Artemether-lumefantrine co-administration with antiretrovirals: population pharmacokinetics and dosing implications.

abstract：:1 Nineteen pregnant patients whose mean arterial pressure (MAP) was persistently greater than or equal to 103.3 mmHg were given labetalol or methyldopa. 2 Singificant falls (P less than 0.001) in BP only occurred in the group treated with labetalol, and daily BP control was better in this group. 3 Two severely hyperte...

journal_title：British journal of clinical pharmacology

authors： Lamming GD,Symonds EB

更新日期：1979-04-01 00:00:00

abstract：:1 The absorption of effervescent aspirin was studied in normal volunteers of both sexes under varied conditions of activity in both fasting and non-fasting states. 2 Moderate activity resulted in no significant changes in absorption compared with that at rest. 3 In non-fasting subjects the absorption was reduced but t...

journal_title：British journal of clinical pharmacology

authors： Volans GN

更新日期：1974-04-01 00:00:00

abstract：AIMS:Dexloxiglumide is a new CCK(1) receptor antagonist under investigation for treatment of functional gastrointestinal disorders and is metabolized by CYP3A4 and CYP2C9. The objectives of these two separate randomized, two-period, two-treatment crossover studies were to investigate the effects of steady-state ketocon...

journal_title：British journal of clinical pharmacology

authors： Jakate AS,Roy P,Patel A,Abramowitz W,Persiani S,Wangsa J,Kapil R

更新日期：2005-11-01 00:00:00

abstract：AIMS:Case reports and small case series suggest increased central nervous system (CNS) toxicity, especially convulsions, after overdose of mefenamic acid, compared with other nonsteroidal anti-inflammatory drugs (NSAIDs), although comparative epidemiological studies have not been conducted. The current study compared r...

journal_title：British journal of clinical pharmacology

authors： Kamour A,Crichton S,Cooper G,Lupton DJ,Eddleston M,Vale JA,Thompson JP,Thomas SH

更新日期：2017-04-01 00:00:00

abstract：:The ability of sulindac to modify the weal response to four doses of intradermal bradykinin in subjects given enalapril was tested in a double-blind cross-over study in normal volunteers. The dose-dependent increase in skin thickness after bradykinin was significantly reduced by prior administration of sulindac. Certa...

journal_title：British journal of clinical pharmacology

authors： Ferner RE,Kamali F,Rawlins MD

更新日期：1990-03-01 00:00:00

abstract：:1. Hydrochlorothiazide (HCT, 50-75 mg) was administered orally to seven patients with cardiac failure. 2. Plasma levels and urinary concentration of HCT were determined by GLC. 3. The gastrointestinal uptake of the diuretic in three patients was reduced to approximately half that seen in healthy controls. 4. Plasma ha...

journal_title：British journal of clinical pharmacology

authors： Beermann B,Groschinsky-Grind M

更新日期：1979-06-01 00:00:00

abstract：:1. The pharmacokinetics of MTX and its 7-hydroxy metabolite (7-OHMTX) were investigated in nine patients with rheumatoid arthritis (RA). Each patient received 15 mg MTX i.v., i.m. and p.o. after an overnight fast in a randomized cross-over design. The plasma concentrations of MTX and 7-OHMTX were measured over 7 days ...

journal_title：British journal of clinical pharmacology

authors： Seideman P,Beck O,Eksborg S,Wennberg M

更新日期：1993-04-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:* Only one other study (Becker et al.) has reported on the influence of smoking cessation and smoking resumption on inhaled insulin pharmacokinetics and glucodynamics, concluding that the rapid changes associated with smoking resumption carry the risk for hypoglycaemia and thus ...

journal_title：British journal of clinical pharmacology

authors： Pan AX,de la Peña A,Yeo KP,Chan C,Loh MT,Wise SD,Silverman BL,Muchmore DB

更新日期：2008-04-01 00:00:00

abstract：:1 Twelve-week courses of oxprenolol and methyldopa were administered in a randomised, double-blind cross over study to ten insulin dependent hypertensive diabetics. 2 Prior to treatment, and at the end of each period of drug administration, fasting levels of high density lipoprotein, triglycerides, free fatty acids an...

journal_title：British journal of clinical pharmacology

authors： Benfield GF,Hunter KR

更新日期：1982-02-01 00:00:00

abstract：:1 The acute and chronic (8 weeks) haemodynamic responses to oral flosequinan have been investigated in 12 male patients of mean age 58.9 years with congestive heart failure of N.Y.H.A. classes II and III. 2 Flosequinan 125 mg orally significantly reduced right atrial pressure, pulmonary artery pressure and pulmonary w...

journal_title：British journal of clinical pharmacology

authors： Thomas P,O'Gorman DJ,Sheridan DJ

更新日期：1993-12-01 00:00:00

abstract：AIMS:Homeopathic medicines are frequently purchased over the counter (OTC). Respiratory complaints are the most frequent reason for such purchases. Children with upper respiratory tract infection (URTI) are frequent users of homeopathy. This study investigates the effect of self treatment with one of three self selecte...

