Population pharmacokinetics and electrocardiographic effects of dihydroartemisinin-piperaquine in healthy volunteers.

abstract：AIM:Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase and are an important group of hypolipidaemic drugs, widely used in the treatment of hypercholesterolaemia and cardiovascular disease. Some studies have shown that statins are able to modulate inflammation and alveolar bone loss. METHODS:In o...

journal_title：British journal of clinical pharmacology

authors： Estanislau IM,Terceiro IR,Lisboa MR,Teles Pde B,Carvalho Rde S,Martins RS,Moreira MM

更新日期：2015-06-01 00:00:00

abstract：:Twelve healthy habitual cigarette smokers and eight non-smokers participated in a double-blind placebo controlled study to determine the effect of smoking on the pharmacokinetics and pharmacodynamics of the H2-receptor antagonist famotidine. In smokers, cigarette smoking was standardised and started 1 h before (A), or...

journal_title：British journal of clinical pharmacology

authors： Baak LC,Ganesh S,Jansen JB,Lamers CB

更新日期：1992-02-01 00:00:00

abstract：:The effect of fatty degeneration of liver parenchyma on drug metabolism was investigated in 21 obese non-insulin-dependent diabetic subjects by measuring plasma antipyrine kinetics, hepatic cytochrome P-450, liver size and the extent of fatty infiltration. The hepatic drug metabolising capacity, as measured by total a...

journal_title：British journal of clinical pharmacology

authors： Pirttiaho HI,Salmela PI,Sotaniemi EA,Pelkonen RO,Pitkänen U,Luoma PV

更新日期：1984-12-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:• The topical second generation anti-histamine azelastine hydrochloride (AZE) and the potent corticosteroid fluticasone propionate (FP) are well established first-line treatments in allergic rhinitis (AR). • MP29-02, a novel intranasal AZE and FP formulation, has been shown to c...

journal_title：British journal of clinical pharmacology

authors： Derendorf H,Munzel U,Petzold U,Maus J,Mascher H,Hermann R,Bousquet J

更新日期：2012-07-01 00:00:00

abstract：:1. We have investigated the effect of repeated s.c. Org 10172 (a low molecular weight heparinoid; Lomoparan) treatment (1000 anti-Xa units twice daily for 5 days) on antipyrine (500 mg orally) metabolism, and the effect of enzyme induction by pentobarbitone (100 mg for 12 days) on the pharmacokinetics and pharmacodyna...

journal_title：British journal of clinical pharmacology

authors： De Boer A,Stiekema JC,Danhof M,Breimer DD

更新日期：1991-07-01 00:00:00

abstract：AIMS:Navoximod (GDC-0919, NLG-919) is a small molecule inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), developed to treat the acquired immune tolerance associated with cancer. The primary objectives of this study were to assess navoximod's absolute bioavailability (aBA), determine the mass balance and routes of elim...

journal_title：British journal of clinical pharmacology

authors： Ma S,Suchomel J,Yanez E,Yost E,Liang X,Zhu R,Le H,Siebers N,Joas L,Morley R,Royer-Joo S,Pirzkall A,Salphati L,Ware JA,Morrissey KM

更新日期：2019-08-01 00:00:00

abstract：AIMS:The aim of the present study was to determine how the pharmacokinetics of meloxicam are affected by kidney dysfunction and consequently to define the appropriate dose for the use of meloxicam in patients with mild or moderate renal impairment. METHODS:Meloxicam was administered to subjects with mild (creatinine c...

journal_title：British journal of clinical pharmacology

authors： Boulton-Jones JM,Geddes CG,Heinzel G,Türck D,Nehmiz G,Bevis PJ

更新日期：1997-01-01 00:00:00

abstract：:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT * Dihydropyrimidine dehydrogenase (DPD) is the enzyme responsible for the elimination of approximately 80% of the administered dose of 5-fluorouracil (5-FU). * Mutations in the DPD-coding gene have been shown to increase the risk of severe toxicity in 5-FU treated patients. * T...

journal_title：British journal of clinical pharmacology

authors： Paré L,Paez D,Salazar J,Del Rio E,Tizzano E,Marcuello E,Baiget M

更新日期：2010-08-01 00:00:00

abstract：AIMS:To explore the feasibility of delivering community-based drug safety testing (drug checking), to trial service design characteristics and to compare with festival-based testing. METHODS:In total, 171 substances of concern were submitted on 5 dates at 3 venues in 2 UK cities and tested using up to 6 analytical tec...

journal_title：British journal of clinical pharmacology

authors： Measham F

更新日期：2020-03-01 00:00:00

abstract：:The excretion of diazepam, N-desmethyldiazepam, temazepam and oxazepam in breast milk was studied during withdrawal of a 22-year-old patient from combined high dose diazepam and oxazepam therapy. Concentrations of these benzodiazepines in plasma from both the woman and her nursing infant (1 year old) were also documen...

