Pharmacokinetics of phenytoin in children.

abstract：:When using biopsy pathology in clinical pharmacology to assess drug efficacy in the gastrointestinal tract, a number of questions must be answered: Is the biopsy necessary or more effective than macroscopic views by endoscopy? Can we extract maximal information from the specimen? Are there surrogate serum or other mar...

journal_title：British journal of clinical pharmacology

authors： Walker MM

更新日期：2003-11-01 00:00:00

abstract：AIMS:To investigate whether the drug-drug interaction between fexofenadine and ketoconazole is localized to efflux transport proteins of the small intestine, and to determine and classify the effective jejunal permeability (Peff) of fexofenadine according to the Biopharmaceutics Classification System (BCS). METHODS:Tw...

journal_title：British journal of clinical pharmacology

authors： Tannergren C,Knutson T,Knutson L,Lennernäs H

更新日期：2003-02-01 00:00:00

abstract：:The effect of liver cirrhosis on plasma clearance and metabolite profile of i.v. administered antipyrine was studied in 23 patients with alcoholic liver cirrhosis (age 37-70 years) and 17 healthy subjects (age 28-55 years). Liver volume was also measured and was found to be larger in patients than in controls, mean va...

journal_title：British journal of clinical pharmacology

authors： Teunissen MW,Spoelstra P,Koch CW,Weeda B,van Duyn W,Janssens AR,Breimer DD

更新日期：1984-11-01 00:00:00

abstract：:Highly active antiretroviral therapy is recommended for HIV-infected pregnant women to prevent mother-to-child transmission. The specific physiological background induced by pregnancy leads to significant changes in maternal pharmacokinetics, suggesting potential variability in plasma concentrations of antiretrovirals...

journal_title：British journal of clinical pharmacology

authors： Roustit M,Jlaiel M,Leclercq P,Stanke-Labesque F

更新日期：2008-08-01 00:00:00

abstract：:1. We have tested the hypothesis that the fall in hepatic mass with age influences the age related increase in sensitivity to warfarin. In 39 otherwise healthy outpatients, aged 50-87 years, stabilised on warfarin for prophylaxis of thromboembolism, age, mean International Normalised Ratio (INR), and mean warfarin dos...

journal_title：British journal of clinical pharmacology

authors： Wynne H,Cope L,Kelly P,Whittingham T,Edwards C,Kamali F

更新日期：1995-09-01 00:00:00

abstract：:Systemic cardiovascular effects during chronic treatment with topical minoxidil vs placebo were evaluated using a double-blind, randomized design for two parallel groups (n = 20 for minoxidil, n = 15 for placebo). During 6 months of follow-up, blood pressure did not change, whereas minoxidil increased heart rate by 3-...

journal_title：British journal of clinical pharmacology

authors： Leenen FH,Smith DL,Unger WP

更新日期：1988-10-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Randomized controlled trials (RCTs) are believed to be one of the best methods of clinical research because they can minimize systematic errors of various types. Temporal trends in the various aspects of RCTs have been studied in several medical fields (e.g. nephrology, hepatolo...

journal_title：British journal of clinical pharmacology

authors： Falagas ME,Pitsouni EI,Bliziotis IA

更新日期：2008-06-01 00:00:00

abstract：AIMS:Antithrombin is increasingly used in paediatric patients, yet there are few age-specific pharmacokinetic data to guide dosing. We aimed to describe the pharmacokinetic profile of human (plasma-derived) antithrombin concentrate in paediatric patients. METHODS:A 5-year retrospective review was performed of patients...

journal_title：British journal of clinical pharmacology

authors： Moffett BS,Diaz R,Galati M,Mahoney D,Teruya J,Yee DL

更新日期：2017-11-01 00:00:00

abstract：:1. A 1.25 mg dose of cilazapril, a new angiotensin-converting enzyme (ACE) inhibitor, was administered orally to two groups of hypertensive patients, five with normal renal function (NRF) and seven with impaired renal function (IRF), once daily for 5 or 8 consecutive days. Blood pressure, heart rate and serum ACE acti...

journal_title：British journal of clinical pharmacology

authors： Shionoiri H,Gotoh E,Sugimoto K,Takasaki I,Minamisawa K,Ishii M

更新日期：1989-01-01 00:00:00

abstract：AIMS:A recent case report had suggested a citrus soft drink (Sun Drop) may have caused clinically relevant elevations in ciclosporin levels through a grapefruit juice-like mechanism via inactivation of intestinal cytochrome P450 3A4 (CYP3A4). This study was conducted to investigate the effect of grapefruit juice and ci...

journal_title：British journal of clinical pharmacology

authors： Schwarz UI,Johnston PE,Bailey DG,Kim RB,Mayo G,Milstone A

更新日期：2006-10-01 00:00:00

abstract：:Widespread use of cocaine and its attendant toxicity has produced a wealth of benchwork studies and small animal investigations that evaluated the effects of cocaine on the cardiovascular system. Despite this wealth of knowledge, very little is known about the frequency or types of arrhythmias in patients with signifi...

