Multicentre 12-week double-blind comparison of doxazosin, prazosin and placebo in patients with mild to moderate essential hypertension.

abstract：:1. The pharmacokinetics of recombinant erythropoietin, r-Epo, were evaluated after intravenous and subcutaneous administration of 50 u kg-1 to six healthy male volunteers. 2. The calculated mean values (+/- s.d.) for volume of distribution at steady state and clearance after an i.v. dose were 76 (+/- 33) ml kg-1 and 1...

journal_title：British journal of clinical pharmacology

authors： Salmonson T,Danielson BG,Wikström B

更新日期：1990-06-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the effect of policosanol on the susceptibility of LDL-C to in vitro lipid peroxidation in human healthy volunteers. METHODS:The effect of policosanol (5 and 10 mg day(-1) on LDL-C oxidation was studied in a double-blind, randomized, placebo-controlled trial conducted in 6...

journal_title：British journal of clinical pharmacology

authors： Menéndez R,Más R,Amor AM,González RM,Fernández JC,Rodeiro I,Zayas M,Jiménez S

更新日期：2000-09-01 00:00:00

abstract：:Both the acute blood pressure lowering and renal effects of the calcium antagonist nicardipine and those after 1 week's treatment were investigated in 10 normotensive volunteers and in 10 patients with mild to moderate essential hypertension. After 1 week of placebo, nicardipine was administered orally for 1 week (20 ...

journal_title：British journal of clinical pharmacology

authors： van Schaik BA,van Nistelrooy AE,Geyskes GG

更新日期：1984-07-01 00:00:00

abstract：:1. Using human mononuclear leucocytes as target cells, we have investigated the bioactivation of dapsone (DDS) to a cytotoxic metabolite in the presence of microsomes from nine human livers. Values for NADPH dependent toxicity ranged from 8.8-27% (15.8 +/- 5.9%) and were similar to those for microsomes from control mi...

journal_title：British journal of clinical pharmacology

authors： Coleman MD,Breckenridge AM,Park BK

更新日期：1989-10-01 00:00:00

abstract：AIMS:Drug-induced liver injury (DILI) is rare compared to the worldwide frequent acute or chronic liver diseases. Therefore, patients included in series of suspected DILI are at high risk of not having DILI, whereby alternative causes may confound the DILI diagnosis. The aim of this review is to evaluate published case...

journal_title：British journal of clinical pharmacology

authors： Teschke R,Danan G

更新日期：2018-07-01 00:00:00

abstract：:1. The purpose of this study was to evaluate possible changes in brain morphology and evoked potentials associated with daily administration of 300 mg kg-1 vigabatrin in dogs. 2. Somatosensory evoked potentials (SEP) and auditory evoked potentials (AEP) were recorded at baseline and weekly for 12 weeks of treatment an...

journal_title：British journal of clinical pharmacology

authors： Arezzo JC,Schroeder CE,Litwak MS,Steward DL

更新日期：1989-01-01 00:00:00

abstract：:1. Alfuzosin is a post-synaptic alpha-adrenoceptor antagonist with antihypertensive and peripheral vasodilator properties. 2. We measured the effect of alfuzosin, 5 mg, on sympathetically-mediated venoconstriction by changes in the venous reflex response (VRR) in a randomised, double-blind, placebo-controlled, crossov...

journal_title：British journal of clinical pharmacology

authors： Sinclair AJ,Davies IB,Warrington SJ

更新日期：1989-01-01 00:00:00

abstract：AIMS:Carbamazepine (CBZ) is an inducer of cytochrome P450 enzymes, which have been implicated in many drug interactions. However, for immunosuppressant and anti-HIV drugs, whose main site of action is the lymphocyte, induction of P-glycoprotein (Pgp) may also be important. In this study, we have investigated whether CB...

journal_title：British journal of clinical pharmacology

authors： Owen A,Goldring C,Morgan P,Park BK,Pirmohamed M

更新日期：2006-08-01 00:00:00

abstract：:Catechol-O-methyltransferase (COMT) is of great importance in pharmacology because it catalyzes the metabolism (methylation) of endogenous and xenobiotic catechols. Moreover, inhibition of COMT is the drug target in the management of central nervous system (CNS) disorders such as Parkinson's disease due to its role in...

journal_title：British journal of clinical pharmacology

authors： Ma Z,Liu H,Wu B

更新日期：2014-03-01 00:00:00

abstract：:1 Isoxicam was found to inhibit monocyte and neutrophil cell chemotaxis at therapeutic concentrations. 2 The effect was observed after in vitro incubation of normal cells and in vivo in patients with rheumatoid arthritis. 3 Compared to other NSAIDs studied in our laboratory, isoxicam was shown to have a broader spectr...

