmacological Society to ascertain facts about the administration of drugs to healthy volunteers over the period October 1986 to September 1987. 2. A response rate of 87.1% was obtained with 114 individuals being involved in he...

journal_title：British journal of clinical pharmacology

authors： Orme M,Harry J,Routledge P,Hobson S

更新日期：1989-02-01 00:00:00

abstract：:The effects of the proton pump inhibitor lansoprazole on the bioavailability of a low-dose oral contraceptive (OC), containing 0.03 mg ethinyloestradiol (EE) and 0.15 mg levonorgestrel (LNG), were investigated. Twenty-four healthy females (aged 19-35 years; weight 60.6 +/- 7.1 kg) participated in a multiple-dose, plac...

journal_title：British journal of clinical pharmacology

authors： Fuchs W,Sennewald R,Klotz U

更新日期：1994-10-01 00:00:00

abstract：:The effect of a high potency antacid and food on the bioavailability of famotidine was studied in 17 healthy volunteers in an open randomized three-way cross-over trial. After an overnight fast, famotidine was administered to each subject as follows: 40 mg famotidine orally alone; 40 mg orally with antacid; and 40 mg ...

journal_title：British journal of clinical pharmacology

authors： Lin JH,Chremos AN,Kanovsky SM,Schwartz S,Yeh KC,Kann J

更新日期：1987-10-01 00:00:00

abstract：:1. A double-blind, four period crossover study was undertaken to test for an interaction between single oral doses of nifedipine retard (20 mg) and lisinopril (20 mg) in normal subjects. 2. Side effects with both drugs were mild and the incidence was additive. 3. Blood pressure (BP) was lowered by nifedipine for 4 h, ...

journal_title：British journal of clinical pharmacology

authors： Lees KR,Reid JL

更新日期：1988-03-01 00:00:00

abstract：:Eight psoriatic patients were treated with etretinate (50 mg daily) for 6 weeks. Skin chamber exudates from involved and uninvolved skin were assayed for arachidonic acid, 12-HETE, PGE2 and for neutrophil chemokinetic activity co-chromatographing with leukotriene B4, before and at weekly intervals during therapy. Pre-...

journal_title：British journal of clinical pharmacology

authors： Wong E,Barr RM,Brain SD,Greaves MW,Olins LA,Mallet AI

更新日期：1984-10-01 00:00:00

abstract：AIMS:To assess whether hospitalization may assist in correcting errors in anticoagulant therapy among patients with atrial fibrillation (AF). METHODS:Our cohort included patients admitted to our institution with a history of AF between 2016 and 2018. We categorized patient's treatment upon admission and discharge as l...

journal_title：British journal of clinical pharmacology

authors： Angel Y,Zeltser D,Berliner S,Ingbir M,Shapira I,Shenhar-Tsarfaty S,Rogowski O

更新日期：2019-12-01 00:00:00

abstract：AIMS:Pupillography is a noninvasive and cost-effective method to determine autonomic nerve activity. Genetic variants in cytochrome P450 (CYP), dopamine receptor (DRD2, DRD3), serotonin receptor (HTR2A, HTR2C) and ATP-binding cassette subfamily B (ABCB1) genes, among others, were previously associated with the pharmaco...

journal_title：British journal of clinical pharmacology

authors： Koller D,Saiz-Rodríguez M,Zubiaur P,Ochoa D,Almenara S,Román M,Romero-Palacián D,de Miguel-Cáceres A,Martín S,Navares-Gómez M,Mejía G,Wojnicz A,Abad-Santos F

更新日期：2020-10-01 00:00:00

abstract：:The mydriatic response to eyedrops of the anticholinergic drug tropicamide at very low concentration (0.01%) was studied in subjects with Alzheimer's disease (AD, n = 10) and multi-infarct dementia (MID, n = 10). There was no significant difference in pupillary response between the two groups. The test is unlikely to ...