journal_title：British journal of clinical pharmacology

authors： Hoffman RS

更新日期：2010-05-01 00:00:00

abstract：:The effect of salbutamol on bronchoconstriction induced by inhaled sodium metabisulphite has been studied in 12 atopic subjects. Salbutamol (200 micrograms, 3.5 x 10(-7) M) and matched placebo were administered by identical metered dose inhaler 15 min before a dose-response to sodium metabisulphite (1.25-100 mg ml-1) ...

journal_title：British journal of clinical pharmacology

authors： Iredale MJ,Dixon CM,Ind PW

更新日期：1991-11-01 00:00:00

abstract：AIMS:To determine role of CYP2D6 activity in the pharmacokinetics of propafenone (PPF) enantiomers in native Chinese subjects. METHODS:Sixteen extensive metabolizers (EMs) and one poor metabolizer (PM), whose phenotype had been previously assessed with dextromethorphan metabolic phenotyping, were enrolled. Blood sampl...

journal_title：British journal of clinical pharmacology

authors： Cai WM,Chen B,Cai MH,Chen Y,Zhang YD

更新日期：1999-05-01 00:00:00

abstract：:1 Previous studies of propranolol disposition in renal failure have been conflicting. 2 Using simultaneous administration of [3H]-propranolol intravenously and unlabelled propranolol orally the principal determinants of drug distribution were calculated in normals, patients with severe renal impairment (creatinine cle...

journal_title：British journal of clinical pharmacology

authors： Wood AJ,Vestal RE,Spannuth CL,Stone WJ,Wilkinson GR,Shand DG

更新日期：1980-12-01 00:00:00

abstract：:Plasma melatonin was used to determine overall beta-adrenergic transmission through pineal neuro-effector junctions during desmethylimipramine (DMI) treatment in 10 normal subjects. Changes in plasma melatonin indicated that an initial increase in noradrenaline (NA) transmission produced by DMI was counteracted by ada...

journal_title：British journal of clinical pharmacology

authors： Cowen PJ,Green AR,Grahame-Smith DG,Braddock LE

更新日期：1985-06-01 00:00:00

abstract：:1 Nineteen pregnant patients whose mean arterial pressure (MAP) was persistently greater than or equal to 103.3 mmHg were given labetalol or methyldopa. 2 Singificant falls (P less than 0.001) in BP only occurred in the group treated with labetalol, and daily BP control was better in this group. 3 Two severely hyperte...

journal_title：British journal of clinical pharmacology

authors： Lamming GD,Symonds EB

更新日期：1979-04-01 00:00:00

abstract：:1. Nine healthy volunteers received 10 mg nitrendipine or placebo orally in random order. 2. In the subsequent 5 h urinary sodium excretion was 20% higher after nitrendipine, without any significant difference between the volume of urine excreted after nitrendipine or placebo. Mean blood pressure fell by 5 mm Hg (P le...

journal_title：British journal of clinical pharmacology

authors： Forsyth DR,Roberts CJ

更新日期：1990-10-01 00:00:00

abstract：:1. The relationship between the metabolism of the antiarrhythmic drug mexiletine and the debrisoquine/sparteine-type polymorphism was studied in vitro, using microsomes from six human livers, and in vivo, in nine healthy drug-free volunteers with wide variation in their ability to hydroxylate debrisoquine. 2. There wa...

journal_title：British journal of clinical pharmacology

authors： Broly F,Vandamme N,Libersa C,Lhermitte M

更新日期：1991-10-01 00:00:00

abstract：:1. The study was performed to determine the sensitivity and short-term and day-to-day variability of a novel technique based on laser interferometry of ocular fundus pulsations and of non-invasive methods for the quantification of haemodynamic drug effects. An additional aim was to assess sex differences in haemodynam...

journal_title：British journal of clinical pharmacology

authors： Wolzt M,Schmetterer L,Rheinberger A,Salomon A,Unfried C,Breiteneder H,Ehringer H,Eichler HG,Fercher AF

更新日期：1995-04-01 00:00:00

abstract：:1 A single-blind randomized study of the effects of a beta-adrenoceptor antagonist with intrinsic sympathomimetic activity (pindolol 0.4 mg i.v., n = 10) and a drug lacking this property (metoprolol 5 mg i.v., n = 11) on local wall motion abnormalities was carried out in 21 patients with coronary heart disease and ant...

journal_title：British journal of clinical pharmacology

authors： Gleichmann U,Fassbender D,Trieb G,Mannebach H,Ohlmeier H

更新日期：1982-01-01 00:00:00

abstract：:1 In healthy male volunteers dazoxiben (UK 37248), an inhibitor of thromboxane synthetase, abolished the arterial and venous vasoconstriction produced in the forearm by cold stimulation. 2 Aspirin alone had no effect on this vasoconstriction but negated the effect of dazoxiben. 3 In vitro dazoxiben increased the produ...

