Effect of an alpha- and beta-adrenoceptor-blocking agent (labetalol) on haemodynamics in hypertension.

abstract：AIMS:The aim of this study was to compare the effects of aspirin on platelet function as measured by the 'classical' template bleeding time with a new ex vivo method measuring closure times using the PFA-100 machine. Platelet aggregation in response to arachidonic acid was also measured ex vivo. METHODS:The trial was ...

journal_title：British journal of clinical pharmacology

authors： Marshall PW,Williams AJ,Dixon RM,Growcott JW,Warburton S,Armstrong J,Moores J

更新日期：1997-08-01 00:00:00

abstract：:The in vitro conversion of enalapril (MK421) to enalaprilic acid (MK422) in human autopsy tissues was examined. MK422 was measured by radioimmunoassay. Human cadaver liver was the only tissue in which significant conversion was demonstrated. The esterase activity was stable after post mortem. Autopsy liver tissues fro...

journal_title：British journal of clinical pharmacology

authors： Larmour I,Jackson B,Cubela R,Johnston CI

更新日期：1985-05-01 00:00:00

abstract：:Pharmacogenetic research dedicated to the investigation of inherited factors that influence drug response has produced exciting results over the past decade. Adding to the knowledge that genetic variation in metabolic enzymes may cause drug-related adverse reactions, recent studies indicate that variation in neurotran...

journal_title：British journal of clinical pharmacology

authors： Shaikh S,Kerwin RW

更新日期：2002-10-01 00:00:00

abstract：AIMS:Potassium channel openers (KCOs) are of potential therapeutic value. Little is known about the effect of these drugs on human conduit arteries used as coronary bypass grafts. The purpose of this study was to determine the effect of the KCO aprikalim (RP52891) on human arteries used as coronary bypass grafts with e...

journal_title：British journal of clinical pharmacology

authors： He GW,Yang CQ

更新日期：1997-10-01 00:00:00

abstract：:1. The in vitro metabolism of omeprazole was studied in human liver microsomes in order to define the secondary metabolic pathways and identify the cytochrome P450 (CYP) isoforms responsible for the formation of the secondary metabolites of omeprazole. 2. The major secondary omeprazole metabolite was the hydroxysulpho...

journal_title：British journal of clinical pharmacology

authors： Andersson T,Miners JO,Veronese ME,Birkett DJ

更新日期：1994-06-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Rotigotine transdermal patch is a new non-ergolinic dopamine agonist developed for the treatment of Parkinson's disease and restless legs syndrome. Peripheral dopaminergic side-effects of dopamine agonists such as nausea and vomiting can be prevented by the antiemetic agent domp...

journal_title：British journal of clinical pharmacology

authors： Braun M,Cawello W,Boekens H,Horstmann R

更新日期：2009-02-01 00:00:00

abstract：AIMS:To develop a population pharmacokinetic model for mycophenolic acid (MPA) in children with idiopathic nephrotic syndrome (INS) treated with mycophenolate mofetil (MMF), identify covariates that explain variability and determine the Bayesian estimator of the area under the concentration-time curve over 12 h (AUC(0-...

journal_title：British journal of clinical pharmacology

authors： Zhao W,Elie V,Baudouin V,Bensman A,André JL,Brochard K,Broux F,Cailliez M,Loirat C,Jacqz-Aigrain E

更新日期：2010-04-01 00:00:00

abstract：AIMS:Case reports and small case series suggest increased central nervous system (CNS) toxicity, especially convulsions, after overdose of mefenamic acid, compared with other nonsteroidal anti-inflammatory drugs (NSAIDs), although comparative epidemiological studies have not been conducted. The current study compared r...

journal_title：British journal of clinical pharmacology

authors： Kamour A,Crichton S,Cooper G,Lupton DJ,Eddleston M,Vale JA,Thompson JP,Thomas SH

更新日期：2017-04-01 00:00:00

abstract：:1. Endogenous dopamine, acting through specific receptors on blood vessels, renal tubules and adrenal cortical cells, may play a role in the development and maintenance of the hypertensive state. 2. In hypertensive patients, activation of the DA1-receptor with intravenous fenoldopam produces a rapid and sustained redu...

journal_title：British journal of clinical pharmacology

authors： Hieble JP,Eden RJ,de Mey C

更新日期：1990-01-01 00:00:00

abstract：:1 Comparison of phenytoin clearance showed a marked increase in people over 65 years of age compared with people under 45 years of age. 2 This difference was apparent if phenytoin was given orally or intravenously. 3 Phenytoin clearance correlated inversely with phenytoin binding and plasma albumin, both of which were...

journal_title：British journal of clinical pharmacology

authors： Hayes MJ,Langman MJ,Short AH

更新日期：1975-02-01 00:00:00

abstract：:Both the acute blood pressure lowering and renal effects of the calcium antagonist nicardipine and those after 1 week's treatment were investigated in 10 normotensive volunteers and in 10 patients with mild to moderate essential hypertension. After 1 week of placebo, nicardipine was administered orally for 1 week (20 ...

