Alfuzosin and the venous reflex response: studies in normal subjects.

Abstract:

:1. Alfuzosin is a post-synaptic alpha-adrenoceptor antagonist with antihypertensive and peripheral vasodilator properties. 2. We measured the effect of alfuzosin, 5 mg, on sympathetically-mediated venoconstriction by changes in the venous reflex response (VRR) in a randomised, double-blind, placebo-controlled, crossover study in a group of 10 healthy volunteers. 3. There was a significant inhibition of the VRR after alfuzosin compared with placebo (P less than 0.001) which was present 1 h after the dose and still evident at 6 h. 4. Supine blood pressure was significantly lower (P less than 0.01) and supine heart rate was significantly higher (P less than 0.001) after alfuzosin compared with placebo. 5. Inhibition of the VRR by alfuzosin was observed to precede the development of reflex tachycardia.

journal_name

Br J Clin Pharmacol

authors

Sinclair AJ,Davies IB,Warrington SJ

doi

10.1111/j.1365-2125.1989.tb05330.x

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

19-22

issue

1

eissn

0306-5251

issn

1365-2125

journal_volume

27

pub_type

临床试验,杂志文章,随机对照试验
  • Effects of the nitric oxide synthase inhibitor ronopterin (VAS203) on renal function in healthy volunteers.

    abstract:AIMS:Reduced nitric oxide (NO) availability may adversely affect renal perfusion and glomerular filtration. The aim of the present study was to characterize in detail the pharmacological effects of VAS203, an inhibitor of NO synthase, on renal haemodynamics in humans. METHODS:This double-blind, randomized, placebo-con...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/bcp.13870

    authors: Ott C,Bosch A,Winzer N,Friedrich S,Schinzel R,Tegtmeier F,Schmieder RE

    更新日期:2019-05-01 00:00:00

  • Creatinine elevation in patients receiving amiodarone correlates with serum amiodarone concentration.

    abstract::Serum creatinine and drug concentrations were measured at 0, 1, 2, 3, 6, 9 and 12 months in 30 consecutive patients started on amiodarone. In 28 of these patients with no obvious cause for altered renal function, mean serum creatinine increased to 11% above baseline (P < 0.005). Rising creatinine concentrations correl...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.1993.tb04207.x

    authors: Pollak PT,Sharma AD,Carruthers SG

    更新日期:1993-08-01 00:00:00

  • Plasma, bone, hip capsule and drain fluid concentrations of ampicillin and flucloxacillin during total hip replacement after intravenous bolus injection of magnapen.

    abstract::1. A rapid intravenous bolus injection of 4.0 g Magnapen (which contains 2.0 g of ampicillin and 2.0 g of flucloxacillin) was to seven patients undergoing total hip replacement immediatly before induction of general anesthesia. Postoperatively the patients patients received 2.0 g Magnapen by intramuscular injection ev...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.1978.tb00838.x

    authors: Parsons RL,Beavis JP,Laurence M,David JA,Paddock GM,Trounce JR

    更新日期:1978-08-01 00:00:00

  • Betaxolol and glucose-insulin relationships: studies in normal subjects taking glibenclamide or metformin.

    abstract::1. The potential interaction between selective beta 1-adrenoceptor blockers and sulphonylureas or biguanides was studied by comparing the beta 1-adrenoceptor antagonist betaxolol with placebo in 12 normal subjects taking glibenclamide or metformin in a single-blind crossover group study. 2. After a 4 day run-in period...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2125.1990.tb03838.x

    authors: Sinclair AJ,Davies IB,Warrington SJ

    更新日期:1990-11-01 00:00:00

  • Lessons learned from the clinical development of oral peptides.

    abstract::The oral delivery of peptides and proteins has been hampered by an array of obstacles. However, several promising novel oral delivery systems have been developed. This paper reviews the most advanced oral formulation technologies, and highlights key lessons and implications from studies undertaken to date with these o...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/bcp.12557

    authors: Karsdal MA,Riis BJ,Mehta N,Stern W,Arbit E,Christiansen C,Henriksen K

    更新日期:2015-05-01 00:00:00

  • Influence of chronic dosing on theophylline clearance.

    abstract::Theophylline clearance was studied in normal healthy volunteers before and after chronic oral dosing. Oral theophylline clearance showed a significant decrease (P less than 0.001) from 59.3 +/- 6.48 ml/min (mean +/- s.e. mean, n = 10) to 48.0 +/- 6.4 ml/min. Steady-state intravenous clearance decreased by 26 +/- 2% fr...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.1984.tb02385.x

    authors: Efthimiou H,Morgan DJ,Ioannides-Demos L,Raymond K,McLean AJ

    更新日期:1984-05-01 00:00:00

  • A mechanism-based binding model for the population pharmacokinetics and pharmacodynamics of omalizumab.