journal_title：British journal of clinical pharmacology

authors： Cowley AJ,Jones EW,Hanley SP

更新日期：1983-01-01 00:00:00

abstract：AIMS:To assess safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity of CNTO 7160, an anti-interleukin-33 receptor (IL-33R) monoclonal antibody, in healthy subjects and patients with asthma or atopic dermatitis (AD). METHODS:In Part 1 of this Phase I, randomized, double-blind, placebo-c...

journal_title：British journal of clinical pharmacology

authors： Nnane I,Frederick B,Yao Z,Raible D,Shu C,Badorrek P,van den Boer M,Branigan P,Duffy K,Baribaud F,Fink D,Yang TY,Xu Z

更新日期：2020-12-01 00:00:00

abstract：:A new osmotic drug delivery system (Oros) has been evaluated in multiple-dose studies in young healthy volunteers as a sustained-release vehicle for once-daily administration of oxprenolol. Two Oros systems were examined in two separate studies, one containing 170 mg oxprenolol succinate with an initial zero-order rel...

journal_title：British journal of clinical pharmacology

authors： Woods KL,Jack DB,Kendall MJ,Halsey A,O'Donnell ML,Warrington SJ,John VA

更新日期：1985-01-01 00:00:00

abstract：AIMS:Potassium channel openers (KCOs) are of potential therapeutic value. Little is known about the effect of these drugs on human conduit arteries used as coronary bypass grafts. The purpose of this study was to determine the effect of the KCO aprikalim (RP52891) on human arteries used as coronary bypass grafts with e...

journal_title：British journal of clinical pharmacology

authors： He GW,Yang CQ

更新日期：1997-10-01 00:00:00

abstract：:Propranolol induced changes in blood plasma chemistry were followed in thirty hypertensive patients (WHO I-II) who were seen each week during 14-15 weeks. The initial 4 weeks were a drug free period and the next 2 weeks were a drug adjustment period. After that the patients were on an unchanged propranolol dose for 8 ...

journal_title：British journal of clinical pharmacology

authors： Andreasen F,Jakobsen P,Kornerup HJ,Pedersen EB,Pedersen OL,Weeke J

更新日期：1984-03-01 00:00:00

abstract：:1. Metoprolol (ME), pindolol (PI) and propranolol (PR) were studied in nine subjects at different doses and at 'maximum beta-adrenoceptor blockade' at a defined exercise load. Exercise tests were performed after each dosing period; isoprenaline stimulation was studied at the highest dose level. 2. ME and PR reduced he...

journal_title：British journal of clinical pharmacology

authors： Gugler R,Krist R,Raczinski H,Höffgen K,Bodem G

更新日期：1980-10-01 00:00:00

abstract：:The present study was designed to evaluate the potential anti-ischaemic activity of R 56865 in patients with coronary artery disease, scheduled to undergo percutaneous transluminal coronary angioplasty (PTCA). At baseline a complete haemodynamic profile, including cardiac output and coronary sinus blood flow (CSBF) wa...

journal_title：British journal of clinical pharmacology

authors： Pijl AJ,Van Wezel HB,Koolen JJ,Piek JJ,Koch K,Swaan A,David GK,Visser CA,Van Zwieten PA

更新日期：1995-05-01 00:00:00

abstract：:1 Chronic treatment with a constant dose of hydrochlorothiazide or tienilic acid increases plasma renin activity (PRA) acutely to reach a maximum within the first week. 2 During chronic diuretic therapy from 1 month to 1 year, PRA remained elevated at a rather constant level, though this was somewhat lower than the ma...

journal_title：British journal of clinical pharmacology

authors： Lijnen P,Fagard R,Staessen J,Amery A

更新日期：1981-09-01 00:00:00

abstract：:1 Norfenfluramine is thought to be the major active metabolite of fenfluramine in man. Therefore its in vitro effect on lipogenesis in human adipose tissue from twelve patients was investigated. 2 Although inhibition of lipogenesis was demonstrated, the concentrations of norfenfluramine necessary (>1 mM) were much hig...

journal_title：British journal of clinical pharmacology

authors： Ashwell M

更新日期：1974-10-01 00:00:00

abstract：AIMS:Variability in responsiveness to clopidogrel is a clinical problem in secondary prevention after cerebral ischaemia which has been suggested to be linked to competitive metabolization of clopidogrel and cytochrome P450 (CYP) 3A4-oxidated statins such as simvastatin. We assessed the hypothesis that simvastatin, in ...

journal_title：British journal of clinical pharmacology

authors： Siepmann T,Heinke D,Kepplinger J,Barlinn K,Gehrisch S,Grählert X,Schwanebeck U,Reichmann H,Puetz V,Bodechtel U,Gahn G

更新日期：2014-11-01 00:00:00