Alfuzosin and the venous reflex response: studies in normal subjects.


:1. Alfuzosin is a post-synaptic alpha-adrenoceptor antagonist with antihypertensive and peripheral vasodilator properties. 2. We measured the effect of alfuzosin, 5 mg, on sympathetically-mediated venoconstriction by changes in the venous reflex response (VRR) in a randomised, double-blind, placebo-controlled, crossover study in a group of 10 healthy volunteers. 3. There was a significant inhibition of the VRR after alfuzosin compared with placebo (P less than 0.001) which was present 1 h after the dose and still evident at 6 h. 4. Supine blood pressure was significantly lower (P less than 0.01) and supine heart rate was significantly higher (P less than 0.001) after alfuzosin compared with placebo. 5. Inhibition of the VRR by alfuzosin was observed to precede the development of reflex tachycardia.


Br J Clin Pharmacol


Sinclair AJ,Davies IB,Warrington SJ




Has Abstract


1989-01-01 00:00:00












  • Adjusted indirect comparisons to assess bioequivalence between generic clopidogrel products in Serbia.

    abstract:AIMS:Generic products can be regarded as therapeutically equivalent and switchable with the reference product. However, switchability between generics is unknown, as direct comparisons between generics are not performed. The aim of this study was to investigate the bioequivalence between generic clopidogrel products by...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Pejčić Z,Vučićević K,García-Arieta A,Miljković B

    更新日期:2019-09-01 00:00:00

  • Pharmacokinetics of bambuterol in healthy subjects.

    abstract:AIMS:To study the pharmacokinetics and bioavailability of the prodrug bambuterol and its bronchodilator moiety terbutaline in healthy subjects. METHODS:Eight healthy subjects (four women) received intravenous doses of bambuterol and terbutaline. On a third occasion, they, plus another four subjects, ingested oral bamb...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nyberg L,Rosenborg J,Weibull E,Jönsson S,Kennedy BM,Nilsson M

    更新日期:1998-05-01 00:00:00

  • Population pharmacokinetic modelling of Emfilermin (recombinant human leukaemia inhibitory factor, r-hLIF) in healthy postmenopausal women and in infertile patients undergoing in vitro fertilization and embryo transfer.

    abstract:AIMS:The aim of this analysis was to develop a population pharmacokinetic model for Emfilermin (recombinant human leukaemia inhibitory factor, r-hLIF) following subcutaneous administration to healthy postmenopausal women and to infertile patients undergoing in vitro fertilization and embryo transfer (IVF-ET). METHODS:...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Goggin T,Nguyen QT,Munafo A

    更新日期:2004-05-01 00:00:00

  • Contrasting effects of fluconazole and ketoconazole on phenytoin and testosterone disposition in man.

    abstract::Nine healthy male subjects received oral fluconazole 400 mg daily, ketoconazole 200 mg twice daily or no treatment for 6 days according to a randomized, cross-over design. A single 250 mg oral dose of phenytoin suspension was administered on day 5 and serum phenytoin concentrations were measured over the following 48 ...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Touchette MA,Chandrasekar PH,Milad MA,Edwards DJ

    更新日期:1992-07-01 00:00:00

  • A comparison of the effects of aspirin on bleeding time measured using the Simplate method and closure time measured using the PFA-100, in healthy volunteers.

    abstract:AIMS:The aim of this study was to compare the effects of aspirin on platelet function as measured by the 'classical' template bleeding time with a new ex vivo method measuring closure times using the PFA-100 machine. Platelet aggregation in response to arachidonic acid was also measured ex vivo. METHODS:The trial was ...

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Marshall PW,Williams AJ,Dixon RM,Growcott JW,Warburton S,Armstrong J,Moores J

    更新日期:1997-08-01 00:00:00

  • Does the benzodiazepine antagonist Ro 15-1788 antagonize the action of ethanol?

