RHC 3659: a new orally active angiotensin converting enzyme inhibitor in normal volunteers.

abstract：:1 Roth et al. (1972) have proposed that within the affective disorders there are two distinct syndromes--anxiety and depression--differentiated by the relative predominance of these symptoms, the presence or absence of premorbid maladaptive traits, and the natural outcome of the disorder. 2 Goldberg (1982) on the othe...

journal_title：British journal of clinical pharmacology

authors： Russell GF,De Silva P

更新日期：1983-01-01 00:00:00

abstract：AIMS:The aim was to examine relationships between total and unbound mycophenolic acid (MPA) and prednisolone exposure and clinical outcomes in patients with lupus nephritis. METHODS:Six blood samples were drawn pre- and at 1, 2, 4, 6 and 8 h post-dose and total and unbound MPA and prednisolone pre-dose (C0 ), maximum ...

journal_title：British journal of clinical pharmacology

authors： Abd Rahman AN,Tett SE,Abdul Gafor HA,McWhinney BC,Staatz CE

更新日期：2015-11-01 00:00:00

abstract：AIMS:To analyse clinical outcomes with direct oral anticoagulants in patients with atrial fibrillation according to geographic region. METHODS:We systematically searched MEDLINE, CENTRAL, websites of regulatory agencies, clinical trials registers and conference proceedings for randomized controlled trials of direct or...

journal_title：British journal of clinical pharmacology

authors： Gómez-Outes A,Terleira-Fernández AI,Calvo-Rojas G,Suárez-Gea ML,Vargas-Castrillón E

更新日期：2016-09-01 00:00:00

abstract：AIMS:Previous pharmacokinetic characterization of a transporter probe cocktail containing digoxin (P-gp), furosemide (OAT1, OAT3), metformin (OCT2, MATE1, MATE2-K) and rosuvastatin (OATP1B1, OATP1B3, BCRP) in healthy subjects showed increases in rosuvastatin systemic exposure compared to rosuvastatin alone. In this tri...

journal_title：British journal of clinical pharmacology

authors： Stopfer P,Giessmann T,Hohl K,Hutzel S,Schmidt S,Gansser D,Ishiguro N,Taub ME,Sharma A,Ebner T,Müller F

更新日期：2018-09-01 00:00:00

abstract：AIMS:Oral L-arginine supplementation has been used in several studies to improve endothelium-dependent, nitric oxide (NO)-mediated vasodilation. L-Arginine treatment is hampered by extensive presystemic elimination due to intestinal arginase activity. In contrast, L-citrulline is readily absorbed and at least in part c...

journal_title：British journal of clinical pharmacology

authors： Schwedhelm E,Maas R,Freese R,Jung D,Lukacs Z,Jambrecina A,Spickler W,Schulze F,Böger RH

更新日期：2008-01-01 00:00:00

abstract：ADVERSE EVENT:Repeated and prolonged episodes of central apnoea and hypoxia after receiving intravenous morphine for analgesia and ketamine for sedation. DRUG IMPLICATED:Intravenous morphine sulfate. THE PATIENT:Previously healthy 12-year-old male with no history of sleep apnoea who presented with distal tibia and fi...

journal_title：British journal of clinical pharmacology

authors： Toce MS,Kim H,Chung S,Krauss BS

更新日期：2019-01-01 00:00:00

abstract：:1 Six healthy male volunteers received a total of 2500 mg of a new cephalosporin antibiotic Ro13-9904 by intramuscular injection in five divided doses at intervals of 12 h. 2 No significant systemic side-effects were observed and this was confirmed haematologically and biochemically. 3 The drug was distributed followi...

journal_title：British journal of clinical pharmacology

authors： Pickup ME,Bird HA,Lowe JR,Lees L,Wright V

更新日期：1981-08-01 00:00:00

abstract：:The effects of ranitidine on the pharmacokinetics of metoprolol were examined in two studies. In the first study, pharmacokinetics of single doses of metoprolol were examined in six subjects before, during and after ranitidine administration for 1 week. Peak concentrations of metoprolol were increased on ranitidine bu...

