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Serum binding of nifedipine and verapamil in patients with ischaemic heart disease on monotherapy.

Abstract：

:Serum free fractions of nifedipine, verapamil and some of their metabolites were measured in patients with ischaemic heart disease receiving single oral dose and chronic monotherapy and were compared with those obtained in vitro. The percentages of unbound nifedipine and verapamil in vitro (concentration range 50-200 and 150-400 ng ml-1, respectively) were 2.51 and 7.23%, respectively, and did not differ from those found on monotherapy with these drugs (2.05 and 8.08%, respectively), and after single dosing. It is suggested that, during treatment with nifedipine or verapamil, their serum metabolites do not affect binding of the parent drugs to serum proteins.

journal_name

Br J Clin Pharmacol

journal_title

British journal of clinical pharmacology

authors

Rumiantsev DO,Piotrovskii VK,Metelitsa VI,Slastnikova ID,Martsevich SYu,Kokurina EV

doi

10.1111/j.1365-2125.1989.tb05438.x

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

357-61

issue

3

eissn

0306-5251

issn

1365-2125

journal_volume

28

pub_type

杂志文章

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