journal_title：British journal of clinical pharmacology

authors： Dusci LJ,Good SM,Hall RW,Ilett KF

更新日期：1990-01-01 00:00:00

abstract：AIMS:To individualize treatment, phenytoin doses are adjusted based on free concentrations, either measured or calculated from total concentrations. As a mechanistic protein binding model may more accurately reflect the protein binding of phenytoin than the empirical Winter-Tozer equation that is routinely used for cal...

journal_title：British journal of clinical pharmacology

authors： Ter Heine R,Kane SP,Huitema ADR,Krasowski MD,van Maarseveen EM

更新日期：2019-10-01 00:00:00

abstract：:1. In a double-blind placebo controlled four-way crossover study the effects and dose response relationships of xamoterol were studied in nine patients with angina and dyspnoea secondary to chronic left ventricular dysfunction. The duration of exercise on a treadmill and heart rate were measured at the end of each pha...

journal_title：British journal of clinical pharmacology

authors： Molajo AO,Bennett DH,Marlow HF,Snow HM,Bastain W

更新日期：1987-09-01 00:00:00

abstract：:1 The pharmacokinetics of single oral doses of nortriptyline were studied in twenty patients with chronic renal failure, eight of whom were receiving treatment with haemodialysis. 2 The median nortriptyline half-life was 25.2 h (range 14.5-140.0 h) and the median nortriptyline clearance was 32.3 l/h (range 8.1-122.0 l...

journal_title：British journal of clinical pharmacology

authors： Dawlilng S,Lynn K,Rosser R,Braithwaite R

更新日期：1981-07-01 00:00:00

abstract：AIMS:To examine the potency of ticlopidine (TCL) as an inhibitor of cytochrome P450s (CYP450s) in vitro using human liver microsomes (HLMs) and recombinant human CYP450s. METHODS:Isoform-specific substrate probes of CYP1A2, 2C19, 2C9, 2D6, 2E1 and 3A4 were incubated in HLMs or recombinant CYPs with or without TCL. Pre...

journal_title：British journal of clinical pharmacology

authors： Ko JW,Desta Z,Soukhova NV,Tracy T,Flockhart DA

更新日期：2000-04-01 00:00:00

abstract：AIM:Sunitinib is an oral tyrosine kinase inhibitor approved for the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST). Because of the large interpatient pharmacokinetic variability and established exposure-response and exposure-toxicity relationships in clinical trial patients, therapeut...

journal_title：British journal of clinical pharmacology

authors： Westerdijk K,Krens SD,van der Graaf WTA,Mulder SF,van Herpen CML,Smilde T,van Erp NP,Desar IME

更新日期：2020-05-01 00:00:00

abstract：AIMS:To determine whether topical ocular chloramphenicol increases the risk of aplastic anaemia and to estimate the magnitude of this risk, if any. METHODS:Population-based prospective case-control surveillance of aplastic anaemia in a community of 4.2 million inhabitants from 1980 to 1995 (67.2 million person-years) ...

journal_title：British journal of clinical pharmacology

authors： Laporte JR,Vidal X,Ballarín E,Ibáñez L

更新日期：1998-08-01 00:00:00

abstract：:Twenty-three elderly hypertensive subjects received nitrendipine 10mg daily by mouth for 8 days. Plasma nitrendipine concentrations were measured after the first and last dose. There was no significant difference in plasma concentrations at any time point between the two days nor in derived pharmacokinetic measurement...

journal_title：British journal of clinical pharmacology

authors： Crome P,Baksi A,MacMahon D,Pandita-Gunawardena ND,Edwards J,Marley J

更新日期：1988-09-01 00:00:00

abstract：AIM:The aim of this study was to investigate the effect of rectal ozone on portal vein oxygenation and the pharmacokinetic changes of propranolol in patients with liver cirrhosis. METHODS:Fifteen patients with liver cirrhosis were included They were given a fixed oral dose of propranolol 80mg on the morning of day 1 a...

journal_title：British journal of clinical pharmacology

authors： Zaky S,Fouad EA,Kotb HI

更新日期：2011-03-01 00:00:00

abstract：:Adverse drug reactions come at a considerable cost on society. Social media are a potentially invaluable reservoir of information for pharmacovigilance, yet their true value remains to be fully understood. In order to realize the benefits social media holds, a number of technical, regulatory and ethical challenges rem...

journal_title：British journal of clinical pharmacology

authors： Sloane R,Osanlou O,Lewis D,Bollegala D,Maskell S,Pirmohamed M

更新日期：2015-10-01 00:00:00

abstract：:1 The effect of RX 72601, neostigmine plus atropine, or saline on neuromuscular blockade with (+)-tubocurarine was studied in a double blind trial in four healthy male volunteers. 2 The methods used to assess neuromuscular function were voluntary grip strength and indirectly evoked muscle twitches. The muscarinic acti...