journal_title：British journal of clinical pharmacology

authors： van Schaik BA,van Nistelrooy AE,Geyskes GG

更新日期：1984-07-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Recently, we have shown that the plasma concentration of R-fexofenadine is greater than that of the S-enantiomer. Although itraconazole co-administration is known to increase the bioavailability of a racemic mixture of fexofenadine, little is known about the stereoselective inhi...

journal_title：British journal of clinical pharmacology

authors： Tateishi T,Miura M,Suzuki T,Uno T

更新日期：2008-05-01 00:00:00

abstract：:The absorption of the antiemetic metopimazine (MPZ) given as a single dose of (a) 40 mg microenema, (b) 40 mg orally and (c) 10 mg as a 60 min i.v. continuous infusion was investigated in six healthy volunteers. Blood samples were drawn and the serum concentrations of MPZ and its acid metabolite were measured. The bio...

journal_title：British journal of clinical pharmacology

authors： Herrstedt J,Jørgensen M,Angelo HR,Rassing MR,Møller-Sonnergaard J,Dombernowsky P

更新日期：1996-06-01 00:00:00

abstract：:1. The three dimensional requirements for inhibition of ACE (angiotensin converting enzyme) were investigated in order to facilitate design of a more potent and selective antihypertensive agent. 2. All compounds designed possessed a bicyclic unit incorporating carboxylate and amidic carbonyl groups together with a thi...

journal_title：British journal of clinical pharmacology

authors： Attwood MR

更新日期：1989-01-01 00:00:00

abstract：:1 The effect of acebutolol, a relatively selective beta-adrenoceptor blocking drug and propranolol, a non-selective one, on the hypoglycaemic action of glibenclamide after an oral glucose load has been investigated in a group of maturity-onset diabetic patients. 2 Glibenclamide significantly reduced the blood glucose ...

journal_title：British journal of clinical pharmacology

authors： Zaman R,Kendall MJ,Biggs PI

更新日期：1982-04-01 00:00:00

abstract：:The pharmacokinetics of single and co-administered didanosine and stavudine were evaluated in 10 HIV-seropositive subjects in an open, within subject design in which each subject received each of three treatments. Single doses of didanosine 100 mg were alternated randomly with single doses of stavudine 40 mg on days 1...

journal_title：British journal of clinical pharmacology

authors： Seifert RD,Stewart MB,Sramek JJ,Conrad J,Kaul S,Cutler NR

更新日期：1994-11-01 00:00:00

abstract：AIMS:Our study aimed to evaluate the impacts of the cytochrome P450 (CYP) 2B6-G516T and CYP2D6 genetic polymorphisms on pharmacokinetic and clinical parameters in patients receiving methadone maintenance treatment. METHODS:Opioid PhArmacoLogy (OPAL) was a clinical survey of the sociodemographic characteristics, histor...

journal_title：British journal of clinical pharmacology

authors： Victorri-Vigneau C,Verstuyft C,Bouquié R,Laforgue EJ,Hardouin JB,Leboucher J,Le Geay B,Dano C,Challet-Bouju G,Grall-Bronnec M

更新日期：2019-07-01 00:00:00

abstract：:1. The effects of salmeterol hydroxynaphthoate (50 micrograms, 8.3 x 10(-8) M) and salbutamol (200 micrograms, 3.5 x 10(-7) M) on sGaw were compared in a double-blind, placebo-controlled, randomised study in 10 normal subjects. 2. SGaw increased by 29% (14-43) (mean (CI)), 5 min after salmeterol and by 35% (19-51) at ...

journal_title：British journal of clinical pharmacology

authors： Spring J,Clague J,Ind PW

更新日期：1992-02-01 00:00:00

abstract：AIMS:To evaluate the potential ethnic differences in the pharmacokinetics (PK) and pharmacodynamics (PD) of evolocumab in Caucasian and Asian populations using population PK/PD modelling analysis. METHODS:Data from different ethnic groups in 5 Phase I clinical trials, including two American studies, one Japanese study...

journal_title：British journal of clinical pharmacology

authors： Wang C,Zheng Q,Zhang M,Lu H

更新日期：2019-01-01 00:00:00

abstract：:1. The oral kinetics of oxazepam after a single 15 mg oral dose was investigated in six healthy volunteers before and during concomitant administration of the beta-adrenoceptor antagonists propranolol (80 mg) and labetalol (200 mg) (racemates). 2. A possible pharmacodynamic interaction between oxazepam and the beta-ad...

journal_title：British journal of clinical pharmacology

authors： Sonne J,Døssing M,Loft S,Olesen KL,Vollmer-Larsen A,Victor MA,Hamberg O,Thyssen H