journal_title：British journal of clinical pharmacology

authors： Treloar AJ,Assin M,Macdonald AJ

更新日期：1996-03-01 00:00:00

abstract：:1 The effect of an intravenous bolus of labetalol (0.6-1.6 mg/kg body weight) on central and peripheral haemodynamics was studied in nine subjects with essential hypertension and in eleven subjects with chronic renal disease and hypertension. 2 The BP reduction amounting to 20/13 mmHg was entirely due to the lowering ...

journal_title：British journal of clinical pharmacology

authors： Bahlmann J,Brod J,Hubrich W,Cachovan M,Pretschner P

更新日期：1979-04-01 00:00:00

abstract：:We have measured the psychological effects of acebutolol and atenolol in sixteen patients with essential hypertension. The drugs were administered in a randomized, placebo-controlled, double-blind manner, in single daily doses of 100 mg atenolol, 400 mg acebutolol or placebo for periods of 6 weeks, each drug period be...

journal_title：British journal of clinical pharmacology

authors： Lewis MJ,Jones DM,Dart AM,Henderson AH

更新日期：1984-03-01 00:00:00

abstract：:The classical taxanes (paclitaxel, docetaxel), the newer taxane cabazitaxel and the nanoparticle-bound nab-paclitaxel are among the most widely used anticancer drugs. Still, the optimal use and the value of pharmacological personalization of the taxanes is still controversial. We give an overview on the pharmacologica...

journal_title：British journal of clinical pharmacology

authors： Muth M,Ojara FW,Kloft C,Joerger M

更新日期：2020-11-28 00:00:00

abstract：AIMS:Variability in responsiveness to clopidogrel is a clinical problem in secondary prevention after cerebral ischaemia which has been suggested to be linked to competitive metabolization of clopidogrel and cytochrome P450 (CYP) 3A4-oxidated statins such as simvastatin. We assessed the hypothesis that simvastatin, in ...

journal_title：British journal of clinical pharmacology

authors： Siepmann T,Heinke D,Kepplinger J,Barlinn K,Gehrisch S,Grählert X,Schwanebeck U,Reichmann H,Puetz V,Bodechtel U,Gahn G

更新日期：2014-11-01 00:00:00

abstract：:1. The metabolic oxidation of debrisoquine (DB) was studied in 89 non-related Cuna Amerindian subjects. 2. Means and standard deviations for urinary recoveries of the intact drug and its 4-hydroxy metabolite (4-HD) were: %DB: 6.8 +/- 4.5; %4-HD: 16.0 +/- 9.1; %sum: 22.8 +/- 12.0. The log10 metabolic ratios for DB (LMR...

journal_title：British journal of clinical pharmacology

authors： Jorge LF,Arias TD,Inaba T,Jackson PR

更新日期：1990-08-01 00:00:00

abstract：:1 The pharmacokinetics of diazepam following intravenous administration have been investigated in six normal volunteers and nine epileptic patients receiving chronic antiepileptic drug therapy. 2 After intravenous administration, serum diazepam levels declined biexponentially in all subjects. The elimination half-life...

journal_title：British journal of clinical pharmacology

authors： Dhillon S,Richens A

更新日期：1981-12-01 00:00:00

abstract：AIM:Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase and are an important group of hypolipidaemic drugs, widely used in the treatment of hypercholesterolaemia and cardiovascular disease. Some studies have shown that statins are able to modulate inflammation and alveolar bone loss. METHODS:In o...

journal_title：British journal of clinical pharmacology

authors： Estanislau IM,Terceiro IR,Lisboa MR,Teles Pde B,Carvalho Rde S,Martins RS,Moreira MM

更新日期：2015-06-01 00:00:00

abstract：:Since platelet activation has been incriminated in the pathogenesis of asthma, we have investigated the effect of one of its major granule-derived mediators, 5-hydroxytryptamine (5-HT, serotonin) on airway calibre in normal (12), atopic non-asthmatic (12) and atopic asthmatic subjects (16). On separate days subjects i...

journal_title：British journal of clinical pharmacology

authors： Cushley MJ,Wee LH,Holgate ST

更新日期：1986-10-01 00:00:00