journal_title：British journal of clinical pharmacology

authors： Kelly JG,Salem SA,Kinney CD,Shanks RG,McDevitt DG

更新日期：1985-02-01 00:00:00

abstract：:1. The primary aim of this study was to assess the impact of renal haemodynamics on the pharmacokinetic behaviour of ibuprofen enantiomers. Thirty-two patients and ten age-matched healthy volunteers participated in this study. These patients had at least one of the following risk factors for cardiovascular disorders: ...

journal_title：British journal of clinical pharmacology

authors： Chen CY,Chen CS

更新日期：1995-07-01 00:00:00

abstract：:The pharmacokinetic basis for using various experimental indices, (urinary drug: metabolite and metabolite:drug + metabolite ratios, urinary metabolite recovery and AUC values), for detecting polymorphic oxidative drug metabolism was examined. Pharmacokinetic determinants in addition to partial metabolic clearance dow...

journal_title：British journal of clinical pharmacology

authors： Jackson PR,Tucker GT,Lennard MS,Woods HF

更新日期：1986-11-01 00:00:00

abstract：:1. Kenyan children with uncomplicated malaria given oral halofantrine (HF; non-micronised suspension; 8 mg base kg-1 body weight 6 hourly for three doses) showed wide variation in the disposition of HF and desbutylhalofantrine (HFm). 2. Eight Kenyan children with severe (prostrate) falciparum malaria who were receivin...

journal_title：British journal of clinical pharmacology

authors： Watkins WM,Winstanley PA,Mberu EK,Kokwaro G,Murphy SA,Newton CJ,Mwangi I,Forster D,Marsh K

更新日期：1995-03-01 00:00:00

abstract：AIMS:To ascertain the effects of the Medicines and Healthcare products Regulatory Agency's (MHRA) safety update in June 2010 on the volume of prescribing of quinine and on indices of quinine toxicity. METHODS:We analysed quarterly primary care total and quinine prescribing data for England and quinine prescribing volu...

journal_title：British journal of clinical pharmacology

authors： Acheampong P,Cooper G,Khazaeli B,Lupton DJ,White S,May MT,Thomas SH

更新日期：2013-12-01 00:00:00

abstract：AIMS:The objectives were to investigate the pharmacokinetics, pharmacodynamics and safety of ilaprazole infusion in healthy subjects and patients with esomeprazole as positive control, and then recommend the dosage regimen for Phase 2b/3 studies. METHODS:Three clinical studies were performed. First, 16 healthy subject...

journal_title：British journal of clinical pharmacology

authors： Wang H,Shao F,Liu X,Xu W,Ou N,Qin X,Liu F,Hou X,Hu H,Jiang J

更新日期：2019-11-01 00:00:00

abstract：:1. In a double-blind, placebo-controlled, cross-over study, acute pharmacokinetic, neurophysiological and psychotropic effects of suriclone, a new cyclopyrrolone derivative, were investigated and compared with alprazolam. 2. Fifteen normal young volunteers received randomized oral single doses of placebo, 0.1, 0.2 and...

journal_title：British journal of clinical pharmacology

authors： Saletu B,Grünberger J,Linzmayer L,Semlitsch HV,Anderer P,Chwatal K

更新日期：1994-02-01 00:00:00

abstract：:1. We investigated the effect of the haemostatic agent ethamsylate on aspirin-induced gastric mucosal bleeding. 2. Eighteen healthy subjects were studied three times: at the end of 48 h periods of treatment with (a) placebo, (b) aspirin 600 mg four times daily, (9 doses) and (c) aspirin 600 mg four times daily with ea...

