Plasma and cerebrospinal fluid pharmacokinetics of ondansetron in humans.

abstract：:Using a variety of radioimmunoassay methods, plasma digoxin concentrations were measured in two patients before and after the administration of ovine Fab antibody fragments to remove the effects of digoxin. Gross method-dependent anomalies in the results due to in vitro drug interaction were observed. More widespread ...

journal_title：British journal of clinical pharmacology

authors： Gibb I,Adams PC,Parnham AJ,Jennings K

更新日期：1983-10-01 00:00:00

abstract：AIMS:Aprepitant and fosaprepitant, commonly used for the prevention of chemotherapy-induced nausea and vomiting, alter cytochrome P450 activity. This systematic review evaluates clinically significant pharmacokinetic drug interactions with aprepitant and fosaprepitant and describes adverse events ascribed to drug inter...

journal_title：British journal of clinical pharmacology

authors： Patel P,Leeder JS,Piquette-Miller M,Dupuis LL

更新日期：2017-10-01 00:00:00

abstract：AIMS:Previously published pharmacokinetic (PK) models for sunitinib and its active metabolite SU12662 were based on a limited dataset or lacked important elements such as correlations between sunitinib and its metabolite. The current study aimed to develop an improved PK model that circumvented these limitations and to...

journal_title：British journal of clinical pharmacology

authors： Yu H,Steeghs N,Kloth JS,de Wit D,van Hasselt JG,van Erp NP,Beijnen JH,Schellens JH,Mathijssen RH,Huitema AD

更新日期：2015-05-01 00:00:00

abstract：AIMS:The aim of this work is to understand the process of drug administration and identify points in the workflow that resulted in interventions by clinical information systems in order to improve patient safety. METHODS:To identify a generic way to structure the drug administration process we performed peer-group dis...

journal_title：British journal of clinical pharmacology

authors： Seidling HM,Lampert A,Lohmann K,Schiele JT,Send AJ,Witticke D,Haefeli WE

更新日期：2013-09-01 00:00:00

abstract：:Cefpiramide is a new parenteral cephalosporin mainly excreted in the bile. Eight patients with cholestasis and 11 healthy subjects received a single 1 g i.v. dose. Cefpiramide concentrations in plasma and urine were measured by h.p.l.c. and plasma binding was determined by ultrafiltration. Total clearance of cefpirami...

journal_title：British journal of clinical pharmacology

authors： Demontes-Mainard F,Vinçon G,Labat L,Amouretti M,Necciari J,Kieffer G,Bannwarth B

更新日期：1994-03-01 00:00:00

abstract：:Since hepatic clearance of ICG is reduced by H2-receptor antagonists in normal subjects, it has been suggested that they reduce liver blood flow. We have studied the effect of intravenous ranitidine on ICG clearance in twelve patients with chronic liver disease. Wedged and free hepatic venous pressure were measured be...

journal_title：British journal of clinical pharmacology

authors： Dunk AA,Jenkins WJ,Burroughs AK,Walt RP,Osuafor TO,Sherlock S,Mackie S,Dick R

更新日期：1983-08-01 00:00:00

abstract：AIMS:A multistudy analysis of cediranib, a potent, selective inhibitor of all three vascular endothelial growth factor receptors (VEGFR-1, -2 and -3), was conducted to establish population exposure-safety models for the relationship of cediranib exposure to the safety endpoints, diastolic and systolic blood pressure (D...

journal_title：British journal of clinical pharmacology

authors： Al-Huniti N,Petersson K,Tang W,Masson E,Li J

更新日期：2018-04-01 00:00:00

abstract：:Serum and milk concentrations of aztreonam were studied in 12 lactating, healthy subjects over the 8 h period after the administration of a single intramuscular or intravenous 1 g dose. Milk concentrations of aztreonam were found to be much lower than serum concentrations at all time points after both routes of inject...

journal_title：British journal of clinical pharmacology

authors： Fleiss PM,Richwald GA,Gordon J,Stern M,Frantz M,Devlin RG

更新日期：1985-04-01 00:00:00

abstract：:1. N-hydroxylation is thought to be an essential step in the haemotoxicity of dapsone (DDS). To investigate both metabolism-dependent and cell-selective drug toxicity in vitro we have developed a three-compartment system in which an hepatic drug metabolizing system is contained within a central compartment separated b...

journal_title：British journal of clinical pharmacology

authors： Tingle MD,Park BK

更新日期：1993-07-01 00:00:00

abstract：AIMS:The aim was to examine relationships between total and unbound mycophenolic acid (MPA) and prednisolone exposure and clinical outcomes in patients with lupus nephritis. METHODS:Six blood samples were drawn pre- and at 1, 2, 4, 6 and 8 h post-dose and total and unbound MPA and prednisolone pre-dose (C0 ), maximum ...