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    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Klotz U,Ziegler G,Rosenkranz B,Mikus G

    更新日期:1986-11-01 00:00:00

  • Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor.

    abstract:AIMS:Navoximod (GDC-0919, NLG-919) is a small molecule inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), developed to treat the acquired immune tolerance associated with cancer. The primary objectives of this study were to assess navoximod's absolute bioavailability (aBA), determine the mass balance and routes of elim...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Ma S,Suchomel J,Yanez E,Yost E,Liang X,Zhu R,Le H,Siebers N,Joas L,Morley R,Royer-Joo S,Pirzkall A,Salphati L,Ware JA,Morrissey KM

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    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Waade RB,Solhaug V,Høiseth G

    更新日期:2020-10-28 00:00:00

  • Plasma nitrendipine concentrations in elderly hypertensive patients after single and multiple dosing.

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    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Crome P,Baksi A,MacMahon D,Pandita-Gunawardena ND,Edwards J,Marley J

    更新日期:1988-09-01 00:00:00

  • Daily administration of the TP receptor antagonist terutroban improved endothelial function in high-cardiovascular-risk patients with atherosclerosis.

    abstract:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:• Terutroban is a selective TP receptor antagonist, i.e. a specific antagonist of the thromboxane A(2) and prostaglandin endoperoxide receptors, shown to improve endothelial function after a single administration in patients with coronary artery disease. WHAT THIS STUDY ADDS:• ...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,随机对照试验


    authors: Lesault PF,Boyer L,Pelle G,Covali-Noroc A,Rideau D,Akakpo S,Teiger E,Dubois-Randé JL,Adnot S

    更新日期:2011-06-01 00:00:00

  • Flecainide: single and multiple oral dose kinetics, absolute bioavailability and effect of food and antacid in man.

    abstract::The kinetics of flecainide after single intravenous (2 mg kg-1) and oral (200 mg) dosing, absolute bioavailability, effects of food and aluminium hydroxide on flecainide absorption and steady-state kinetics following twice daily oral dosing (200 mg) have been evaluated in ten healthy subjects. Absolute bioavailability...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Tjandra-Maga TB,Verbesselt R,Van Hecken A,Mullie A,De Schepper PJ

    更新日期:1986-09-01 00:00:00

  • Reversal of mecamylamine-induced effects in healthy subjects by nicotine receptor agonists: Cognitive and (electro) physiological responses.

    abstract:AIMS:Establishing a pharmacological challenge model could yield an important tool to understand the complex role of the nicotinic cholinergic system in cognition and to develop novel compounds acting on the nicotinic acetylcholine receptor. METHODS:This randomized, double-blind, double-dummy, placebo-controlled, four-...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,随机对照试验


    authors: Alvarez-Jimenez R,Hart EP,Prins S,de Kam M,van Gerven JMA,Cohen AF,Groeneveld GJ

    更新日期:2018-05-01 00:00:00

  • Selective beta-adrenoceptor partial agonist effects of pindolol and xamoterol on skeletal muscle assessed by plasma creatine kinase changes in healthy subjects.

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    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tomlinson B,Cruickshank JM,Hayes Y,Renondin JC,Lui JB,Graham BR,Jones A,Lewis AD,Prichard BN

    更新日期:1990-11-01 00:00:00

  • Effect of an alpha- and beta-adrenoceptor-blocking agent (labetalol) on haemodynamics in hypertension.

    abstract::1 The effect of an intravenous bolus of labetalol (0.6-1.6 mg/kg body weight) on central and peripheral haemodynamics was studied in nine subjects with essential hypertension and in eleven subjects with chronic renal disease and hypertension. 2 The BP reduction amounting to 20/13 mmHg was entirely due to the lowering ...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Bahlmann J,Brod J,Hubrich W,Cachovan M,Pretschner P

    更新日期:1979-04-01 00:00:00

  • Self treatment with one of three self selected, ultramolecular homeopathic medicines for the prevention of upper respiratory tract infections in children. A double-blind randomized placebo controlled trial.

    abstract:AIMS:Homeopathic medicines are frequently purchased over the counter (OTC). Respiratory complaints are the most frequent reason for such purchases. Children with upper respiratory tract infection (URTI) are frequent users of homeopathy. This study investigates the effect of self treatment with one of three self selecte...

