Nitrendipine and the humoral control of sodium homeostasis.

abstract：AIMS:This study investigates paediatric drug dosage guidelines with the aim of investigating their agreement with body surface area (BSA) scaling principles. METHODS:A total of 454 drug dosage guidelines listed in the AMH-CDC 2015 were examined. Data extracted included the administration, frequency and dose per age br...

journal_title：British journal of clinical pharmacology

authors： Chitty KM,Chan B,Pulanco CL,Luu S,Egunsola O,Buckley NA

更新日期：2018-05-01 00:00:00

abstract：:1. In order to investigate accurately the biochemical effects of renin inhibition in man, we have developed a sensitive assay to measure angiotensin I (1-10) decapeptide. 2. Angiotensins were extracted from plasma by adsorption to phenylsilylsilica, and angiotensin I (Ang I) was quantified by radioimmunoassay. The det...

journal_title：British journal of clinical pharmacology

authors： Chauveau D,Guyenne TT,Cumin F,Chatellier G,Corvol P,Ménard J

更新日期：1992-03-01 00:00:00

abstract：AIMS:To assess whether hospitalization may assist in correcting errors in anticoagulant therapy among patients with atrial fibrillation (AF). METHODS:Our cohort included patients admitted to our institution with a history of AF between 2016 and 2018. We categorized patient's treatment upon admission and discharge as l...

journal_title：British journal of clinical pharmacology

authors： Angel Y,Zeltser D,Berliner S,Ingbir M,Shapira I,Shenhar-Tsarfaty S,Rogowski O

更新日期：2019-12-01 00:00:00

abstract：:Nine young and 12 elderly healthy volunteers received nisoldipine 10 mg once a day for 7 days. Plasma nisoldipine concentrations were measured on Day 1 and on Day 7. Higher plasma drug concentrations were observed in the elderly group than in the young group with the values for AUC being approximately doubled in the e...

journal_title：British journal of clinical pharmacology

authors： Baksi AK,Edwards JS,Ahr G

更新日期：1991-03-01 00:00:00

abstract：AIMS:The aim of the present study was to investigate whether differences in total and peak drug exposure upon generic substitution are due to differences between formulations or to intrasubject pharmacokinetic variability of the active substance. METHODS:The study was designed as a retrospective reanalysis of existing...

journal_title：British journal of clinical pharmacology

authors： Yu Y,Teerenstra S,Neef C,Burger D,Maliepaard M

更新日期：2016-04-01 00:00:00

abstract：AIMS:Ibandronate, a highly potent nitrogen-containing bisphosphonate, is the subject of an ongoing clinical development programme that aims to maximize the potential of simplified, less frequent oral and intravenous (i.v.) administration in osteoporosis. A modelling and simulation project was undertaken to characterize...

journal_title：British journal of clinical pharmacology

authors： Pillai G,Gieschke R,Goggin T,Jacqmin P,Schimmer RC,Steimer JL

更新日期：2004-12-01 00:00:00

abstract：AIMS:To characterize the pharmacokinetics (PK) of moxetumomab pasudotox, an anti-CD22 recombinant immunotoxin, in adults with relapsed or refractory hairy cell leukaemia, we examined data from a phase 1 study (Study 1001; n = 49) and from the pivotal clinical study (Study 1053; n = 74). METHODS:Data from both studies ...

journal_title：British journal of clinical pharmacology

authors： Kuruvilla D,Chia YL,Balic K,Yao NS,Kreitman RJ,Pastan I,Li X,Standifer N,Liang M,Tseng CM,Faggioni R,Roskos L

更新日期：2020-07-01 00:00:00

abstract：AIMS:Statins have been suggested to prevent haematological malignancies. Several epidemiological studies have evaluated this association, while randomized controlled trials (RCTs) on cardiovascular outcomes have provided relevant data as secondary end-points. Our aim was to examine the strength of this association thro...

journal_title：British journal of clinical pharmacology

authors： Bonovas S,Filioussi K,Tsantes A,Sitaras NM

更新日期：2007-09-01 00:00:00

abstract：:1. The objective of this study was to investigate the efficacy of home-medicated non-steroidal anti-inflammatory (NSAID) analgesics, using an electronic patient diary. Single doses of ketoprofen 25 mg and ketoprofen 50 mg were compared with ibuprofen 200 mg and placebo in the treatment of a single occasion of episodic...

journal_title：British journal of clinical pharmacology

authors： van Gerven JM,Schoemaker RC,Jacobs LD,Reints A,Ouwersloot-van der Meij MJ,Hoedemaker HG,Cohen AF

更新日期：1996-10-01 00:00:00

abstract：:In a double-blind, placebo-controlled, randomised, cross-over study of six healthy male subjects, the effect of nicardipine (5 mg h-1 for 3 h) on basal and stimulated pituitary hormone release was examined. Statistically significant differences between nicardipine and placebo were seen occasionally for follicle-stimul...

