Association between SCN1A polymorphism and carbamazepine-resistant epilepsy.

abstract：AIMS:BG00010 is a protein in the glial cell line-derived neurotrophic factor (GDNF) family. It is a selective ligand for the GDNF family receptor alpha-3 (GFRα3) co-receptor that normalizes cellular changes resulting from damage or disease, and potentially alleviates neuropathic pain. The main objectives of this study ...

journal_title：British journal of clinical pharmacology

authors： Okkerse P,Hay JL,Versage E,Tang Y,Galluppi G,Ravina B,Verma A,Williams L,Aycardi E,Groeneveld GJ

更新日期：2016-07-01 00:00:00

abstract：AIM:To evaluate safety, tolerability and pharmacokinetics of oral PF-05190457, an oral ghrelin receptor inverse agonist, in healthy adults. METHODS:Single (SAD) and multiple ascending dose (MAD) studies were randomised, placebo-controlled, double-blind studies. Thirty-five healthy men (age 38.2 ± 10.4 years; body mass...

journal_title：British journal of clinical pharmacology

authors： Denney WS,Sonnenberg GE,Carvajal-Gonzalez S,Tuthill T,Jackson VM

更新日期：2017-02-01 00:00:00

abstract：AIMS:Recently, an apparent protective effect of statins against upper gastrointestinal bleeding (UGB) was postulated in a post hoc analysis of a randomized trial. We aimed to evaluate the effect of statin use on acute nonvariceal UGB alone or in combinations with low-dose aspirin and other antithrombotic drugs. METHOD...

journal_title：British journal of clinical pharmacology

authors： Gulmez SE,Lassen AT,Aalykke C,Dall M,Andries A,Andersen BS,Hansen JM,Andersen M,Hallas J

更新日期：2009-04-01 00:00:00

abstract：:1 Benzodiazepines are regarded as pure anxiolytics, and their value in the treatment of depression is controversial. Nevertheless, symptoms of anxiety and depression coexist in patients with endogenous or neurotic depression, and clinical trials indicate that depressed patients respond better to a benzodiazepine-tricy...

journal_title：British journal of clinical pharmacology

authors： Cassano GB,Conti L

更新日期：1981-01-01 00:00:00

abstract：:For people seeking treatment, the course of heroin addiction tends to be chronic and relapsing, and longer duration of treatment is associated with better outcomes. Heroin addiction is strongly associated with deviant behaviour and crime, and the objectives in treating heroin addiction have been a blend of humane supp...

journal_title：British journal of clinical pharmacology

authors： Bell J

更新日期：2014-02-01 00:00:00

abstract：:1 In a preliminary double-blind trial the effects of ephedrine and pseudoephedrine on the blood pressure and heart rate of resting healthy volunteers were compared. Ephedrine 60 or 90 mg were required to raise the diastolic blood pressure above 90 mmHg, whereas 210 or 240 mg pseudoephedrine were required to produce th...

journal_title：British journal of clinical pharmacology

authors： Drew CD,Knight GT,Hughes DT,Bush M

更新日期：1978-09-01 00:00:00

abstract：AIM:We encountered a case of fetal toxicity due to ductus arteriosus (DA) constriction in a 36-week pregnant woman who had applied multiple ketoprofen patches. The aim of the present study was to present the case and develop a model to predict quantitatively the fetal toxicity risk of transdermal administration of keto...

journal_title：British journal of clinical pharmacology

authors： Tanaka S,Kanagawa T,Momma K,Hori S,Satoh H,Nagamatsu T,Fujii T,Kimura T,Sawada Y

更新日期：2017-11-01 00:00:00

abstract：AIMS:Infection-induced inflammation is associated with adverse long-term outcomes in preterm infants. Pentoxifylline (PTX) is a candidate for adjunct immunomodulatory therapy in preterm infants with late-onset sepsis (LOS) and necrotizing enterocolitis (NEC), but pharmacokinetic data in this population are extremely li...

journal_title：British journal of clinical pharmacology

authors： Salman S,Hibbert J,Page-Sharp M,Manning L,Simmer K,Doherty DA,Patole S,Batty KT,Strunk T

更新日期：2019-01-01 00:00:00

abstract：:1 We have given fifteen healthy volunteers single doses of racemic (+/-)-propranolol orally (40 mg) and intravenously (5-10 mg) to find out how large the variation was of the ratio between (-)- and (+)-propranolol plasma levels in relation to that of total levels of propranolol and 4-hydroxypropranolol. 2 Total propra...

journal_title：British journal of clinical pharmacology

authors： Von Bahr C,Hermansson J,Tawara K

更新日期：1982-07-01 00:00:00

abstract：AIM:We compared the pharmacokinetic (PK) profiles of co-crystal of tramadol-celecoxib (CTC) vs. each reference product (alone and in open combination) after single (first dose) and multiple dosing. METHODS:Healthy adults aged 18-50 years received, under fasted conditions, 15 twice-daily doses of the following treatmen...

