Abstract:
:1. Alfuzosin is a post-synaptic alpha-adrenoceptor antagonist with antihypertensive and peripheral vasodilator properties. 2. We measured the effect of alfuzosin, 5 mg, on sympathetically-mediated venoconstriction by changes in the venous reflex response (VRR) in a randomised, double-blind, placebo-controlled, crossover study in a group of 10 healthy volunteers. 3. There was a significant inhibition of the VRR after alfuzosin compared with placebo (P less than 0.001) which was present 1 h after the dose and still evident at 6 h. 4. Supine blood pressure was significantly lower (P less than 0.01) and supine heart rate was significantly higher (P less than 0.001) after alfuzosin compared with placebo. 5. Inhibition of the VRR by alfuzosin was observed to precede the development of reflex tachycardia.
journal_name
Br J Clin Pharmacoljournal_title
British journal of clinical pharmacologyauthors
Sinclair AJ,Davies IB,Warrington SJdoi
10.1111/j.1365-2125.1989.tb05330.xsubject
Has Abstractpub_date
1989-01-01 00:00:00pages
19-22issue
1eissn
0306-5251issn
1365-2125journal_volume
27pub_type
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journal_title:British journal of clinical pharmacology
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pub_type: 临床试验,杂志文章,随机对照试验
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