Abstract:
AIMS:Various mathematical models have been developed to estimate glomerular filtration rate (GFR) incorporating variables such as age, gender, height, weight, serum creatinine, and body surface area (BSA). Because adjustments in drug dosing are often based on estimated values of renal function, it is important to define which, if any, of the available models, is appropriate for a specific patient population. A study was undertaken to determine the bias and precision of four mathematical models to estimate GFR in renal allograft recipients. METHODS:A retrospective review of 142 stable renal allograft patients, using iohexol clearance as a determinant of GFR, was performed. Renal allograft recipients followed in an outpatient clinic setting underwent iohexol clearance studies as part of clinical monitoring in the post-transplant period. Measured GFR values were compared with four mathematical models used to estimate GFR: the Cockcroft-Gault equation, the Jelliffe equation, the Walser equation, and the Mawer equation. Bias and precision were determined for each model as the mean squared error and the mean squared error, respectively. RESULTS:Patients had a mean age of 44 +/- 13 years, 92 were male, and 50 were female. The serum creatinine concentration was 176.8 +/- 88.4 mumol l-1 (mean +/- s.d.). The mean time post-transplant was 5.1 +/- 5.0 years and 38% of patients had insulin-requiring diabetes mellitus. The bias and precision results for the Jelliffe, Walser, Cockcroft-Gault, and Mawer models were: -3 and 414; -5 and 381; 16 and 688; and 23 and 1084, respectively. CONCLUSIONS:The Jelliffe and Walser equations gave the least biased and most precise estimations of GFR when compared with iohexol-derived measures in patients with renal allografts.
journal_name
Br J Clin Pharmacoljournal_title
British journal of clinical pharmacologyauthors
Goerdt PJ,Heim-Duthoy KL,Macres M,Swan SKdoi
10.1046/j.1365-2125.1997.t01-1-00567.xsubject
Has Abstractpub_date
1997-09-01 00:00:00pages
261-5issue
3eissn
0306-5251issn
1365-2125journal_volume
44pub_type
杂志文章abstract:AIMS:To analyse clinical outcomes with direct oral anticoagulants in patients with atrial fibrillation according to geographic region. METHODS:We systematically searched MEDLINE, CENTRAL, websites of regulatory agencies, clinical trials registers and conference proceedings for randomized controlled trials of direct or...
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pub_type: 杂志文章,meta分析,评审
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journal_title:British journal of clinical pharmacology
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更新日期:1984-08-01 00:00:00
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更新日期:2017-12-01 00:00:00
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journal_title:British journal of clinical pharmacology
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更新日期:2012-06-01 00:00:00
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journal_title:British journal of clinical pharmacology
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更新日期:1981-09-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2001-02-01 00:00:00
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journal_title:British journal of clinical pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-01-01 00:00:00
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-10-01 00:00:00
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journal_title:British journal of clinical pharmacology
pub_type: 临床试验,杂志文章
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更新日期:1999-09-01 00:00:00
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journal_title:British journal of clinical pharmacology
pub_type: 杂志文章
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更新日期:1998-10-01 00:00:00
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journal_title:British journal of clinical pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-02-01 00:00:00