journal_title：British journal of clinical pharmacology

authors： Martinez JG,Murakami SI,Scheinberg MA

更新日期：1986-01-01 00:00:00

abstract：:Adverse drug reactions come at a considerable cost on society. Social media are a potentially invaluable reservoir of information for pharmacovigilance, yet their true value remains to be fully understood. In order to realize the benefits social media holds, a number of technical, regulatory and ethical challenges rem...

journal_title：British journal of clinical pharmacology

authors： Sloane R,Osanlou O,Lewis D,Bollegala D,Maskell S,Pirmohamed M

更新日期：2015-10-01 00:00:00

abstract：AIMS:Breakthrough bleeding or even unwanted pregnancies have been reported in women during concomitant therapy with oral contraceptives and St John's wort extract. The aim of the present study was to investigate the effects of St John's wort extract on oral contraceptive therapy with respect to ovarian activity, breakt...

journal_title：British journal of clinical pharmacology

authors： Pfrunder A,Schiesser M,Gerber S,Haschke M,Bitzer J,Drewe J

更新日期：2003-12-01 00:00:00

abstract：AIMS:The aim was to describe the utilization of antidiabetic agents, in terms of persistence and regimen change, in the management of a cohort of newly treated type 2 diabetes patients and to investigate associated socio-demographic and treatment factors. METHODS:A population-based retrospective cohort study was condu...

journal_title：British journal of clinical pharmacology

authors： Grimes RT,Bennett K,Tilson L,Usher C,Smith SM,Henman MC

更新日期：2015-06-01 00:00:00

abstract：:Exposure-response (ER) analysis has emerged as an important tool to interpret QT data from thorough QT (TQT) studies and allows the prediction of effects in the targeted patient population. Recently, ER analysis has also been applied to data from early clinical pharmacology studies, such as single and multiple ascendi...

journal_title：British journal of clinical pharmacology

authors： Darpo B,Garnett C

更新日期：2013-11-01 00:00:00

abstract：AIMS:We aimed to examine the frequency of high-dose (defined as mean chlorpromazine mg equivalent doses above 1000) antipsychotic prescriptions in schizophrenia and their clinical correlates in the context of a comparison between studies in 2001 and 2004 within six East Asian countries and territories. METHODS:Prescri...

journal_title：British journal of clinical pharmacology

authors： Sim K,Su HC,Fujii S,Yang SY,Chong MY,Ungvari G,Si T,He YL,Chung EK,Chan YH,Shinfuku N,Kua EH,Tan CH,Sartorius N

更新日期：2009-01-01 00:00:00

abstract：:1 A single-blind randomized study of the effects of a beta-adrenoceptor antagonist with intrinsic sympathomimetic activity (pindolol 0.4 mg i.v., n = 10) and a drug lacking this property (metoprolol 5 mg i.v., n = 11) on local wall motion abnormalities was carried out in 21 patients with coronary heart disease and ant...

journal_title：British journal of clinical pharmacology

authors： Gleichmann U,Fassbender D,Trieb G,Mannebach H,Ohlmeier H

更新日期：1982-01-01 00:00:00

abstract：:Both empirical epidemiological data on the causes of traffic accidents and conceptual models of skilled human performance stress the central role of perception and cognition. This paper examines the effects of drugs on two major components of cognitive perceptual performance, namely, concentrated attention or vigilanc...

journal_title：British journal of clinical pharmacology

authors： Moskowitz H

更新日期：1984-01-01 00:00:00

abstract：:The discovery of immune checkpoints and their role in modulating immune response have revolutionised cancer treatment in recent years. The immune checkpoints, cytotoxic T-lymphocyte-associated protein 4, programmed cell death protein 1 and its ligand, programmed cell death-ligand 1, have been extensively studied. Curr...

journal_title：British journal of clinical pharmacology

authors： Chew HY,Dolcetti R,Simpson F

更新日期：2020-09-01 00:00:00

abstract：AIM:This study evaluated the safety and pharmacokinetics (PK) of donepezil HCl and sertraline HCl when administered separately and in combination. METHODS:This was a randomized, open-label, three-period crossover study. In consecutive dosing periods separated by washout periods of > or = 3 weeks, healthy volunteers re...

journal_title：British journal of clinical pharmacology

authors： Nagy CF,Kumar D,Perdomo CA,Wason S,Cullen EI,Pratt RD

更新日期：2004-11-01 00:00:00

abstract：:The effect of a high potency antacid and food on the bioavailability of famotidine was studied in 17 healthy volunteers in an open randomized three-way cross-over trial. After an overnight fast, famotidine was administered to each subject as follows: 40 mg famotidine orally alone; 40 mg orally with antacid; and 40 mg ...

journal_title：British journal of clinical pharmacology

authors： Lin JH,Chremos AN,Kanovsky SM,Schwartz S,Yeh KC,Kann J

更新日期：1987-10-01 00:00:00

abstract：:The pharmacokinetics of antipyrine were studied in 12 healthy volunteers and 10 patients of Kenya African origin with Hodgkin's lymphoma. The half-life of antipyrine was 12.2 +/- 1.3 h (mean + s.d.), while the apparent volume of distribution (V) was 0.67 +/- 0.11 l kg-1 (mean +/- s.d.) and the total body clearance was...