journal_title：British journal of clinical pharmacology

authors： Abd Rahman AN,Tett SE,Abdul Gafor HA,McWhinney BC,Staatz CE

更新日期：2015-11-01 00:00:00

abstract：AIMS:To characterize determinants of the elimination of methotrexate (MTX) and 7-hydroxy-methotrexate (7-OH-MTX) in patients receiving high-dose MTX therapy (HDMTX). METHODS:24 and 48-h blood samples from 76 patients receiving HDMTX (dose range 300 mg m-2 to 12 g m-2) were analysed, and concentration-time data were su...

journal_title：British journal of clinical pharmacology

authors： Joerger M,Huitema AD,van den Bongard HJ,Baas P,Schornagel JH,Schellens JH,Beijnen JH

更新日期：2006-07-01 00:00:00

abstract：:Although blood pressure measured at the brachial artery plays a central role in our understanding and management of cardiovascular risk, in recent years great emphasis has been placed on the importance of central blood pressure. It seems straightforward that knowledge of the blood pressure directly affecting the major...

journal_title：British journal of clinical pharmacology

authors： Tomlinson LA,Wilkinson IB

更新日期：2012-08-01 00:00:00

abstract：:The effects of single doses of anhydrous caffeine (250 mg and 500 mg) and placebo on physiological, psychological measures and subjective feelings were studied in a double-blind, cross-over study in nine healthy subjects who had abstained from caffeine-containing beverages for 24 h before each occasion. Caffeine and c...

journal_title：British journal of clinical pharmacology

authors： Bruce M,Scott N,Lader M,Marks V

更新日期：1986-07-01 00:00:00

abstract：AIMS:To study the potential drug interaction between cimetidine and caffeine in a group of children who received cimetidine for gastritis. METHODS:The caffeine breath test was carried out prior to the administration of cimetidine and after 2-3 weeks therapy. The children (n = 1) received 300-800 mg cimetidine daily (1...

journal_title：British journal of clinical pharmacology

authors： Parker AC,Pritchard P,Preston T,Dalzell AM,Choonara I

更新日期：1997-05-01 00:00:00

abstract：:In a dog model of partial myocardial ischaemia, superimposed ST segment elevations in epicardial ECGs were inhibited by nicardipine over a cumulative i.v. dose range of 1-20 micrograms kg-1. Over the cumulative i.v. dose range of 0.5-166.5 micrograms kg-1, nicardipine had little overall effect on gross cardiac conduct...

journal_title：British journal of clinical pharmacology

authors： Alps BJ,Calder C,Wilson A

更新日期：1985-01-01 00:00:00

abstract：AIMS:To explore longitudinal changes in the number and type of medicines used among older people who experience polypharmacy. METHODS:We used pharmaceutical claims for a 10% sample of Australian Pharmaceutical Benefits Scheme beneficiaries to identify people aged 70 years and older who were exposed to 5 or more medici...

journal_title：British journal of clinical pharmacology

authors： Falster MO,Charrier R,Pearson SA,Buckley NA,Daniels B

更新日期：2020-07-31 00:00:00

abstract：:1 The absorption of effervescent aspirin was studied in normal volunteers of both sexes under varied conditions of activity in both fasting and non-fasting states. 2 Moderate activity resulted in no significant changes in absorption compared with that at rest. 3 In non-fasting subjects the absorption was reduced but t...

journal_title：British journal of clinical pharmacology

authors： Volans GN

更新日期：1974-04-01 00:00:00

abstract：AIMS:To investigate the extent of concomitant use of analgesic and psychotropic medicines among home-dwelling elderly people aged at least 75 years in Finland. METHODS:This was a population-based study in Finland, performed as part of Kuopio 75 + study focusing on the clinical epidemiology of diseases, medication and ...

journal_title：British journal of clinical pharmacology

authors： Hartikainen S,Mäntyselkä P,Louhivuori-Laako K,Enlund H,Sulkava R

更新日期：2005-09-01 00:00:00

abstract：:The pharmacokinetics of four sustained-release formulations of theophylline have been examined after single doses (Nuelin SA, Phyllocontin, Slo-phyllin and Theo-Dur) and at steady-state (Phyllocontin, Theo-Dur) in six healthy adult volunteers, selected because they all eliminated theophylline rapidly after an intraven...

journal_title：British journal of clinical pharmacology

authors： Mucklow JC,Kuhn S

更新日期：1985-12-01 00:00:00

abstract：:In a randomised crossover study in volunteers plasma midazolam levels were estimated for 24 h following 15 mg by mouth, either preceded by no medication or following 24 h therapy with ranitidine. Administration of the H2-receptor blocker significantly increased bioavailability of the benzodiazepine and resulted in hig...

journal_title：British journal of clinical pharmacology

authors： Elwood RJ,Hildebrand PJ,Dundee JW,Collier PS

更新日期：1983-06-01 00:00:00

abstract：AIMS:To develop a population pharmacokinetic model for mycophenolic acid (MPA) in children with idiopathic nephrotic syndrome (INS) treated with mycophenolate mofetil (MMF), identify covariates that explain variability and determine the Bayesian estimator of the area under the concentration-time curve over 12 h (AUC(0-...