journal_title：British journal of clinical pharmacology

authors： Steinsbekk A,Bentzen N,Fønnebø V,Lewith G

更新日期：2005-04-01 00:00:00

abstract：UNLABELLED:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT?: * Two chemically diverse CCK1 receptor antagonists have been shown clinically to inhibit CCK-evoked contraction of human gallbladder [2, 3]. These studies have not examined the relationship between plasma concentration and effect, the latter usually considered to be...

journal_title：British journal of clinical pharmacology

authors： Gerskowitch VP,Hodge J,Hull RA,Shankley NP,Kalindjian SB,McEwen J,Black JW

更新日期：2007-05-01 00:00:00

abstract：:1. Milk and plasma metronidazole and hydroxymetronidazole concentrations were measured in 12 breast-feeding patients following multiple doses of metronidazole (400 mg three times daily). All patients received metronidazole in combination with other broad spectrum antibiotics. 2. Plasma concentrations of both parent dr...

journal_title：British journal of clinical pharmacology

authors： Passmore CM,McElnay JC,Rainey EA,D'Arcy PF

更新日期：1988-07-01 00:00:00

abstract：:Pharmacological interactions in both directions between phenprocoumon and atenolol and metoprolol were investigated using a crossover trial. Co-administration of phenprocoumon did not significantly affect Cmax, tmax, t1/2,22, AUC for atenolol or metoprolol. Co-administration of metoprolol, but not atenolol, increased ...

journal_title：British journal of clinical pharmacology

authors： Spahn H,Kirch W,Mutschler E,Ohnhaus EE,Kitteringham NR,Lögering HJ,Paar D

更新日期：1984-01-01 00:00:00

abstract：AIMS:The inhaled allergen challenge model has been used previously to investigate the effects of novel anti-inflammatory drugs in inhaled corticosteroid (ICS)-naïve asthmatics. The aim of this study was to characterize high- and low-dose allergen challenges in asthmatic patients using ICS. METHODS:Twenty-eight asthmat...

journal_title：British journal of clinical pharmacology

authors： Lee WY,Southworth T,Booth S,Singh D

更新日期：2015-03-01 00:00:00

abstract：AIMS:To determine whether preclinical medical students are able to learn therapeutic problem solving simultaneously with gaining knowledge of pharmacology. METHODS:A randomized controlled pre/post-test study among 85 3rd year preclinical medical students from two medical faculties in Amsterdam. In addition to the norm...

journal_title：British journal of clinical pharmacology

authors： Vollebregt JA,Metz JC,de Haan M,Richir MC,Hugtenburg JG,de Vries TP

更新日期：2006-03-01 00:00:00

abstract：:1 beta-adrenoceptor blockade with metoprolol provoked, both at rest and during exercise, a decrease of 'active' renin and angiotensin II together with an increase of 'inactive' renin and unchanged 'total' renin. The significant exercise-provoked increases in angiotensin II, plasma renin activity and 'active', 'inactiv...

journal_title：British journal of clinical pharmacology

authors： Lijnen PJ,Amery AK,Fagard RH,Reybrouck TM,Moerman EJ,De Schaepdryver AF

更新日期：1979-02-01 00:00:00

abstract：:We define a me-too drug as a pharmacologically active compound that is structurally related to a first-in-class compound, regarded as belonging to the same therapeutic class as the original compound, and used for the same therapeutic purposes, but which may differ in some respects, such as specificity of pharmacologic...

journal_title：British journal of clinical pharmacology

authors： Aronson JK,Green AR

更新日期：2020-11-01 00:00:00

abstract：AIMS:To demonstrate the bioequivalence of macitentan/tadalafil fixed-dose combination (FDC) tablets with single-component tablets of macitentan and tadalafil in healthy subjects. METHODS:Studies AC-077-101 and AC-077-103 were single-centre, open-label, single-dose, 2-period, randomized, crossover Phase 1 studies condu...

journal_title：British journal of clinical pharmacology

authors： Grill S,Bruderer S,Sidharta PN,Antonova M,Globig S,Carlson J,Schultz A,Csonka D

更新日期：2020-12-01 00:00:00

abstract：:1. This study further examines the quinoline-derivative abanoquil with particular respect to the duration of its alpha 1-adrenoceptor antagonist activity and its concentration-effect relationship following a single intravenous bolus dose of 0.5 micrograms kg-1 in young, normotensive males. 2. alpha 1-adrenoceptor anta...

journal_title：British journal of clinical pharmacology

authors： Schafers RF,Elliott HL,Meredith PA,Miller SH,Reid JL

更新日期：1991-11-01 00:00:00

abstract：AIMS:Intravenous formulations of busulfan have recently become available. Although busulfan is used frequently in children as part of a myeloablative regimen prior to bone marrow transplantation, pharmacokinetic data on intravenous busulfan in children are scarce. The aim was to investigate intravenous busulfan pharmac...

