A possible role for mono (ADP-ribosyl) transferase in the signalling pathway mediating neutrophil chemotaxis.

abstract：:1. Hydrochlorothiazide (HCT, 50-75 mg) was administered orally to seven patients with cardiac failure. 2. Plasma levels and urinary concentration of HCT were determined by GLC. 3. The gastrointestinal uptake of the diuretic in three patients was reduced to approximately half that seen in healthy controls. 4. Plasma ha...

journal_title：British journal of clinical pharmacology

authors： Beermann B,Groschinsky-Grind M

更新日期：1979-06-01 00:00:00

abstract：AIMS:Prescribing errors are common and inadequate preparation of prescribers appears to contribute. A junior doctor-led prescribing tutorial programme has been developed for Edinburgh final year medical students to increase exposure to common prescribing tasks. The aim of this study was to assess the impact of these tu...

journal_title：British journal of clinical pharmacology

authors： Gibson KR,Qureshi ZU,Ross MT,Maxwell SR

更新日期：2014-01-01 00:00:00

abstract：AIMS:To evaluate if rivaroxaban, an oral factor Xa (FXa) inhibitor, could modify the expression in vitro of inflammatory and oxidative stress biomarkers in abdominal aortic aneurysmal (AAA) sites showing intraluminal thrombus. METHODS:AAA sites with intraluminal mural thrombus were obtained from six patients undergoin...

journal_title：British journal of clinical pharmacology

authors： Moñux G,Zamorano-León JJ,Marqués P,Sopeña B,García-García JM,Laich de Koller G,Calvo-Rico B,García-Fernandez MA,Serrano J,López-Farré A

更新日期：2017-12-01 00:00:00

abstract：:Quantitative systems pharmacology (QSP) is a relatively new discipline within modelling and simulation that has gained wide attention over the past few years. The application of QSP models spans drug-target identification and validation, through all drug development phases as well as clinical applications. Due to thei...

journal_title：British journal of clinical pharmacology

authors： Derbalah A,Al-Sallami H,Hasegawa C,Gulati A,Duffull SB

更新日期：2020-07-04 00:00:00

abstract：AIMS:To describe age- and gender-related prescription patterns of diuretics in community-dwelling elderly, and to compare diuretics to other cardiovascular (CV) medications. METHODS:Cross-sectional study of patient-specific prescription data derived from a panel of 10 Dutch community pharmacies. Determination of propo...

journal_title：British journal of clinical pharmacology

authors： van Kraaij DJ,Jansen RW,de Gier JJ,Gribnau FW,Hoefnagels WH

更新日期：1998-10-01 00:00:00

abstract：:The thermogenic beta 3-adrenoceptor agonist BRL 26830A has been shown to increase weight loss in dieting subjects but tremor was a frequent adverse effect. We have investigated the magnitude and nature of this tremor after a single oral dose in 18 subjects. Two complementary techniques were used to attach the recordin...

journal_title：British journal of clinical pharmacology

authors： Connacher AA,Lakie M,Powers N,Elton RA,Walsh EG,Jung RT

更新日期：1990-10-01 00:00:00

abstract：:Adverse drug reactions come at a considerable cost on society. Social media are a potentially invaluable reservoir of information for pharmacovigilance, yet their true value remains to be fully understood. In order to realize the benefits social media holds, a number of technical, regulatory and ethical challenges rem...

journal_title：British journal of clinical pharmacology

authors： Sloane R,Osanlou O,Lewis D,Bollegala D,Maskell S,Pirmohamed M

更新日期：2015-10-01 00:00:00

abstract：AIMS:The objective of this study was to estimate the number of fractures attributed to oral corticosteroid use. METHODS:Information was obtained from the General Practice Research Database which contains medical records of general practitioners in the UK. The total number of corticosteroid-related fractures during a c...

journal_title：British journal of clinical pharmacology

authors： van Staa TP,Abenhaim L,Cooper C,Zhang B,Leufkens HG

更新日期：2001-06-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:The dominant health economic units upon which new treatment funding decisions are made are the incremental cost per life year gained (LYG) or the cost per quality-adjusted life year (QALY) gained. Neither of these units modifies the amount of health gained, by the amount of heal...

journal_title：British journal of clinical pharmacology

authors： Camidge DR,Oliver JJ,Skinner C,Attwood B,Nussey F,Jodrell D,Webb DJ

更新日期：2008-02-01 00:00:00

abstract：AIMS:To assess the duration and consistency of the pharmacological activity of the dihydropyridine calcium antagonist drug, lacidipine. METHODS:Eight healthy normotensive young males participated in a double-blind randomised crossover comparison of single and multiple doses (for 2 weeks) of lacidipine and placebo. The...