journal_title：British journal of clinical pharmacology

authors： Daneshmend TK,Stein AG,Bhaskar NK,Hawkey CJ

更新日期：1989-07-01 00:00:00

abstract：AIMS:The aim of the present study was to investigate whether differences in total and peak drug exposure upon generic substitution are due to differences between formulations or to intrasubject pharmacokinetic variability of the active substance. METHODS:The study was designed as a retrospective reanalysis of existing...

journal_title：British journal of clinical pharmacology

authors： Yu Y,Teerenstra S,Neef C,Burger D,Maliepaard M

更新日期：2016-04-01 00:00:00

abstract：:Aims We investigated whether venoconstriction by α-adrenoceptor stimulation, and venodilation by β-adrenoceptor stimulation and nitroglycerin are altered in patients with diabetes mellitus (DM). Methods Eight male patients with non insulin-dependent DM and eight age-matched control subjects were included. The patients...

journal_title：British journal of clinical pharmacology

authors： Harada K,Ohmori M,Kitoh Y,Sugimoto KI,Fujimura A

更新日期：1999-04-01 00:00:00

abstract：:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT * Dihydropyrimidine dehydrogenase (DPD) is the enzyme responsible for the elimination of approximately 80% of the administered dose of 5-fluorouracil (5-FU). * Mutations in the DPD-coding gene have been shown to increase the risk of severe toxicity in 5-FU treated patients. * T...

journal_title：British journal of clinical pharmacology

authors： Paré L,Paez D,Salazar J,Del Rio E,Tizzano E,Marcuello E,Baiget M

更新日期：2010-08-01 00:00:00

abstract：AIM:To investigate the effect of the P-glycoprotein inhibitor verapamil on the pharmacokinetics and pharmacodynamics of dabigatran etexilate (DE). METHOD:In this two part multiple crossover trial in 40 healthy subjects, DE 150 mg was given alone or with verapamil at different doses, duration of treatment (single vs. m...

journal_title：British journal of clinical pharmacology

authors： Härtter S,Sennewald R,Nehmiz G,Reilly P

更新日期：2013-04-01 00:00:00

abstract：AIMS:To investigate uptake of fluconazole into the interstitial fluid of human subcutaneous tissue using the microdialysis and suction blister techniques. METHODS:A sterile microdialysis probe (CMA/60) was inserted subcutaneously into the upper arm of five healthy volunteers following an overnight fast. Blisters were ...

journal_title：British journal of clinical pharmacology

authors： Sasongko L,Williams KM,Day RO,McLachlan AJ

更新日期：2003-11-01 00:00:00

abstract：AIMS:Changes in serotonergic sensory modulation associated with overexpression of 5-HT3 receptors in the central nervous system (CNS) have been implicated in the pathophysiology of neuropathic pain after peripheral nerve damage. 5-HT3 receptor antagonists such as ondansetron can potentially alleviate neuropathic pain, ...

journal_title：British journal of clinical pharmacology

authors： Chiang MD,Frey K,Lee C,Kharasch ED,Tallchief D,Sawyer C,Blood J,Back H,Kagan L,Haroutounian S

更新日期：2020-06-04 00:00:00

abstract：:1. Nitric oxide is recognised as an important biological mediator, which is thought to be involved in cardiovascular homeostasis. The purpose of this study was to investigate the effects of basal nitric oxide synthesis on cardiac function in man, by blocking nitric oxide synthesis with NG-monomethyl-L-arginine (L-NMMA...

journal_title：British journal of clinical pharmacology

authors： Clarkson PB,Lim PO,MacDonald TM

更新日期：1995-10-01 00:00:00

abstract：AIM:The combination of ephedrine and caffeine has been used in herbal products for weight loss and athletic performance-enhancement, but the pharmacokinetic profiles of these compounds have not been well characterized. This study aimed to develop a mechanistic model describing ephedrine, norephedrine, and caffeine phar...

