Public health impact of adverse bone effects of oral corticosteroids.

abstract：:1. The effect of neuropeptide Y (NPY) on cardiovascular function at three levels of the noradrenergic axis where the peptide is known to co-exist with noradrenaline (NA) and or adrenaline (A) was studied in normotensive Sprague-Dawley (SD), Wistar-Kyoto (WKY) or spontaneously hypertensive rats (SHR). 2. In the perfuse...

journal_title：British journal of clinical pharmacology

authors： Westfall TC,Han SP,Knuepfer M,Martin J,Chen XL,del Valle K,Ciarleglio A,Naes L

更新日期：1990-01-01 00:00:00

abstract：AIMS:To predict the drug interactions of amiodarone and other drugs, the inhibitory effects and inactivation potential for human cytochrome P450 (CYP) enzymes by amiodarone and its N-dealkylated metabolite, desethylamiodarone were examined. METHODS:The inhibition or inactivation potency of amiodarone and desethylamiod...

journal_title：British journal of clinical pharmacology

authors： Ohyama K,Nakajima M,Suzuki M,Shimada N,Yamazaki H,Yokoi T

更新日期：2000-03-01 00:00:00

abstract：:1 The new converting enzyme inhibitor RHC 3659 was tested in 15 male volunteers. The study consisted of two parts: first, the ability of a single oral dose (5, 10, 20, 40 or 80 mg) to inhibit the pressor response to exogenous angiotensin I was tested with blood pressure and heart rate monitored continuously through an...

journal_title：British journal of clinical pharmacology

authors： Burnier M,Turini GA,Brunner HR,Porchet M,Kruithof D,Vukovich RA,Gavras H

更新日期：1981-12-01 00:00:00

abstract：AIMS:Antithrombin is increasingly used in paediatric patients, yet there are few age-specific pharmacokinetic data to guide dosing. We aimed to describe the pharmacokinetic profile of human (plasma-derived) antithrombin concentrate in paediatric patients. METHODS:A 5-year retrospective review was performed of patients...

journal_title：British journal of clinical pharmacology

authors： Moffett BS,Diaz R,Galati M,Mahoney D,Teruya J,Yee DL

更新日期：2017-11-01 00:00:00

abstract：:After oral administration of 100 mg dapsone (DDS) to 25 healthy volunteers peak serum DDS concentrations between 1.10 and 2.33 mg l-1 were reached within 0.5 to 4 h. AUCs varied from 20.3 to 75.4 mg l-1 h, while the elimination half-lives ranged from 11.5 to 29.2 h. The apparent volumes of distribution were 0.84 to 1....

journal_title：British journal of clinical pharmacology

authors： Pieters FA,Zuidema J

更新日期：1986-10-01 00:00:00

abstract：:It is recognised that randomised controlled trials are not feasible for capturing rare adverse events. There is an increasing trend towards observational research methodologies using large population-based health databases. These databases offer more scope for adequate sample sizes, allowing for comprehensive patient ...

journal_title：British journal of clinical pharmacology

authors： Chan EW,Liu KQ,Chui CS,Sing CW,Wong LY,Wong IC

更新日期：2015-10-01 00:00:00

abstract：AIM:Pharmacokinetics of small molecule kinase inhibitors (KIs) used in cancer treatment may alter with increasing age, but results are conflicting. This study aims to compare exposure to KIs between older and younger patients (≥70 and <70 years) in clinical practice. METHODS:KI plasma concentrations of routinely treat...

journal_title：British journal of clinical pharmacology

authors： Crombag MBS,van Doremalen JGC,Janssen JM,Rosing H,Schellens JHM,Beijnen JH,Steeghs N,Huitema ADR

更新日期：2018-12-01 00:00:00

abstract：:1 The concentrations of cyclophosphamide in plasma and saliva were determined in seven patients following administration of single doses of cyclophosphamide during chemotherapy for lymphoma. 2 The saliva/plasma ratio was 0.77 +/- 0.24 (s.d.) and showed no time-dependence being rapidly established following intravenous...

journal_title：British journal of clinical pharmacology

authors： Juma FD,Rogers HJ,Trounce JR

更新日期：1979-11-01 00:00:00

abstract：AIM:To investigate the effect of sepsis upon the volume of distribution (Vd) of gentamicin in neonates. METHODS:A retrospective chart review was conducted of neonates admitted to Dunedin Hospital who had gentamicin concentrations performed between 1st January 2000 and 30th October 2003. Data from 277 neonates, includi...

journal_title：British journal of clinical pharmacology

authors： Lingvall M,Reith D,Broadbent R

更新日期：2005-01-01 00:00:00

abstract：:The airway and cardiovascular effects of intravenous neurokinin A (NKA) and substance P (SP) were compared in six normal subjects. Both SP and NKA increased skin temperature (SkT) and heart rate (HR), but SP was more potent than NKA by factors of 6 and 20 respectively. No change in systolic blood pressure (BP) occurre...