journal_title：British journal of clinical pharmacology

authors： Zhao W,Elie V,Baudouin V,Bensman A,André JL,Brochard K,Broux F,Cailliez M,Loirat C,Jacqz-Aigrain E

更新日期：2010-04-01 00:00:00

abstract：AIMS:Aldosterone has been found to influence cancer cell growth, cell cycle regulation and cell migration, including in prostate cancer cells. Spironolactone is an aldosterone antagonist used for managing chronic heart failure (HF) with known antiandrogenic effects. We examined the effect of spironolactone exposure amo...

journal_title：British journal of clinical pharmacology

authors： Hiebert BM,Janzen BW,Sanjanwala RM,Ong AD,Feldman RD,Kim JO

更新日期：2020-09-28 00:00:00

abstract：AIMS:The present pharmacokinetic study was undertaken to determine the dose proportionality of three different doses of budesonide-400 microg, 800 microg or 1600 microg administered twice daily by a dry-powder inhaler (Turbuhaler ) in adult patients with mild asthma. METHODS:A total of 38 patients received budesonide ...

journal_title：British journal of clinical pharmacology

authors： Kaiser H,Aaronson D,Dockhorn R,Edsbäcker S,Korenblat P,Källén A

更新日期：1999-09-01 00:00:00

abstract：:The pharmacokinetic behaviour and the bioavailability of midazolam were investigated in six volunteers after intravenous (0.15 mg/kg) and oral administration (10, 20 and 40 mg). Following rapid intravenous injection of midazolam, the plasma concentration of the substance decreased to approximately 10% within 2 h owing...

journal_title：British journal of clinical pharmacology

authors： Heizmann P,Eckert M,Ziegler WH

更新日期：1983-01-01 00:00:00

abstract：AIM:Lamivudine is used as first line therapy in HIV-infected children. Yet, like many other paediatric drugs, its dose rationale has been based on limited clinical data, without thorough understanding of the effects of growth on drug disposition. Here we use lamivudine to show how a comprehensive population pharmacokin...

journal_title：British journal of clinical pharmacology

authors： Piana C,Zhao W,Adkison K,Burger D,Jacqz-Aigrain E,Danhof M,Della Pasqua O

更新日期：2014-05-01 00:00:00

abstract：:1. The effect of icatibant (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8] bradykinin) a potent B2-kinin receptor antagonist, was studied on bradykinin-induced vasodilation in the human forearm. 2. Eight healthy normotensive men were studied in a rising dose random-placebo controlled study. Placebo and icatibant (20, 50 and 100 mic...

journal_title：British journal of clinical pharmacology

authors： Cockcroft JR,Chowienczyk PJ,Brett SE,Bender N,Ritter JM

更新日期：1994-10-01 00:00:00

abstract：:1. The pharmacokinetics of physostigmine were investigated in a three-way cross-over design in six healthy, male volunteers comparing a physostigmine transdermal system (PTS), an oral solution and an i.v. infusion. 2. A single application of the patch over 24 h produced detectable plasma drug concentrations after a me...

journal_title：British journal of clinical pharmacology

authors： Walter K,Müller M,Barkworth MF,Nieciecki AV,Stanislaus F

更新日期：1995-01-01 00:00:00

abstract：:The pharmacokinetics of CGP 15 210 G, a new 5-HT uptake inhibitor in poor and extensive metabolisers of debrisoquine, give indirect evidence of an association between its metabolism and polymorphic hydroxylation of the debrisoquine type. ...

journal_title：British journal of clinical pharmacology

authors： Gleiter CH,Aichele G,Nilsson E,Hengen N,Antonin KH,Bieck PR

更新日期：1985-07-01 00:00:00

abstract：AIMS:To determine whether and to what extent bronchoconstriction affects plasma concentrations of fluticasone and budesonide following inhalation. METHODS:Twenty people with mild asthma inhaled 1000 microg fluticasone (Accuhaler) plus 800 microg budesonide (Turbohaler) on two visits. On one occasion, prior to drug inh...

journal_title：British journal of clinical pharmacology

authors： Mortimer KJ,Tattersfield AE,Tang Y,Wu K,Lewis S,Hochhaus G,Harrison TW

更新日期：2007-10-01 00:00:00

abstract：:The disposition and effect of orally administered prazosin have been studied in eight women with hypertension which was uncontrolled by beta-adrenoceptor blockade during the last trimester of pregnancy. Results were compared with healthy men of similar age. The median time to peak concentration was 165 min during preg...

journal_title：British journal of clinical pharmacology

authors： Rubin PC,Butters L,Low RA,Reid JL

更新日期：1983-11-01 00:00:00