更新日期：1990-01-01 00:00:00

abstract：:The airway and cardiovascular effects of intravenous neurokinin A (NKA) and substance P (SP) were compared in six normal subjects. Both SP and NKA increased skin temperature (SkT) and heart rate (HR), but SP was more potent than NKA by factors of 6 and 20 respectively. No change in systolic blood pressure (BP) occurre...

journal_title：British journal of clinical pharmacology

authors： Evans TW,Dixon CM,Clarke B,Conradson TB,Barnes PJ

更新日期：1988-02-01 00:00:00

abstract：INTRODUCTION:Irrational medicine use is a global crisis, but incidences are proportionately higher in low and middle-income countries like Sierra Leone. This study explores the structure, functions, and challenges of Drug and Therapeutics Committees (DTC) an intervention towards irrational medicines use recently pilote...

journal_title：British journal of clinical pharmacology

authors： Kabba JA,Koroma MM,James PB,Kitchen C,Xu S,Chang J,Saeed A,Malik UR,Jiang M,Fang Y

更新日期：2021-01-04 00:00:00

abstract：:1. The pharmacokinetics of didanosine, trimethoprim, and sulphamethoxazole were evaluated in ten HIV seropositive asymptomatic patients as single agents and upon coadministration of single doses. 2. Using a randomized, balanced incomplete block crossover study with at least a 1-week washout period between successive t...

journal_title：British journal of clinical pharmacology

authors： Srinivas NR,Knupp CA,Batteiger B,Smith RA,Barbhaiya RH

更新日期：1996-03-01 00:00:00

abstract：AIMS:Roux-en-Y gastric bypass (RYGB) alters the anatomical structure of the gastrointestinal tract, which can result in alterations in drug disposition. The aim of the present study was to evaluate the oral disposition of two compounds belonging to the Biopharmaceutical Classification System Class II - fenofibrate (bil...

journal_title：British journal of clinical pharmacology

authors： Gesquiere I,Hens B,Van der Schueren B,Mols R,de Hoon J,Lannoo M,Matthys C,Foulon V,Augustijns P

更新日期：2016-11-01 00:00:00

abstract：AIMS:The aim of the present study was to determine how the pharmacokinetics of meloxicam are affected by kidney dysfunction and consequently to define the appropriate dose for the use of meloxicam in patients with mild or moderate renal impairment. METHODS:Meloxicam was administered to subjects with mild (creatinine c...

journal_title：British journal of clinical pharmacology

authors： Boulton-Jones JM,Geddes CG,Heinzel G,Türck D,Nehmiz G,Bevis PJ

更新日期：1997-01-01 00:00:00

abstract：AIMS:To study the pharmacokinetics and bioavailability of the prodrug bambuterol and its bronchodilator moiety terbutaline in healthy subjects. METHODS:Eight healthy subjects (four women) received intravenous doses of bambuterol and terbutaline. On a third occasion, they, plus another four subjects, ingested oral bamb...

journal_title：British journal of clinical pharmacology

authors： Nyberg L,Rosenborg J,Weibull E,Jönsson S,Kennedy BM,Nilsson M

更新日期：1998-05-01 00:00:00

abstract：AIMS:The aim was to examine relationships between total and unbound mycophenolic acid (MPA) and prednisolone exposure and clinical outcomes in patients with lupus nephritis. METHODS:Six blood samples were drawn pre- and at 1, 2, 4, 6 and 8 h post-dose and total and unbound MPA and prednisolone pre-dose (C0 ), maximum ...

journal_title：British journal of clinical pharmacology

authors： Abd Rahman AN,Tett SE,Abdul Gafor HA,McWhinney BC,Staatz CE

更新日期：2015-11-01 00:00:00

abstract：:1. The pharmacokinetics of butorphanol were evaluated in 18 female volunteers with varying degrees of renal function following a single, 1 mg transnasal dose of butorphanol tartrate. The creatinine clearance (CLCR) values for subjects in the normal (NOR), moderately impaired (MI), and severely impaired (SI) groups wer...

journal_title：British journal of clinical pharmacology

authors： Shyu WC,Morgenthien EA,Barbhaiya RH

更新日期：1996-05-01 00:00:00

abstract：:Widespread use of cocaine and its attendant toxicity has produced a wealth of benchwork studies and small animal investigations that evaluated the effects of cocaine on the cardiovascular system. Despite this wealth of knowledge, very little is known about the frequency or types of arrhythmias in patients with signifi...

journal_title：British journal of clinical pharmacology

authors： Hoffman RS

更新日期：2010-05-01 00:00:00

abstract：:1. The purpose of this study was to evaluate possible changes in brain morphology and evoked potentials associated with daily administration of 300 mg kg-1 vigabatrin in dogs. 2. Somatosensory evoked potentials (SEP) and auditory evoked potentials (AEP) were recorded at baseline and weekly for 12 weeks of treatment an...

journal_title：British journal of clinical pharmacology

authors： Arezzo JC,Schroeder CE,Litwak MS,Steward DL

更新日期：1989-01-01 00:00:00