journal_title：British journal of clinical pharmacology

authors： Dettmar PW,Metcalf G,Smith MH,Gillett GB,Hedges A,Richens A

更新日期：1974-06-01 00:00:00

abstract：AIMS:The use of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients treated with oral anticoagulants is generally discouraged due to the risk of interactions that could increase the risk of bleeding complications. Available data suggest the NSAID, nabumetone, does not produce such an interaction. We investigated ...

journal_title：British journal of clinical pharmacology

authors： Pardo A,García-Losa M,Fernández-Pavón A,del Castillo S,Pascual-García T,García-Méndez E,Dal-Ré R

更新日期：1999-04-01 00:00:00

abstract：:1. Alfuzosin is a post-synaptic alpha-adrenoceptor antagonist with antihypertensive and peripheral vasodilator properties. 2. We measured the effect of alfuzosin, 5 mg, on sympathetically-mediated venoconstriction by changes in the venous reflex response (VRR) in a randomised, double-blind, placebo-controlled, crossov...

journal_title：British journal of clinical pharmacology

authors： Sinclair AJ,Davies IB,Warrington SJ

更新日期：1989-01-01 00:00:00

abstract：AIM:To review the literature on adverse drug reactions (ADRs) in children with respect to occurrence, seriousness, type, therapeutic group, age and gender of the child and category of reporter. METHODS:Medline and Embase databases were searched from origin and updated until February 2010. We included empirically based...

journal_title：British journal of clinical pharmacology

authors： Aagaard L,Christensen A,Hansen EH

更新日期：2010-10-01 00:00:00

abstract：:1 The inotropic effect of penbutolol, a new beta-adrenergic receptor blocking drug, has been compared with that of propranolol in two similar groups of six subjects each. 2 Inotropic changes were assessed from changes in myocardial contractility index [LV dp-dt/11 T] as well as the slope of the regression line relatin...

journal_title：British journal of clinical pharmacology

authors： Sapru RP,Sharma PL

更新日期：1978-12-01 00:00:00

abstract：:The pharmacokinetics of single and co-administered didanosine and stavudine were evaluated in 10 HIV-seropositive subjects in an open, within subject design in which each subject received each of three treatments. Single doses of didanosine 100 mg were alternated randomly with single doses of stavudine 40 mg on days 1...

journal_title：British journal of clinical pharmacology

authors： Seifert RD,Stewart MB,Sramek JJ,Conrad J,Kaul S,Cutler NR

更新日期：1994-11-01 00:00:00

abstract：:Twelve patients with acute uncomplicated falciparum malaria were admitted to the Hospital for Tropical Diseases for 42 days. The patients were treated with halofantrine 500 mg 6 hourly for three doses and halofantrine and its desbutyl metabolite were analysed in plasma by h.p.l.c. Cmax values of halofantrine and desbu...

journal_title：British journal of clinical pharmacology

authors： Karbwang J,Milton KA,Na Bangchang K,Ward SA,Edwards G,Bunnag D

更新日期：1991-04-01 00:00:00

abstract：AIMS:Intravenous formulations of busulfan have recently become available. Although busulfan is used frequently in children as part of a myeloablative regimen prior to bone marrow transplantation, pharmacokinetic data on intravenous busulfan in children are scarce. The aim was to investigate intravenous busulfan pharmac...

journal_title：British journal of clinical pharmacology

authors： Cremers S,Schoemaker R,Bredius R,den Hartigh J,Ball L,Twiss I,Vermeij P,Vossen J

更新日期：2002-04-01 00:00:00

abstract：:1. Ten healthy subjects received two treatments: a single 1 g oral dose of nalidixic acid (NA) followed 1 h later by either an infinitesimal dilution of the drug (NA 7CH) or by succussed water which served as placebo. The study was repeated 18 months later in 10 different subjects. 2. A further 10 healthy subjects rec...

journal_title：British journal of clinical pharmacology

authors： Ferry N,Bernard N,Pozet N,Gardes E,Bruguier M,Cuisinaud G,Sassard J

更新日期：1991-07-01 00:00:00

abstract：:1 Six healthy male volunteers received a total of 2500 mg of a new cephalosporin antibiotic Ro13-9904 by intramuscular injection in five divided doses at intervals of 12 h. 2 No significant systemic side-effects were observed and this was confirmed haematologically and biochemically. 3 The drug was distributed followi...

journal_title：British journal of clinical pharmacology

authors： Pickup ME,Bird HA,Lowe JR,Lees L,Wright V

更新日期：1981-08-01 00:00:00

abstract：:The effects of high and low urine flow rates on the urinary metabolic ratios for paracetamol glucuronidation, sulphation and oxidation were determined at steady-state in seven healthy young adult volunteers. Metabolic partial clearances were unaffected by urine flow rate, but individual paracetamol metabolic ratios va...

journal_title：British journal of clinical pharmacology

authors： Miners JO,Osborne NJ,Tonkin AL,Birkett DJ

更新日期：1992-10-01 00:00:00