journal_title：British journal of clinical pharmacology

authors： Ueda S,Donnelly R,Panfilov V,Morris AD,Elliott HL

更新日期：1998-08-01 00:00:00

abstract：AIMS:To describe the pharmacokinetic-pharmacodynamic (PK-PD) characteristics of the direct thrombin inhibitor dabigatran in hip replacement patients by assessing coagulation parameters activated partial thromboplastin time (aPTT) and ecarin clotting time (ECT), interindividual variability and factors affecting PD respo...

journal_title：British journal of clinical pharmacology

authors： Liesenfeld KH,Schäfer HG,Trocóniz IF,Tillmann C,Eriksson BI,Stangier J

更新日期：2006-11-01 00:00:00

abstract：:The fall in blood pressure produced by captopril is not accompanied by a compensatory tachycardia. Angiotensin converting enzyme may participate in the metabolism of endogenous opioids and these substances can lower blood pressure without reflex tachycardia. It is therefore possible that the hypotensive effect of capt...

journal_title：British journal of clinical pharmacology

authors： Rubin PC,Millar JA,Sturani S,Lawrie C,Reid JL

更新日期：1984-06-01 00:00:00

abstract：:1. The N-acetylation of dapsone (DDS) was studied in 182 unrelated healthy Japanese subjects. The frequency of slow acetylators determined using the plasma monoacetyldapsone (MADDS) to DDS ratio (MADDS/DDS, slow acetylators less than 0.30 and rapid acetylators greater than 0.35) at 3 h after an oral dose of DDS (100 m...

journal_title：British journal of clinical pharmacology

authors： Horai Y,Ishizaki T

更新日期：1988-04-01 00:00:00

abstract：AIMS:5-hydroxytryptamine3 receptor antagonists act antiemetically and slow colonic transit. This study evaluated effects of the high-affinity 5-HT3 antagonist, cilansetron, on fasting, meal-and anticholinesterase-stimulated phasic contractile activity of the human sigmoid colon as well as on bowel habits and stool cons...

journal_title：British journal of clinical pharmacology

authors： Stacher G,Weber U,Stacher-Janotta G,Bauer P,Huber K,Holzäpfel A,Krause G,Steinborn C

更新日期：2000-05-01 00:00:00

abstract：:1. The conversion of haloperidol (HAL) to reduced haloperidol (RHAL) and then back to HAL has been established in vivo and observed in psychiatric patients. The reduction of HAL to RHAL is known to be catalysed by a ketone reductase, while the nature of oxidation back to HAL is the subject of the present study. 2. We ...

journal_title：British journal of clinical pharmacology

authors： Tyndale RF,Kalow W,Inaba T

更新日期：1991-06-01 00:00:00

abstract：:There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of ca...

journal_title：British journal of clinical pharmacology

authors： Yang L,Mäki-Petäjä K,Cheriyan J,McEniery C,Wilkinson IB

更新日期：2015-07-01 00:00:00

abstract：:1. We have measured [3H]-ouabain binding to lymphocyte membranes in eight healthy volunteers before and after they had taken lithium carbonate for 14 days in doses which maintained the serum lithium concentration in the range 0.5-1.0 mmol 1-1. 2. There was a statistically significant increase in the [3H]-ouabain bindi...

journal_title：British journal of clinical pharmacology

authors： Antia IJ,Dorkins CE,Wood AJ,Aronson JK

更新日期：1992-12-01 00:00:00

abstract：:1 Cardiovascular responses to intravenous prizidilol hydrochloride (SK&F 92657) 0.86 mg/kg were studied in eight supine resting healthy volunteers. Five subjects were slow and the remaining three were fast acetylators of sulphamethazine. Compared with pre-infusion values, mean resting systolic and diastolic blood pres...

journal_title：British journal of clinical pharmacology

authors： Edmonstone WM,Manghani KK,Bell AJ,McLeod M,Milton-Thompson GJ,Burland WL

更新日期：1981-10-01 00:00:00

abstract：AIMS:The Transdermal Delivery System (TDS) is a liquid formulation that can be applied to the skin via a metered pump spray to deliver drug to the systemic circulation. The aims of this study were to assess the ability of the TDS preparation to deliver testosterone systemically, and to characterize the pharmacokinetic ...

journal_title：British journal of clinical pharmacology

authors： Chik Z,Johnston A,Tucker AT,Chew SL,Michaels L,Alam CA

更新日期：2006-03-01 00:00:00

abstract：AIMS:Changes in serotonergic sensory modulation associated with overexpression of 5-HT3 receptors in the central nervous system (CNS) have been implicated in the pathophysiology of neuropathic pain after peripheral nerve damage. 5-HT3 receptor antagonists such as ondansetron can potentially alleviate neuropathic pain, ...

journal_title：British journal of clinical pharmacology

authors： Chiang MD,Frey K,Lee C,Kharasch ED,Tallchief D,Sawyer C,Blood J,Back H,Kagan L,Haroutounian S