journal_title：British journal of clinical pharmacology

authors： Evans TW,Dixon CM,Clarke B,Conradson TB,Barnes PJ

更新日期：1988-02-01 00:00:00

abstract：AIMS:Surgical site infections contribute to morbidity and mortality after surgery. The authors hypothesized that higher antibiotic tissue concentrations can be reached for a prolonged time span by continuous administration of prophylactic cefuroxime compared to bolus administration. METHODS:Twelve patients undergoing ...

journal_title：British journal of clinical pharmacology

authors： Skhirtladze-Dworschak K,Hutschala D,Reining G,Dittrich P,Bartunek A,Dworschak M,Tschernko EM

更新日期：2019-04-01 00:00:00

abstract：:1 Cimetidine has been reported to reduce serum calcium and parathyroid hormone (PTH) levels in primary hyperparathyroidism, but some studies have reported negative findings. 2 A double-blind, controlled trial of cimetidine in this condition was, therefore, conducted. Eight patients were given cimetidine and placebo fo...

journal_title：British journal of clinical pharmacology

authors： Fisken RA,Wilkinson R,Heath DA

更新日期：1982-11-01 00:00:00

abstract：:1. We have tested the hypothesis that the fall in hepatic mass with age influences the age related increase in sensitivity to warfarin. In 39 otherwise healthy outpatients, aged 50-87 years, stabilised on warfarin for prophylaxis of thromboembolism, age, mean International Normalised Ratio (INR), and mean warfarin dos...

journal_title：British journal of clinical pharmacology

authors： Wynne H,Cope L,Kelly P,Whittingham T,Edwards C,Kamali F

更新日期：1995-09-01 00:00:00

abstract：:1. The purpose of this study was to determine the effects of cardiac output on distribution and elimination kinetics of the marker compound sorbitol. 2. The disposition kinetics of sorbitol were investigated after rapid intravenous injection and arterial sampling in nine patients who had undergone cardiac catheterizat...

journal_title：British journal of clinical pharmacology

authors： Weiss M,Hübner GH,Hübner IG,Teichmann W

更新日期：1996-04-01 00:00:00

abstract：:In order to elucidate the mechanisms by which beta-adrenoceptor blockade leads to a reduction in portal pressure, we have measured portal pressure, heart rate and cardiac index in 17 patients with cirrhosis and portal hypertension following the oral administration of the selective beta 2-adrenoceptor blocking agent, I...

journal_title：British journal of clinical pharmacology

authors： Bihari D,Westaby D,Gimson A,Crossley I,Harry J,Williams R

更新日期：1984-06-01 00:00:00

abstract：AIMS:In experimental studies, morphine pharmacokinetics is different in the brain compared with other tissues due to the properties of the blood-brain barrier, including action of efflux pumps. It was hypothesized in this clinical study that active efflux of morphine occurs also in human brain, and that brain injury wo...

journal_title：British journal of clinical pharmacology

authors： Ederoth P,Tunblad K,Bouw R,Lundberg CJ,Ungerstedt U,Nordström CH,Hammarlund-Udenaes M

更新日期：2004-04-01 00:00:00

abstract：:The effect of isotonic bicycle exercise on beta 2-adrenoceptors and cAMP production in lymphocytes was studied. The origin of the newly exposed receptors was studied by measuring radioligand binding in the presence of hydrophylic or lipophylic 'cold' ligands. During exercise beta 2-adrenoceptor density increased from ...

journal_title：British journal of clinical pharmacology

authors： Graafsma SJ,van Tits LJ,Willems PH,Hectors MP,Rodrigues de Miranda JF,De Pont JJ,Thien T

更新日期：1990-01-01 00:00:00

abstract：:The influence of cimetidine pretreatment on the pharmacokinetics of 5-fluorouracil (5FU) has been studied in 15 ambulant patients with carcinoma. Neither pretreatment with a single dose of cimetidine (400 mg) nor with daily treatment at 1000 mg for 1 week altered 5FU pharmacokinetics. Pretreatment with cimetidine for ...

journal_title：British journal of clinical pharmacology

authors： Harvey VJ,Slevin ML,Dilloway MR,Clark PI,Johnston A,Lant AF

更新日期：1984-09-01 00:00:00

abstract：AIMS:The aim of this study was to compare the effects of the ACE-inhibitor lisinopril and the angiotensin II receptor antagonist losartan on insulin sensitivity in the treatment of non diabetic hypertensives. METHODS:Twenty-five non diabetic subjects with mild to moderate hypertension, 11 females and 14 males, aged 44...

journal_title：British journal of clinical pharmacology

authors： Fogari R,Zoppi A,Corradi L,Lazzari P,Mugellini A,Lusardi P

更新日期：1998-11-01 00:00:00

abstract：:1 Evidence concerning the convulsant effects of non-monoamine oxidase inhibitor antidepressant drugs has been reviewed. 2 Mianserin is convulsant in therapeutic doses but seizures have not been reported following overdose. 3 The convulsant effects of mianserin are probably no greater than for other non-monoamine oxida...

