Lack of inhibitory effect of cimetidine on caffeine metabolism in children using the caffeine breath test.

Abstract:

AIMS:To study the potential drug interaction between cimetidine and caffeine in a group of children who received cimetidine for gastritis. METHODS:The caffeine breath test was carried out prior to the administration of cimetidine and after 2-3 weeks therapy. The children (n = 1) received 300-800 mg cimetidine daily (11-36 mg kg(-1) day(-1)). RESULTS:There was no significant change in the 2 h cumulative labelled CO2 following the administration of cimetidine (mean values 5.61% before and 4.87% during cimetidine; Student's t-test P > 0.2). CONCLUSIONS:Cimetidine did not have an inhibitory effect on the metabolism of caffeine in this group of children studied.

journal_name

Br J Clin Pharmacol

authors

Parker AC,Pritchard P,Preston T,Dalzell AM,Choonara I

doi

10.1046/j.1365-2125.1997.00589.x

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

467-70

issue

5

eissn

0306-5251

issn

1365-2125

journal_volume

43

pub_type

临床试验,杂志文章
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