journal_title：British journal of clinical pharmacology

authors： Videla S,Lahjou M,Vaqué A,Sust M,Escriche M,Soler L,Sans A,Sicard E,Gascón N,Encina G,Plata-Salamán C

更新日期：2018-01-01 00:00:00

abstract：:1. To assess the risk of end-stage renal disease (ESRD) associated with the regular use of three classes of non-narcotic analgesics, we performed a case-control study of 340 patients with ESRD on a haemodialysis maintenance program and 673 hospital controls. 2. The overall odds ratio estimate for non-narcotic analgesi...

journal_title：British journal of clinical pharmacology

authors： Morlans M,Laporte JR,Vidal X,Cabeza D,Stolley PD

更新日期：1990-11-01 00:00:00

abstract：:1 The effect of labetalol has been assessed in an open clinical trial in 19 patients with sub-optimal control of blood pressure on other therapy, and in a placebo-controlled cross-over study. Most patients were taking a diuretic before the trial and they continued to do so during the trial. 2 In the open trial, labeta...

journal_title：British journal of clinical pharmacology

authors： Bolli P,Waal-Manning J,Wood AJ,Simpson FO

更新日期：1976-08-01 00:00:00

abstract：AIMS:The cytochrome P450 enzyme CYP2C9 catalyses the 4'-hydroxylation of the nonsteroidal analgesic drug diclofenac in humans. We studied the influences of the known amino acid variants, CYP2C9*2 (Arg144Cys) and CYP2C9*3 (Ile359Leu), on diclofenac pharmacokinetics after a 50-mg oral dose of diclofenac in healthy volunt...

journal_title：British journal of clinical pharmacology

authors： Kirchheiner J,Meineke I,Steinbach N,Meisel C,Roots I,Brockmöller J

更新日期：2003-01-01 00:00:00

abstract：:1 The clinical pharmacokinetics of the many benzodiazepines used to treat numerous and varied clinical conditions can be influenced by many factors. 2 Combinations of drugs efficacious in the central nervous system can change the onset, intensity and duration of effect as a result of pharmacological, physiological and...

journal_title：British journal of clinical pharmacology

authors： van der Kleijn E,Vree TB,Baars AM,Wijsman R,Edmunds LC,Knop HJ

更新日期：1981-01-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:• The CYP3A4 inhibition by lipophilic statins may attenuate the effectiveness of clopidogrel. • No studies have measured drug exposure in a time-varying manner that detects discontinuation and restart of clopidogrel and statin therapy, allowing clinical quantification of the int...

journal_title：British journal of clinical pharmacology

authors： Schmidt M,Johansen MB,Maeng M,Kaltoft A,Jensen LO,Tilsted HH,Bøtker HE,Baron JA,Sørensen HT

更新日期：2012-07-01 00:00:00

abstract：:1. In a double-blind placebo controlled four-way crossover study the effects and dose response relationships of xamoterol were studied in nine patients with angina and dyspnoea secondary to chronic left ventricular dysfunction. The duration of exercise on a treadmill and heart rate were measured at the end of each pha...

journal_title：British journal of clinical pharmacology

authors： Molajo AO,Bennett DH,Marlow HF,Snow HM,Bastain W

更新日期：1987-09-01 00:00:00

abstract：AIM:Drug-induced liver injury (DILI) is often responsible for acute liver failure, drug withdrawal, boxed warnings or drug non-approval. Therefore, we conducted a case-control study to determine the hepatotoxic risk of a wide range of drugs. METHODS:The Berlin Case-Control Surveillance Study FAKOS included all 51 Berl...

journal_title：British journal of clinical pharmacology

authors： Douros A,Bronder E,Andersohn F,Klimpel A,Thomae M,Sarganas G,Kreutz R,Garbe E

更新日期：2015-06-01 00:00:00

abstract：AIMS:To examine the influence of a pharmaceutical care programme on disease control and health-related quality of life in Type 2 diabetes patients in the United Arab Emirates. METHODS:A total of 240 Type 2 diabetes patients were recruited into a randomized, controlled, prospective clinical trial with a 12-month follow...

journal_title：British journal of clinical pharmacology

authors： Al Mazroui NR,Kamal MM,Ghabash NM,Yacout TA,Kole PL,McElnay JC

更新日期：2009-05-01 00:00:00

abstract：AIMS:Statins have been suggested to prevent haematological malignancies. Several epidemiological studies have evaluated this association, while randomized controlled trials (RCTs) on cardiovascular outcomes have provided relevant data as secondary end-points. Our aim was to examine the strength of this association thro...

journal_title：British journal of clinical pharmacology

authors： Bonovas S,Filioussi K,Tsantes A,Sitaras NM

更新日期：2007-09-01 00:00:00

abstract：AIMS:Endothelins (ETs) may play a role in the pathogenesis of a variety of cardiovascular diseases. The present study was designed to investigate the pharmacokinetic and pharmacodynamic effects of the orally active ETA selective receptor antagonist ABT-627 in healthy humans. METHODS:Healthy volunteers were included in...