journal_title：British journal of clinical pharmacology

authors： Isles TE,Baty J,Dow RJ

更新日期：1985-01-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:• Terutroban is a selective TP receptor antagonist, i.e. a specific antagonist of the thromboxane A(2) and prostaglandin endoperoxide receptors, shown to improve endothelial function after a single administration in patients with coronary artery disease. WHAT THIS STUDY ADDS:• ...

journal_title：British journal of clinical pharmacology

authors： Lesault PF,Boyer L,Pelle G,Covali-Noroc A,Rideau D,Akakpo S,Teiger E,Dubois-Randé JL,Adnot S

更新日期：2011-06-01 00:00:00

abstract：:Ten volunteers carried a 10 mg 24 h -1 transdermal glyceryl trinitrate (GTN) patch for 24 h before moderate exercise. Plasma GTN-concentration increased significantly (P less than 0.05) by 19% to peak value at 15 min. Two hours after patch renewal repeat exercise increased GTN concentration by 56% (P less than 0.001)....

journal_title：British journal of clinical pharmacology

authors： Gjesdal K,Klemsdal TO,Rykke EO,Bredesen JE

更新日期：1991-05-01 00:00:00

abstract：:The pharmacokinetics of four sustained-release formulations of theophylline have been examined after single doses (Nuelin SA, Phyllocontin, Slo-phyllin and Theo-Dur) and at steady-state (Phyllocontin, Theo-Dur) in six healthy adult volunteers, selected because they all eliminated theophylline rapidly after an intraven...

journal_title：British journal of clinical pharmacology

authors： Mucklow JC,Kuhn S

更新日期：1985-12-01 00:00:00

abstract：:The airway and cardiovascular effects of intravenous neurokinin A (NKA) and substance P (SP) were compared in six normal subjects. Both SP and NKA increased skin temperature (SkT) and heart rate (HR), but SP was more potent than NKA by factors of 6 and 20 respectively. No change in systolic blood pressure (BP) occurre...

journal_title：British journal of clinical pharmacology

authors： Evans TW,Dixon CM,Clarke B,Conradson TB,Barnes PJ

更新日期：1988-02-01 00:00:00

abstract：:1 The effects of the thromboxane synthetase inhibitor dazoxiben (UK 37248) on haemodynamics, blood gases, thromboxane and prostacyclin release and on arrhythmias were examined in anaesthetised greyhounds subject to acute coronary artery occlusion and reperfusion. 2 Ten minutes after the administration of UK 37248 2 mg...

journal_title：British journal of clinical pharmacology

authors： Coker SJ,Parratt JR

更新日期：1983-01-01 00:00:00

abstract：:1. Using human mononuclear leucocytes as target cells, we have investigated the bioactivation of dapsone (DDS) to a cytotoxic metabolite in the presence of microsomes from nine human livers. Values for NADPH dependent toxicity ranged from 8.8-27% (15.8 +/- 5.9%) and were similar to those for microsomes from control mi...

journal_title：British journal of clinical pharmacology

authors： Coleman MD,Breckenridge AM,Park BK

更新日期：1989-10-01 00:00:00

abstract：:Quantitative systems pharmacology (QSP) is a relatively new discipline within modelling and simulation that has gained wide attention over the past few years. The application of QSP models spans drug-target identification and validation, through all drug development phases as well as clinical applications. Due to thei...

journal_title：British journal of clinical pharmacology

authors： Derbalah A,Al-Sallami H,Hasegawa C,Gulati A,Duffull SB

更新日期：2020-07-04 00:00:00

abstract：BACKGROUND:Benzodiazepines and "Z drugs" are often prescribed in residents of nursing homes (NH) despite their well-known deleterious effects. We aimed to investigate if a general intervention on quality of care led to discontinuation of benzodiazepine, and to examine which NH-related factors were associated in change ...

journal_title：British journal of clinical pharmacology

authors： de Souto Barreto P,Lapeyre-Mestre M,Cestac P,Vellas B,Rolland Y

更新日期：2016-04-01 00:00:00

abstract：AIMS:To study reporting of hypoglycaemia in angiotensin receptor blocker (ARB) users, and to investigate the possibility of confounding. METHODS:The French pharmacovigilance database was examined for an association between hypoglycaemia and ARBs or other drugs using reports notified between 1996 and 2005. This associa...

journal_title：British journal of clinical pharmacology

authors： Grégoire F,Pariente A,Fourrier-Reglat A,Haramburu F,Bégaud B,Moore N

更新日期：2008-07-01 00:00:00

abstract：:Essential hypertension is an escalating problem for industrialized populations. It is currently seen as a 'complex' genetic trait caused by multiple susceptibility genes the effects of which are modulated by gene-environment and gene-gene interactions. Nevertheless, the success to date in identifying these susceptibil...