    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Steinsbekk A,Bentzen N,Fønnebø V,Lewith G

    更新日期:2005-04-01 00:00:00

  • Oral diacetylmorphine (heroin) yields greater morphine bioavailability than oral morphine: bioavailability related to dosage and prior opioid exposure.

    abstract:AIMS:In the Swiss heroin substitution trials, patients are treated with self-administered diacetylmorphine (heroin). Intravenous administration is not possible in patients that have venosclerosis. Earlier studies have demonstrated that oral diacetylmorphine may be used, although it is completely converted to morphine p...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Halbsguth U,Rentsch KM,Eich-Höchli D,Diterich I,Fattinger K

    更新日期:2008-12-01 00:00:00

  • Pharmacological maintenance treatments of opiate addiction.

    abstract::For people seeking treatment, the course of heroin addiction tends to be chronic and relapsing, and longer duration of treatment is associated with better outcomes. Heroin addiction is strongly associated with deviant behaviour and crime, and the objectives in treating heroin addiction have been a blend of humane supp...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Bell J

    更新日期:2014-02-01 00:00:00

  • Treatment of severe 2,4-D and mecoprop intoxication with alkaline diuresis.

    abstract::1 Self-poisoning with a selective weedkiller containing 2,4-D and mecoprop in a 39 year old man resulted in prolonged deep coma, pyrexia, hyperventilation, hypoxaemia, myotonia, skeletal muscle damage and electrocardiographic changes consistent with cardiomyopathy. 2 The admission plasma concentrations of 2,4-D and me...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Prescott LF,Park J,Darrien I

    更新日期:1979-01-01 00:00:00

  • Comparison of the effects of moclobemide and selegiline on tyramine-evoked mydriasis in man.

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    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bitsios P,Langley RW,Tavernor S,Pyykkö K,Scheinin M,Szabadi E,Bradshaw CM

    更新日期:1998-06-01 00:00:00

  • Comparison of digoxin and medigoxin in normal subjects.

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    journal_title:British journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hayward RP,Greenwood H,Hamer J

    更新日期:1978-07-01 00:00:00

  • Assessment of endothelial function: comparison of the pulse wave response to beta 2-adrenoceptor stimulation with flow mediated dilatation.

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    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Rambaran C,Jiang B,Ritter JM,Shah A,Kalra L,Chowienczyk PJ

    更新日期:2008-02-01 00:00:00

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    pub_type: 杂志文章,多中心研究


    authors: Sim K,Su HC,Fujii S,Yang SY,Chong MY,Ungvari G,Si T,He YL,Chung EK,Chan YH,Shinfuku N,Kua EH,Tan CH,Sartorius N

    更新日期:2009-01-01 00:00:00

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    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Gulmez SE,Lassen AT,Aalykke C,Dall M,Andries A,Andersen BS,Hansen JM,Andersen M,Hallas J

    更新日期:2009-04-01 00:00:00

  • Pharmacogenetics of plasma efavirenz exposure in HIV-infected adults and children in South Africa.

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    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Sinxadi PZ,Leger PD,McIlleron HM,Smith PJ,Dave JA,Levitt NS,Maartens G,Haas DW

    更新日期:2015-07-01 00:00:00

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    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Sasongko L,Williams KM,Day RO,McLachlan AJ

    更新日期:2003-11-01 00:00:00

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    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,随机对照试验


    authors: Morganroth J,Wang Y,Thorn M,Kumagai Y,Harris S,Stockbridge N,Kleiman R,Shah R

    更新日期:2015-09-01 00:00:00

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    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Koomen JV,Stevens J,Heerspink HJL

    更新日期:2020-11-01 00:00:00

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    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Tello-Montoliu A,Tomasello SD,Ueno M,Angiolillo DJ

    更新日期:2011-10-01 00:00:00

  • Determinants of hepatotoxicity after repeated supratherapeutic paracetamol ingestion: systematic review of reported cases.

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    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Acheampong P,Thomas SH

    更新日期:2016-10-01 00:00:00

  • Comparison of medroxalol and labetalol, drugs with combined alpha- and beta-adrenoceptor antagonist properties.

    abstract::Medroxalol, a new drug which has been reported to possess both alpha- and beta-adrenoceptor antagonist properties, was compared with labetalol in single dose studies in normotensive males. Oral doses of 400 mg of each drug significantly reduced blood pressure, both supine and erect, without significant changes in hear...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Elliott HL,McLean K,Meredith PA,Sumner DJ,Reid JL

    更新日期:1984-05-01 00:00:00