journal_title：British journal of clinical pharmacology

authors： Verhaar MC,Grahn AY,Van Weerdt AW,Honing ML,Morrison PJ,Yang YP,Padley RJ,Rabelink TJ

更新日期：2000-06-01 00:00:00

abstract：:Studies were done to examine the influence of the menstrual cycle on the elimination kinetics of paracetamol. Salivary concentrations of paracetamol were determined after oral administration of 1 g of paracetamol on day 3, 10, 14, 20 and 25 of the menstrual cycle in normal healthy women volunteers with regular menstru...

journal_title：British journal of clinical pharmacology

authors： Somaja L,Thangam J

更新日期：1987-03-01 00:00:00

abstract：AIMS:Pravastatin is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, which is widely used both in primary and secondary prevention of coronary heart disease (CHD). Pravastatin is not subject to metabolism by cytochrome P450s, but it is actively transported from blood into target tissues (e.g. hepa...

journal_title：British journal of clinical pharmacology

authors： Zhang W,Chen BL,Ozdemir V,He YJ,Zhou G,Peng DD,Deng S,Xie QY,Xie W,Xu LY,Wang LC,Fan L,Wang A,Zhou HH

更新日期：2007-09-01 00:00:00

abstract：:1. The antitussive properties of bronchodilators were evaluated in a total of 47 normal volunteers. 2. Cough was induced by inhalation of ultrasonically nebulized solutions of distilled water and hypotonic saline. 3. Inhaled fenoterol hydrobromide (360 micrograms; 20 volunteers) and inhaled ipratropium bromide (72 mic...

journal_title：British journal of clinical pharmacology

authors： Lowry R,Higenbottam T,Johnson T,Godden D

更新日期：1987-10-01 00:00:00

abstract：:1 The relationship between serum theophylline concentration and daily dose was studied in 45 patients receiving aminophylline orally and in 36 patients receiving it by constant intravenous infusion. 2 Patients were categorized as uncomplicated chronic obstructive pulmonary disease (COPD) or COPD with cor pulmonale (...

journal_title：British journal of clinical pharmacology

authors： Vicuna N,McNay JL,Ludden TM,Schwertner H

更新日期：1979-01-01 00:00:00

abstract：AIMS:To investigate presence or absence of clinically relevant drug interactions (pharmacokinetic and safety/tolerability) of OBE022 with standard-of-care medicines for preterm labour, enabling coadministration and further clinical development. METHODS:Part A: open-label, randomized, 3-period crossover assessing coadm...

journal_title：British journal of clinical pharmacology

authors： Pohl O,Marchand L,Gotteland JP,Coates S,Täubel J,Lorch U

更新日期：2019-07-01 00:00:00

abstract：:Regulating drugs does not end when market access has been granted. Monitoring drugs over the life cycle has become state of the art, inherent to evolving legislation and societal need. Here, we explore how the drug label could move along in a changing playing-field and become a sustainable label for the future. A dial...

journal_title：British journal of clinical pharmacology

authors： Gispen-de Wied CC,Weemers J,Boon W,Mol PGM,Stolk P

更新日期：2019-10-01 00:00:00

abstract：:The steady-state pharmacokinetic interaction between nefazodone and cimetidine was evaluated in a three-period crossover study consisting of three treatments of 1 week duration with a 1 week washout between treatments. The 18 healthy, male study subjects received: nefazodone hydrochloride 200 mg twice daily (every 12 ...

journal_title：British journal of clinical pharmacology

authors： Barbhaiya RH,Shukla UA,Greene DS

更新日期：1995-08-01 00:00:00

abstract：:Mirabegron is used for the treatment of symptoms associated with overactive bladder syndrome. It selectively stimulates the β3 -adrenoreceptor, which relaxes the detrusor muscle. This improves urine storage by distension of the bladder body. ...

journal_title：British journal of clinical pharmacology

authors： Goulooze SC,Cohen AF,Rissmann R

更新日期：2015-10-01 00:00:00

abstract：AIM:To evaluate the efficacy of scopolamine administered transdermally for the treatment of drooling in severely disabled patients. METHODS:A prospective, randomized, double-blind, crossover, placebo-controlled clinical trial was designed. The study group consisted of 30 handicapped patients with persistent drooling. ...

journal_title：British journal of clinical pharmacology

authors： Mato A,Limeres J,Tomás I,Muñoz M,Abuín C,Feijoo JF,Diz P

更新日期：2010-06-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Recent studies on pharmacogenetics of warfarin have implicated apolipoprotein E (APOE) polymorphisms to influence the vitamin K dependent coagulation cascade and hence the efficacy of warfarin. Studies among Caucasian and African Americans showed a significant but conflicting ro...

journal_title：British journal of clinical pharmacology

authors： Lal S,Sandanaraj E,Jada SR,Kong MC,Lee LH,Goh BC,Lee SC,Chowbay B

更新日期：2008-02-01 00:00:00