journal_title：British journal of clinical pharmacology

authors： O'Shaughnessy KM

更新日期：2001-01-01 00:00:00

abstract：:1 The bronchodilating efficacy and the degree of beta2-adrenoceptor selectivity of rimiterol, salbutamol and isoprenaline were determined in seven subjects who exhibited histamine-induced bronchoconstriction. 2 Rimiterol, 0.5 (high dose) and 0.05 (low dose) mug kg-1 min-1, salbutamol, 0.3 and 0.03 mug kg-1 min-1, isop...

journal_title：British journal of clinical pharmacology

authors： Marlin GE,Turner P

更新日期：1975-02-01 00:00:00

abstract：AIMS:Hypertension is a common comorbidity of patients with COVID-19, SARS or HIV infection. Such patients are often concomitantly treated with antiviral and antihypertensive agents, including ritonavir and nifedipine. Since ritonavir is a strong inhibitor of CYP3A and nifedipine is mainly metabolized via CYP3A, the com...

journal_title：British journal of clinical pharmacology

authors： Niu W,Li S,Jin S,Lin X,Zhang M,Cai W,Jiao Z,Xiang X

更新日期：2020-12-02 00:00:00

abstract：:The burgeoning problem of malaria in the developing world and the relentless march of drug resistance demand that we continue to seek new chemotherapeutic strategies. Given the enormous expense of developing and marketing new chemical entities, we often rely on an increased understanding of the pharmacology of older d...

journal_title：British journal of clinical pharmacology

authors： Edwards G,Biagini GA

更新日期：2006-06-01 00:00:00

abstract：AIMS:To compare the disposition of fluoxetine and norfluoxetine enantiomers in the mother, foetus and infant. METHODS:Blood from pregnant women taking fluoxetine (n = 9), during pregnancy was sampled in the third trimester and at delivery (maternal and cord venous blood), and from the infants 48 h after delivery. The ...

journal_title：British journal of clinical pharmacology

authors： Kim J,Riggs KW,Misri S,Kent N,Oberlander TF,Grunau RE,Fitzgerald C,Rurak DW

更新日期：2006-02-01 00:00:00

abstract：:In many endoscopy units midazolam is replacing diazepam as the intravenous sedative of first choice. Midazolam is approximately twice as potent as diazepam. Although generally considered a safe drug, there have been a number of recent reports, particularly in the elderly, of the drug causing hypotension, respiratory d...

journal_title：British journal of clinical pharmacology

authors： Bell GD,Spickett GP,Reeve PA,Morden A,Logan RF

更新日期：1987-02-01 00:00:00

abstract：AIMS:The aim was to examine relationships between total and unbound mycophenolic acid (MPA) and prednisolone exposure and clinical outcomes in patients with lupus nephritis. METHODS:Six blood samples were drawn pre- and at 1, 2, 4, 6 and 8 h post-dose and total and unbound MPA and prednisolone pre-dose (C0 ), maximum ...

journal_title：British journal of clinical pharmacology

authors： Abd Rahman AN,Tett SE,Abdul Gafor HA,McWhinney BC,Staatz CE

更新日期：2015-11-01 00:00:00

abstract：AIMS:This double-blind, randomized, four-period, two-way crossover study was conducted to evaluate the acute effects of oral sildenafil (100-mg single dose) on sperm motility, count, density, morphology and vitality as well as ejaculate volume and viscosity in healthy male subjects. The concentrations of sildenafil and...

journal_title：British journal of clinical pharmacology

authors： Purvis K,Muirhead GJ,Harness JA

更新日期：2002-01-01 00:00:00

abstract：:1 A double-blind trial with parallel treatment groups was conducted to compare the safety and efficacy of mianserin with amitriptyline. 2 This was a six week trial with weekly visits. Measurements at each visit included: 21 item Hamilton Depression (HAMD) Scale. Clinical Global Impression (CGI) Scale and Treatment Eme...

journal_title：British journal of clinical pharmacology

authors： Feighner JP,Jacobs RS,Jackson RE,Hendrickson G,Merideth CH,O'Meara PD

更新日期：1983-01-01 00:00:00

abstract：:1. The efficacy of a metered dose inhaler (MDI) is highly dependent on the mode of inhalation. The relatively high built-in resistance in the Turbohaler (TBH), a new dry powder inhaler device for inhalation of terbutaline sulphate and budesonide, reduces the flow during inhalation. We compared five different modes of ...

journal_title：British journal of clinical pharmacology

authors： Engel T,Scharling B,Skovsted B,Heinig JH

更新日期：1992-04-01 00:00:00

abstract：:1 The new converting enzyme inhibitor RHC 3659 was tested in 15 male volunteers. The study consisted of two parts: first, the ability of a single oral dose (5, 10, 20, 40 or 80 mg) to inhibit the pressor response to exogenous angiotensin I was tested with blood pressure and heart rate monitored continuously through an...

journal_title：British journal of clinical pharmacology

authors： Burnier M,Turini GA,Brunner HR,Porchet M,Kruithof D,Vukovich RA,Gavras H

更新日期：1981-12-01 00:00:00