journal_title：British journal of clinical pharmacology

authors： Juma FD

更新日期：1987-12-01 00:00:00

abstract：AIMS:Data regarding the cardiac toxicity of cabozantinib lacks. The aim of our study was to assess the risk of cabozantinib-related cardiotoxicity in mRCC patients. METHODS:We performed a multicentre prospective study on mRCC patients treated with cabozantinib between October 2016 and November 2017. Transthoracic echo...

journal_title：British journal of clinical pharmacology

authors： Iacovelli R,Ciccarese C,Fornarini G,Massari F,Bimbatti D,Mosillo C,Rebuzzi SE,Di Nunno V,Grassi M,Fantinel E,Ardizzoni A,Tortora G

更新日期：2019-06-01 00:00:00

abstract：:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Reflux oesophagitis is a common clinical disorder associated with significant morbidity. Proton pump inhibitors are the current pharmacotherapy of choice, but not all treated patients achieve symptom relief. Little is known about the efficacy of mosapride, a prokinetic agent wh...

journal_title：British journal of clinical pharmacology

authors： Hsu YC,Yang TH,Hsu WL,Wu HT,Cheng YC,Chiang MF,Wang CS,Lin HJ

更新日期：2010-08-01 00:00:00

abstract：:The plasma concentrations of sodium cromoglycate were measured for 4 h following a single dose of 20 mg given by inhalation to six normal volunteers. A series of forced expiratory manoeuvres was performed 2 h after the dose, which resulted in a rapid and marked increase in the plasma concentrations of the drug. A simi...

journal_title：British journal of clinical pharmacology

authors： Richards R,Fowler C,Simpson SF,Renwick AG,Holgate ST

更新日期：1989-06-01 00:00:00

abstract：AIMS:A systematic review of the literature published in English over 10 years was undertaken in order to describe the use of electronic healthcare data in the identification of potential adverse drug reactions (ADRs) in children. METHODS:MEDLINE and EMBASE were searched using MESH headings and text words. Titles, keyw...

journal_title：British journal of clinical pharmacology

authors： Black C,Tagiyeva-Milne N,Helms P,Moir D

更新日期：2015-10-01 00:00:00

abstract：:1. A double-blind, four period crossover study was undertaken to test for an interaction between single oral doses of nifedipine retard (20 mg) and lisinopril (20 mg) in normal subjects. 2. Side effects with both drugs were mild and the incidence was additive. 3. Blood pressure (BP) was lowered by nifedipine for 4 h, ...

journal_title：British journal of clinical pharmacology

authors： Lees KR,Reid JL

更新日期：1988-03-01 00:00:00

abstract：AIMS:The present study aimed to evaluate the associations between medication use and falls and to identify high risk medications that acted as a trigger for the onset of falls in an acute care hospital setting. METHODS:We applied a case-crossover design wherein cases served as their own controls and comparisons were m...

journal_title：British journal of clinical pharmacology

authors： Shuto H,Imakyure O,Matsumoto J,Egawa T,Jiang Y,Hirakawa M,Kataoka Y,Yanagawa T

更新日期：2010-05-01 00:00:00

abstract：:1 The effects of the thromboxane synthetase inhibitor dazoxiben (UK 37248) on haemodynamics, blood gases, thromboxane and prostacyclin release and on arrhythmias were examined in anaesthetised greyhounds subject to acute coronary artery occlusion and reperfusion. 2 Ten minutes after the administration of UK 37248 2 mg...

journal_title：British journal of clinical pharmacology

authors： Coker SJ,Parratt JR

更新日期：1983-01-01 00:00:00

abstract：AIMS:Thiazolidinediones (TZDs) not only enhance cellular glucose transport but are reported to have potent anti-inflammatory effects. These effects may play an important role in the insulin sensitizing mechanism, and possibly precede the effects on parameters of glucoregulation. We sought to investigate whether these a...

journal_title：British journal of clinical pharmacology

authors： van Doorn M,Kemme M,Ouwens M,van Hoogdalem EJ,Jones R,Romijn H,de Kam M,Schoemaker R,Burggraaf K,Cohen A

更新日期：2006-10-01 00:00:00

abstract：:Ten healthy volunteers were treated for 4 days with 160 mg propranolol HCl and placebo in random order. At the end of each treatment salivary antipyrine kinetics and the plasma kinetics and urinary excretion of paracetamol and its major metabolites were measured following a 1500 mg oral dose. Propranolol prolonged the...

journal_title：British journal of clinical pharmacology

authors： Baraka OZ,Truman CA,Ford JM,Roberts CJ

更新日期：1990-02-01 00:00:00