journal_title：British journal of clinical pharmacology

authors： Cremers S,Schoemaker R,Bredius R,den Hartigh J,Ball L,Twiss I,Vermeij P,Vossen J

更新日期：2002-04-01 00:00:00

abstract：:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Reflux oesophagitis is a common clinical disorder associated with significant morbidity. Proton pump inhibitors are the current pharmacotherapy of choice, but not all treated patients achieve symptom relief. Little is known about the efficacy of mosapride, a prokinetic agent wh...

journal_title：British journal of clinical pharmacology

authors： Hsu YC,Yang TH,Hsu WL,Wu HT,Cheng YC,Chiang MF,Wang CS,Lin HJ

更新日期：2010-08-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Performance-enhancing dietary supplements have not been clinically tested for safety or efficacy. In clinical trials performed under resting conditions, performance-enhancing supplements raise blood pressure and affect glucose homeostasis. The effect of exercise on the pharmacok...

journal_title：British journal of clinical pharmacology

authors： Haller CA,Duan M,Jacob P 3rd,Benowitz N

更新日期：2008-06-01 00:00:00

abstract：AIMS:Recently, an apparent protective effect of statins against upper gastrointestinal bleeding (UGB) was postulated in a post hoc analysis of a randomized trial. We aimed to evaluate the effect of statin use on acute nonvariceal UGB alone or in combinations with low-dose aspirin and other antithrombotic drugs. METHOD...

journal_title：British journal of clinical pharmacology

authors： Gulmez SE,Lassen AT,Aalykke C,Dall M,Andries A,Andersen BS,Hansen JM,Andersen M,Hallas J

更新日期：2009-04-01 00:00:00

abstract：:1 Chronic treatment with a constant dose of hydrochlorothiazide or tienilic acid increases plasma renin activity (PRA) acutely to reach a maximum within the first week. 2 During chronic diuretic therapy from 1 month to 1 year, PRA remained elevated at a rather constant level, though this was somewhat lower than the ma...

journal_title：British journal of clinical pharmacology

authors： Lijnen P,Fagard R,Staessen J,Amery A

更新日期：1981-09-01 00:00:00

abstract：AIMS:Therapeutic drug monitoring of infliximab can guide clinical decisions in patients with loss of response and in those who can benefit from a de-intensification. The aim of this study was to determine the impact of therapeutic drug monitoring combined with Bayesian forecasting methodology on clinical response in a ...

journal_title：British journal of clinical pharmacology

authors： Santacana Juncosa E,Rodríguez-Alonso L,Padullés Zamora A,Guardiola J,Rodríguez-Moranta F,Serra Nilsson K,Bas Minguet J,Morandeira Rego F,Colom Codina H,Padullés Zamora N

更新日期：2020-06-03 00:00:00

abstract：:The safety of trial subjects is the tenet that guides the regulatory assessment of a Clinical Trial Authorization application and applies equally to trials involving small molecules and those with biological/biotechnological products, including Advanced Therapy Medicinal Products. The objective of a regulator is to en...

journal_title：British journal of clinical pharmacology

authors： Jones DR,McBlane JW,McNaughton G,Rajakumaraswamy N,Wydenbach K

更新日期：2013-08-01 00:00:00

abstract：:1. Six healthy male human volunteers of mean age 30.8 years (range 23-37) were given single oral doses of xamoterol (20, 50, 100 or 250 mg) and placebo with a 1 week interval between each dose. Xamoterol produced a significant decrease in systolic time intervals (QS2I, LVETI and PEPI) and a significant increase in sys...

journal_title：British journal of clinical pharmacology

authors： James MA,Papouchado M,Channer KS,Jones JV,Marlow HF,Bastain W,Barker NP,Harry JD,Wardleworth AG

更新日期：1990-04-01 00:00:00

abstract：AIMS:Various mathematical models have been developed to estimate glomerular filtration rate (GFR) incorporating variables such as age, gender, height, weight, serum creatinine, and body surface area (BSA). Because adjustments in drug dosing are often based on estimated values of renal function, it is important to defin...

journal_title：British journal of clinical pharmacology

authors： Goerdt PJ,Heim-Duthoy KL,Macres M,Swan SK

更新日期：1997-09-01 00:00:00

abstract：AIMS:Increased exposure to fondaparinux, as observed in patients with renal impairment, may increase bleeding risk. This study aims to determine the time course of major bleeding after major orthopaedic surgery, identify predictors of bleeding and simulate the effect of a reduced dose of fondaparinux on bleeding for pa...

journal_title：British journal of clinical pharmacology

authors： Zufferey PJ,Ollier E,Delavenne X,Laporte S,Mismetti P,Duffull SB

更新日期：2018-10-01 00:00:00