    abstract:AIM:Omalizumab, a humanized IgG monoclonal antibody that binds to human immunoglobulin E (IgE), interrupts the allergic cascade in asthmatic patients. The aim was to compare simultaneously drug exposure and IgE biomarker responses in Japanese and White patient populations. METHODS:An instantaneous equilibrium drug-lig...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2125.2006.02803.x

    authors: Hayashi N,Tsukamoto Y,Sallas WM,Lowe PJ

    更新日期:2007-05-01 00:00:00

  • Inhibition of vasoconstriction by AJ-2615, a novel calcium antagonist with alpha(1)-adrenergic receptor blocking activity in human conduit arteries used as bypass grafts.

    abstract:AIMS:Graft spasm may develop during coronary artery bypass grafting and reversal of spasm is still challenging. The purpose of this study was to investigate the in vitro vascular relaxant properties of AJ-2615 in human internal mammary artery (IMA). METHODS:We studied 264 IMA rings taken from 65 patients undergoing co...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1046/j.0306-5251.2001.01444.x

    authors: Liu MH,Floten SH,Yang Q,He GW

    更新日期:2001-09-01 00:00:00

  • A multiple dose comparative study of the pharmacodynamic and pharmacokinetic behaviour of polymer-matrix and Oros dosage forms of oxprenolol in healthy volunteers.

    abstract::A new osmotic drug delivery system (Oros) has been evaluated in multiple-dose studies in young healthy volunteers as a sustained-release vehicle for once-daily administration of oxprenolol. Two Oros systems were examined in two separate studies, one containing 170 mg oxprenolol succinate with an initial zero-order rel...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2125.1985.tb02759.x

    authors: Woods KL,Jack DB,Kendall MJ,Halsey A,O'Donnell ML,Warrington SJ,John VA

    更新日期:1985-01-01 00:00:00

  • Inhibition of bradykinin-induced vasodilation in human forearm vasculature by icatibant, a potent B2-receptor antagonist.

    abstract::1. The effect of icatibant (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8] bradykinin) a potent B2-kinin receptor antagonist, was studied on bradykinin-induced vasodilation in the human forearm. 2. Eight healthy normotensive men were studied in a rising dose random-placebo controlled study. Placebo and icatibant (20, 50 and 100 mic...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2125.1994.tb04360.x

    authors: Cockcroft JR,Chowienczyk PJ,Brett SE,Bender N,Ritter JM

    更新日期:1994-10-01 00:00:00

  • Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans.

    abstract:AIMS:To assess the utility of human hepatic microsomes for predicting in vivo intrinsic clearance (CLint ) via the use of four cytochrome P450 2C9 substrates: phenytoin, tolbutamide (S)-ibuprofen (two pathways) and diclofenac, and to examine the role of exogenous albumin within the microsomal incubation. METHODS:V max...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2125.1999.00935.x

    authors: Carlile DJ,Hakooz N,Bayliss MK,Houston JB

    更新日期:1999-06-01 00:00:00

  • Preliminary assessment of RX 72601, a new anticholinesterase in man: reversal of competitive neuromuscular blockade.

    abstract::1 The effect of RX 72601, neostigmine plus atropine, or saline on neuromuscular blockade with (+)-tubocurarine was studied in a double blind trial in four healthy male volunteers. 2 The methods used to assess neuromuscular function were voluntary grip strength and indirectly evoked muscle twitches. The muscarinic acti...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.1974.tb00239.x

    authors: Dettmar PW,Metcalf G,Smith MH,Gillett GB,Hedges A,Richens A

    更新日期:1974-06-01 00:00:00

  • Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985).

    abstract::1 A total of three hundred and nineteen new chemical entities (NCEs) were investigated in man for the first time between 1964 and 1985 by seven UK-owned pharmaceutical companies. The majority (96.2%), were self-originated by the UK company or one of its overseas subsidiaries. 2 There was an increase in the number of N...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.1988.tb03318.x

    authors: Prentis RA,Lis Y,Walker SR

    更新日期:1988-03-01 00:00:00

  • Reversal of mecamylamine-induced effects in healthy subjects by nicotine receptor agonists: Cognitive and (electro) physiological responses.