journal_title：British journal of clinical pharmacology

authors： Richens A,Nawishy S,Trimble M

更新日期：1983-01-01 00:00:00

abstract：:The effects of single oral doses of atenolol 50 mg and xamoterol 200 mg (a recently developed partial beta 1-adrenoceptor agonist) on lung function, heart rate and blood pressure were investigated in 11 patients with asthma. Xamoterol caused a significant increase in heart rate and systolic blood pressure, which chang...

journal_title：British journal of clinical pharmacology

authors： Lammers JW,Müller ME,Folgering HT,van Herwaarden CL

更新日期：1986-11-01 00:00:00

abstract：:A single oral dose of sotalol (160 mg) was administered to control subjects with normal renal function and patients with chronic renal failure in the interdialysis period to estimate the elimination kinetics of the drug. Sotalol concentrations in body fluids were measured fluorimetrically using a modified Garrett and ...

journal_title：British journal of clinical pharmacology

authors： Tjandramaga TB,Verbeeck R,Thomas J,Verbesselt R,Verberckmoes R,Schepper PJ

更新日期：1976-04-01 00:00:00

abstract：:The thermogenic beta 3-adrenoceptor agonist BRL 26830A has been shown to increase weight loss in dieting subjects but tremor was a frequent adverse effect. We have investigated the magnitude and nature of this tremor after a single oral dose in 18 subjects. Two complementary techniques were used to attach the recordin...

journal_title：British journal of clinical pharmacology

authors： Connacher AA,Lakie M,Powers N,Elton RA,Walsh EG,Jung RT

更新日期：1990-10-01 00:00:00

abstract：AIMS:The efflux transporter P-glycoprotein (ABCB1) acts at the blood-brain barrier (BBB) to restrict the distribution of many different drugs from blood to the brain. Previous data suggest an age-associated decrease in the expression and function of ABCB1 at the BBB. In the present study, we investigated the influence ...

journal_title：British journal of clinical pharmacology

authors： Bauer M,Wulkersdorfer B,Karch R,Philippe C,Jäger W,Stanek J,Wadsak W,Hacker M,Zeitlinger M,Langer O

更新日期：2017-09-01 00:00:00

abstract：AIMS:Vancomycin is an important antibiotic for critically ill patients with Gram-positive bacterial infections. Critically ill patients typically have severely altered pathophysiology, which leads to inefficacy or toxicity. Model-informed precision dosing may aid in optimizing the dose, but prospectively validated tool...

journal_title：British journal of clinical pharmacology

authors： Ter Heine R,Keizer RJ,van Steeg K,Smolders EJ,van Luin M,Derijks HJ,de Jager CPC,Frenzel T,Brüggemann R

更新日期：2020-12-01 00:00:00

abstract：:1 The relationship between serum theophylline concentration and daily dose was studied in 45 patients receiving aminophylline orally and in 36 patients receiving it by constant intravenous infusion. 2 Patients were categorized as uncomplicated chronic obstructive pulmonary disease (COPD) or COPD with cor pulmonale (...

journal_title：British journal of clinical pharmacology

authors： Vicuna N,McNay JL,Ludden TM,Schwertner H

更新日期：1979-01-01 00:00:00

abstract：:Ethanol aggravates benzodiazepine-induced central nervous depression by pharmacokinetic and/or pharmacodynamic interactions and Ro 15-1788 reverses promptly the hypnotic effects of benzodiazepines. We therefore studied the acute effects of Ro 15-1788 on the ethanol-induced sedation in six healthy male subjects. Subseq...

journal_title：British journal of clinical pharmacology

authors： Klotz U,Ziegler G,Rosenkranz B,Mikus G

更新日期：1986-11-01 00:00:00

abstract：:1 The effect of acebutolol, a relatively selective beta-adrenoceptor blocking drug and propranolol, a non-selective one, on the hypoglycaemic action of glibenclamide after an oral glucose load has been investigated in a group of maturity-onset diabetic patients. 2 Glibenclamide significantly reduced the blood glucose ...

journal_title：British journal of clinical pharmacology

authors： Zaman R,Kendall MJ,Biggs PI

更新日期：1982-04-01 00:00:00

abstract：AIMS:Inhaled corticosteroids alone or in combination with long acting beta2-agonists are indicated for use in mild persistent asthmatics. We set out to evaluate effects on airway hyperresponsiveness (AHR) and airway calibre using hydrofluoroalkane fluticasone/salmeterol (FP/SM) vs. double the dose of fluticasone alone ...

journal_title：British journal of clinical pharmacology

authors： Currie GP,Stenback S,Lipworth BJ

更新日期：2003-07-01 00:00:00

abstract：:1 Methimazole plasma concentrations were measured in two groups of hyperthyroid subjects after the oral administration of either carbimazole or methimazole. 2 With the HPLC method it was also possible to measure the concentration of a methimazole metabolite, 3-methyl-2-thiohydantoin in one patient. 3 Large interindivi...

journal_title：British journal of clinical pharmacology

authors： Skellern GG,Knight BI,Low CK,Alexander WD,McLarty DG,Kalk WJ

更新日期：1980-02-01 00:00:00