journal_title：British journal of clinical pharmacology

authors： Csajka C,Haller CA,Benowitz NL,Verotta D

更新日期：2005-03-01 00:00:00

abstract：AIMS:The cytochrome P450 enzyme CYP2C9 catalyses the 4'-hydroxylation of the nonsteroidal analgesic drug diclofenac in humans. We studied the influences of the known amino acid variants, CYP2C9*2 (Arg144Cys) and CYP2C9*3 (Ile359Leu), on diclofenac pharmacokinetics after a 50-mg oral dose of diclofenac in healthy volunt...

journal_title：British journal of clinical pharmacology

authors： Kirchheiner J,Meineke I,Steinbach N,Meisel C,Roots I,Brockmöller J

更新日期：2003-01-01 00:00:00

abstract：:Ten patients with mild to moderate hypertension were treated for 9 weeks with a tablet formulation of pinacidil. Mean supine blood pressure fell from 174/100 to 148/84 mm Hg and mean supine pulse increased by 3 beats/min. Daily dosage was 40-100 mg, given in two or three divided doses. Plasma urea increased significan...

journal_title：British journal of clinical pharmacology

authors： Ward JW

更新日期：1984-08-01 00:00:00

abstract：:1. The effect of neuropeptide Y (NPY) on cardiovascular function at three levels of the noradrenergic axis where the peptide is known to co-exist with noradrenaline (NA) and or adrenaline (A) was studied in normotensive Sprague-Dawley (SD), Wistar-Kyoto (WKY) or spontaneously hypertensive rats (SHR). 2. In the perfuse...

journal_title：British journal of clinical pharmacology

authors： Westfall TC,Han SP,Knuepfer M,Martin J,Chen XL,del Valle K,Ciarleglio A,Naes L

更新日期：1990-01-01 00:00:00

abstract：:Serum creatinine and drug concentrations were measured at 0, 1, 2, 3, 6, 9 and 12 months in 30 consecutive patients started on amiodarone. In 28 of these patients with no obvious cause for altered renal function, mean serum creatinine increased to 11% above baseline (P < 0.005). Rising creatinine concentrations correl...

journal_title：British journal of clinical pharmacology

authors： Pollak PT,Sharma AD,Carruthers SG

更新日期：1993-08-01 00:00:00

abstract：AIMS:To determine whether enzyme-inducing antiseizure drugs (ASDs) affect the risk of developing chronic obstructive pulmonary disease (COPD) or lung cancer in smokers. METHODS:Cases of COPD and lung cancer and matched controls without these conditions were identified from a population of smokers with ≥1 prescription ...

journal_title：British journal of clinical pharmacology

authors： Leuppi-Taegtmeyer AB,Reinau D,Yilmaz S,Rüegg S,Krähenbühl S,Jick SS,Leuppi JD,Meier CR

更新日期：2020-08-01 00:00:00

abstract：:The oxidative O-de-ethylation and aromatic 2-hydroxylation of phenacetin have been investigated in panels of extensive (EM, n = 13) and poor (PM, n = 10) metabolizers of debrisoquine. The EM group excreted in the urine significantly more paracetamol (EM: 40.8 +/- 14.9% dose/0-8 h; PM: 29.2 +/- 8.7% dose/0-8 h, 2P less...

journal_title：British journal of clinical pharmacology

authors： Devonshire HW,Kong I,Cooper M,Sloan TP,Idle JR,Smith RL

更新日期：1983-08-01 00:00:00

abstract：:The plasma concentrations of sodium cromoglycate were measured for 4 h following a single dose of 20 mg given by inhalation to six normal volunteers. A series of forced expiratory manoeuvres was performed 2 h after the dose, which resulted in a rapid and marked increase in the plasma concentrations of the drug. A simi...

journal_title：British journal of clinical pharmacology

authors： Richards R,Fowler C,Simpson SF,Renwick AG,Holgate ST

更新日期：1989-06-01 00:00:00