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Unimodal distribution of the metabolic ratio for debrisoquine in Cuna Amerindians of Panama.

Abstract：

:1. The metabolic oxidation of debrisoquine (DB) was studied in 89 non-related Cuna Amerindian subjects. 2. Means and standard deviations for urinary recoveries of the intact drug and its 4-hydroxy metabolite (4-HD) were: %DB: 6.8 +/- 4.5; %4-HD: 16.0 +/- 9.1; %sum: 22.8 +/- 12.0. The log10 metabolic ratios for DB (LMRDB) were distributed within a single mode of insignificant skewness (-0.01, P greater than 0.10), which was unimodal (log kernel density and maximum likelihood methods) and normal (chi 2 = 22.5; d.f. = 15; P greater than 0.09; power of the test greater than 80%). 3. Therefore, no poor metabolizers (95% C.I.: 0.1%, 5.2%) were detected in the population sample studied.

journal_name

Br J Clin Pharmacol

journal_title

British journal of clinical pharmacology

authors

Jorge LF,Arias TD,Inaba T,Jackson PR

doi

10.1111/j.1365-2125.1990.tb03776.x

subject

Has Abstract

pub_date

1990-08-01 00:00:00

pages

281-5

issue

2

eissn

0306-5251

issn

1365-2125

journal_volume

30

pub_type

杂志文章

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