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Medication use as a risk factor for inpatient falls in an acute care hospital: a case-crossover study.

Abstract：

AIMS:The present study aimed to evaluate the associations between medication use and falls and to identify high risk medications that acted as a trigger for the onset of falls in an acute care hospital setting. METHODS:We applied a case-crossover design wherein cases served as their own controls and comparisons were made within each participant. The 3-day period (days 0 to -2) and the 3-day periods (days -6 to -8, days -9 to -11 and days -12 to -14) before the fall event were defined as the case period and the control periods, respectively. Exposures to medications were compared between the case and control periods. Odds ratios (OR) and 95% confidence intervals (CI) for the onset of falls with respect to medication use were computed using conditional logistic regression analyses. RESULTS:A total of 349 inpatients who fell during their hospitalization were recorded on incident report forms between March 2003 and August 2005. The initial use of antihypertensive, antiparkinsonian, anti-anxiety and hypnotic agents as medication classes was significantly associated with an increased risk of falls, and these ORs (95% CI) were 8.42 (3.12, 22.72), 4.18 (1.75, 10.02), 3.25 (1.62, 6.50) and 2.44 (1.32, 4.51), respectively. The initial use of candesartan, etizolam, biperiden and zopiclone was also identified as a potential risk factor for falls. CONCLUSIONS:Medical professionals should be aware of the possibility that starting a new medication such as an antihypertensive agent, including candesartan, and antiparkinsonian, anti-anxiety and hypnotic agents, may act as a trigger for the onset of a fall.

journal_name

Br J Clin Pharmacol

journal_title

British journal of clinical pharmacology

authors

Shuto H,Imakyure O,Matsumoto J,Egawa T,Jiang Y,Hirakawa M,Kataoka Y,Yanagawa T

doi

10.1111/j.1365-2125.2010.03613.x

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

535-42

issue

5

eissn

0306-5251

issn

1365-2125

pii

BCP3613

journal_volume

69

pub_type

杂志文章

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