    abstract:AIMS:Establishing a pharmacological challenge model could yield an important tool to understand the complex role of the nicotinic cholinergic system in cognition and to develop novel compounds acting on the nicotinic acetylcholine receptor. METHODS:This randomized, double-blind, double-dummy, placebo-controlled, four-...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/bcp.13507

    authors: Alvarez-Jimenez R,Hart EP,Prins S,de Kam M,van Gerven JMA,Cohen AF,Groeneveld GJ

    更新日期:2018-05-01 00:00:00

  • Lack of effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of amlodipine.

    abstract:AIMS:To determine whether repeated once daily administration of grapefruit juice altered the pharmacokinetics or pharmacodynamics of the calcium antagonist amlodipine. METHOD:S The effects of grapefruit juice on the pharmacokinetics and pharmacodynamics of oral and intravenous amlodipine were assessed in 20 healthy me...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2125.2000.00283.x

    authors: Vincent J,Harris SI,Foulds G,Dogolo LC,Willavize S,Friedman HL

    更新日期:2000-11-01 00:00:00

  • The influence of age, liver size and enantiomer concentrations on warfarin requirements.

    abstract::1. We have tested the hypothesis that the fall in hepatic mass with age influences the age related increase in sensitivity to warfarin. In 39 otherwise healthy outpatients, aged 50-87 years, stabilised on warfarin for prophylaxis of thromboembolism, age, mean International Normalised Ratio (INR), and mean warfarin dos...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:

    authors: Wynne H,Cope L,Kelly P,Whittingham T,Edwards C,Kamali F

    更新日期:1995-09-01 00:00:00

  • Does it matter where we measure blood pressure?

    abstract::Although blood pressure measured at the brachial artery plays a central role in our understanding and management of cardiovascular risk, in recent years great emphasis has been placed on the importance of central blood pressure. It seems straightforward that knowledge of the blood pressure directly affecting the major...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2125.2012.04203.x

    authors: Tomlinson LA,Wilkinson IB

    更新日期:2012-08-01 00:00:00

  • Tremor and the anti-obesity drug BRL 26830A.

    abstract::The thermogenic beta 3-adrenoceptor agonist BRL 26830A has been shown to increase weight loss in dieting subjects but tremor was a frequent adverse effect. We have investigated the magnitude and nature of this tremor after a single oral dose in 18 subjects. Two complementary techniques were used to attach the recordin...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.1990.tb03821.x

    authors: Connacher AA,Lakie M,Powers N,Elton RA,Walsh EG,Jung RT

    更新日期:1990-10-01 00:00:00

  • Post-market safety warnings for drugs approved in Canada under the Notice of Compliance with conditions policy.

    abstract:AIMS:Health Canada has developed a pathway to approve drugs that have limited efficacy and safety data, the Notice of Compliance with conditions (NOC/c) policy. Increased safety reporting is required for these drugs but there has not been any systematic review of their post-market safety. This study compares safety war...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.12552

    authors: Lexchin J

    更新日期:2015-05-01 00:00:00

  • Pregabalin poisoning and rising recreational use: a retrospective observational series.

    abstract:AIMS:With rising use worldwide, pregabalin is increasingly implicated in poisoning deaths. We aimed to investigate the clinical effects and complications of pregabalin poisoning. METHODS:This is a retrospective review of patients presenting with pregabalin poisoning to two tertiary toxicology units from 1 July 2014 to...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14348

    authors: Isoardi KZ,Polkinghorne G,Harris K,Isbister GK

    更新日期:2020-12-01 00:00:00

  • Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding.

    abstract::1 Comparison of phenytoin clearance showed a marked increase in people over 65 years of age compared with people under 45 years of age. 2 This difference was apparent if phenytoin was given orally or intravenously. 3 Phenytoin clearance correlated inversely with phenytoin binding and plasma albumin, both of which were...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2125.1975.tb00475.x

    authors: Hayes MJ,Langman MJ,Short AH

    更新日期:1975-02-01 00:00:00

  • Effect of azole antifungals ketoconazole and fluconazole on the pharmacokinetics of dexloxiglumide.

    abstract:AIMS:Dexloxiglumide is a new CCK(1) receptor antagonist under investigation for treatment of functional gastrointestinal disorders and is metabolized by CYP3A4 and CYP2C9. The objectives of these two separate randomized, two-period, two-treatment crossover studies were to investigate the effects of steady-state ketocon...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1365-2125.2005.02465.x

    authors: Jakate AS,Roy P,Patel A,Abramowitz W,Persiani S,Wangsa J,Kapil R

    更新日期:2005-11-01 00:00:00

  • Myopathy in older people receiving statin therapy: a systematic review and meta-analysis.

