The effect of acebutolol and propranolol on the hypoglycaemic action of glibenclamide.

abstract：:1. The human isolated basilar artery has been used as a model to investigate the aetiology of cerebral arterial spasm associated with rupture of intracranial aneurysms. 2. The isolated artery is contracted by 5-hydroxytryptamine, noradrenaline, six prostaglandins and cerebrospinal fluid from patients with ruptured ane...

journal_title：British journal of clinical pharmacology

authors： Boullin DJ,Mohan J

更新日期：1977-02-01 00:00:00

abstract：INTRODUCTION:Irrational medicine use is a global crisis, but incidences are proportionately higher in low and middle-income countries like Sierra Leone. This study explores the structure, functions, and challenges of Drug and Therapeutics Committees (DTC) an intervention towards irrational medicines use recently pilote...

journal_title：British journal of clinical pharmacology

authors： Kabba JA,Koroma MM,James PB,Kitchen C,Xu S,Chang J,Saeed A,Malik UR,Jiang M,Fang Y

更新日期：2021-01-04 00:00:00

abstract：AIMS:The effects of biologics on reproduction/lactation are mostly unknown although many patients that receive biologics are women of reproductive age. The first objective of this study was to investigate the publicly available data on pregnancy/lactation before and after marketing authorization in Europe of biologics ...

journal_title：British journal of clinical pharmacology

authors： Ghalandari N,Dolhain RJEM,Hazes JMW,Siezen CLE,van der Laan JW,Crijns HJMJ,van Puijenbroek EP,van der Woude CJ

更新日期：2020-03-01 00:00:00

abstract：AIMS:To characterize the pharmacokinetics (PK) of moxetumomab pasudotox, an anti-CD22 recombinant immunotoxin, in adults with relapsed or refractory hairy cell leukaemia, we examined data from a phase 1 study (Study 1001; n = 49) and from the pivotal clinical study (Study 1053; n = 74). METHODS:Data from both studies ...

journal_title：British journal of clinical pharmacology

authors： Kuruvilla D,Chia YL,Balic K,Yao NS,Kreitman RJ,Pastan I,Li X,Standifer N,Liang M,Tseng CM,Faggioni R,Roskos L

更新日期：2020-07-01 00:00:00

abstract：:1. In nine patients with essential hypertension, following single and multiple doses of ketanserin, assessments were made of blood pressure and heart rate, QT interval, and pressor responses to phenylephrine and angiotensin II. 2. Significant reductions in blood pressure occurred for 6 h after the first dose, on avera...

journal_title：British journal of clinical pharmacology

authors： Donnelly R,Elliott HL,Meredith PA,Reid JL

更新日期：1987-11-01 00:00:00

abstract：:The effect of anticonvulsant therapy on early morning concentration of cortisol in saliva and plasma was assessed in a group of epileptic patients receiving regular phenytoin medication and the results compared with those obtained from a group of normal subjects not receiving drug therapy. Values of cortisol in matche...

journal_title：British journal of clinical pharmacology

authors： Evans PJ,Walker RF,Peters JR,Dyas J,Riad-Fahmy D,Thomas JP,Rimmer E,Tsanaclis L,Scanlon MF

更新日期：1985-08-01 00:00:00

abstract：:A possible route of metabolism of beta-adrenoceptor stimulating drugs used in obstetrics consists of conjugation by the enzyme phenol sulphotransferase. The substrate specificities of the platelet and the placental enzymes towards these drugs were tested. The specific activities of the beta-adrenoceptor agonists were ...

journal_title：British journal of clinical pharmacology

authors： Sodha RJ,Schneider H

更新日期：1984-01-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the impact of new insights and revised guidelines on initial and follow-up treatment with antihyperglycaemic drugs over the period 1998-2003. METHODS:The InterAction Database (IADB), which contains pharmacy dispensing data from 53 community pharmacies in the Northern and E...

journal_title：British journal of clinical pharmacology

authors： Lub R,Denig P,van den Berg PB,Hoogenberg K,de Jong-van den Berg LT

更新日期：2006-12-01 00:00:00

abstract：:1. This study further examines the quinoline-derivative abanoquil with particular respect to the duration of its alpha 1-adrenoceptor antagonist activity and its concentration-effect relationship following a single intravenous bolus dose of 0.5 micrograms kg-1 in young, normotensive males. 2. alpha 1-adrenoceptor anta...

journal_title：British journal of clinical pharmacology

authors： Schafers RF,Elliott HL,Meredith PA,Miller SH,Reid JL

更新日期：1991-11-01 00:00:00

abstract：AIMS:Paracetamol-containing combination analgesics are widely prescribed but the use of paracetamol/dextropropoxyphene (co-proxamol) is particularly controversial. We aim to examine the prescribing patterns of the paracetamol-containing analgesics in Ireland. METHODS:A national primary care prescribing database was us...

