Abstract：
:1. The primary aim of this study was to assess the impact of renal haemodynamics on the pharmacokinetic behaviour of ibuprofen enantiomers. Thirty-two patients and ten age-matched healthy volunteers participated in this study. These patients had at least one of the following risk factors for cardiovascular disorders: hypertension, diabetes mellitus, hyperlipidaemia and hyperuricaemia with or without consequent complications such as coronary artery disease, congestive heart failure, cerebral vascular disease, and chronic renal failure. Renal function in these patients was thus characterized by unstable renal haemodynamics that might render them susceptible to ibuprofen-incurred renal damage. 2. Each subject received a single oral dose of 800 mg of racemic ibuprofen. The pharmacokinetic parameters of (S)- and (R)-ibuprofen, t 1/2(S), t 1/2(R), AUC(S), AUC(R), V/F(R), and CL/F(R), for each individual were determined from respective plasma concentration-time curves. To assess the effect of individual clinical conditions on the disposition of ibuprofen enantiomers, the arithmetic means of these pharmacokinetic parameters for each disease group were compared with those of the healthy volunteers by a t-test. 3. All of these disease groups showed elevated AUC(S) and higher (S)/(R) AUC ratios. These disease states along with gender and age were analyzed by multiple linear regression to discern significant factors for elevating AUC(S). Of these, advanced age (P = 0.02) and hypertension (P = 0.03) were identified as independent factors contributing to AUC(S) increase in this population. Thus, patients with these two clinical conditions are at particular risk from the adverse renal effect of ibuprofen.
journal_name
Br J Clin Pharmacoljournal_title
British journal of clinical pharmacologyauthors
Chen CY,Chen CSdoi
10.1111/j.1365-2125.1995.tb04536.xsubject
Has Abstractpub_date
1995-07-01 00:00:00pages
67-72issue
1eissn
0306-5251issn
1365-2125journal_volume
40pub_type
杂志文章abstract：AIMS:The main goal of the study was to describe the pharmacokinetics of maternal zidovudine (ZDV) administration during pregnancy and labour and to evaluate their impact on fetal concentrations and exposures. METHODS:A total of 195 HIV-infected pregnant and non-pregnant women aged 16-59 years were included and 273 mat...
journal_title：British journal of clinical pharmacology
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1046/j.1365-2125.2000.00262.x
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journal_title：British journal of clinical pharmacology
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doi：10.1111/j.1365-2125.1980.tb00511.x
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journal_title：British journal of clinical pharmacology
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journal_title：British journal of clinical pharmacology
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：British journal of clinical pharmacology
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journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1365-2125.1995.tb04491.x
更新日期：1995-05-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章,多中心研究
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更新日期：2019-07-01 00:00:00
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journal_title：British journal of clinical pharmacology
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journal_title：British journal of clinical pharmacology
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doi：10.1111/bcp.13767
更新日期：2019-01-01 00:00:00
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journal_title：British journal of clinical pharmacology
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journal_title：British journal of clinical pharmacology
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更新日期：2018-04-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1365-2125.2007.02990.x
更新日期：2008-01-01 00:00:00