更新日期：2020-06-04 00:00:00

abstract：:Highly active antiretroviral therapy is recommended for HIV-infected pregnant women to prevent mother-to-child transmission. The specific physiological background induced by pregnancy leads to significant changes in maternal pharmacokinetics, suggesting potential variability in plasma concentrations of antiretrovirals...

journal_title：British journal of clinical pharmacology

authors： Roustit M,Jlaiel M,Leclercq P,Stanke-Labesque F

更新日期：2008-08-01 00:00:00

abstract：:A method is described for the simultaneous determination of amodiaquine (AQ) and desethylamodiaquine (AQm) in plasma, urine, whole blood and packed red cells. After oral administration of AQ (600 mg) to seven healthy subjects, absorption of AQ was rapid, reaching peak concentrations in plasma, whole blood, and packed ...

journal_title：British journal of clinical pharmacology

authors： Winstanley P,Edwards G,Orme M,Breckenridge A

更新日期：1987-01-01 00:00:00

abstract：:Plasma and synovial fluid concentrations of the enantiomers of flurbiprofen were measured in 15 rheumatoid patients receiving 100 mg racemic flurbiprofen twice daily. Pharmacokinetic parameters showed considerable variability within the group of patients, although differences in S(+)/R(-) plasma concentration ratios w...

journal_title：British journal of clinical pharmacology

authors： Young MA,Aarons L,Toon S

更新日期：1991-01-01 00:00:00

abstract：:1. The effects of heart failure due to chronic myocardial infarction on the responsiveness to injected angiotensin I and ACE inhibition by intravenous cilazapril (1 mg kg-1) were evaluated. 2. For this purpose one group of 17 rats with a 4-week old myocardial infarction was compared with a group of 10 sham operated ra...

journal_title：British journal of clinical pharmacology

authors： Clozel JP

更新日期：1989-01-01 00:00:00

abstract：:The pharmacokinetics of L-tryptophan (5 g and 7.5 g) have been studied after its intravenous administration to healthy subjects and the results compared with those obtained after oral administration (0.7 g-3.5 g). In order to do this, we have re-analysed previously published data relating to oral administration. The d...

journal_title：British journal of clinical pharmacology

authors： Green AR,Aronson JK,Cowen PJ

更新日期：1985-10-01 00:00:00

abstract：AIMS:Ibandronate, a highly potent nitrogen-containing bisphosphonate, is the subject of an ongoing clinical development programme that aims to maximize the potential of simplified, less frequent oral and intravenous (i.v.) administration in osteoporosis. A modelling and simulation project was undertaken to characterize...

journal_title：British journal of clinical pharmacology

authors： Pillai G,Gieschke R,Goggin T,Jacqmin P,Schimmer RC,Steimer JL

更新日期：2004-12-01 00:00:00

abstract：:1 A single-blind randomized study of the effects of a beta-adrenoceptor antagonist with intrinsic sympathomimetic activity (pindolol 0.4 mg i.v., n = 10) and a drug lacking this property (metoprolol 5 mg i.v., n = 11) on local wall motion abnormalities was carried out in 21 patients with coronary heart disease and ant...

journal_title：British journal of clinical pharmacology

authors： Gleichmann U,Fassbender D,Trieb G,Mannebach H,Ohlmeier H

更新日期：1982-01-01 00:00:00

abstract：AIMS:To investigate the extent of dose-related off-label antibiotic paediatric prescribing in primary care and to identify any potential clinical effects, particularly of lower than recommended dose prescribing. METHODS:Assessment of antibiotic prescribing in 168 396 children aged 0-16 years for the year 1999-2000 fro...

journal_title：British journal of clinical pharmacology

authors： Ekins-Daukes S,McLay JS,Taylor MW,Simpson CR,Helms PJ

更新日期：2003-07-01 00:00:00

abstract：:Serum free fractions of nifedipine, verapamil and some of their metabolites were measured in patients with ischaemic heart disease receiving single oral dose and chronic monotherapy and were compared with those obtained in vitro. The percentages of unbound nifedipine and verapamil in vitro (concentration range 50-200 ...

journal_title：British journal of clinical pharmacology

authors： Rumiantsev DO,Piotrovskii VK,Metelitsa VI,Slastnikova ID,Martsevich SYu,Kokurina EV

更新日期：1989-09-01 00:00:00

abstract：AIMS:The aim of the present study was to assess the effect of policy interventions - i.e. reimbursement decisions, guidelines and regional recommendations - on the prescribing of oral anticoagulant treatment in patients with atrial fibrillation (AF). METHODS:Interrupted time series analyses were carried out using mont...

journal_title：British journal of clinical pharmacology

authors： Komen J,Forslund T,Hjemdahl P,Andersen M,Wettermark B

更新日期：2017-03-01 00:00:00