journal_title：British journal of clinical pharmacology

authors： Usher C,Teeling M,Bennett K,McGowan B,Feely J

更新日期：2005-12-01 00:00:00

abstract：AIMS:SNF472 is a calcification inhibitor being developed for the treatment of cardiovascular calcification in haemodialysis (HD) and in calciphylaxis patients. This study investigated the safety, tolerability and pharmacokinetics (PK) of intravenous (IV) SNF472 in healthy volunteers (HV) and HD patients. METHODS:This ...

journal_title：British journal of clinical pharmacology

authors： Perelló J,Joubert PH,Ferrer MD,Canals AZ,Sinha S,Salcedo C

更新日期：2018-12-01 00:00:00

abstract：AIMS:To characterize determinants of the elimination of methotrexate (MTX) and 7-hydroxy-methotrexate (7-OH-MTX) in patients receiving high-dose MTX therapy (HDMTX). METHODS:24 and 48-h blood samples from 76 patients receiving HDMTX (dose range 300 mg m-2 to 12 g m-2) were analysed, and concentration-time data were su...

journal_title：British journal of clinical pharmacology

authors： Joerger M,Huitema AD,van den Bongard HJ,Baas P,Schornagel JH,Schellens JH,Beijnen JH

更新日期：2006-07-01 00:00:00

abstract：AIMS:To develop a population pharmacokinetic model for mycophenolic acid (MPA) in children with idiopathic nephrotic syndrome (INS) treated with mycophenolate mofetil (MMF), identify covariates that explain variability and determine the Bayesian estimator of the area under the concentration-time curve over 12 h (AUC(0-...

journal_title：British journal of clinical pharmacology

authors： Zhao W,Elie V,Baudouin V,Bensman A,André JL,Brochard K,Broux F,Cailliez M,Loirat C,Jacqz-Aigrain E

更新日期：2010-04-01 00:00:00

abstract：:The effects of separate 7 day pretreatments with sulphinpyrazone (800 mg daily) and cimetidine (1 g daily) on the disposition of (+/-)-verapamil have been examined in eight healthy volunteers (four male, four female). Each subject received single oral (80 mg) and intravenous (0.15 mg/kg) doses of verapamil on differen...

journal_title：British journal of clinical pharmacology

authors： Wing LM,Miners JO,Lillywhite KJ

更新日期：1985-03-01 00:00:00

abstract：:1. The effects of a single oral dose of enalapril 10 mg on serum ACE activity and blood pressure in relation to the ACE genotype were studied in 27 healthy men, n = 9 each of genotype DD, ID and II, in a parallel group study design. 2. Before treatment serum ACE activity differed significantly between the genotypes, w...

journal_title：British journal of clinical pharmacology

authors： Todd GP,Chadwick IG,Higgins KS,Yeo WW,Jackson PR,Ramsay LE

更新日期：1995-02-01 00:00:00

abstract：AIMS:To study the potential drug interaction between cimetidine and caffeine in a group of children who received cimetidine for gastritis. METHODS:The caffeine breath test was carried out prior to the administration of cimetidine and after 2-3 weeks therapy. The children (n = 1) received 300-800 mg cimetidine daily (1...

journal_title：British journal of clinical pharmacology

authors： Parker AC,Pritchard P,Preston T,Dalzell AM,Choonara I

更新日期：1997-05-01 00:00:00

abstract：:1 Apparent Vmax and Km for phenytoin were estimated in 40 children (aged 8--33 months) and 21 adults (aged 18--66 years). 2 The derived values of Vmax and Km were used to predict the plasma and salivary concentrations of phenytoin following a change in dose. There was a highly significant correlation between observed ...

journal_title：British journal of clinical pharmacology

authors： Blain PG,Mucklow JC,Bacon CJ,Rawlins MD

更新日期：1981-11-01 00:00:00

abstract：AIMS:Post licensing, the evaluation of drug safety relies heavily on the collation of sporadic, spontaneous reports on adverse effects. The aim was to assess the potential utility of a more systematic approach to the detection of adverse events that utilizes routinely collected clinical data from a large primary care p...

journal_title：British journal of clinical pharmacology

authors： Grosso A,Douglas I,Hingorani A,MacAllister R,Smeeth L

更新日期：2008-11-01 00:00:00

abstract：:We have measured the psychological effects of acebutolol and atenolol in sixteen patients with essential hypertension. The drugs were administered in a randomized, placebo-controlled, double-blind manner, in single daily doses of 100 mg atenolol, 400 mg acebutolol or placebo for periods of 6 weeks, each drug period be...

journal_title：British journal of clinical pharmacology

authors： Lewis MJ,Jones DM,Dart AM,Henderson AH

更新日期：1984-03-01 00:00:00

abstract：AIMS:The cytochrome P-450 2D6 (CYP2D6) gene duplication/multiduplication producing an increase in enzyme activity, and the common Japanese mutation, CYP2D6*10A producing a decrease of enzyme activity were screened in a large number of Japanese psychiatric subjects (n = 111) in order to investigate whether these mutated...