    abstract:OBJECTIVE:The aim of the present study was to determine the risk of myopathy in older people receiving statin therapy. METHODS:Eligible studies were identified searching Ovid Medline, EMBASE, Scopus, CINAHL, Cochrane and PSYCHINFO databases (1987 to July 2014). The selection criteria comprised randomized controlled st...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/bcp.12687

    authors: Iwere RB,Hewitt J

    更新日期:2015-09-01 00:00:00

  • Characterization of the human cytochrome P450 enzymes involved in the metabolism of dihydrocodeine.

    abstract:AIMS:Using human liver microsomes from donors of the CYP2D6 poor and extensive metabolizer genotypes, the role of individual cytochromes P-450 in the oxidative metabolism of dihydrocodeine was investigated. METHODS:The kinetics of formation of N- and O-demethylated metabolites, nordihydrocodeine and dihydromorphine, w...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2125.1997.t01-1-00626.x

    authors: Kirkwood LC,Nation RL,Somogyi AA

    更新日期:1997-12-01 00:00:00

  • Efficacy and safety of nebulized glycopyrrolate for administration using a high efficiency nebulizer in patients with chronic obstructive pulmonary disease.

    abstract:AIMS:To establish the dose-response for pharmacodynamics (bronchodilatation), safety and pharmacokinetics for a nebulized formulation of the long acting muscarinic antagonist glycopyrrolate (EP-101) with a high efficiency nebulizer in patients with chronic obstructive pulmonary disease (COPD). METHODS:Patients with mo...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/bcp.12517

    authors: Leaker BR,Barnes PJ,Jones CR,Tutuncu A,Singh D

    更新日期:2015-03-01 00:00:00

  • Toward a robust tool for pharmacokinetic-based personalization of treatment with tacrolimus in solid organ transplantation: A model-based meta-analysis approach.

    abstract:AIMS:The objective of this study is to develop a generic model for tacrolimus pharmacokinetics modelling using a meta-analysis approach, that could serve as a first step towards a prediction tool to inform pharmacokinetics-based optimal dosing of tacrolimus in different populations and indications. METHODS:A systemati...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,meta分析

    doi:10.1111/bcp.14110

    authors: Nanga TM,Doan TTP,Marquet P,Musuamba FT

    更新日期:2019-12-01 00:00:00

  • Prolonged central apnoea after intravenous morphine administration in a 12-year-old male with a UGT1A1 loss-of-function polymorphism.

    abstract:ADVERSE EVENT:Repeated and prolonged episodes of central apnoea and hypoxia after receiving intravenous morphine for analgesia and ketamine for sedation. DRUG IMPLICATED:Intravenous morphine sulfate. THE PATIENT:Previously healthy 12-year-old male with no history of sleep apnoea who presented with distal tibia and fi...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.13779

    authors: Toce MS,Kim H,Chung S,Krauss BS

    更新日期:2019-01-01 00:00:00

  • Effects of a medicine review and education programme for older people in general practice.

    abstract:AIMS:To determine whether a medicine review and education programme influences the compliance and knowledge of older people in general practice. METHODS:Older people taking at least three medicines were randomly allocated to a control or intervention group. Both groups received three visits from a clinical pharmacist:...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1365-2125.2000.00247.x

    authors: Lowe CJ,Raynor DK,Purvis J,Farrin A,Hudson J

    更新日期:2000-08-01 00:00:00

  • Effect of charcoal-drug ratio on antidotal efficacy of oral activated charcoal in man.

    abstract::The effect of charcoal-drug ratio on the antidotal efficacy of oral activated charcoal was studied in six healthy volunteers in a randomized cross-over study and compared with the adsorption capacity of activated charcoal in vitro. Aminosalicylic acid (PAS) 1 g and 5 g were ingested on an empty stomach in 30 ml of wat...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2125.1985.tb02712.x

    authors: Olkkola KT

    更新日期:1985-06-01 00:00:00

  • Characterizing variability in warfarin dose requirements in children using modelling and simulation.

    abstract:AIMS:Although genetic, clinical and demographic factors have been shown to explain approximately half of the inter-individual variability in warfarin dose requirement in adults, less is known about causes of dose variability in children. This study aimed to identify and quantify major genetic, clinical and demographic ...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.12308

    authors: Hamberg AK,Wadelius M,Friberg LE,Biss TT,Kamali F,Jonsson EN

    更新日期:2014-07-01 00:00:00