journal_title：British journal of clinical pharmacology

authors： Ohnuma T,Shibata N,Matsubara Y,Arai H

更新日期：2003-09-01 00:00:00

abstract：:1 The relationship between serum quinidine levels and rate-corrected QT (QTc) interval after administration of single identical doses of quinidine was assessed. Quinidine concentrations were determined by a modification of Hamfelt & Malers' (1963) method. The significance and clinical application of our findings is di...

journal_title：British journal of clinical pharmacology

authors： Edwards IR,Hancock BW,Saynor R

更新日期：1974-12-01 00:00:00

abstract：:At a James Black Conference held in Oxford on 20-22 June 2011, a group of senior clinical pharmacologists and their junior colleagues, other medical specialists, and pharmacists discussed an agenda for UK clinical pharmacology for the next 5 years, addressing the following broad questions. How should UK clinical pharm...

journal_title：British journal of clinical pharmacology

authors： Aronson JK

更新日期：2012-06-01 00:00:00

abstract：AIMS:Previously published pharmacokinetic (PK) models for sunitinib and its active metabolite SU12662 were based on a limited dataset or lacked important elements such as correlations between sunitinib and its metabolite. The current study aimed to develop an improved PK model that circumvented these limitations and to...

journal_title：British journal of clinical pharmacology

authors： Yu H,Steeghs N,Kloth JS,de Wit D,van Hasselt JG,van Erp NP,Beijnen JH,Schellens JH,Mathijssen RH,Huitema AD

更新日期：2015-05-01 00:00:00

abstract：AIM:Elevated serum creatinine (sCr) and low estimated glomerular filtration rate (eGFR) are associated with poor outcomes in patients with pulmonary arterial hypertension (PAH) whereas sildenafil treatment improves PAH outcomes. This post hoc analysis assessed the effect of sildenafil on kidney function and links with ...

journal_title：British journal of clinical pharmacology

authors： Webb DJ,Vachiery JL,Hwang LJ,Maurey JO

更新日期：2015-08-01 00:00:00

abstract：:1 A system is described for screening new chemical entities in normal human subjects, which is designed to search for novel drug actions at an early stage of drug development. 2 In single (subject) blind experiments, doses are increased incrementally from one subject to next, with immediate feed-back of results from e...

journal_title：British journal of clinical pharmacology

authors： Sullivan TJ,Croft AR,Hanka R,Roberts SJ

更新日期：1980-04-01 00:00:00

abstract：AIM:Drug-drug interactions between antimalarial and antiretroviral drugs may influence antimalarial treatment outcomes. The aim of this study was to investigate the potential drug-drug interactions between the antimalarial drugs, lumefantrine, artemether and their respective metabolites desbutyl-lumefantrine and dihydr...

journal_title：British journal of clinical pharmacology

authors： Hoglund RM,Byakika-Kibwika P,Lamorde M,Merry C,Ashton M,Hanpithakpong W,Day NP,White NJ,Äbelö A,Tarning J

更新日期：2015-04-01 00:00:00

abstract：:1. The study was performed to determine the sensitivity and short-term and day-to-day variability of a novel technique based on laser interferometry of ocular fundus pulsations and of non-invasive methods for the quantification of haemodynamic drug effects. An additional aim was to assess sex differences in haemodynam...

journal_title：British journal of clinical pharmacology

authors： Wolzt M,Schmetterer L,Rheinberger A,Salomon A,Unfried C,Breiteneder H,Ehringer H,Eichler HG,Fercher AF

更新日期：1995-04-01 00:00:00

abstract：AIMS:Genetic factors, notably CYP2B6 516G→T [rs3745274] and 983T→C [rs28399499], explain much of the interindividual variability in efavirenz pharmacokinetics, but data from Africa are limited. We characterized relationships between genetic polymorphisms and plasma efavirenz concentrations in HIV-infected Black South A...

journal_title：British journal of clinical pharmacology

authors： Sinxadi PZ,Leger PD,McIlleron HM,Smith PJ,Dave JA,Levitt NS,Maartens G,Haas DW

更新日期：2015-07-01 00:00:00

abstract：:1. We present a novel index for expressing the exposure of the infant to drugs in breast milk, which unifies two independent factors: a pharmacokinetic parameter, drug clearance, and a physiochemical parameter, i.e. milk-to-maternal plasma drug concentration ratio (M/P ratio). 2. During breast-feeding by a woman recei...

journal_title：British journal of clinical pharmacology

authors： Ito S,Koren G

更新日期：1994-08-01 00:00:00

abstract：:Acute myeloid leukaemia (AML) is a haematopoietic stem cell disorder, that is characterized by the clonal expansion of myeloid blasts and suppression of normal haematopoiesis. The 3 + 7 regimen is the backbone of standard first-line induction therapy among young/fit patients. However, in elderly and/or unfit patients ...

journal_title：British journal of clinical pharmacology

authors： Kucukyurt S,Eskazan AE

更新日期：2019-12-01 00:00:00